EB-PRS is a novel method that leverages information for effect sizes across all the markers to improve the prediction accuracy. No parameter tuning is needed in the method, and no external information is needed. This R-package provides the calculation of polygenic risk scores from the given training summary statistics and testing data. We can use EB-PRS to extract main information, estimate Empirical Bayes parameters, derive polygenic risk scores for each individual in testing data, and evaluate the PRS according to AUC and predictive r2. See Song et al. (2020) <doi:10.1371/journal.pcbi.1007565> for a detailed presentation of the method.

This package provides tools for the analysis of epidemiological and surveillance data. Contains functions for directly and indirectly adjusting measures of disease frequency, quantifying measures of association on the basis of single or multiple strata of count data presented in a contingency table, computation of confidence intervals around incidence risk and incidence rate estimates and sample size calculations for cross-sectional, case-control and cohort studies. Surveillance tools include functions to calculate an appropriate sample size for 1- and 2-stage representative freedom surveys, functions to estimate surveillance system sensitivity and functions to support scenario tree modelling analyses.

This package provides tools for integrated sensitivity analysis of evidence factors in observational studies. When an observational study allows for multiple independent or nearly independent inferences which, if vulnerable, are vulnerable to different biases, we have multiple evidence factors. This package provides methods that respect type I error rate control. Examples are provided of integrated evidence factors analysis in a longitudinal study with continuous outcome and in a case-control study. Karmakar, B., French, B., and Small, D. S. (2019)<DOI:10.1093/biomet/asz003>.

Three functional modules, including genetic features, differential expression analysis and non-additive expression analysis were integrated into the package. And the package is suitable for RNA-seq and small RNA sequencing data. Besides, two methods of non-additive expression analysis were provided. One is the calculation of the additive (a) and dominant (d), the other is the evaluation of expression level dominance by comparing the total expression of the gene in hybrid offspring with the expression level in parents. For non-additive expression analysis of RNA-seq data, it is only applicable to hybrid offspring (including two sub-genomes) species for the time being.

An implementation for estimating Effective control to 50% of growth inhibition (EC50) for multi isolates and stratified datasets. It implements functions from the drc package in a way that is displayed a tidy data.frame as output. Info about the drc package is available in Ritz C, Baty F, Streibig JC, Gerhard D (2015) <doi:10.1371/journal.pone.0146021>.

This SVG elements generator can easily generate SVG elements such as rect, line, circle, ellipse, polygon, polyline, text and group. Also, it can combine and output SVG elements into a SVG file.

Extends the ergm.multi packages from the Statnet suite to fit (temporal) exponential-family random graph models for signed networks. The framework models positive and negative ties as interdependent, which allows estimation and testing of structural balance theory. The package also includes options for descriptive summaries, visualization, and simulation of signed networks. See Krivitsky, Koehly, and Marcum (2020) <doi:10.1007/s11336-020-09720-7> and Fritz, C., Mehrl, M., Thurner, P. W., & Kauermann, G. (2025) <doi:10.1017/pan.2024.21>.

Create causal models for use in epidemiological studies, including sufficient-component cause models as introduced by Rothman (1976) <doi:10.1093/oxfordjournals.aje.a112335>.

Constructing an epistemic model such that, for every player i and for every choice c(i) which is optimal, there is one type that expresses common belief in rationality.

This package provides a collection of fast and flexible functions for analyzing omics data in observational studies. Multiple different approaches for integrating multiple environmental/genetic factors, omics data, and/or phenotype data are implemented. This includes functions for performing omics wide association studies with one or more variables of interest as the exposure or outcome; a function for performing a meet in the middle analysis for linking exposures, omics, and outcomes (as described by Chadeau-Hyam et al., (2010) <doi:10.3109/1354750X.2010.533285>); and a function for performing a mixtures analysis across all omics features using quantile-based g-Computation (as described by Keil et al., (2019) <doi:10.1289/EHP5838>).

Maximum likelihood estimation of an extended class of row-column (RC) association models for two-dimensional contingency tables, which are formulated by a condition of reduced rank on a matrix of extended association parameters; see Forcina (2019) <arXiv:1910.13848>. These parameters are defined by choosing the logit type for the row and column variables among four different options and a transformation derived from suitable divergence measures.

