Calculate clinical scores for hidradenitis suppurativa (HS), a dermatologic disease. The scores are typically used for evaluation of efficacy in clinical trials. The scores are not commonly used in clinical practice. The specific scores implemented are Hidradenitis Suppurativa Clinical Response (HiSCR) (Kimball, et al. (2015) <doi:10.1111/jdv.13216>), Hidradenitis Suppurativa Area and Severity Index Revised (HASI-R) (Goldfarb, et al. (2020) <doi:10.1111/bjd.19565>), hidradenitis suppurativa Physician Global Assessment (HS PGA) (Marzano, et al. (2020) <doi:10.1111/jdv.16328>), and the International Hidradenitis Suppurativa Severity Score System (IHS4) (Zouboulis, et al. (2017) <doi:10.1111/bjd.15748>).

This package provides functions for the estimation, plotting, predicting and cross-validation of hierarchical feature regression models as described in Pfitzinger (2024). Cluster Regularization via a Hierarchical Feature Regression. Econometrics and Statistics (in press). <doi:10.1016/j.ecosta.2024.01.003>.

Harmony is a tool using AI which allows you to compare items from questionnaires and identify similar content. You can try Harmony at <https://harmonydata.ac.uk/app/> and you can read our blog at <https://harmonydata.ac.uk/blog/> or at <https://fastdatascience.com/how-does-harmony-work/>. Documentation at <https://harmonydata.ac.uk/harmony-r-released/>.

Implementation of S4 class of sets and multisets of numbers. The implementation is based on the hash table from the package hash'. Quick operations are allowed when the set is a dynamic object. The implementation is discussed in detail in Ceoldo and Wit (2023) <arXiv:2304.09809>.

This package provides tools for accessing various open data APIs in the Helsinki region in Finland. Current data sources include the Service Map API, Linked Events API, and Helsinki Region Infoshare statistics API.

This package provides a set of tools to analyze and visualize the relationships between host-associated microbiomes of hybrid organisms and those of their progenitor species. Though not necessary, installing the microViz package is recommended as a check for phyloseq objects. To install microViz from R Universe use the following command: install.packages("microViz", repos = c(davidbarnett = "https://david-barnett.r-universe.dev", getOption("repos"))). To install microViz from GitHub use the following commands: install.packages("devtools") followed by devtools::install_github("david-barnett/microViz").

This package performs Gaussian process regression with heteroskedastic noise following the model by Binois, M., Gramacy, R., Ludkovski, M. (2016) <doi:10.48550/arXiv.1611.05902>, with implementation details in Binois, M. & Gramacy, R. B. (2021) <doi:10.18637/jss.v098.i13>. The input dependent noise is modeled as another Gaussian process. Replicated observations are encouraged as they yield computational savings. Sequential design procedures based on the integrated mean square prediction error and lookahead heuristics are provided, and notably fast update functions when adding new observations.

This package provides access to Uber's H3 library for geospatial indexing via its JavaScript transpile h3-js <https://github.com/uber/h3-js> and V8 <https://github.com/jeroen/v8>.

Identifying labeled compounds in a 13C-tracer experiment in non-targeted fashion is a cumbersome process. This package facilitates such type of analyses by providing high level quality control plots, deconvoluting and evaluating spectra and performing a multitude of tests in an automatic fashion. The main idea is to use changing intensity ratios of ion pairs from peak list generated with xcms as candidates and evaluate those against base peak chromatograms and spectra information within the raw measurement data automatically. The functionality is described in Hoffmann et al. (2018) <doi:10.1021/acs.analchem.8b00356>.

Computation of generalized hypergeometric function with tunable high precision in a vectorized manner, with the floating-point datatypes from mpfr or gmp library. The computation is limited to real numbers.

This package provides methods for closed testing using Simes local tests. In particular, calculates adjusted p-values for Hommel's multiple testing method, and provides lower confidence bounds for true discovery proportions. A robust but more conservative variant of the closed testing procedure that does not require the assumption of Simes inequality is also implemented. The methods have been described in detail in Goeman et al (Biometrika 106, 841-856, 2019).

Historical borrowing in clinical trials can improve precision and operating characteristics. This package supports a hierarchical model and a mixture model to borrow historical control data from other studies to better characterize the control response of the current study. It also quantifies the amount of borrowing through benchmark models (independent and pooled). Some of the methods are discussed by Viele et al. (2013) <doi:10.1002/pst.1589>.

Homomorphic encryption (Brakerski and Vaikuntanathan (2014) <doi:10.1137/120868669>) using Ring Learning with Errors (Lyubashevsky et al. (2012) <https://eprint.iacr.org/2012/230>) is a form of Learning with Errors (Regev (2005) <doi:10.1145/1060590.1060603>) using polynomial rings over finite fields. Functions to generate the required polynomials (using polynom'), with various distributions of coefficients are provided. Additionally, functions to generate and take coefficient modulo are provided.

