This package provides functions are provided for quantifying evolution and selection on complex traits. The package implements effective handling and analysis algorithms scaled for genome-wide data and calculates a composite statistic, denoted Ghat, which is used to test for selection on a trait. The package provides a number of simple examples for handling and analysing the genome data and visualising the output and results. Beissinger et al., (2018) <doi:10.1534/genetics.118.300857>.

Segmentation and classification procedures for data from the Activinsights GENEActiv <https://activinsights.com/technology/geneactiv/> accelerometer that provides the user with a model to guess behaviour from test data where behaviour is missing. Includes a step counting algorithm, a function to create segmented data with custom features and a function to use recursive partitioning provided in the function rpart() of the rpart package to create classification models.

These Rcpp'-based functions compute the efficient score statistics for grouped time-to-event data (Prentice and Gloeckler, 1978), with the optional inclusion of baseline covariates. Functions for estimating the parameter of interest and nuisance parameters, including baseline hazards, using maximum likelihood are also provided. A parallel set of functions allow for the incorporation of family structure of related individuals (e.g., trios). Note that the current implementation of the frailty model (Ripatti and Palmgren, 2000) is sensitive to departures from model assumptions, and should be considered experimental. For these data, the exact proportional-hazards-model-based likelihood is computed by evaluating multiple variable integration. The integration is accomplished using the Cuba library (Hahn, 2005), and the source files are included in this package. The maximization process is carried out using Brent's algorithm, with the C++ code file from John Burkardt and John Denker (Brent, 2002).

Understanding spatial association is essential for spatial statistical inference, including factor exploration and spatial prediction. Geographically optimal similarity (GOS) model is an effective method for spatial prediction, as described in Yongze Song (2022) <doi:10.1007/s11004-022-10036-8>. GOS was developed based on the geographical similarity principle, as described in Axing Zhu (2018) <doi:10.1080/19475683.2018.1534890>. GOS has advantages in more accurate spatial prediction using fewer samples and critically reduced prediction uncertainty.

This package provides adaptive association tests for SNP level, gene level and pathway level analyses.

This package provides tools for plotting gene clusters and transcripts by importing data from GenBank, FASTA, and GFF files. It performs BLASTP and MUMmer alignments [Altschul et al. (1990) <doi:10.1016/S0022-2836(05)80360-2>; Delcher et al. (1999) <doi:10.1093/nar/27.11.2369>] and displays results on gene arrow maps. Extensive customization options are available, including legends, labels, annotations, scales, colors, tooltips, and more.

Numerical integration with Gram polynomials (based on <arXiv:2106.14875> [math.NA] 28 Jun 2021, by Irfan Muhammad [School of Computer Science, University of Birmingham, UK]).

This package provides tools for fitting sparse generalised linear mixed models with l0 regularisation. Selects fixed and random effects under the hierarchy constraint that fixed effects must precede random effects. Uses coordinate descent and local search algorithms to rapidly deliver near-optimal estimates. Gaussian and binomial response families are currently supported. For more details see Thompson, Wand, and Wang (2025) <doi:10.48550/arXiv.2506.20425>.

This package provides a GraphQL client, with an R6 interface for initializing a connection to a GraphQL instance, and methods for constructing queries, including fragments and parameterized queries. Queries are checked with the libgraphqlparser C++ parser via the graphql package.

This package implements a new multiple imputation method that draws imputations from a latent joint multivariate normal model which underpins generally structured data. This model is constructed using a sequence of flexible conditional linear models that enables the resulting procedure to be efficiently implemented on high dimensional datasets in practice. See Robbins (2021) <arXiv:2008.02243>.

Interacts with the Glassdoor API <https://www.glassdoor.com/developer/index.htm>. Allows the user to search job statistics, employer statistics, and job progression, where Glassdoor provides a breakdown of other jobs a person did after their current one.

Datasets analysed in the book Antony Unwin (2024, ISBN:978-0367674007) "Getting (more out of) Graphics".

Decomposes observed growth in agricultural and livestock systems into interpretable component effects. Depending on the application, the total change in output can be attributed to components such as area effect, yield effect, herd or slaughter effect, productivity effect, and interaction effect. Details can be found in Rakshit and Bardhan (2026) <doi:10.1007/s11250-026-04988-w>.

This package implements short-time Fourier transform (STFT) based processing of strong-motion time series: time-grid regularisation, STFT-window and anti-alias-resampling strategy selection, edge tapering, and frequency-domain integration and differentiation, mapping a single input (acceleration, velocity, or displacement) to a consistent triplet under a chosen analysis bandwidth. Also provides intrinsic-mode-function decomposition via empirical mode decomposition (EMD), ensemble EMD (EEMD), and variational mode decomposition (VMD) with optional band-rule filtering; elastic single-degree-of-freedom (SDOF) response spectra (pseudo-spectral acceleration, velocity, and displacement) by exact state-space integration; intensity measures including peak, root-mean-square (RMS), Arias intensity, significant-duration, cumulative absolute velocity, mean period, and the derived indices earthquake destructiveness potential (EPI) and power-of-input (PDI); and D50 and D100 horizontal response spectra. Methods: Huang et al. (1998) <doi:10.1098/rspa.1998.0193>, Wu and Huang (2009) <doi:10.1142/S1793536909000047>, Dragomiretskiy and Zosso (2014) <doi:10.1109/TSP.2013.2288675>, Boore (2010) <doi:10.1785/0120090179>. An optional indexing layer parses provider files in formats including PEER NGA-West2 AT2', CESMD V2'/'V2c', NWZ V2A', Geological Survey of Canada TR', IGP'/'UCR AC variants, and generic two-column ASCII text, normalises components, writes per-record CSV (comma-separated values) and JSON (JavaScript Object Notation) pairs, and assembles a master record table.