An interface for performing climate matching using the Euclidean "Climatch" algorithm. Functions provide a vector of climatch scores (0-10) for each location (i.e., grid cell) within the recipient region, the percent of climatch scores >= a threshold value, and mean climatch score. Tools for parallelization and visualizations are also provided. Note that the floor function that rounds the climatch score down to the nearest integer has been removed in this implementation and the â Climatchâ algorithm, also referred to as the â Climateâ algorithm, is described in: Crombie, J., Brown, L., Lizzio, J., & Hood, G. (2008). â Climatch user manualâ . The method for the percent score is described in: Howeth, J.G., Gantz, C.A., Angermeier, P.L., Frimpong, E.A., Hoff, M.H., Keller, R.P., Mandrak, N.E., Marchetti, M.P., Olden, J.D., Romagosa, C.M., and Lodge, D.M. (2016). <doi:10.1111/ddi.12391>.

This package provides tools for measuring empirically the effects of entry in concentrated markets, based in Bresnahan and Reiss (1991) <https://www.jstor.org/stable/2937655>.

Estimates RxC (R by C) vote transfer matrices (ecological contingency tables) from aggregate data building on Thomsen (1987) and Park (2008) approaches. References: Park, W.-H. (2008). Ecological Inference and Aggregate Analysis of Election''. PhD Dissertation. University of Michigan. <https://deepblue.lib.umich.edu/bitstream/handle/2027.42/58525/wpark_1.pdf> Thomsen, S.R. (1987, ISBN:87-7335-037-2). Danish Elections 1920 79: a Logit Approach to Ecological Analysis and Inference''. Politica, Aarhus, Denmark.

Support for measurement errors in R vectors, matrices and arrays: automatic uncertainty propagation and reporting. Documentation about errors is provided in the paper by Ucar, Pebesma & Azcorra (2018, <doi:10.32614/RJ-2018-075>), included in this package as a vignette; see citation("errors") for details.

Easily import multi-frequency acoustic data stored in HAC files (see <doi:10.17895/ices.pub.5482> for more information on the format), and produce echogram visualisations with predefined or customized color palettes. It is also possible to merge consecutive echograms; mask or delete unwanted echogram areas; model and subtract background noise; and more important, develop, test and interpret different combinations of frequencies in order to perform acoustic filtering of the echogram's data.

Figures, data sets and examples from the book "A practical guide to ecological modelling - using R as a simulation platform" by Karline Soetaert and Peter MJ Herman (2009). Springer. All figures from chapter x can be generated by "demo(chapx)", where x = 1 to 11. The R-scripts of the model examples discussed in the book are in subdirectory "examples", ordered per chapter. Solutions to model projects are in the same subdirectories.

Estimates extinction risk from population time series under a drifted Wiener process using the w-z method for accurate confidence intervals.

This package provides a dataframe-friendly implementation of ComBat Harmonization which uses an empirical Bayesian framework to remove batch effects. Johnson WE & Li C (2007) <doi:10.1093/biostatistics/kxj037> "Adjusting batch effects in microarray expression data using empirical Bayes methods." Fortin J-P, Cullen N, Sheline YI, Taylor WD, Aselcioglu I, Cook PA, Adams P, Cooper C, Fava M, McGrath PJ, McInnes M, Phillips ML, Trivedi MH, Weissman MM, & Shinohara RT (2017) <doi:10.1016/j.neuroimage.2017.11.024> "Harmonization of cortical thickness measurements across scanners and sites." Fortin J-P, Parker D, Tun<e7> B, Watanabe T, Elliott MA, Ruparel K, Roalf DR, Satterthwaite TD, Gur RC, Gur RE, Schultz RT, Verma R, & Shinohara RT (2017) <doi:10.1016/j.neuroimage.2017.08.047> "Harmonization of multi-site diffusion tensor imaging data.".

Fast and memory-less computation of the energy statistics related quantities for vectors and matrices. References include: Szekely G. J. and Rizzo M. L. (2014), <doi:10.1214/14-AOS1255>. Szekely G. J. and Rizzo M. L. (2023), <ISBN:9781482242744>. Tsagris M. and Papadakis M. (2025). <doi:10.48550/arXiv.2501.02849>.

Computes temporal trends in environmental suitability obtained from ecological niche models, based on a set of species presence point coordinates and predictor variables.

Computation of the EQL for a given family of variance functions, Saddlepoint-approximations and related auxiliary functions (e.g. Hermite polynomials).

Computes various effect sizes of the difference, their variance, and confidence interval. This package treats Cohen's d, Hedges d, biased/unbiased c (an effect size between a mean and a constant) and e (an effect size between means without assuming the variance equality).

This package provides functions for converting objects to scalars (vectors of length 1) and a more inclusive definition of data that can be interpreted as numbers (numeric and complex alike).