Facilitates building topology preserving maps for data analysis.

This package provides tools to calculate Mean Corpuscular Volume, Mean Corpuscular Hemoglobin, and Mean Corpuscular Hemoglobin Concentration, which are essential for assessing red blood cell health and diagnosing blood disorders.

Several functions that allow by different methods to infer a piecewise polynomial regression model under regularity constraints, namely continuity or differentiability of the link function. The implemented functions are either specific to data with two regimes, or generic for any number of regimes, which can be given by the user or learned by the algorithm. A paper describing all these methods will be submitted soon. The reference will be added to this file as soon as available.

User-friendly functions for leveraging (multiple) historical data set(s) in Bayesian analysis of generalized linear models (GLMs) and survival models, along with support for Bayesian model averaging (BMA). The package provides functions for sampling from posterior distributions under various informative priors, including the prior induced by the Bayesian hierarchical model, power prior by Ibrahim and Chen (2000) <doi:10.1214/ss/1009212673>, normalized power prior by Duan et al. (2006) <doi:10.1002/env.752>, normalized asymptotic power prior by Ibrahim et al. (2015) <doi:10.1002/sim.6728>, commensurate prior by Hobbs et al. (2011) <doi:10.1111/j.1541-0420.2011.01564.x>, robust meta-analytic-predictive prior by Schmidli et al. (2014) <doi:10.1111/biom.12242>, latent exchangeability prior by Alt et al. (2024) <doi:10.1093/biomtc/ujae083>, and a normal (or half-normal) prior. The package also includes functions for computing model averaging weights, such as BMA, pseudo-BMA, pseudo-BMA with the Bayesian bootstrap, and stacking (Yao et al., 2018 <doi:10.1214/17-BA1091>), as well as for generating posterior samples from the ensemble distributions to reflect model uncertainty. In addition to GLMs, the package supports survival models including: (1) accelerated failure time (AFT) models, (2) piecewise exponential (PWE) models, i.e., proportional hazards models with piecewise constant baseline hazards, and (3) mixture cure rate models that assume a common probability of cure across subjects, paired with a PWE model for the non-cured population. Functions for computing marginal log-likelihoods under each implemented prior are also included. The package compiles all the CmdStan models once during installation using the instantiate package.

Allows users to create high-quality heatmaps from labelled, hierarchical data. Specifically, for data with a two-level hierarchical structure, it will produce a heatmap where each row and column represents a category at the lower level. These rows and columns are then grouped by the higher-level group each category belongs to, with the names for each category and groups shown in the margins. While other packages (e.g. dendextend') allow heatmap rows and columns to be arranged by groups only, hhmR also allows the labelling of the data at both the category and group level.

This package provides a multiple-testing procedure for high-dimensional mediation hypotheses. Mediation analysis is of rising interest in epidemiology and clinical trials. Among existing methods for mediation analyses, the popular joint significance (JS) test yields an overly conservative type I error rate and therefore low power. In the R package HDMT we implement a multiple-testing procedure that accurately controls the family-wise error rate (FWER) and the false discovery rate (FDR) when using JS for testing high-dimensional mediation hypotheses. The core of our procedure is based on estimating the proportions of three component null hypotheses and deriving the corresponding mixture distribution of null p-values. Results of the data examples include better-behaved quantile-quantile plots and improved detection of novel mediation relationships on the role of DNA methylation in genetic regulation of gene expression. With increasing interest in mediation by molecular intermediaries such as gene expression, the proposed method addresses an unmet methodological challenge. Methods used in the package refer to James Y. Dai, Janet L. Stanford & Michael LeBlanc (2020) <doi:10.1080/01621459.2020.1765785>.

Hospital data analysis workflow tools, modeling, and automations. This library provides many useful tools to review common administrative hospital data. Some of these include average length of stay, readmission rates, average net pay amounts by service lines just to name a few. The aim is to provide a simple and consistent verb framework that takes the guesswork out of everything.

This package provides a method for estimating the correlation matrix of the Gaussian copula from the observed data. This package also contains a penalized estimation of the corresponding precision matrix, and enables to generate random vectors that are distributed according to a Gaussian copula.

This package contains functions for fitting hierarchical versions of EVSD, UVSD, DPSD, DPSD with d restricted to be positive, and our gamma signal detection model to recognition memory confidence-ratings data.

This package provides a program that conducts group variable selection for quantile and robust mean regression (Sherwood and Li, 2022). The group lasso penalty (Yuan and Lin, 2006) is used for group-wise variable selection. Both of the quantile and mean regression models are based on the Huber loss. Specifically, with the tuning parameter in the Huber loss approaching to 0, the quantile check function can be approximated by the Huber loss for the median and the tilted version of Huber loss at other quantiles. Such approximation provides computational efficiency and stability, and has also been shown to be statistical consistent.

The Harmonised Index of Consumer Prices (HICP) is the key economic figure to measure inflation in the euro area. The methodology underlying the HICP is documented in the HICP Methodological Manual (<https://ec.europa.eu/eurostat/web/products-manuals-and-guidelines/w/ks-gq-24-003>). Based on the manual, this package provides functions to access and work with HICP data from Eurostat's public database (<https://ec.europa.eu/eurostat/data/database>).

