At Novartis, we aimed at standardizing the set of diagnostic plots used for modeling activities in order to reduce the overall effort required for generating such plots. For this, we developed a guidance that proposes an adequate set of diagnostics and a toolbox, called ggPMX to execute them. ggPMX is a toolbox that can generate all diagnostic plots at a quality sufficient for publication and submissions using few lines of code. This package focuses on plots recommended by ISoP <doi:10.1002/psp4.12161>. While not required, you can get/install the R lixoftConnectors package in the Monolix installation, as described at the following url <https://monolixsuite.slp-software.com/r-functions/2024R1/installation-and-initialization>. When lixoftConnectors is available, R can use Monolix directly to create the required Chart Data instead of exporting it from the Monolix gui.

Download geyser eruption and observation data from the GeyserTimes site (<https://geysertimes.org>) and optionally store it locally. The vignette shows a simple analysis of downloading, accessing, and summarizing the data.

Simulates from discrete and continuous target distributions using geometric Metropolis-Hastings (MH) algorithms. Users specify the target distribution by an R function that evaluates the log un-normalized pdf or pmf. The package also contains a function implementing a specific geometric MH algorithm for performing high-dimensional Bayesian variable selection.

R Interface to C API of GLPK, depends on GLPK Version >= 4.42.

This package provides stat_isotonic() to add weighted univariate isotonic regression curves.

Performing the different steps of gene set enrichment meta-analysis. It provides different functions that allow the application of meta-analysis based on the combination of effect sizes from different pathways in different studies to obtain significant pathways that are common to all of them.

Automated model selection and model-averaging. Provides a wrapper for glm and other functions, automatically generating all possible models (under constraints set by the user) with the specified response and explanatory variables, and finding the best models in terms of some Information Criterion (AIC, AICc or BIC). Can handle very large numbers of candidate models. Features a Genetic Algorithm to find the best models when an exhaustive screening of the candidates is not feasible.

This package implements a basic version of the hierarchical clustering algorithm Genie which links two point groups in such a way that an inequity measure (namely, the Gini index) of the cluster sizes does not significantly increase above a given threshold. This method most often outperforms many other data segmentation approaches in terms of clustering quality as tested on a wide range of benchmark datasets. At the same time, Genie retains the high speed of the single linkage approach, therefore it is also suitable for analysing larger data sets. For more details see (Gagolewski et al. 2016 <DOI:10.1016/j.ins.2016.05.003>). For a faster and more feature-rich implementation, see the genieclust package (Gagolewski, 2021 <DOI:10.1016/j.softx.2021.100722>).

Penalised likelihood estimation of a covariance matrix via the ridge-regularised covglasso estimator described in Cibinel et al. (2024) <doi:10.48550/arXiv.2410.02403>. Based on the C++ code of the R package covglasso (by Michael Fop, <https://orcid.org/0000-0003-3936-2757>) and the R code of icf (by Mathias Drton, <https://orcid.org/0000-0001-5614-3025>) within the R package ggm'.

Interface for extra high-dimensional smooth functions for Generalized Additive Models for Location Scale and Shape (GAMLSS) including (adaptive) lasso, ridge, elastic net and least angle regression.

An ensemble of algorithms that enable the clustering of networks and data matrices (such as counts, categorical or continuous) with different type of generative models. Model selection and clustering is performed in combination by optimizing the Integrated Classification Likelihood (which is equivalent to minimizing the description length). Several models are available such as: Stochastic Block Model, degree corrected Stochastic Block Model, Mixtures of Multinomial, Latent Block Model. The optimization is performed thanks to a combination of greedy local search and a genetic algorithm (see <arXiv:2002:11577> for more details).

Find the permutation symmetry group such that the covariance matrix of the given data is approximately invariant under it. Discovering such a permutation decreases the number of observations needed to fit a Gaussian model, which is of great use when it is smaller than the number of variables. Even if that is not the case, the covariance matrix found with gips approximates the actual covariance with less statistical error. The methods implemented in this package are described in Graczyk et al. (2022) <doi:10.1214/22-AOS2174>. Documentation about gips is provided via its website at <https://przechoj.github.io/gips/> and the paper by Chojecki, Morgen, KoÅ odziejek (2025, <doi:10.18637/jss.v112.i07>).

This package provides a function that reads in the GEO code of a gene expression dataset, retrieves its data from GEO, (optionally) retrieves the gene symbols of the dataset, and returns a simple dataframe table containing all the data. Platforms available: GPL11532, GPL23126, GPL6244, GPL8300, GPL80, GPL96, GPL570, GPL571, GPL20115, GPL1293, GPL6102, GPL6104, GPL6883, GPL6884, GPL13497, GPL14550, GPL17077, GPL6480. GEO: Gene Expression Omnibus. ID: identifier code. The GEO datasets are downloaded from the URL <https://ftp.ncbi.nlm.nih.gov/geo/series/>. More information can be found in the following manuscript: Davide Chicco, "geneExpressionFromGEO: an R package to facilitate data reading from Gene Expression Omnibus (GEO)". Microarray Data Analysis, Methods in Molecular Biology, volume 2401, chapter 12, pages 187-194, Springer Protocols, 2021, <doi:10.1007/978-1-0716-1839-4_12>.

