This package implements a constrained version of hierarchical agglomerative clustering, in which each observation is associated to a position, and only adjacent clusters can be merged. Typical application fields in bioinformatics include Genome-Wide Association Studies or Hi-C data analysis, where the similarity between items is a decreasing function of their genomic distance. Taking advantage of this feature, the implemented algorithm is time and memory efficient. This algorithm is described in Ambroise et al (2019) <doi:10.1186/s13015-019-0157-4>.

Easily estimate the introduction rates of alien species given first records data. It specializes in addressing the role of sampling on the pattern of discoveries, thus providing better estimates than using Generalized Linear Models which assume perfect immediate detection of newly introduced species.

This package provides the infrastructure for association rule-based classification including the algorithms CBA, CMAR, CPAR, C4.5, FOIL, PART, PRM, RCAR, and RIPPER to build associative classifiers. Hahsler et al (2019) <doi:10.32614/RJ-2019-048>.

Statistical analysis of archaeological dates and groups of dates. This package allows to post-process Markov Chain Monte Carlo (MCMC) simulations from ChronoModel <https://chronomodel.com/>, Oxcal <https://c14.arch.ox.ac.uk/oxcal.html> or BCal <https://bcal.shef.ac.uk/>. It provides functions for the study of rhythms of the long term from the posterior distribution of a series of dates (tempo and activity plot). It also allows the estimation and visualization of time ranges from the posterior distribution of groups of dates (e.g. duration, transition and hiatus between successive phases) as described in Philippe and Vibet (2020) <doi:10.18637/jss.v093.c01>.

Model adsorption behavior using classical isotherms, including Langmuir, Freundlich, Brunauerâ Emmettâ Teller (BET), and Temkin models. The package supports parameter estimation through both linearized and non-linear fitting techniques and generates high-quality plots for model diagnostics. It is intended for environmental scientists, chemists, and researchers working on adsorption phenomena in soils, water treatment, and material sciences. Functions are compatible with base R and ggplot2 for visualization.

Amiga Disk Files (ADF) are virtual representations of 3.5 inch floppy disks for the Commodore Amiga. Most disk drives from other systems (including modern drives) are not able to read these disks. The adfExplorer package enables you to establish R connections to files on such virtual DOS-formatted disks, which can be use to read from and write to those files.

Perform first- and second-order multi-scale analyses derived from Ripley K-function (Ripley B. D. (1977) <doi:10.1111/j.2517-6161.1977.tb01615.x>), for univariate, multivariate and marked mapped data in rectangular, circular or irregular shaped sampling windows, with tests of statistical significance based on Monte Carlo simulations.

Aho-Corasick is an optimal algorithm for finding many keywords in a text. It can locate all matches in a text in O(N+M) time; i.e., the time needed scales linearly with the number of keywords (N) and the size of the text (M). Compare this to the naive approach which takes O(N*M) time to loop through each pattern and scan for it in the text. This implementation builds the trie (the generic name of the data structure) and runs the search in a single function call. If you want to search multiple texts with the same trie, the function will take a list or vector of texts and return a list of matches to each text. By default, all 128 ASCII characters are allowed in both the keywords and the text. A more efficient trie is possible if the alphabet size can be reduced. For example, DNA sequences use at most 19 distinct characters and usually only 4; protein sequences use at most 26 distinct characters and usually only 20. UTF-8 (Unicode) matching is not currently supported.

Evaluates acute lymphoblastic leukemia maintenance therapy practice at patient and cohort level.

For a binary classification the adjusted sensitivity and specificity are measured for a given fixed threshold. If the threshold for either sensitivity or specificity is not given, the crossing point between the sensitivity and specificity curves are returned. For bootstrap procedures, mean and CI bootstrap values of sensitivity, specificity, crossing point between specificity and specificity as well as AUC and AUCPR can be evaluated.

This package provides a simulations-first sample size determination package that aims at making sample size formulae obsolete for most easily computable statistical experiments ; the main envisioned use case is clinical trials. The proposed clinical trial must be written by the user in the form of a function that takes as argument a sample size and returns a boolean (for whether or not the trial is a success). The adsasi functions will then use it to find the correct sample size empirically. The unavoidable mis-specification is obviated by trying sample size values close to the right value, the latter being understood as the value that gives the probability of success the user wants (usually 80 or 90% in biostatistics, corresponding to 20 or 10% type II error).

It implemented Age-Period-Interaction Model (APC-I Model) proposed in the paper of Liying Luo and James S. Hodges in 2019. A new age-period-cohort model for describing and investigating inter-cohort differences and life course dynamics.

Developed for Computing the probability density function, cumulative distribution function, random generation, estimating the parameters of asymmetric exponential power distribution, and robust regression analysis with error term that follows asymmetric exponential power distribution. The asymmetric exponential power distribution studied here is a special case of that introduced by Dongming and Zinde-Walsh (2009) <doi:10.1016/j.jeconom.2008.09.038>.