You can use this function to easily draw a combined histogram and restricted cubic spline. The function draws the graph through ggplot2'. RCS fitting requires the use of the rcs() function of the rms package. Can fit cox regression, logistic regression. This method was described by Per Kragh (2003) <doi:10.1002/sim.1497>.

Evaluate and validate the Geboes score for histological assessment of inflammation in ulcerative colitis. The original Geboes score from Geboes, et al. (2000) <doi:10.1136/gut.47.3.404>, binary version from Li, et al. (2019) <doi:10.1093/ecco-jcc/jjz022>, and continuous version from Magro, et al. (2020) <doi:10.1093/ecco-jcc/jjz123> are all described and implemented.

Cross validation informed Relaxed LASSO (or more generally elastic net), gradient boosting machine ('xgboost'), Random Forest ('RandomForestSRC'), Oblique Random Forest ('aorsf'), Artificial Neural Network (ANN), Recursive Partitioning ('RPART') or step wise regression models are fit. Cross validation leave out samples (leading to nested cross validation) or bootstrap out-of-bag samples are used to evaluate and compare performances between these models with results presented in tabular or graphical means. Calibration plots can also be generated, again based upon (outer nested) cross validation or bootstrap leave out (out of bag) samples. Note, at the time of this writing, in order to fit gradient boosting machine models one must install the packages DiceKriging and rgenoud using the install.packages() function. For some datasets, for example when the design matrix is not of full rank, glmnet may have very long run times when fitting the relaxed lasso model, from our experience when fitting Cox models on data with many predictors and many patients, making it difficult to get solutions from either glmnet() or cv.glmnet(). This may be remedied by using the path=TRUE option when calling glmnet() and cv.glmnet(). Within the glmnetr package the approach of path=TRUE is taken by default. other packages doing similar include nestedcv <https://cran.r-project.org/package=nestedcv>, glmnetSE <https://cran.r-project.org/package=glmnetSE> which may provide different functionality when performing a nested CV. Use of the glmnetr has many similarities to the glmnet package and it could be helpful for the user of glmnetr also become familiar with the glmnet package <https://cran.r-project.org/package=glmnet>, with the "An Introduction to glmnet'" and "The Relaxed Lasso" being especially useful in this regard.

Detailed functionality for working with the univariate and multivariate Generalized Hyperbolic distribution and its special cases (Hyperbolic (hyp), Normal Inverse Gaussian (NIG), Variance Gamma (VG), skewed Student-t and Gaussian distribution). Especially, it contains fitting procedures, an AIC-based model selection routine, and functions for the computation of density, quantile, probability, random variates, expected shortfall and some portfolio optimization and plotting routines as well as the likelihood ratio test. In addition, it contains the Generalized Inverse Gaussian distribution. See Chapter 3 of A. J. McNeil, R. Frey, and P. Embrechts. Quantitative risk management: Concepts, techniques and tools. Princeton University Press, Princeton (2005).

Geoms for placing arrowheads at multiple points along a segment, not just at the end; position function to shift starts and ends of arrows to avoid exactly intersecting points.

This package provides a user-friendly interface for characterizing gene function by disease type and tissue site, integrating curated data from publicly available genomic and proteomic databases to support candidate gene prioritization in experimental workflows.

Simplifies regression modeling in R by integrating multiple modeling and summarization tools into a cohesive, user-friendly interface. Designed to be accessible for researchers, particularly those in Low- and Middle-Income Countries (LMIC). Built upon widely accepted statistical methods, including logistic regression (Hosmer et al. 2013, ISBN:9781118548429), log-binomial regression (Spiegelman and Hertzmark 2005 <doi:10.1093/aje/kwi188>), Poisson and robust Poisson regression (Zou 2004 <doi:10.1093/aje/kwh090>), negative binomial regression (Hilbe 2011, ISBN:9780521179515), and linear regression (Kutner et al. 2005, ISBN:9780071122214). Leverages multiple dependencies to ensure high-quality output and generate reproducible, publication-ready tables in alignment with best practices in epidemiology and applied statistics.

This package provides tools for assessing and diagnosing convergence of Markov Chain Monte Carlo simulations, as well as for graphically display results from full MCMC analysis. The package also facilitates the graphical interpretation of models by providing flexible functions to plot the results against observed variables, and functions to work with hierarchical/multilevel batches of parameters (Fernández-i-Marà n, 2016 <doi:10.18637/jss.v070.i09>).

This package provides functions for simulating and estimating parameters of various growth models, including Logistic, Exponential, Theta-logistic, Von-Bertalanffy, and Gompertz models. The package supports both simulated and real data analysis, including parameter estimation, visualization, and calculation of global and local estimates. The methods are based on research described by Md Aktar Ul Karim and Amiya Ranjan Bhowmick (2022) in (<https://www.researchsquare.com/article/rs-2363586/v1>). An interactive web application is also available at [GPEMR Web App](<https://gpem-r.shinyapps.io/GPEM-R/>).

This package implements the G-Formula method for causal inference with time-varying treatments and confounders using Bayesian multiple imputation methods, as described by Bartlett et al (2025) <doi:10.1177/09622802251316971>. It creates multiple synthetic imputed datasets under treatment regimes of interest using the mice package. These can then be analysed using rules developed for analysing multiple synthetic datasets.