Calculates a suite of hydrologic indices for daily time series data that are widely used in hydrology and stream ecology.

An S4 implementation of Eq. (3) and Eq. (7) by David J. Hand and Robert J. Till (2001) <DOI:10.1023/A:1010920819831>.

Interact with the application programming interface for the web annotation service Hypothes.is (See <http://hypothes.is> for more information.) Allows users to download data about public annotations, and create, retrieve, update, and delete their own annotations.

This package provides a set of tools supporting more flexible heatmaps. The graphics is grid-like using the old graphics system. The main function is heatmap.n2(), which is a wrapper around the various functions constructing individual parts of the heatmap, like sidebars, picket plots, legends etc. The function supports zooming and splitting, i.e., having (unlimited) small heatmaps underneath each other in one plot deriving from the same data set, e.g., clustered and ordered by a supervised clustering method.

Construction and analysis of multivalued zero-sum matrix games over the abstract space of probability distributions, which describe the losses in each scenario of defense vs. attack action. The distributions can be compiled directly from expert opinions or other empirical data (insofar available). The package implements the methods put forth in the EU project HyRiM (Hybrid Risk Management for Utility Networks), FP7 EU Project Number 608090. The method has been published in Rass, S., König, S., Schauer, S., 2016. Decisions with Uncertain Consequences-A Total Ordering on Loss-Distributions. PLoS ONE 11, e0168583. <doi:10.1371/journal.pone.0168583>, and applied for advanced persistent thread modeling in Rass, S., König, S., Schauer, S., 2017. Defending Against Advanced Persistent Threats Using Game-Theory. PLoS ONE 12, e0168675. <doi:10.1371/journal.pone.0168675>. A volume covering the wider range of aspects of risk management, partially based on the theory implemented in the package is the book edited by S. Rass and S. Schauer, 2018. Game Theory for Security and Risk Management: From Theory to Practice. Springer, <doi:10.1007/978-3-319-75268-6>, ISBN 978-3-319-75267-9.

This package provides pipe-friendly (%>%) wrapper functions for MASS::mvrnorm() to create simulated multivariate data sets with groups of variables with different degrees of variance, covariance, and effect size.

This package implements Data Envelopment Analysis (DEA) with a hyperbolic orientation using a non-linear programming solver. It enables flexible estimations with weight restrictions, non-discretionary variables, and a generalized distance function. Additionally, it allows for the calculation of slacks and super-efficiency scores. The methods are detailed in à ttl et al. (2023), <doi:10.1016/j.dajour.2023.100343>. Furthermore, the package provides a non-linear profitability estimation built upon the DEA framework.

This package provides a data only package containing commercial domestic flights that departed Houston (IAH and HOU) in 2011.

State-of-the-art Multi-Objective Particle Swarm Optimiser (MOPSO), based on the algorithm developed by Lin et al. (2018) <doi:10.1109/TEVC.2016.2631279> with improvements described by Marinao-Rivas & Zambrano-Bigiarini (2020) <doi:10.1109/LA-CCI48322.2021.9769844>. This package is inspired by and closely follows the philosophy of the single objective hydroPSO R package ((Zambrano-Bigiarini & Rojas, 2013) <doi:10.1016/j.envsoft.2013.01.004>), and can be used for global optimisation of non-smooth and non-linear R functions and R-base models (e.g., TUWmodel', GR4J', GR6J'). However, the main focus of hydroMOPSO is optimising environmental and other real-world models that need to be run from the system console (e.g., SWAT+'). hydroMOPSO communicates with the model to be optimised through its input and output files, without requiring modifying its source code. Thanks to its flexible design and the availability of several fine-tuning options, hydroMOPSO can tackle a wide range of multi-objective optimisation problems (e.g., multi-objective functions, multiple model variables, multiple periods). Finally, hydroMOPSO is designed to run on multi-core machines or network clusters, to alleviate the computational burden of complex models with long execution time.

There are growing concerns on flow data in diverse fields including trade, migration, knowledge diffusion, disease spread, and transportation. The package is an effective visual support to learn the pattern of flow which is called halfcircle diagram. The flow between two nodes placed on the center line of a circle is represented using a half circle drawn from the origin to the destination in a clockwise direction. Through changing the order of nodes, the halfcircle diagram enables users to examine the complex relationship between bidirectional flow and each potential determinants. Furthermore, the halfmeancenter function, which calculates (un) weighted mean center of half circles, makes the comparison easier.

This package implements marker-based estimation of heritability when observations on genetically identical replicates are available. These can be either observations on individual plants or plot-level data in a field trial. Heritability can then be estimated using a mixed model for the individual plant or plot data. For comparison, also mixed-model based estimation using genotypic means and estimation of repeatability with ANOVA are implemented. For illustration the package contains several datasets for the model species Arabidopsis thaliana.