Dry seed germinates by imbibing water from soil where the physiological process of germination starts after sufficient water has been imbibed by the seed. The germination time of the seed is inversely proportion to the difference between soil water potential and the base seed water potential which is described by hydro time model (Bradford, 2002 <https://www.jstor.org/stable/4046371>). The parameters of the model like speed of germination, stress tolerance, uniformity of germination are unknown fixed values (Ghosh et al., 2026 <doi:10.1111/aab.70041>) which are to be estimated using statistical regression model where the validity of the adopted statistical model has been established theoretically. The package will help to estimate the tuning parameter for proportion of viable seeds along with standard error and p- values for inference.

This package provides a methodology simple and trustworthy for the analysis of extreme values and multiple threshold tests for a generalized Pareto distribution, together with an automatic threshold selection algorithm. See del Castillo, J, Daoudi, J and Lockhart, R (2014) <doi:10.1111/sjos.12037>.

DNA methylation is essential for human, and environment can change the DNA methylation and affect body status. Epigenome-Wide Mediation Analysis Study (EMAS) can find potential mediator CpG sites between exposure (x) and outcome (y) in epigenome-wide. For more information on the methods we used, please see the following references: Tingley, D. (2014) <doi:10.18637/jss.v059.i05>, Turner, S. D. (2018) <doi:10.21105/joss.00731>, Rosseel, D. (2012) <doi:10.18637/jss.v048.i02>.

Estimation of fully and partially observed Exponential-Family Random Network Models (ERNM). Exponential-family Random Graph Models (ERGM) and Gibbs Fields are special cases of ERNMs and can also be estimated with the package. Please cite Fellows and Handcock (2012), "Exponential-family Random Network Models" available at <doi:10.48550/arXiv.1208.0121>.

This package provides a small set of functions for managing R environments, with defaults designed to encourage usage patterns that scale well to larger code bases. It provides: import_from(), a flexible way to assign bindings that defaults to the current environment; include(), a vectorized alternative to base::source() that also default to the current environment; and attach_eval() and attach_source(), a way to evaluate expressions in attached environments. Together, these (and other) functions pair to provide a robust alternative to base::library() and base::source().

Provide an optimal histogram, in the sense of probability density estimation and features detection, by means of multiscale variational inference. In other words, the resulting histogram servers as an optimal density estimator, and meanwhile recovers the features, such as increases or modes, with both false positive and false negative controls. Moreover, it provides a parsimonious representation in terms of the number of blocks, which simplifies data interpretation. The only assumption for the method is that data points are independent and identically distributed, so it applies to fairly general situations, including continuous distributions, discrete distributions, and mixtures of both. For details see Li, Munk, Sieling and Walther (2016) <arXiv:1612.07216>.

Expert Algorithm Verbal Autopsy assigns causes of death to 2016 WHO Verbal Autopsy Questionnaire data. odk2EAVA() converts data to a standard input format for cause of death determination building on the work of Thomas (2021) <https://cran.r-project.org/src/contrib/Archive/CrossVA/>. codEAVA() uses the presence and absence of signs and symptoms reported in the Verbal Autopsy interview to diagnose common causes of death. A deterministic algorithm assigns a single cause of death to each Verbal Autopsy interview record using a hierarchy of all common causes for neonates or children 1 to 59 months of age.

Total Time on Test plot and routines for parameter estimation of any lifetime distribution implemented in R via maximum likelihood (ML) given a data set. It is implemented thinking on parametric survival analysis, but it feasible to use in parameter estimation of probability density or mass functions in any field. The main routines maxlogL and maxlogLreg are wrapper functions specifically developed for ML estimation. There are included optimization procedures such as nlminb and optim from base package, and DEoptim Mullen (2011) <doi:10.18637/jss.v040.i06>. Standard errors are estimated with numDeriv Gilbert (2011) <https://CRAN.R-project.org/package=numDeriv> or the option Hessian = TRUE of optim function.

Analysis of temporal changes (i.e. dynamics) of ecological entities, defined as trajectories on a chosen multivariate space, by providing a set of trajectory metrics and visual representations [De Caceres et al. (2019) <doi:10.1002/ecm.1350>; and Sturbois et al. (2021) <doi:10.1016/j.ecolmodel.2020.109400>; Djeghri et al. (2026a) <doi:10.1002/ecm.70058>; Djeghri et al. (2026b) <doi:10.24072/pcjournal.736>]. Includes functions to estimate metrics for individual trajectories (length, directionality, angles, ...) as well as metrics to relate pairs of trajectories (dissimilarity and convergence). Functions are also provided to estimate the ecological quality of ecosystem with respect to reference conditions [Sturbois et al. (2023) <doi:10.1002/ecs2.4726>].

This dataset contains population estimates of all European cities with at least 10,000 inhabitants during the period 1500-1800. These data are adapted from Jan De Vries, "European Urbanization, 1500-1800" (1984).

Estimates the time-varying reproduction number, rate of spread, and doubling time using a renewal equation approach combined with Bayesian inference via Stan. Supports Gaussian process and random walk priors for modelling changes in transmission over time. Accounts for delays between infection and observation (incubation period, reporting delays), right-truncation in recent data, day-of-week effects, and observation overdispersion. Can estimate relationships between primary and secondary outcomes (e.g., cases to hospitalisations or deaths) and forecast both. Runs across multiple regions in parallel. Based on Abbott et al. (2020) <doi:10.12688/wellcomeopenres.16006.1> and Gostic et al. (2020) <doi:10.1101/2020.06.18.20134858>.

