Fits a linear-binomial model using a modified Newton-type algorithm for solving the maximum likelihood estimation problem under linear box constraints. Similar methods are described in Wagenpfeil, Schöpe and Bekhit (2025, ISBN:9783111341972) "Estimation of adjusted relative risks in log-binomial regression using the BSW algorithm". In: Mau, Mukhin, Wang and Xu (Eds.), Biokybernetika. De Gruyter, Berlin, pp. 665â 676.

This package provides an htmlwidgets interface to apexcharts.js'. Apexcharts is a modern JavaScript charting library to build interactive charts and visualizations with simple API. Apexcharts examples and documentation are available here: <https://apexcharts.com/>.

This package implements several new association indices that can control for various types of errors. Also includes existing association indices and functions for simulating the effects of different rates of error on estimates of association strength between individuals using each method.

Optimize one or two-arm, two-stage designs for clinical trials with respect to several implemented objective criteria or custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz et al. (2019) <doi:10.1002/sim.8291> and Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09> for details.

Compute the R-squared measure under the accelerated failure time (AFT) models proposed in Chan et. al. (2018) <doi:10.1080/03610918.2016.1177072>.

Visualization of Design of Experiments from the agricolae package with ggplot2 framework The user provides an experiment design from the agricolae package, calls the corresponding function and will receive a visualization with ggplot2 based functions that are specific for each design. As there are many different designs, each design is tested on its type. The output can be modified with standard ggplot2 commands or with other packages with ggplot2 function extensions.

This package implements the Agnostic Fay-Herriot model, an extension of the traditional small area model. In place of normal sampling errors, the sampling error distribution is estimated with a Gaussian process to accommodate a broader class of distributions. This flexibility is most useful in the presence of bounded, multi-modal, or heavily skewed sampling errors.

Datasets to be used primarily in conjunction with Ascent training materials but also for the book SAMS Teach Yourself R in 24 Hours (ISBN: 978-0-672-33848-9). Version 1.0-7 is largely for use with the book; however, version 1.1 has a much greater focus on use with training materials, whilst retaining compatibility with the book.

This package provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.

Interact with Google Ads Data Hub API <https://developers.google.com/ads-data-hub/reference/rest>. The functionality allows to fetch customer details, submit queries to ADH.

Estimate the Å estákâ Berggren kinetic model (degradation model) from experimental data. A closed-form (analytic) solution to the degradation model is implemented as a non-linear fit, allowing for the extrapolation of the degradation of a drug product - both in time and temperature. Parametric bootstrap, with kinetic parameters drawn from the multivariate t-distribution, and analytical formulae (the delta method) are available options to calculate the confidence and prediction intervals. The results (modelling, extrapolations and statistical intervals) can be visualised with multiple plots. The examples illustrate the accelerated stability modelling in drugs and vaccines development.

Fast partial least squares (PLS) for dense and out-of-core data. Provides SIMPLS (straightforward implementation of a statistically inspired modification of the PLS method) and NIPALS (non-linear iterative partial least-squares) solvers, plus kernel-style PLS variants ('kernelpls and widekernelpls') with parity to pls'. Optimized for bigmemory'-backed matrices with streamed cross-products and chunked BLAS (Basic Linear Algebra Subprograms) (XtX/XtY and XXt/YX), optional file-backed score sinks, and deterministic testing helpers. Includes an auto-selection strategy that chooses between XtX SIMPLS, XXt (wide) SIMPLS, and NIPALS based on (n, p) and a configurable memory budget. About the package, Bertrand and Maumy (2023) <https://hal.science/hal-05352069>, and <https://hal.science/hal-05352061> highlighted fitting and cross-validating PLS regression models to big data. For more details about some of the techniques featured in the package, Dayal and MacGregor (1997) <doi:10.1002/(SICI)1099-128X(199701)11:1%3C73::AID-CEM435%3E3.0.CO;2-%23>, Rosipal & Trejo (2001) <https://www.jmlr.org/papers/v2/rosipal01a.html>, Tenenhaus, Viennet, and Saporta (2007) <doi:10.1016/j.csda.2007.01.004>, Rosipal (2004) <doi:10.1007/978-3-540-45167-9_17>, Rosipal (2019) <https://ieeexplore.ieee.org/document/8616346>, Song, Wang, and Bai (2024) <doi:10.1016/j.chemolab.2024.105238>. Includes kernel logistic PLS with C++'-accelerated alternating iteratively reweighted least squares (IRLS) updates, streamed reproducing kernel Hilbert space (RKHS) solvers with reusable centering statistics, and bootstrap diagnostics with graphical summaries for coefficients, scores, and cross-validation workflows, alongside dedicated plotting utilities for individuals, variables, ellipses, and biplots. The streaming backend uses far less memory and keeps memory bounded across data sizes. For PLS1, streaming is often fast enough while preserving a small memory footprint; for PLS2 it remains competitive with a bounded footprint. On small problems that fit comfortably in RAM (random-access memory), dense in-memory solvers are slightly faster; the crossover occurs as n or p grow and the Gram/cross-product cost dominates.

