When performing multiple imputations, while 5-10 imputations are sufficient for obtaining point estimates, a larger number of imputations are needed for proper standard error estimates. This package allows you to calculate how many imputations are needed, following the work of von Hippel (2020) <doi:10.1177/0049124117747303>.

Add, share and manage annotations for Shiny applications and R Markdown documents via hypothes.is'.

This package provides a forecasting method that efficiently maps vast numbers of (scalar-valued) signals into an aggregate density forecast in a time-varying and computationally fast manner. The method proceeds in two steps: First, it transforms a predictive signal into a density forecast and, second, it combines the resulting candidate density forecasts into an ultimate aggregate density forecast. For a detailed explanation of the method, please refer to Adaemmer et al. (2025) <doi:10.1080/07350015.2025.2526424>.

This package provides functions to implement a hierarchical approach which is designed to perform joint analysis of summary statistics using the framework of Mendelian Randomization or transcriptome analysis. Reference: Lai Jiang, Shujing Xu, Nicholas Mancuso, Paul J. Newcombe, David V. Conti (2020). "A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis." <bioRxiv><doi:10.1101/2020.02.03.924241>.

This package provides the posterior estimates of the regression coefficients when horseshoe prior is specified. The regression models considered here are logistic model for binary response and log normal accelerated failure time model for right censored survival response. The linear model analysis is also available for completeness. All models provide deviance information criterion and widely applicable information criterion. See <doi:10.1111/rssc.12377> Maity et. al. (2019) <doi:10.1111/biom.13132> Maity et. al. (2020).

Wrapper for Stan that offers a number of in-built models to implement a hierarchical Bayesian longitudinal model for repeat observation data. Model choice selects the differential equation that is fit to the observations. Single and multi-individual models are available. O'Brien et al. (2024) <doi:10.1111/2041-210X.14463>.

This package performs multiple hot-deck imputation of categorical and continuous variables in a data frame.

User-friendly functions for leveraging (multiple) historical data set(s) in Bayesian analysis of generalized linear models (GLMs) and survival models, along with support for Bayesian model averaging (BMA). The package provides functions for sampling from posterior distributions under various informative priors, including the prior induced by the Bayesian hierarchical model, power prior by Ibrahim and Chen (2000) <doi:10.1214/ss/1009212673>, normalized power prior by Duan et al. (2006) <doi:10.1002/env.752>, normalized asymptotic power prior by Ibrahim et al. (2015) <doi:10.1002/sim.6728>, commensurate prior by Hobbs et al. (2011) <doi:10.1111/j.1541-0420.2011.01564.x>, robust meta-analytic-predictive prior by Schmidli et al. (2014) <doi:10.1111/biom.12242>, latent exchangeability prior by Alt et al. (2024) <doi:10.1093/biomtc/ujae083>, and a normal (or half-normal) prior. The package also includes functions for computing model averaging weights, such as BMA, pseudo-BMA, pseudo-BMA with the Bayesian bootstrap, and stacking (Yao et al., 2018 <doi:10.1214/17-BA1091>), as well as for generating posterior samples from the ensemble distributions to reflect model uncertainty. In addition to GLMs, the package supports survival models including: (1) accelerated failure time (AFT) models, (2) piecewise exponential (PWE) models, i.e., proportional hazards models with piecewise constant baseline hazards, and (3) mixture cure rate models that assume a common probability of cure across subjects, paired with a PWE model for the non-cured population. Functions for computing marginal log-likelihoods under each implemented prior are also included. The package compiles all the CmdStan models once during installation using the instantiate package.

This package provides tools for accessing various open data APIs in the Helsinki region in Finland. Current data sources include the Service Map API, Linked Events API, and Helsinki Region Infoshare statistics API.

Set of tools to help interested researchers to build hospital networks from data on hospitalized patients transferred between hospitals. Methods provided have been used in Donker T, Wallinga J, Grundmann H. (2010) <doi:10.1371/journal.pcbi.1000715>, and Nekkab N, Crépey P, Astagneau P, Opatowski L, Temime L. (2020) <doi:10.1038/s41598-020-71212-6>.

This package provides a novel decision tree algorithm in the hypothesis testing framework. The algorithm examines the distribution difference between two child nodes over all possible binary partitions. The test statistic of the hypothesis testing is equivalent to the generalized energy distance, which enables the algorithm to be more powerful in detecting the complex structure, not only the mean difference. It is applicable for numeric, nominal, ordinal explanatory variables and the response in general metric space of strong negative type. The algorithm has superior performance compared to other tree models in type I error, power, prediction accuracy, and complexity.

