The aim of the package is to provide some basic functions for doing statistics with trapezoidal fuzzy numbers. In particular, the package contains several functions for simulating trapezoidal fuzzy numbers, as well as for calculating some central tendency measures (mean and two types of median), some scale measures (variance, ADD, MDD, Sn, Qn, Tn and some M-estimators) and one diversity index and one inequality index. Moreover, functions for calculating the 1-norm distance, the mid/spr distance and the (phi,theta)-wabl/ldev/rdev distance between fuzzy numbers are included, and a function to calculate the value phi-wabl given a sample of trapezoidal fuzzy numbers.

This is a method for Allele-specific DNA Copy Number profiling for whole-Exome sequencing data. Given the allele-specific coverage and site biases at the variant loci, this program segments the genome into regions of homogeneous allele-specific copy number. It requires, as input, the read counts for each variant allele in a pair of case and control samples, as well as the site biases. For detection of somatic mutations, the case and control samples can be the tumor and normal sample from the same individual. The implemented method is based on the paper: Chen, H., Jiang, Y., Maxwell, K., Nathanson, K. and Zhang, N. (under review). Allele-specific copy number estimation by whole Exome sequencing.

Useful functions to standardize software outputs from ProteomeDiscoverer, Spectronaut, DIA-NN and MaxQuant on precursor, modified peptide and proteingroup level and to trace software differences for identifications such as varying proteingroup denotations for common precursor.

This package provides the Big Merge Tracker and COSCI algorithms for convex clustering and feature screening using L1 fusion penalty. See Radchenko, P. and Mukherjee, G. (2017) <doi:10.1111/rssb.12226> and T.Banerjee et al. (2017) <doi:10.1016/j.jmva.2017.08.001> for more details.

This package provides a handy tool to calculate carbon footprints from air travel based on three-letter International Air Transport Association (IATA) airport codes or latitude and longitude. footprint first calculates the great-circle distance between departure and arrival destinations. It then uses the Department of Environment, Food & Rural Affairs (DEFRA) greenhouse gas conversion factors for business air travel to estimate the carbon footprint. These conversion factors consider trip length, flight class (e.g. economy, business), and emissions metric (e.g. carbon dioxide equivalent, methane).

This package provides a study based on the screened selection design (SSD) is an exploratory phase II randomized trial with two or more arms but without concurrent control. The primary aim of the SSD trial is to pick a desirable treatment arm (e.g., in terms of the response rate) to recommend to the subsequent randomized phase IIb (with the concurrent control) or phase III. The proposed designs can â partiallyâ control or provide the empirical type I error/false positive rate by an optimal algorithm (implemented by the optimal_2arm_binary() or optimal_3arm_binary() function) for each arm. All the design needed components (sample size, operating characteristics) are supported.

On import, the XML information is converted to a dataframe that reflects the hierarchical XML structure. Intuitive functions allow to navigate within this transparent XML data structure (without any knowledge of XPath'). flatXML also provides tools to extract data from the XML into a flat dataframe that can be used to perform statistical operations. It also supports converting dataframes to XML.

This package provides tools, helpers and data structures for developing models and time series functions for fable and extension packages. These tools support a consistent and tidy interface for time series modelling and analysis.

This package provides a tool for spatial/spatio-temporal modelling and prediction with large datasets. The approach models the field, and hence the covariance function, using a set of basis functions. This fixed-rank basis-function representation facilitates the modelling of big data, and the method naturally allows for non-stationary, anisotropic covariance functions. Discretisation of the spatial domain into so-called basic areal units (BAUs) facilitates the use of observations with varying support (i.e., both point-referenced and areal supports, potentially simultaneously), and prediction over arbitrary user-specified regions. `FRK` also supports inference over various manifolds, including the 2D plane and 3D sphere, and it provides helper functions to model, fit, predict, and plot with relative ease. Version 2.0.0 and above also supports the modelling of non-Gaussian data (e.g., Poisson, binomial, negative-binomial, gamma, and inverse-Gaussian) by employing a generalised linear mixed model (GLMM) framework. Zammit-Mangion and Cressie <doi:10.18637/jss.v098.i04> describe `FRK` in a Gaussian setting, and detail its use of basis functions and BAUs, while Sainsbury-Dale, Zammit-Mangion, and Cressie <doi:10.18637/jss.v108.i10> describe `FRK` in a non-Gaussian setting; two vignettes are available that summarise these papers and provide additional examples.

This package provides a toolkit for Flux Balance Analysis and related metabolic modeling techniques. Functions are provided for: parsing models in tabular format, converting parsed metabolic models to input formats for common linear programming solvers, and evaluating and applying gene-protein-reaction mappings. In addition, there are wrappers to parse a model, select a solver, find the metabolic fluxes, and return the results applied to the original model. Compared to other packages in this field, this package puts a much heavier focus on providing reusable components that can be used in the design of new implementation of new techniques, in particular those that involve large parameter sweeps. For a background on the theory, see What is Flux Balance Analysis <doi:10.1038/nbt.1614>.

Provide a range of plugins for fiery web servers that handle different aspects of server-side web security. Be aware that security cannot be handled blindly, and even though these plugins will raise the security of your server you should not build critical infrastructure without the aid of a security expert.

