This package provides a reproducible pipeline to conduct genome-wide association studies (GWAS) and extract single-nucleotide polymorphisms (SNPs) for a human trait or disease. Given aggregated GWAS dataset(s) and a user-defined significance threshold, the package retrieves significant SNPs from the GWAS Catalog using supported trait identifiers, annotates their gene context, and can write a harmonised metadata table in comma-separated values (CSV) format, genomic intervals in the Browser Extensible Data (BED) format, and sequences in the FASTA (text-based sequence) format with user-defined flanking regions for clustered regularly interspaced short palindromic repeats (CRISPR) guide design. The existing efo_id argument is retained for backward compatibility. The package prepares computational artifacts for downstream workflows; it does not perform biological causality testing, clinical interpretation, therapeutic design, or wet-lab validation. For details on the resources and methods see: Buniello et al. (2019) <doi:10.1093/nar/gky1120>; Sollis et al. (2023) <doi:10.1093/nar/gkac1010>; Jinek et al. (2012) <doi:10.1126/science.1225829>.

This function converts mfpr, numeric, or character strings representing numbers to bigq format without loss of precision.

This package implements the Generalized Method of Wavelet Moments with Exogenous Inputs estimator (GMWMX) presented in Voirol, L., Xu, H., Zhang, Y., Insolia, L., Molinari, R. and Guerrier, S. (2024) <doi:10.48550/arXiv.2409.05160>. The GMWMX estimator allows to estimate functional and stochastic parameters of linear models with correlated residuals in presence of missing data. The gmwmx2 package provides functions to load and plot Global Navigation Satellite System (GNSS) data from the Nevada Geodetic Laboratory and functions to estimate linear model model with correlated residuals in presence of missing data.

An implementation of the International Bureau of Weights and Measures (BIPM) generalized consensus estimators used to assign the reference value in a key comparison exercise. This can also be applied to any interlaboratory study. Given a set of different sources, primary laboratories or measurement methods this package provides an evaluation of the variance components according to the selected statistical method for consensus building. It also implements the comparison among different consensus builders and evaluates the participating method or sources against the consensus reference value. Based on a diverse set of references, DerSimonian-Laird (1986) <doi:10.1016/0197-2456(86)90046-2>, for a complete list of references look at the reference section in the package documentation.

GEE estimation of the parameters in mean structures with possible correlation between the outcomes. User-specified mean link and variance functions are allowed, along with observation weighting. The M in the name geeM is meant to emphasize the use of the Matrix package, which allows for an implementation based fully in R.

This package provides functions and data are provided that support a course that emphasizes statistical issues of inference and generalizability. The functions are designed to make it straightforward to illustrate the use of cross-validation, the training/test approach, simulation, and model-based estimates of accuracy. Methods considered are Generalized Additive Modeling, Linear and Quadratic Discriminant Analysis, Tree-based methods, and Random Forests.

Write SARIMA models in (finite) AR representation and simulate generalized multiplicative seasonal autoregressive moving average (time) series with Normal / Gaussian, Poisson or negative binomial distribution. The methodology of this method is described in Briet OJT, Amerasinghe PH, and Vounatsou P (2013) <doi:10.1371/journal.pone.0065761>.

This package provides tools to adjust estimates of learning for guessing-related bias in educational and survey research. Implements standard guessing correction methods and a sophisticated latent class model that leverages informative pre-post test transitions to account for guessing behavior. The package helps researchers obtain more accurate estimates of actual learning when respondents may guess on closed-ended knowledge items. For theoretical background and empirical validation, see Cor and Sood (2018) <https://gsood.com/research/papers/guess.pdf>.

Second-order summary statistics K- and pair-correlation functions describe interactions in point pattern data. This package provides computations to estimate those statistics on inhomogeneous point processes, using the methods of in T Shaw, J Møller, R Waagepetersen, 2020 <doi:10.48550/arXiv.2004.00527>.

Streamlines downloading and cleaning biodiversity data from Integrated Digitized Biocollections (iDigBio) and the Global Biodiversity Information Facility (GBIF).

Informal implementation of some algorithms from Graph Theory and Combinatorial Optimization which arise in the subject "Graphs and Network Optimization" from first course of the EUPLA degree of Data Engineering in Industrial Processes.