Stepwise Uncertainty Reduction criterion and algorithm for sequentially learning a Gaussian Process Classifier as described in Menz et al. (2025).

Training of neural networks for classification and regression tasks using mini-batch gradient descent. Special features include a function for training autoencoders, which can be used to detect anomalies, and some related plotting functions. Multiple activation functions are supported, including tanh, relu, step and ramp. For the use of the step and ramp activation functions in detecting anomalies using autoencoders, see Hawkins et al. (2002) <doi:10.1007/3-540-46145-0_17>. Furthermore, several loss functions are supported, including robust ones such as Huber and pseudo-Huber loss, as well as L1 and L2 regularization. The possible options for optimization algorithms are RMSprop, Adam and SGD with momentum. The package contains a vectorized C++ implementation that facilitates fast training through mini-batch learning.

Designed to help health economic modellers when building and reviewing models. The visualisation functions allow users to more easily review the network of functions in a project, and get lay summaries of them. The asserts included are intended to check for common errors, thereby freeing up time for modellers to focus on tests specific to the individual model in development or review. For more details see Smith and colleagues (2024)<doi:10.12688/wellcomeopenres.23180.1>.

Randomly splits data into testing and training sets. Then, uses stepwise selection to fit numerous multiple regression models on the training data, and tests them on the test data. Returned for each model are plots comparing model Akaike Information Criterion (AIC), Pearson correlation coefficient (r) between the predicted and actual values, Mean Absolute Error (MAE), and R-Squared among the models. Each model is ranked relative to the other models by the model evaluation metrics (i.e., AIC, r, MAE, and R-Squared) and the model with the best mean ranking among the model evaluation metrics is returned. Model evaluation metric weights for AIC, r, MAE, and R-Squared are taken in as arguments as aic_wt, r_wt, mae_wt, and r_squ_wt, respectively. They are equally weighted as default but may be adjusted relative to each other if the user prefers one or more metrics to the others, Field, A. (2013, ISBN:978-1-4462-4918-5).

Adaptive wavelet lifting transforms for signal denoising using optimal local neighbourhood regression, from Nunes et al. (2006) <doi:10.1007/s11222-006-6560-y>.

The irregularly-spaced data are interpolated onto regular latitude-longitude grids by weighting each station according to its distance and angle from the center of a search radius. In addition to this, we also provide a simple way (Jones and Hulme, 1996) to grid the irregularly-spaced data points onto regular latitude-longitude grids by averaging all stations in grid-boxes.

This package provides a high-performance, flexible and extensible framework to develop continuous-time agent based models. Its high performance allows it to simulate millions of agents efficiently. Agents are defined by their states (arbitrary R lists). The events are handled in chronological order. This avoids the multi-event interaction problem in a time step of discrete-time simulations, and gives precise outcomes. The states are modified by provided or user-defined events. The framework provides a flexible and customizable implementation of state transitions (either spontaneous or caused by agent interactions), making the framework suitable to apply to epidemiology and ecology, e.g., to model life history stages, competition and cooperation, and disease and information spread. The agent interactions are flexible and extensible. The framework provides random mixing and network interactions, and supports multi-level mixing patterns. It can be easily extended to other interactions such as inter- and intra-households (or workplaces and schools) by subclassing an R6 class. It can be used to study the effect of age-specific, group-specific, and contact- specific intervention strategies, and complex interactions between individual behavior and population dynamics. This modeling concept can also be used in business, economical and political models. As a generic event based framework, it can be applied to many other fields. More information about the implementation and examples can be found at <https://github.com/junlingm/ABM>.

Power and associated functions useful in prospective planning and monitoring of a clinical trial when a recurrent event endpoint is to be assessed by the robust Andersen-Gill model, see Lin, Wei, Yang, and Ying (2010) <doi:10.1111/1467-9868.00259>. The equations developed in Ingel and Jahn-Eimermacher (2014) <doi:10.1002/bimj.201300090> and their consequences are employed.

Formatter functions in the apa package take the return value of a statistical test function, e.g. a call to chisq.test() and return a string formatted according to the guidelines of the APA (American Psychological Association).

Programming vaccine specific Clinical Data Interchange Standards Consortium (CDISC) compliant Analysis Data Model (ADaM) datasets in R'. Flat model is followed as per Center for Biologics Evaluation and Research (CBER) guidelines for creating vaccine specific domains. ADaM datasets are a mandatory part of any New Drug or Biologics License Application submitted to the United States Food and Drug Administration (FDA). Analysis derivations are implemented in accordance with the "Analysis Data Model Implementation Guide" (CDISC Analysis Data Model Team (2021), <https://www.cdisc.org/standards/foundational/adam/adamig-v1-3-release-package>). The package is an extension package of the admiral package.

Argument parsing for R scripts, with support for long and short Unix-style options including option clustering, positional arguments including those of variable length, and multiple usage patterns which may take different subsets of options.