Two papers published in the early 2000's (Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) and (Zeeberg, B.R., Qin, H., Narashimhan, S., et al. (2005) <doi:10.1186/1471-2105-6-168>) implement GoMiner and High Throughput GoMiner ('HTGM') to map lists of genes to the Gene Ontology (GO) <https://geneontology.org>. Until recently, these were hosted on a server at The National Cancer Institute (NCI). In order to continue providing these services to the bio-medical community, I have developed stand-alone versions. The current package HTGM builds upon my recent package GoMiner'. The output of GoMiner is a heatmap showing the relationship of a single list of genes and the significant categories into which they map. High Throughput GoMiner ('HTGM') integrates the results of the individual GoMiner analyses. The output of HTGM is a heatmap showing the relationship of the significant categories derived from each gene list. The heatmap has only 2 axes, so the identity of the genes are unfortunately "integrated out of the equation." Because the graphic for the heatmap is implemented in Scalable Vector Graphics (SVG) technology, it is relatively easy to hyperlink each picture element to the relevant list of genes. By clicking on the desired picture element, the user can recover the "lost" genes.

The conditional treatment effect for competing risks data in observational studies is estimated. While it is described as a constant difference between the hazard functions given the covariates, we do not assume specific functional forms for the covariates. Rava, D. and Xu, R. (2021) <arXiv:2112.09535>.

Perform high dimensional Feature Selection in the presence of survival outcome. Based on Feature Selection method and different survival analysis, it will obtain the best markers with optimal threshold levels according to their effect on disease progression and produce the most consistent level according to those threshold values. The functions methodology is based on by Sonabend et al (2021) <doi:10.1093/bioinformatics/btab039> and Bhattacharjee et al (2021) <arXiv:2012.02102>.

Automatic open data acquisition from resources of IGN ('Institut National de Information Geographique et forestiere') (<https://www.ign.fr/>). Available datasets include various types of raster and vector data, such as digital elevation models, state borders, spatial databases, cadastral parcels, and more. happign also provide access to API Carto (<https://apicarto.ign.fr/api/doc/>).

Compute 21 summary measures of health inequality and its corresponding confidence intervals for ordered and non-ordered dimensions using disaggregated data. Measures for ordered dimensions (e.g., Slope Index of Inequality, Absolute Concentration Index) also accept individual and survey data.

Helper functions designed to make dynamically generating R Markdown documents easier by providing a simple and tidy way to create report pieces, shape them to your data, and combine them for exporting into a single R Markdown document.

Generalized additive models with a numeric hyper column. Sign-adjustment based on the correlation of model prediction and a selected slice of the hyper column. Visualization of the integrand surface over the hyper column.

The holonomic gradient method (HGM, hgm) gives a way to evaluate normalization constants of unnormalized probability distributions by utilizing holonomic systems of differential or difference equations. The holonomic gradient descent (HGD, hgd) gives a method to find maximal likelihood estimates by utilizing the HGM.

Computes the ACMIF test and Bonferroni-adjusted p-value of interaction in two-factor studies. Produces corresponding interaction plot and analysis of variance tables and p-values from several other tests of non-additivity.

Allows users to create time series of tropical storm exposure histories for chosen counties for a number of hazard metrics (wind, rain, distance from the storm, etc.). This package interacts with data available through the hurricaneexposuredata package, which is available in a drat repository. To access this data package, see the instructions at <https://github.com/geanders/hurricaneexposure>. The size of the hurricaneexposuredata package is approximately 20 MB. This work was supported in part by grants from the National Institute of Environmental Health Sciences (R00ES022631), the National Science Foundation (1331399), and a NASA Applied Sciences Program/Public Health Program Grant (NNX09AV81G).

Discriminant analysis and data clustering methods for high dimensional data, based on the assumption that high-dimensional data live in different subspaces with low dimensionality proposing a new parametrization of the Gaussian mixture model which combines the ideas of dimension reduction and constraints on the model.

Inference of chromosome-length haplotypes using a few haploid gametes of an individual. The gamete genotype data may be generated from various platforms including genotyping arrays and sequencing even with low-coverage. Hapi simply takes genotype data of known hetSNPs in single gamete cells as input and report the high-resolution haplotypes as well as confidence of each phased hetSNPs. The package also includes a module allowing downstream analyses and visualization of identified crossovers in the gametes.

This package provides flexible maximum likelihood estimation and inference for Hidden Markov Models (HMMs) and Hidden Semi-Markov Models (HSMMs), as well as the underlying systems in which they operate. The package supports a wide range of observation and dwell-time distributions, offering a flexible modelling framework suitable for diverse practical data. Efficient implementations of the forward-backward and Viterbi algorithms are provided via Rcpp for enhanced computational performance. Additional functionality includes model simulation, residual analysis, non-initialised estimation, local and global decoding, calculation of diverse information criteria, computation of confidence intervals using parametric bootstrap methods, numerical covariance matrix estimation, and comprehensive visualisation functions for interpreting the data-generating processes inferred from the models. Methods follow standard approaches described by Guédon (2003) <doi:10.1198/1061860032030>, Zucchini and MacDonald (2009, ISBN:9781584885733), and O'Connell and Højsgaard (2011) <doi:10.18637/jss.v039.i04>.