Aids the programming of Clinical Data Standards Interchange Consortium (CDISC) compliant Ophthalmology Analysis Data Model (ADaM) datasets in R. ADaM datasets are a mandatory part of any New Drug or Biologics License Application submitted to the United States Food and Drug Administration (FDA). Analysis derivations are implemented in accordance with the "Analysis Data Model Implementation Guide" (CDISC Analysis Data Model Team, 2021, <https://www.cdisc.org/standards/foundational/adam/adamig-v1-3-release-package>).

Plot stacked areas and confidence bands as filled polygons, or add polygons to existing plots. A variety of input formats are supported, including vectors, matrices, data frames, formulas, etc.

This package provides several methods for aggregating probabilistic forecasts. You have a group of people who have made probabilistic forecasts for the same event. You want to take advantage of the "wisdom of the crowd" and combine these forecasts in some sensible way. This package provides implementations of several strategies, including geometric mean of odds, an extremized aggregate (Neyman, Roughgarden (2021) <doi:10.1145/3490486.3538243>), and "high-density trimmed mean" (Powell et al. (2022) <doi:10.1037/dec0000191>).

The AFfunction() is a function which returns an estimate of the Attributable Fraction (AF) and a plot of the AF as a function of heritability, disease prevalence, size of target group and intervention effect. Since the AF is a function of several factors, a shiny app is used to better illustrate how the relationship between the AF and heritability depends on several other factors. The app is ran by the function runShinyApp(). For more information see Dahlqwist E et al. (2019) <doi:10.1007/s00439-019-02006-8>.

Using of the accelerated line search algorithm for simultaneously diagonalize a set of symmetric positive definite matrices.

Another implementation of object-orientation in R. It provides syntactic sugar for the S4 class system and two alternative new implementations. One is an experimental version built around S4 and the other one makes it more convenient to work with lists as objects.

This package provides functions for calculating the acute chronic workload ratio using three different methods: exponentially weighted moving average (EWMA), rolling average coupled (RAC) and rolling averaged uncoupled (RAU). Examples of this methods can be found in Williams et al. (2017) <doi:10.1136/bjsports-2016-096589> for EWMA and Windt & Gabbet (2018) for RAC and RAU <doi: 10.1136/bjsports-2017-098925>.

Evaluates acute lymphoblastic leukemia maintenance therapy practice at patient and cohort level.

In order to make Arrow Database Connectivity ('ADBC <https://arrow.apache.org/adbc/>) accessible from R, an interface compliant with the DBI package is provided, using driver back-ends that are implemented in the adbcdrivermanager framework. This enables interacting with database systems using the Arrow data format, thereby offering an efficient alternative to ODBC for analytical applications.

This package provides a few functions aim to provide a statistic tool for three purposes. First, simulate kin pairs data based on the assumption that every trait is affected by genetic effects (A), common environmental effects (C) and unique environmental effects (E).Second, use kin pairs data to fit an ACE model and get model fit output.Third, calculate power of A estimate given a specific condition. For the mechanisms of power calculation, we suggest to check Visscher(2004)<doi:10.1375/twin.7.5.505>.

Arrays of structured data types can require large volumes of disk space to store. Blosc is a library that provides a fast and efficient way to compress such data. It is often applied in storage of n-dimensional arrays, such as in the case of the geo-spatial zarr file format. This package can be used to compress and decompress data using Blosc'.

This package implements the Bayesian Synthetic Control method for causal inference in comparative case studies. This package provides tools for estimating treatment effects in settings with a single treated unit and multiple control units, allowing for uncertainty quantification and flexible modeling of time-varying effects. The methodology is based on the paper by Vives and Martinez (2022) <doi:10.48550/arXiv.2206.01779>.

Real-time quantitative polymerase chain reaction (qPCR) data sets by Boggy et al. (2008) <doi:10.1371/journal.pone.0012355>. This package provides a dilution series for one PCR target: a random sequence that minimizes secondary structure and off-target primer binding. The data set is a six-point, ten-fold dilution series. For each concentration there are two replicates. Each amplification curve is 40 cycles long. Original raw data file: <https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0012355.s004>.

Statistical classification and regression have been popular among various fields and stayed in the limelight of scientists of those fields. Examples of the fields include clinical trials where the statistical classification of patients is indispensable to predict the clinical courses of diseases. Considering the negative impact of diseases on performing daily tasks, correctly classifying patients based on the clinical information is vital in that we need to identify patients of the high-risk group to develop a severe state and arrange medical treatment for them at an opportune moment. Deep learning - a part of artificial intelligence - has gained much attention, and research on it burgeons during past decades: see, e.g, Kazemi and Mirroshandel (2018) <DOI:10.1016/j.artmed.2017.12.001>. It is a veritable technique which was originally designed for the classification, and hence, the Buddle package can provide sublime solutions to various challenging classification and regression problems encountered in the clinical trials. The Buddle package is based on the back-propagation algorithm - together with various powerful techniques such as batch normalization and dropout - which performs a multi-layer feed-forward neural network: see Krizhevsky et. al (2017) <DOI:10.1145/3065386>, Schmidhuber (2015) <DOI:10.1016/j.neunet.2014.09.003> and LeCun et al. (1998) <DOI:10.1109/5.726791> for more details. This package contains two main functions: TrainBuddle() and FetchBuddle(). TrainBuddle() builds a feed-forward neural network model and trains the model. FetchBuddle() recalls the trained model which is the output of TrainBuddle(), classifies or regresses given data, and make a final prediction for the data.

