Group Bayesian Networks: This package implements the inference of group Bayesian networks based on hierarchical feature clustering, and the adaptive refinement of the grouping regarding an outcome of interest, as described in Becker et. al (2021) <doi: 10.1371/journal.pcbi.1008735>.

Boosting models for fitting generalized additive models for location, shape and scale ('GAMLSS') to potentially high dimensional data.

This package provides a system for fitting Gompertz Curve in a Time Series Data.

Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the gimap package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) <doi:10.1016/j.celrep.2021.109597>.

Graceful ggplot'-based graphics and utility functions for working with generalized additive models (GAMs) fitted using the mgcv package. Provides a reimplementation of the plot() method for GAMs that mgcv provides, as well as tidyverse compatible representations of estimated smooths.

The functionality provided by this package is an expansion of the code of the statebins package, created by B. Rudis (2022), <doi:10.32614/CRAN.package.statebins>. It allows for the creation of square choropleths for the entire world, provided an appropriate specified grid is supplied.

This package implements the generalized integration model, which integrates individual-level data and summary statistics under a generalized linear model framework. It supports continuous and binary outcomes to be modeled by the linear and logistic regression models. For binary outcome, data can be sampled in prospective cohort studies or case-control studies. Described in Zhang et al. (2020)<doi:10.1093/biomet/asaa014>.

This package provides a pipeline with high specificity and sensitivity in extracting proteins from the RefSeq database (National Center for Biotechnology Information). Manual identification of gene families is highly time-consuming and laborious, requiring an iterative process of manual and computational analysis to identify members of a given family. The pipelines implements an automatic approach for the identification of gene families based on the conserved domains that specifically define that family. See Die et al. (2018) <doi:10.1101/436659> for more information and examples.

This package provides convenient wrapper functions around the glue library for common string interpolation tasks. The package simplifies the process of combining glue string templating with common R functions like message(), warning(), stop(), print(), cat(), and file writing operations. Instead of manually calling glue() and then passing the result to these functions, glueDo provides direct wrapper functions that handle both steps in a single call. This is particularly useful for logging, error handling, and formatted output in R scripts and packages. The main reference for the underlying glue package is Hester and Bryan (2022) <https://CRAN.R-project.org/package=glue>.

Spatial stratified heterogeneity (SSH), referring to the within strata are more similar than the between strata, a model with global parameters would be confounded if input data is SSH. Note that the "spatial" here can be either geospatial or the space in mathematical meaning. Geographical detector is a novel tool to investigate SSH: (1) measure and find SSH of a variable Y; (2) test the power of determinant X of a dependent variable Y according to the consistency between their spatial distributions; and (3) investigate the interaction between two explanatory variables X1 and X2 to a dependent variable Y (Wang et al 2014 <doi:10.1080/13658810802443457>, Wang, Zhang, and Fu 2016 <doi:10.1016/j.ecolind.2016.02.052>).

Generalized meta-analysis is a technique for estimating parameters associated with a multiple regression model through meta-analysis of studies which may have information only on partial sets of the regressors. It estimates the effects of each variable while fully adjusting for all other variables that are measured in at least one of the studies. Using algebraic relationships between regression parameters in different dimensions, a set of moment equations is specified for estimating the parameters of a maximal model through information available on sets of parameter estimates from a series of reduced models available from the different studies. The specification of the equations requires a reference dataset to estimate the joint distribution of the covariates. These equations are solved using the generalized method of moments approach, with the optimal weighting of the equations taking into account uncertainty associated with estimates of the parameters of the reduced models. The proposed framework is implemented using iterated reweighted least squares algorithm for fitting generalized linear regression models. For more details about the method, please see pre-print version of the manuscript on generalized meta-analysis by Prosenjit Kundu, Runlong Tang and Nilanjan Chatterjee (2018) <doi:10.1093/biomet/asz030>.The current version (0.2.0) is updated to address some of the stability issues in the previous version (0.1).