This package provides a high performance interface to the Global Biodiversity Information Facility, GBIF'. In contrast to rgbif', which can access small subsets of GBIF data through web-based queries to a central server, gbifdb provides enhanced performance for R users performing large-scale analyses on servers and cloud computing providers, providing full support for arbitrary SQL or dplyr operations on the complete GBIF data tables (now over 1 billion records, and over a terabyte in size). gbifdb accesses a copy of the GBIF data in parquet format, which is already readily available in commercial computing clouds such as the Amazon Open Data portal and the Microsoft Planetary Computer, or can be accessed directly without downloading, or downloaded to any server with suitable bandwidth and storage space. The high-performance techniques for local and remote access are described in <https://duckdb.org/why_duckdb> and <https://arrow.apache.org/docs/r/articles/fs.html> respectively.

For spatial data analysis; provides exploratory spatial analysis tools, spatial regression, spatial econometric, and disease mapping models, model diagnostics, and special methods for inference with small area survey data (e.g., the America Community Survey (ACS)) and censored population health monitoring data. Models are pre-specified using the Stan programming language, a platform for Bayesian inference using Markov chain Monte Carlo (MCMC). References: Carpenter et al. (2017) <doi:10.18637/jss.v076.i01>; Donegan (2021) <doi:10.31219/osf.io/3ey65>; Donegan (2022) <doi:10.21105/joss.04716>; Donegan, Chun and Hughes (2020) <doi:10.1016/j.spasta.2020.100450>; Donegan, Chun and Griffith (2021) <doi:10.3390/ijerph18136856>; Morris et al. (2019) <doi:10.1016/j.sste.2019.100301>.

Finds subsets of sets of genotypes with a high Heterozygosity, and Mean of Transformed Kinships (MTK), measures that can indicate a subset would be beneficial for rare-trait discovery and genome-wide association scanning, respectively.

Create epicurves, epigantt charts, and diverging bar charts using ggplot2'. Prepare data for visualisation or other reporting for infectious disease surveillance and outbreak investigation (time series data). Includes tidy functions to solve date based transformations for common reporting tasks, like (A) seasonal date alignment for respiratory disease surveillance, (B) date-based case binning based on specified time intervals like isoweek, epiweek, month and more, (C) automated detection and marking of the new year based on the date/datetime axis of the ggplot2', (D) labelling of the last value of a time-series. An introduction on how to use epicurves can be found on the US CDC website (2012, <https://www.cdc.gov/training/quicklearns/epimode/index.html>).

The Graphical Group Ridge GGRidge package package classifies ridge regression predictors in disjoint groups of conditionally correlated variables and derives different penalties (shrinkage parameters) for these groups of predictors. It combines the ridge regression method with the graphical model for high-dimensional data (i.e. the number of predictors exceeds the number of cases) or ill-conditioned data (e.g. in the presence of multicollinearity among predictors). The package reduces the mean square errors and the extent of over-shrinking of predictors as compared to the ridge method.Aldahmani, S. and Zoubeidi, T. (2020) <DOI:10.1080/00949655.2020.1803320>.

Uses an approach based on k-nearest neighbor information to sequentially detect change-points. Offers analytic approximations for false discovery control given user-specified average run length. Can be applied to any type of data (high-dimensional, non-Euclidean, etc.) as long as a reasonable similarity measure is available. See references (1) Chen, H. (2019) Sequential change-point detection based on nearest neighbors. The Annals of Statistics, 47(3):1381-1407. (2) Chu, L. and Chen, H. (2018) Sequential change-point detection for high-dimensional and non-Euclidean data <arXiv:1810.05973>.

This package provides functions to produce ggplot2'-based plots of objects produced by functions in the vegan package. Provides fortify()', autoplot()', and tidy() methods for many of vegan''s functions. The aim of ggvegan is to make it easier to work within the tidyverse with vegan'.

This package provides an interface to the system-level grep utility for efficiently reading, filtering, and aggregating data from multiple flat files. By pre-filtering data at the command line before it enters the R environment, the package reduces memory overhead and improves ingestion speed. Includes functions for counting records across large file systems and supports recursive directory searching.

Allows plotting data on bathymetric maps using ggplot2'. Plotting oceanographic spatial data is made as simple as feasible, but also flexible for custom modifications. Data that contain geographic information from anywhere around the globe can be plotted on maps generated by the basemap() or qmap() functions using ggplot2 layers separated by the + operator. The package uses spatial shape- ('sf') and raster ('stars') files, geospatial packages for R to manipulate, and the ggplot2 package to plot these files. The package ships with low-resolution spatial data files and higher resolution files for detailed maps are stored in the ggOceanMapsLargeData repository on GitHub and downloaded automatically when needed.

Read all commit messages of your local git repository and sort them according to tags or specific text pattern into chapters of a HTML book using bookdown'. The git history book presentation helps organisms required to testify for every changes in their source code, in relation to features requests.

This package provides plotting functions for visualizing pedigrees and family trees. The package complements a behavior genetics package BGmisc [Garrison et al. (2024) <doi:10.21105/joss.06203>] by rendering pedigrees using the ggplot2 framework. Features include support for duplicated individuals, complex mating structures, integration with simulated pedigrees, and layout customization. Due to the impending deprecation of kinship2, version 1.0 incorporates the layout helper functions from kinship2. The pedigree alignment algorithms are adapted from kinship2 [Sinnwell et al. (2014) <doi:10.1159/000363105>]. We gratefully acknowledge the original authors: Jason Sinnwell, Terry Therneau, Daniel Schaid, and Elizabeth Atkinson for their foundational work.