In medical research, supervised heterogeneity analysis has important implications. Assume that there are two types of features. Using both types of features, our goal is to conduct the first supervised heterogeneity analysis that satisfies a hierarchical structure. That is, the first type of features defines a rough structure, and the second type defines a nested and more refined structure. A penalization approach is developed, which has been motivated by but differs significantly from penalized fusion and sparse group penalization. Reference: Ren, M., Zhang, Q., Zhang, S., Zhong, T., Huang, J. & Ma, S. (2022). "Hierarchical cancer heterogeneity analysis based on histopathological imaging features". Biometrics, <doi:10.1111/biom.13426>.

Allows to detect spatial clusters of abnormal values on multivariate or functional data (Frévent et al. (2022) <doi:10.32614/RJ-2022-045>). See also: Frévent et al. (2023) <doi:10.1093/jrsssc/qlad017>, Smida et al. (2022) <doi:10.1016/j.csda.2021.107378>, Frévent et al. (2021) <doi:10.1016/j.spasta.2021.100550>. Cucala et al. (2019) <doi:10.1016/j.spasta.2018.10.002>, Cucala et al. (2017) <doi:10.1016/j.spasta.2017.06.001>, Jung and Cho (2015) <doi:10.1186/s12942-015-0024-6>, Kulldorff et al. (2009) <doi:10.1186/1476-072X-8-58>.

This package provides functions for visualization and decomposition in hierarchical linear models (HLM) for applications in education, psychology, and the social sciences. Includes variance decomposition for two-level and three-level data structures following Snijders and Bosker (2012, ISBN:9781849202015), intraclass correlation (ICC) estimation and design effect computation as described in Shrout and Fleiss (1979) <doi:10.1037/0033-2909.86.2.420>, and contextual effect decomposition via the Mundlak (1978) <doi:10.2307/1913646> specification distinguishing within- and between-cluster components. Supports visualization of random slopes and cross-level interactions following Hofmann and Gavin (1998) <doi:10.1177/014920639802400504> and Hamaker and Muthen (2020) <doi:10.1037/met0000239>. Multilevel models are estimated using lme4 (Bates et al., 2015 <doi:10.18637/jss.v067.i01>). An optional Shiny application enables interactive exploration of model components and parameter variation. The implementation follows the multilevel modeling framework of Raudenbush and Bryk (2002, ISBN:9780761919049).

The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.

This package provides a handy collection of utility functions designed to aid in package development, plotting and scientific research. Package development functionalities includes among others tools such as cross-referencing package imports with the description file, analysis of redundant package imports, editing of the description file and the creation of package badges for GitHub. Some of the other functionalities include automatic package installation and loading, plotting points without overlap, creating nice breaks for plots, overview tables and many more handy utility functions.

Hypergeometric Intersection distributions are a broad group of distributions that describe the probability of picking intersections when drawing independently from two (or more) urns containing variable numbers of balls belonging to the same n categories. <arXiv:1305.0717>.

This package implements hierarchical Bayesian inference, robust frequentist inference, and distribution-free inference for dependent and unbalanced data under strong-mixing conditions. Supports triangular-array, weighted-sum and mixingale convergence regimes with Whittle and composite likelihoods, heteroskedasticity-and-autocorrelation-consistent variance estimation, block bootstrap with automatic block length, fixed-bandwidth HAR inference, adaptive conformal prediction, Bayesian decision under Region of Practical Equivalence, bridge-sampling Bayes factors, and predictive comparison via the Widely Applicable Information Criterion and leave-future-out cross-validation. Methods follow Andrews (1991) <doi:10.2307/2938229>, Kiefer and Vogelsang (2005) <doi:10.1017/S0266466605050565>, Patton, Politis and White (2009) <doi:10.1080/07474930802459016>, Vehtari, Gelman and Gabry (2017) <doi:10.1007/s11222-016-9696-4>, Kruschke (2018) <doi:10.1177/2515245918771304>, and Gibbs and Candes (2021) <doi:10.48550/arXiv.2106.00170>.

Helper functions for creating reproducible hexagon sticker purely in R.

Palettes generated from Hello Kitty cartoon.

This package provides a comprehensive suite of tools for processing, analyzing, and visualizing hydrochemical data in a reproducible and programmatic workflow. Implements unit conversion, censored data management, ionic balance calculation, water type classification, and a range of hydrochemical indices relevant to water quality assessment. Offers advanced visualization functions for generating Piper (Piper, 1944, <doi:10.1029/TR025i006p00914>), Durov (Durov, 1948), Stiff (Stiff, 1951, <doi:10.2118/951376-G>), Collins (Collins, 1923, <doi:10.1021/ie50160a030>), Schoeller (Schoeller, 1935), Gibbs (Gibbs, 1970, <doi:10.1126/science.170.3962.1088>), and ternary diagrams â the standard graphical tools used in hydrochemical interpretation. Unlike existing solutions that rely on spreadsheets or proprietary graphical software, hydrochem is designed for scalability and reproducibility, lowering the technical barrier for hydrochemists working with datasets of varying complexity. It integrates seamlessly into modern R workflows and supports rigorous water resource management and research.

To test the homogeneity of stratum effects in stratified paired binary data.

This package provides functions to assess and test for heterogeneity in the utility of a surrogate marker with respect to a baseline covariate using censored (survival data), and to test for heterogeneity across multiple time points. More details are available in Parast et al (2024) <doi:10.1002/sim.10122>.

Deprecated.