This package provides functions to compute various germination indices such as germinability, median germination time, mean germination time, mean germination rate, speed of germination, Timson's index, germination value, coefficient of uniformity of germination, uncertainty of germination process, synchrony of germination etc. from germination count data. Includes functions for fitting cumulative seed germination curves using four-parameter hill function and computation of associated parameters. See the vignette for more, including full list of citations for the methods implemented.

This package implements the non-iterative conditional expectation (NICE) algorithm of the g-formula algorithm (Robins (1986) <doi:10.1016/0270-0255(86)90088-6>, Hernán and Robins (2024, ISBN:9781420076165)). The g-formula can estimate an outcome's counterfactual mean or risk under hypothetical treatment strategies (interventions) when there is sufficient information on time-varying treatments and confounders. This package can be used for discrete or continuous time-varying treatments and for failure time outcomes or continuous/binary end of follow-up outcomes. The package can handle a random measurement/visit process and a priori knowledge of the data structure, as well as censoring (e.g., by loss to follow-up) and two options for handling competing events for failure time outcomes. Interventions can be flexibly specified, both as interventions on a single treatment or as joint interventions on multiple treatments. See McGrath et al. (2020) <doi:10.1016/j.patter.2020.100008> for a guide on how to use the package.

Modified versions of the lag() and summary() functions: glag() and gsummary(). The prefix g is a reminder of who to blame if things do not work as they should.

This package implements the Goldilocks adaptive trial design for a time to event outcome using a piecewise exponential model and conjugate Gamma prior distributions. The method closely follows the article by Broglio and colleagues <doi:10.1080/10543406.2014.888569>, which allows users to explore the operating characteristics of different trial designs.

Generalized estimating equations with the original sandwich variance estimator proposed by Liang and Zeger (1986), and eight types of more recent modified variance estimators for improving the finite small-sample performance.

Simple interface to query gitignore.io to fetch gitignore templates that can be included in the .gitignore file. More than 450 templates are currently available.

This package performs genomic mediation analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) <doi:10.1101/gr.216754.116>. It implements large scale mediation analysis and adaptively selects potential confounding variables to adjust for each mediation test from a pool of candidate confounders. The package is tailored for but not limited to genomic mediation analysis (e.g., cis-gene mediating trans-gene regulation pattern where an eQTL, its cis-linking gene transcript, and its trans-gene transcript play the roles as treatment, mediator and the outcome, respectively), restricting to scenarios with the presence of cis-association (i.e., treatment-mediator association) and random eQTL (i.e., treatment).

The getDTeval() function facilitates the translation of the original coding statement to an optimized form for improved runtime efficiency without compromising on the programmatic coding design. The function can either provide a translation of the coding statement, directly evaluate the translation to return a coding result, or provide both of these outputs.

We define generalized multipartite networks as the joint observation of several networks implying some common pre-specified groups of individuals. The aim is to fit an adapted version of the popular stochastic block model to multipartite networks, as described in Bar-hen, Barbillon and Donnet (2020) <arXiv:1807.10138>.

Multidimensional systems allow complex queries to be carried out in an easy way. The geographical dimension, together with the temporal dimension, plays a fundamental role in multidimensional systems. Through this package, vector geographic data layers can be associated to the attributes of geographic dimensions, so that the results of multidimensional queries can be obtained directly as vector layers. The multidimensional structures on which we can define the queries can be created from a flat table or imported directly using functions from this package.

Density, distribution function, quantile function and random generation for the bimodal skew symmetric normal distribution of Hassan and El-Bassiouni (2016) <doi:10.1080/03610926.2014.882950>.

Implementation of the Generalized Score Matching estimator in Yu et al. (2019) <https://jmlr.org/papers/v20/18-278.html> for non-negative graphical models (truncated Gaussian, exponential square-root, gamma, a-b models) and univariate truncated Gaussian distributions. Also includes the original estimator for untruncated Gaussian graphical models from Lin et al. (2016) <doi:10.1214/16-EJS1126>, with the addition of a diagonal multiplier.

This package provides publication-ready volcano plots for visualizing differential expression results, commonly used in RNA-seq and similar analyses. This tool helps create high-quality visual representations of data using the ggplot2 framework Wickham (2016) <doi:10.1007/978-3-319-24277-4>.