The EvoPER, Evolutionary Parameter Estimation for Individual-based Models is an extensible package providing optimization driven parameter estimation methods using metaheuristics and evolutionary computation techniques (Particle Swarm Optimization, Simulated Annealing, Ant Colony Optimization for continuous domains, Tabu Search, Evolutionary Strategies, ...) which could be more efficient and require, in some cases, fewer model evaluations than alternatives relying on experimental design. Currently there are built in support for models developed with Repast Simphony Agent-Based framework (<https://repast.github.io/>) and with NetLogo (<https://www.netlogo.org/>) which are the most used frameworks for Agent-based modeling.

This package provides a tool for conducting exact parametric regression-based causal mediation analysis of binary outcomes as described in Samoilenko, Blais and Lefebvre (2018) <doi:10.1353/obs.2018.0013>; Samoilenko, Lefebvre (2021) <doi:10.1093/aje/kwab055>; and Samoilenko, Lefebvre (2023) <doi:10.1002/sim.9621>.

This package provides classes and helper functions for loading, extracting, converting, manipulating, plotting and aggregating epidemiological parameters for infectious diseases. Epidemiological parameters extracted from the literature are loaded from the epiparameterDB R package.

Package implements the EDNE-test for equivalence according to Hoffelder et al. (2015) <DOI:10.1080/10543406.2014.920344>. "EDNE" abbreviates "Euclidean Distance between the Non-standardized Expected values". The EDNE-test for equivalence is a multivariate two-sample equivalence test. Distance measure of the test is the Euclidean distance. The test is an asymptotically valid test for the family of distributions fulfilling the assumptions of the multivariate central limit theorem (see Hoffelder et al.,2015). The function EDNE.EQ() implements the EDNE-test for equivalence according to Hoffelder et al. (2015). The function EDNE.EQ.dissolution.profiles() implements a variant of the EDNE-test for equivalence analyses of dissolution profiles (see Suarez-Sharp et al.,2020 <DOI:10.1208/s12248-020-00458-9>). EDNE.EQ.dissolution.profiles() checks whether the quadratic mean of the differences of the expected values of both dissolution profile populations is statistically significantly smaller than 10 [\% of label claim]. The current regulatory standard approach for equivalence analyses of dissolution profiles is the similarity factor f2. The statistical hypotheses underlying EDNE.EQ.dissolution.profiles() coincide with the hypotheses for f2 (see Hoffelder et al.,2015, Suarez-Sharp et al., 2020).

Gene information from Ensembl genome builds GRCh38.p14 and GRCh37.p13 to use with the topr package. The datasets were originally downloaded from <https://ftp.ensembl.org/pub/current/gtf/homo_sapiens/Homo_sapiens.GRCh38.111.gtf.gz> and <https://ftp.ensembl.org/pub/grch37/current/gtf/homo_sapiens/Homo_sapiens.GRCh37.87.gtf.gz> and converted into the format required by the topr package. See <https://github.com/totajuliusd/topr?tab=readme-ov-file#how-to-use-topr-with-other-species-than-human> to see the required format.

Biotracers and stomach content analyses are combined in a Bayesian hierarchical model to estimate a probabilistic topology matrix (all trophic link probabilities) and a diet matrix (all diet proportions). The package relies on the JAGS software and the jagsUI package to run a Markov chain Monte Carlo approximation of the different variables.

This package implements an explicit exploration strategy for evolutionary algorithms in order to have a more effective search in solving optimization problems. Along with this exploration search strategy, a set of four different Estimation of Distribution Algorithms (EDAs) are also implemented for solving optimization problems in continuous domains. The implemented explicit exploration strategy in this package is described in Salinas-Gutiérrez and Muñoz Zavala (2023) <doi:10.1016/j.asoc.2023.110230>.

We implement (or re-implements in R) a variety of statistical tools. They are focused on non-parametric two-sample (or k-sample) distribution comparisons in the univariate or multivariate case. See the vignette for more info.

Fitting and testing multi-attribute probabilistic choice models, especially the Bradley-Terry-Luce (BTL) model (Bradley & Terry, 1952 <doi:10.1093/biomet/39.3-4.324>; Luce, 1959), elimination-by-aspects (EBA) models (Tversky, 1972 <doi:10.1037/h0032955>), and preference tree (Pretree) models (Tversky & Sattath, 1979 <doi:10.1037/0033-295X.86.6.542>).

Implementation of the Centre of Gravity method and the Extrapolated Centre of Gravity method. It supports replicated observations. Cameron, D.G., et al (1982) <doi:10.1366/0003702824638610> JCGM (2008) <doi:10.59161/JCGM100-2008E>.

The confusion matrix (CM) is used to get a classifier's evaluation measure in order to select a method among many. A stochastic matrix and its transformation are computed from the CM. The eigenvalues of the transformed symmetric matrix are used to get an entropy which appears to be a good evaluation measure. Many other measures, commonly used, are provided for comparison purpose.

This package provides a system to facilitate designing comparative (and non-comparative) experiments using the grammar of experimental designs <https://emitanaka.org/edibble-book/>. An experimental design is treated as an intermediate, mutable object that is built progressively by fundamental experimental components like units, treatments, and their relation. The system aids in experimental planning, management and workflow.

This package provides a comprehensive toolkit for discovering differential and difference equations from empirical time series data using symbolic regression. The package implements a complete workflow from data preprocessing (including Total Variation Regularized differentiation for noisy economic data), visual exploration of dynamical structure, and symbolic equation discovery via genetic algorithms. It leverages a high-performance Julia backend ('SymbolicRegression.jl') to provide industrial-grade robustness, physics-informed constraints, and rigorous out-of-sample validation. Designed for economists, physicists, and researchers studying dynamical systems from observational data.