Computation of test statistics of independence between (continuous) innovations of time series. They can be used with stochastic volatility models and Hidden Markov Models (HMM). This improves the results in Duchesne, Ghoudi & Remillard (2012) <doi:10.1002/cjs.11141>.

This package implements likelihood based methods for mediation analysis.

We construct the explicit form of clamped cubic interpolating spline (both uniform - knots are equidistant and non-uniform - knots are arbitrary). Using this form, we propose a linear regression model suitable for real data smoothing.

This package provides a graphical user interface to the IsoplotR package for radiometric geochronology. The GUI runs in an internet browser and can either be used offline, or hosted on a server to provide online access to the IsoplotR toolbox.

Using embedded sdmx queries, get the data of more than 150 000 insee series from bdm macroeconomic database.

This package provides a comprehensive toolkit for clinical Human Leukocyte Antigen (HLA) informatics, built on tidyverse <https://tidyverse.tidyverse.org/> principles and making use of genotype list string (GL string, Mack et al. (2023) <doi:10.1111/tan.15126>) for storing and computing HLA genotype data. Specific functionalities include: coercion of HLA data in tabular format to and from GL string; calculation of matching and mismatching in all directions, with multiple output formats; automatic formatting of HLA data for searching within a GL string; truncation of molecular HLA data to a specific number of fields; and reading HLA genotypes in HML files and extracting the GL string. This library is intended for research use. Any application making use of this package in a clinical setting will need to be independently validated according to local regulations.

The iterLap (iterated Laplace approximation) algorithm approximates a general (possibly non-normalized) probability density on R^p, by repeated Laplace approximations to the difference between current approximation and true density (on log scale). The final approximation is a mixture of multivariate normal distributions and might be used for example as a proposal distribution for importance sampling (eg in Bayesian applications). The algorithm can be seen as a computational generalization of the Laplace approximation suitable for skew or multimodal densities.

This package provides advanced functions for image processing based on the package imager'.

Partitioning clustering algorithms divide data sets into k subsets or partitions so-called clusters. They require some initialization procedures for starting the algorithms. Initialization of cluster prototypes is one of such kind of procedures for most of the partitioning algorithms. Cluster prototypes are the centers of clusters, i.e. centroids or medoids, representing the clusters in a data set. In order to initialize cluster prototypes, the package inaparc contains a set of the functions that are the implementations of several linear time-complexity and loglinear time-complexity methods in addition to some novel techniques. Initialization of fuzzy membership degrees matrices is another important task for starting the probabilistic and possibilistic partitioning algorithms. In order to initialize membership degrees matrices required by these algorithms, a number of functions based on some traditional and novel initialization techniques are also available in the package inaparc'.

This package provides a procedure for seeding R's built in random number generators using a variable-length sequence of values. Accumulates input entropy into a 256-bit hash digest or "ironseed" and is able to generate a variable-length sequence of output seeds from an ironseed.

Carries out integrative clustering analysis using multiple types of genomic dataset using integrative Non-negative Matrix factorization.

The Importance Index (I.I.) can determine the loss and solution sources for a system in certain knowledge areas (e.g., agronomy), when production (e.g., fruits) is known (Demolin-Leite, 2021). Events (e.g., agricultural pest) can have different magnitudes (numerical measurements), frequencies, and distributions (aggregate, random, or regular) of event occurrence, and I.I. bases in this triplet (Demolin-Leite, 2021) <https://cjascience.com/index.php/CJAS/article/view/1009/1319>. Usually, the higher the magnitude and frequency of aggregated distribution, the greater the problem or the solution (e.g., natural enemies versus pests) for the system (Demolin-Leite, 2021). However, the final production of the system is not always known or is difficult to determine (e.g., degraded area recovery). A derivation of the I.I. is the percentage of Importance Index-Production Unknown (% I.I.-PU) that can detect the loss or solution sources, when production is unknown for the system (Demolin-Leite, 2024) <DOI:10.1590/1519-6984.253218>.

Sieve semiparametric likelihood methods for analyzing interval-censored failure time data from an outcome-dependent sampling (ODS) design and from a case-cohort design. Zhou, Q., Cai, J., and Zhou, H. (2018) <doi:10.1111/biom.12744>; Zhou, Q., Zhou, H., and Cai, J. (2017) <doi:10.1093/biomet/asw067>.

Two functions for running and then post-estimating an Interrupted Time Series Analysis model. This is a solution for running time series analyses on temporally short data. See English (2019) The its.analysis R package - Modelling short time series data <https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3398189> for an overview of the method.

Use R to make requests to the US Census Bureau's International Data Base API. Results are returned as R data frames. For more information about the IDB API, visit <https://www.census.gov/data/developers/data-sets/international-database.html>.

This package provides a runtime type system, allowing users to define and implement interfaces, enums, typed data.frame/data.table, as well as typed functions. This package enables stricter type checking and validation, improving code structure, robustness and reliability.

Automatically detects Copy Number Variations (CNV) from Next Generation Sequencing data using a machine learning algorithm, Isolation forest. More details about the method can be found in the paper by Cabello-Aguilar (2022) <doi:10.1101/2022.01.03.474771>.

This package provides tools for multivariate nonparametrics, as location tests based on marginal ranks, spatial median and spatial signs computation, Hotelling's T-test, estimates of shape are implemented.

This package provides a set of tools to i) identify geographic areas with significant change over time in drug utilization, and ii) characterize common change over time patterns among the time series for multiple geographic areas. For reference, see below: 1. Song, J., Carey, M., Zhu, H., Miao, H., Ram´ırez, J. C., & Wu, H. (2018) <doi:10.1504/IJCBDD.2018.10011910> 2. Wu, S., Wu, H. (2013) <doi:10.1186/1471-2105-14-6> 3. Carey, M., Wu, S., Gan, G. & Wu, H. (2016) <doi:10.1016/j.idm.2016.07.001>.

Web scraping the <https://www.dallasfed.org> for up-to-date data on international house prices and exuberance indicators. Download data in tidy format.

This package provides a collection of several functions related to construction and analysis of incomplete split-plot designs. The package contains functions to obtain and analyze incomplete split-plot designs for three kinds of situations namely (i) when blocks are complete with respect to main plot treatments and main plots are incomplete with respect to subplot treatments, (ii) when blocks are incomplete with respect to main plot treatments and main plots are complete with respect to subplot treatments and (iii) when blocks are incomplete with respect to main plot treatments and main plots are incomplete with respect to subplot treatments.

This package provides a collection of datasets containing a variety of in vitro toxicokinetic measurements including -- but not limited to -- chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The datasets provided by the package were processed and analyzed with the companion invitroTKstats package.

Implementation of analytical and sampling-based power analyses for the Wald, likelihood ratio (LR), score, and gradient tests. Can be applied to item response theory (IRT) models that are fitted using marginal maximum likelihood estimation. The methods are described in our paper (Zimmer et al. (2022) <doi:10.1007/s11336-022-09883-5>).

This package provides access to granular socioeconomic indicators from the Spanish Statistical Office (INE) Household Income Distribution Atlas. The package downloads and processes data from a companion GitHub repository (<https://github.com/pablogguz/ineAtlas.data/>) which contains processed versions of the official INE Atlas data. Functions are provided to fetch data at multiple geographic levels (municipalities, districts, and census tracts), including income indicators, demographic characteristics, and inequality metrics. The data repository is updated every year when new releases are published by INE.