This package provides tools to process the information obtained from experiments conducted in the Barnes Maze. These tools enable the detection of trajectories generated by subjects during trials, as well as the acquisition of precise coordinates and relevant statistical data regarding the results. Through this approach, it aims to facilitate the analysis and interpretation of observed behaviors, thereby contributing to a deeper understanding of learning and memory processes in such experiments.

Estimate the correlation between two irregular time series that are not necessarily sampled on identical time points. This program is also applicable to the situation of two evenly spaced time series that are not on the same time grid. BINCOR is based on a novel estimation approach proposed by Mudelsee (2010, 2014) to estimate the correlation between two climate time series with different timescales. The idea is that autocorrelation (AR1 process) allows to correlate values obtained on different time points. BINCOR contains four functions: bin_cor() (the main function to build the binned time series), plot_ts() (to plot and compare the irregular and binned time series, cor_ts() (to estimate the correlation between the binned time series) and ccf_ts() (to estimate the cross-correlation between the binned time series). A description of the method and package is provided in Polanco-Martà nez et al. (2019), <doi:10.32614/RJ-2019-035>.

Fit (using Bayesian methods) and simulate mixtures of univariate and bivariate angular distributions. Chakraborty and Wong (2021) <doi:10.18637/jss.v099.i11>.

This package provides functions to fit, via Expectation-Maximization (EM) algorithm, the Bessel and Beta regressions to a data set with a bounded continuous response variable. The Bessel regression is a new and robust approach proposed in the literature. The EM version for the well known Beta regression is another major contribution of this package. See details in the references Barreto-Souza, Mayrink and Simas (2022) <doi:10.1111/anzs.12354> and Barreto-Souza, Mayrink and Simas (2020) <arXiv:2003.05157>.

Bayesian estimation and variable selection for quantile regression models.

Code for backShift', an algorithm to estimate the connectivity matrix of a directed (possibly cyclic) graph with hidden variables. The underlying system is required to be linear and we assume that observations under different shift interventions are available. For more details, see <arXiv:1506.02494>.

Inflammation can affect many micronutrient biomarkers and can thus lead to incorrect diagnosis of individuals and to over- or under-estimate the prevalence of deficiency in a population. Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) is a multi-agency and multi-country partnership designed to improve the interpretation of nutrient biomarkers in settings of inflammation and to generate context-specific estimates of risk factors for anemia (Suchdev (2016) <doi:10.3945/an.115.010215>). In the past few years, BRINDA published a series of papers to provide guidance on how to adjust micronutrient biomarkers, retinol binding protein, serum retinol, serum ferritin by Namaste (2020), soluble transferrin receptor (sTfR), serum zinc, serum and Red Blood Cell (RBC) folate, and serum B-12, using inflammation markers, alpha-1-acid glycoprotein (AGP) and/or C-Reactive Protein (CRP) by Namaste (2020) <doi:10.1093/ajcn/nqaa141>, Rohner (2017) <doi:10.3945/ajcn.116.142232>, McDonald (2020) <doi:10.1093/ajcn/nqz304>, and Young (2020) <doi:10.1093/ajcn/nqz303>. The BRINDA inflammation adjustment method mainly focuses on Women of Reproductive Age (WRA) and Preschool-age Children (PSC); however, the general principle of the BRINDA method might apply to other population groups. The BRINDA R package is a user-friendly all-in-one R package that uses a series of functions to implement BRINDA adjustment method, as described above. The BRINDA R package will first carry out rigorous checks and provides users guidance to correct data or input errors (if they occur) prior to inflammation adjustments. After no errors are detected, the package implements the BRINDA inflammation adjustment for up to five micronutrient biomarkers, namely retinol-binding-protein, serum retinol, serum ferritin, sTfR, and serum zinc (when appropriate), using inflammation indicators of AGP and/or CRP for various population groups. Of note, adjustment for serum and RBC folate and serum B-12 is not included in the R package, since evidence shows that no adjustment is needed for these micronutrient biomarkers in either WRA or PSC groups (Young (2020) <doi:10.1093/ajcn/nqz303>).

The mixed model for repeated measures (MMRM) is a popular model for longitudinal clinical trial data with continuous endpoints, and brms is a powerful and versatile package for fitting Bayesian regression models. The brms.mmrm R package leverages brms to run MMRMs, and it supports a simplified interfaced to reduce difficulty and align with the best practices of the life sciences. References: Bürkner (2017) <doi:10.18637/jss.v080.i01>, Mallinckrodt (2008) <doi:10.1177/009286150804200402>.

The backtest package provides facilities for exploring portfolio-based conjectures about financial instruments (stocks, bonds, swaps, options, et cetera).

The Philippines frequently experiences tropical cyclones (called bagyo in the Filipino language) because of its geographical position. These cyclones typically bring heavy rainfall, leading to widespread flooding, as well as strong winds that cause significant damage to human life, crops, and property. Data on cyclones are collected and curated by the Philippine Atmospheric, Geophysical, and Astronomical Services Administration or PAGASA and made available through its website <https://bagong.pagasa.dost.gov.ph/tropical-cyclone/publications/annual-report>. This package contains Philippine tropical cyclones data in a machine-readable format. It is hoped that this data package provides an interesting and unique dataset for data exploration and visualisation.