This package implements GINA-X, a genome-wide iterative fine-mapping method designed for non-Gaussian traits. It supports the identification of credible sets of genetic variants.

This package provides a ggplot2 extension for visualizing vector fields in two-dimensional space. Provides flexible tools for creating vector and stream field layers, visualizing gradients and potential fields, and smoothing vector and scalar data to estimate underlying patterns.

Readable, complete and pretty graphs for correspondence analysis made with FactoMineR'. They can be rendered as interactive HTML plots, showing useful informations at mouse hover. The interest is not mainly visual but statistical: it helps the reader to keep in mind the data contained in the cross-table or Burt table while reading the correspondence analysis, thus preventing over-interpretation. Most graphs are made with ggplot2', which means that you can use the + syntax to manually add as many graphical pieces you want, or change theme elements. 3D graphs are made with plotly'.

Finds adaptive strategies for sequential symmetric games using a genetic algorithm. Currently, any symmetric two by two matrix is allowed, and strategies can remember the history of an opponent's play from the previous three rounds of moves in iterated interactions between players. The genetic algorithm returns a list of adaptive strategies given payoffs, and the mean fitness of strategies in each generation.

This package provides a coherent interface and implementation for creating grouped date classes.

This package provides a ggplot2'-consistent approach to generating 2D displays of volumetric brain imaging data. Display data from multiple NIfTI images using standard ggplot2 conventions such scales, limits, and themes to control the appearance of displays. The resulting plots are returned as patchwork objects, inheriting from ggplot', allowing for any standard modifications of display aesthetics supported by ggplot2'.

Using simple input, this package creates plots of gene models. Users can create plots of alternatively spliced gene variants and the positions of mutations and other gene features.

Mark your interesting genes on plot and support more parameters to handle your own gene set enrichment analysis plot.

Genomic biology is not limited to the confines of the canonical B-forming DNA duplex, but includes over ten different types of other secondary structures that are collectively termed non-B DNA structures. Of these non-B DNA structures, the G-quadruplexes are highly stable four-stranded structures that are recognized by distinct subsets of nuclear factors. This package provide functions for predicting intramolecular G quadruplexes. In addition, functions for predicting other intramolecular nonB DNA structures are included.

This package implements the generalized integration model, which integrates individual-level data and summary statistics under a generalized linear model framework. It supports continuous and binary outcomes to be modeled by the linear and logistic regression models. For binary outcome, data can be sampled in prospective cohort studies or case-control studies. Described in Zhang et al. (2020)<doi:10.1093/biomet/asaa014>.

An R package that allows for combining tree-boosting with Gaussian process and mixed effects models. It also allows for independently doing tree-boosting as well as inference and prediction for Gaussian process and mixed effects models. See <https://github.com/fabsig/GPBoost> for more information on the software and Sigrist (2022, JMLR) <https://www.jmlr.org/papers/v23/20-322.html> and Sigrist (2023, TPAMI) <doi:10.1109/TPAMI.2022.3168152> for more information on the methodology.

Using the DNA sequence and gene annotation files provided in ENSEMBL <https://www.ensembl.org/index.html>, the functions implemented in the package try to find the DNA sequences and protein sequences of any given genomic loci, and to find the genomic coordinates and protein sequences of any given protein locations, which are the frequent tasks in the analysis of genomic and proteomic data.

Analyze small-sample clustered or longitudinal data with binary outcome using modified generalized estimating equations (GEE) with bias-adjusted covariance estimator. The package provides any combination of three GEE methods and 12 covariance estimators.

Fits geographically weighted regression (GWR) models and has tools to diagnose and remediate collinearity in the GWR models. Also fits geographically weighted ridge regression (GWRR) and geographically weighted lasso (GWL) models. See Wheeler (2009) <doi:10.1068/a40256> and Wheeler (2007) <doi:10.1068/a38325> for more details.

This package provides ggplot2 equivalents of fixest::coefplot() and fixest::iplot(), for producing nice coefficient plots and interaction plots. Enables some additional functionality and convenience features, including grouped multi-'fixest object faceting and programmatic updates to existing plots (e.g., themes and aesthetics).