This package provides functions for analysing and modelling extreme events in financial time Series. The topics include: (i) data pre-processing, (ii) explorative data analysis, (iii) peak over threshold modelling, (iv) block maxima modelling, (v) estimation of VaR and CVaR, and (vi) the computation of the extreme index.

Fuel economy data from the EPA, 1985-2015, conveniently packaged for consumption by R users.

This package provides a persistent datastore for fiery apps. The datastore is build on top of the storr package and can thus be based on a variety of backends. The datastore contains both a global and session-scoped section.

Interactive data visualization for data practitioners. flourishcharts allows users to visualize their data using Flourish graphs that are grounded in data storytelling principles. Users can create racing bar & line charts, as well as other interactive elements commonly found in D3 graphics, easily in R and Python'. The package relies on an enterprise API provided by Flourish', a data visualization platform <https://developers.flourish.studio/api/introduction/>.

Frequentist assisted by Bayes (FAB) p-values and confidence interval construction. See Hoff (2019) <arXiv:1907.12589> "Smaller p-values via indirect information", Hoff and Yu (2019) <doi:10.1214/18-EJS1517> "Exact adaptive confidence intervals for linear regression coefficients", and Yu and Hoff (2018) <doi:10.1093/biomet/asy009> "Adaptive multigroup confidence intervals with constant coverage".

Does family-based gene by environment interaction tests, joint gene, gene-environment interaction test, and a test of a set of genes conditional on another set of genes.

Uses raw vectors to minimize memory consumption of categorical variables with fewer than 256 unique values. Useful for analysis of large datasets involving variables such as age, years, states, countries, or education levels.

This package provides very fast logistic regression with coefficient inferences plus other useful methods such as a forward stepwise model generator (see the benchmarks by visiting the github page at the URL below). The inputs are flexible enough to accomodate GPU computations. The coefficient estimation employs the fastLR() method in the RcppNumerical package by Yixuan Qiu et al. This package allows their work to be more useful to a wider community that consumes inference.

The algorithm assigns rareness/ outlierness score to every sample in voluminous datasets. The algorithm makes multiple estimations of the proximity between a pair of samples, in low-dimensional spaces. To compute proximity, FiRE uses Sketching, a variant of locality sensitive hashing. For more details: Jindal, A., Gupta, P., Jayadeva and Sengupta, D., 2018. Discovery of rare cells from voluminous single cell expression data. Nature Communications, 9(1), p.4719. <doi:10.1038/s41467-018-07234-6>.

This presents a comprehensive set of tools for the analysis and visualization of drug formulation data. It includes functions for statistical analysis, regression modeling, hypothesis testing, and comparative analysis to assess the impact of formulation parameters on drug release and other critical attributes. Additionally, the package offers a variety of data visualization functions, such as scatterplots, histograms, and boxplots, to facilitate the interpretation of formulation data. With its focus on usability and efficiency, this package aims to streamline the drug formulation process and aid researchers in making informed decisions during formulation design and optimization.

Upload, download, and edit internet maps with the Felt API (<https://developers.felt.com/rest-api/getting-started>). Allows users to create new maps, edit existing maps, and extract data. Provides tools for working with layers, which represent geographic data, and elements, which are interactive annotations. Spatial data accessed from the API is transformed to work with sf'.

Streamlines Quarto workflows by providing tools for consistent project setup and documentation. Enables portability through reusable metadata, automated project structure creation, and standardized templates. Features include enhanced project initialization, pre-formatted Quarto documents, inclusion of Quarto brand functionality, comprehensive data protection settings, custom styling, and structured documentation generation. Designed to improve efficiency and collaboration in R data science projects by reducing repetitive setup tasks while maintaining consistent formatting across multiple documents.

This package provides a variety of original and flexible user-friendly statistical latent variable models for the simultaneous clustering and segmentation of heterogeneous functional data (i.e time series, or more generally longitudinal data, fitted by unsupervised algorithms, including EM algorithms. Functional Latent Data Models for Clustering heterogeneous curves ('FLaMingos') are originally introduced and written in Matlab by Faicel Chamroukhi <https://github.com/fchamroukhi?utf8=?&tab=repositories&q=mix&type=public&language=matlab>. The references are mainly the following ones. Chamroukhi F. (2010) <https://chamroukhi.com/FChamroukhi-PhD.pdf>. Chamroukhi F., Same A., Govaert, G. and Aknin P. (2010) <doi:10.1016/j.neucom.2009.12.023>. Chamroukhi F., Same A., Aknin P. and Govaert G. (2011). <doi:10.1109/IJCNN.2011.6033590>. Same A., Chamroukhi F., Govaert G. and Aknin, P. (2011) <doi:10.1007/s11634-011-0096-5>. Chamroukhi F., and Glotin H. (2012) <doi:10.1109/IJCNN.2012.6252818>. Chamroukhi F., Glotin H. and Same A. (2013) <doi:10.1016/j.neucom.2012.10.030>. Chamroukhi F. (2015) <https://chamroukhi.com/FChamroukhi-HDR.pdf>. Chamroukhi F. and Nguyen H-D. (2019) <doi:10.1002/widm.1298>.