It brings together several aspects of biodiversity data-cleaning in one place. bdc is organized in thematic modules related to different biodiversity dimensions, including 1) Merge datasets: standardization and integration of different datasets; 2) Pre-filter: flagging and removal of invalid or non-interpretable information, followed by data amendments; 3) Taxonomy: cleaning, parsing, and harmonization of scientific names from several taxonomic groups against taxonomic databases locally stored through the application of exact and partial matching algorithms; 4) Space: flagging of erroneous, suspect, and low-precision geographic coordinates; and 5) Time: flagging and, whenever possible, correction of inconsistent collection date. In addition, it contains features to visualize, document, and report data quality â which is essential for making data quality assessment transparent and reproducible. The reference for the methodology is Bruno et al. (2022) <doi:10.1111/2041-210X.13868>.

This package contains functions for estimating above-ground biomass/carbon and its uncertainty in tropical forests. These functions allow to (1) retrieve and correct taxonomy, (2) estimate wood density and its uncertainty, (3) build height-diameter models, (4) manage tree and plot coordinates, (5) estimate above-ground biomass/carbon at stand level with associated uncertainty. To cite â BIOMASSâ , please use citation(â BIOMASSâ ). For more information, see Réjou-Méchain et al. (2017) <doi:10.1111/2041-210X.12753>.

Prior transcription factor binding knowledge and target gene expression data are integrated in a Bayesian framework for functional cis-regulatory module inference. Using Gibbs sampling, we iteratively estimate transcription factor associations for each gene, regulation strength for each binding event and the hidden activity for each transcription factor.

This package implements functions that calculate upper prediction bounds on the false discovery proportion (FDP) in the list of discoveries returned by competition-based setups, implementing Ebadi et al. (2022) <arXiv:2302.11837>. Such setups include target-decoy competition (TDC) in computational mass spectrometry and the knockoff construction in linear regression (note this package typically uses the terminology of TDC). Included is the standardized (TDC-SB) and uniform (TDC-UB) bound on TDC's FDP, and the simultaneous standardized and uniform bands. Requires pre-computed Monte Carlo statistics available at <https://github.com/uni-Arya/fdpbandsdata>. This data can be downloaded by running the command devtools::install_github("uni-Arya/fdpbandsdata") in R and restarting R after installation. The size of this data is roughly 81Mb.

Included here are babel routines for identifying unusual ribosome protected fragment counts given mRNA counts.

This package implements the bolasso algorithm for consistent variable selection and estimation accuracy. Includes support for many parallel backends via the future package. For details see: Bach (2008), Bolasso: model consistent Lasso estimation through the bootstrap', <doi:10.48550/arXiv.0804.1302>.

Compose and send out responsive HTML email messages that render perfectly across a range of email clients and device sizes. Helper functions let the user insert embedded images, web link buttons, and ggplot2 plot objects into the message body. Messages can be sent through an SMTP server, through the Posit Connect service, or through the Mailgun API service <https://www.mailgun.com/>.

This package provides tools for constructing board/grid based games, as well as readily available game(s) for your entertainment.

The sample size according to the Bethel's procedure.

This package provides an alternative approach to aoristic analyses for archaeological datasets by fitting Bayesian parametric growth models and non-parametric random-walk Intrinsic Conditional Autoregressive (ICAR) models on time frequency data (Crema (2024)<doi:10.1111/arcm.12984>). It handles event typo-chronology based timespans defined by start/end date as well as more complex user-provided vector of probabilities.

This package provides a continuous date scale, omitting weekends and holidays.

Box-Cox-type transformations for linear and logistic models with random effects using non-parametric profile maximum likelihood estimation, as introduced in Almohaimeed (2018) <http://etheses.dur.ac.uk/12831/> and Almohaimeed and Einbeck (2022) <doi:10.1177/1471082X20966919>. The main functions are optim.boxcox() for linear models with random effects and boxcoxtype() for logistic models with random effects.