Analysis of multivariate data using generalized linear latent variable models (gllvm). Estimation is performed using either the Laplace method, variational approximations, or extended variational approximations, implemented via TMB (Kristensen et al. (2016), <doi:10.18637/jss.v070.i05>).

This package provides one-liner functions for common legend and guide operations in ggplot2'. Simplifies legend positioning, styling, wrapping, and collection across multi-panel plots created with patchwork or cowplot'.

Create epicurves, epigantt charts, and diverging bar charts using ggplot2'. Prepare data for visualisation or other reporting for infectious disease surveillance and outbreak investigation (time series data). Includes tidy functions to solve date based transformations for common reporting tasks, like (A) seasonal date alignment for respiratory disease surveillance, (B) date-based case binning based on specified time intervals like isoweek, epiweek, month and more, (C) automated detection and marking of the new year based on the date/datetime axis of the ggplot2', (D) labelling of the last value of a time-series. An introduction on how to use epicurves can be found on the US CDC website (2012, <https://www.cdc.gov/training/quicklearns/epimode/index.html>).

Gaussian processes are flexible distributions to model functional data. Whilst theoretically appealing, they are computationally cumbersome except for small datasets. This package implements two methods for scaling Gaussian process inference in Stan'. First, a sparse approximation of the likelihood that is generally applicable and, second, an exact method for regularly spaced data modeled by stationary kernels using fast Fourier methods. Utility functions are provided to compile and fit Stan models using the cmdstanr interface. References: Hoffmann and Onnela (2025) <doi:10.18637/jss.v112.i02>.

Extend ggplot2 facets to panel layouts arranged in a grid with ragged edges. facet_ragged_rows() groups panels into rows that can vary in length, facet_ragged_cols() does the same but for columns. These can be useful, for example, to represent nested or partially crossed relationships between faceting variables.

Add vector field layers to ggplots. Ideal for visualising wind speeds, water currents, electric/magnetic fields, etc. Accepts data.frames, simple features (sf), and spatiotemporal arrays (stars) objects as input. Vector fields are depicted as arrows starting at specified locations, and with specified angles and radii.

Dynamically retrieve data from the web to render HTML tables on inspection in R Markdown HTML documents.

Process in-situ Gamma-Ray Spectrometry for Luminescence Dating. This package allows to import, inspect and correct the energy shifts of gamma-ray spectra. It provides methods for estimating the gamma dose rate by the use of a calibration curve as described in Mercier and Falguères (2007). The package only supports Canberra CNF and TKA and Kromek SPE files.

This package provides a variable selection approach for generalized linear mixed models by L1-penalized estimation is provided, see Groll and Tutz (2014) <doi:10.1007/s11222-012-9359-z>. See also Groll and Tutz (2017) <doi:10.1007/s10985-016-9359-y> for discrete survival models including heterogeneity.

This package provides a ggplot2 extension that supports arbitrary hand-crafted colourable & fillable shapes. New shapes may be feature requested via a Github issue.

This package implements statistical methods for group factor analysis, focusing on estimating the number of global and local factors and extracting them. Several algorithms are implemented, including Canonical Correlation-based Estimation by Choi et al. (2021) <doi:10.1016/j.jeconom.2021.09.008>, Generalised Canonical Correlation Estimation by Lin and Shin (2023) <doi:10.2139/ssrn.4295429>, Circularly Projected Estimation by Chen (2022) <doi:10.1080/07350015.2022.2051520>, and the Aggregated Projection Method by Hu et al. (2025) <doi:10.1080/01621459.2025.2491154>.

This package performs Gamma regression, where both mean and shape parameters follows lineal regression structures.

When the number of treatments is large with limited experimental resources then Row-Column(RC) designs with multiple units per cell can be used. These designs are called Generalized Row-Column (GRC) designs and are defined as designs with v treatments in p rows and q columns such that the intersection of each row and column (cell) consists of k experimental units. For example (Bailey & Monod (2001)<doi:10.1111/1467-9469.00235>), to conduct an experiment for comparing 4 treatments using 4 plants with leaves at 2 different heights row-column design with two units per cell can be used. A GRC design is said to be structurally complete if corresponding to the intersection of each row and column, there appears at least two treatments. A GRC design is said to be structurally incomplete if corresponding to the intersection of any row and column, there is at least one cell which does not contain any treatment.