Spatio-temporal causal inference based on point process data. You provide the raw data of locations and timings of treatment and outcome events, specify counterfactual scenarios, and the package estimates causal effects over specified spatial and temporal windows. See Papadogeorgou, et al. (2022) <doi:10.1111/rssb.12548> and Mukaigawara, et al. (2024) <doi:10.31219/osf.io/5kc6f>.

This package implements several extensions of the elastic net regularization scheme. These extensions include individual feature penalties for the L1 term, feature-feature penalties for the L2 term, as well as translation coefficients for the latter.

Simplifies the creation, management, and updating of local databases using data extracted from Google Earth Engine ('GEE'). It integrates with GEE to store, aggregate, and process spatio-temporal data, leveraging SQLite for efficient, serverless storage. The geeLite package provides utilities for data transformation and supports real-time monitoring and analysis of geospatial features, making it suitable for researchers and practitioners in geospatial science. For details, see Kurbucz and Andrée (2025) "Building and Managing Local Databases from Google Earth Engine with the geeLite R Package" <https://hdl.handle.net/10986/43165>.

Implementation of spatial graph-theoretic genetic gravity models. The model framework is applicable for other types of spatial flow questions. Includes functions for constructing spatial graphs, sampling and summarizing associated raster variables and building unconstrained and singly constrained gravity models.

Estimation and inference using the Generalized Maximum Entropy (GME) and Generalized Cross Entropy (GCE) framework, a flexible method for solving ill-posed inverse problems and parameter estimation under uncertainty (Golan, Judge, and Miller (1996, ISBN:978-0471145925) "Maximum Entropy Econometrics: Robust Estimation with Limited Data"). The package includes routines for generalized cross entropy estimation of linear models including the implementation of a GME-GCE two steps approach. Diagnostic tools, and options to incorporate prior information through support and prior distributions are available (Macedo, Cabral, Afreixo, Macedo and Angelelli (2025) <doi:10.1007/978-3-031-97589-9_21>). In particular, support spaces can be defined by the user or be internally computed based on the ridge trace or on the distribution of standardized regression coefficients. Different optimization methods for the objective function can be used. An adaptation of the normalized entropy aggregation (Macedo and Costa (2019) <doi:10.1007/978-3-030-26036-1_2> "Normalized entropy aggregation for inhomogeneous large-scale data") and a two-stage maximum entropy approach for time series regression (Macedo (2022) <doi:10.1080/03610918.2022.2057540>) are also available. Suitable for applications in econometrics, health, signal processing, and other fields requiring robust estimation under data constraints.

This package provides functions for implementing the Generalized Bayesian Optimal Phase II (G-BOP2) design using various Particle Swarm Optimization (PSO) algorithms, including: - PSO-Default, based on Kennedy and Eberhart (1995) <doi:10.1109/ICNN.1995.488968>, "Particle Swarm Optimization"; - PSO-Quantum, based on Sun, Xu, and Feng (2004) <doi:10.1109/ICCIS.2004.1460396>, "A Global Search Strategy of Quantum-Behaved Particle Swarm Optimization"; - PSO-Dexp, based on Stehlà k et al. (2024) <doi:10.1016/j.asoc.2024.111913>, "A Double Exponential Particle Swarm Optimization with Non-Uniform Variates as Stochastic Tuning and Guaranteed Convergence to a Global Optimum with Sample Applications to Finding Optimal Exact Designs in Biostatistics"; - and PSO-GO.

This package provides a quick and easy way of plotting the columns of two matrices or data frames against each other using ggplot2'. Although ggmatplot doesn't provide the same flexibility as ggplot2', it can be used as a workaround for having to wrangle wide format data into long format for plotting with ggplot2'.

This package provides functions and a graphical user interface for graphical described multiple test procedures.

Reconstruction of muscle fibers from image stacks using textural analysis. Includes functions for tracking, smoothing, cleaning, plotting and exporting muscle fibers. Also calculates basic fiber properties (e.g., length and curvature).