This package provides a set of tools to i) identify geographic areas with significant change over time in drug utilization, and ii) characterize common change over time patterns among the time series for multiple geographic areas. For reference, see below: 1. Song, J., Carey, M., Zhu, H., Miao, H., Ram´ırez, J. C., & Wu, H. (2018) <doi:10.1504/IJCBDD.2018.10011910> 2. Wu, S., Wu, H. (2013) <doi:10.1186/1471-2105-14-6> 3. Carey, M., Wu, S., Gan, G. & Wu, H. (2016) <doi:10.1016/j.idm.2016.07.001>.

This software does Multi-Reader, Multi-Case (MRMC) analyses of data from imaging studies where clinicians (readers) evaluate patient images (cases). What does this mean? ... Many imaging studies are designed so that every reader reads every case in all modalities, a fully-crossed study. In this case, the data is cross-correlated, and we consider the readers and cases to be cross-correlated random effects. An MRMC analysis accounts for the variability and correlations from the readers and cases when estimating variances, confidence intervals, and p-values. The functions in this package can treat arbitrary study designs and studies with missing data, not just fully-crossed study designs. An overview of this software, including references presenting details on the methods, can be found here: <https://www.fda.gov/medical-devices/science-and-research-medical-devices/imrmc-software-do-multi-reader-multi-case-statistical-analysis-reader-studies>.

Routines and tools for assessing the quality of content analysis on the basis of the Iota Reliability Concept. The concept is inspired by item response theory and can be applied to any kind of content analysis which uses a standardized coding scheme and discrete categories. It is also applicable for content analysis conducted by artificial intelligence. The package provides reliability measures for a complete scale as well as for every single category. Analysis of subgroup-invariance and error corrections are implemented. This information can support the development process of a coding scheme and allows a detailed inspection of the quality of the generated data. Equations and formulas working in this package are part of Berding et al. (2022)<doi:10.3389/feduc.2022.818365> and Berding and Pargmann (2022) <doi:10.30819/5581>.

This package provides a simplified version of the IDSL.UFA package to calculate isotopic profiles and adduct formulas from molecular formulas with no dependency on other R packages for online tools and educational mass spectrometry courses. The IDSL.SUFA package also provides an ancillary module to process user-defined adduct formulas.

This package provides a set of functions for performing null hypothesis testing on samples of persistence diagrams using the theory of permutations. Currently, only two-sample testing is implemented. Inputs can be either samples of persistence diagrams themselves or vectorizations. In the former case, they are embedded in a metric space using either the Bottleneck or Wasserstein distance. In the former case, persistence data becomes functional data and inference is performed using tools available in the fdatest package. Main reference for the interval-wise testing method: Pini A., Vantini S. (2017) "Interval-wise testing for functional data" <doi:10.1080/10485252.2017.1306627>. Main reference for inference on populations of networks: Lovato, I., Pini, A., Stamm, A., & Vantini, S. (2020) "Model-free two-sample test for network-valued data" <doi:10.1016/j.csda.2019.106896>.

Contain code to work with a C struct, in short cgeneric, to define a Gaussian Markov random (GMRF) model. The cgeneric contain code to specify GMRF elements such as the graph and the precision matrix, and also the initial and prior for its parameters, useful for model inference. It can be accessed from a C program and is the recommended way to implement new GMRF models in the INLA package (<https://www.r-inla.org>). The INLAtools implement functions to evaluate each one of the model specifications from R. The implemented functionalities leverage the use of cgeneric models and provide a way to debug the code as well to work with the prior for the model parameters and to sample from it. A very useful functionality is the Kronecker product method that creates a new model from multiple cgeneric models. It also works with the rgeneric, the R version of the cgeneric intended to easy try implementation of new GMRF models. The Kronecker between two cgeneric models was used in Sterrantino et. al. (2024) <doi:10.1007/s10260-025-00788-y>, and can be used to build the spatio-temporal intrinsic interaction models for what the needed constraints are automatically set.

Fit joint mean-covariance models for longitudinal data. The models and their components are represented using S4 classes and methods. The core computational algorithms are implemented using the Armadillo C++ library for numerical linear algebra and RcppArmadillo glue.

Interface to JSON-stat <https://json-stat.org/>, a simple lightweight JSON format for data dissemination.

Template engine powered by the inja C++ library. Users write a template document, using syntax inspired by the Jinja Python package, and then render the final document by passing data from R. The template syntax supports features such as variables, loops, conditions and inheritance.

Generates interactive Jellyfish plots to visualize spatiotemporal tumor evolution by integrating sample and phylogenetic trees into a unified plot. This approach provides an intuitive way to analyze tumor heterogeneity and evolution over time and across anatomical locations. The Jellyfish plot visualization design was first introduced by Lahtinen, Lavikka, et al. (2023, <doi:10.1016/j.ccell.2023.04.017>). This package also supports visualizing ClonEvol results, a tool developed by Dang, et al. (2017, <doi:10.1093/annonc/mdx517>), for analyzing clonal evolution from multi-sample sequencing data. The clonevol package is not available on CRAN but can be installed from its GitHub repository (<https://github.com/hdng/clonevol>).

Minimal and memory efficient implementation of the junction tree algorithm using the Lauritzen-Spiegelhalter scheme; S. L. Lauritzen and D. J. Spiegelhalter (1988) <https://www.jstor.org/stable/2345762?seq=1>. The jti package is part of the paper <doi:10.18637/jss.v111.i02>.

Reproducible work requires a record of where every statistic originated. When writing reports, some data is too big to load in the same environment and some statistics take a while to compute. This package offers a way to keep notes on statistics, simple functions, and small objects. Notepads can be locked to avoid accidental updates. Notepads keep track of who added the notes and when the notes were added. A simple text representation is used to allow for clear version histories.

Shared parameter models for the joint modeling of longitudinal and time-to-event data.

Generates image data for fractals (Julia and Mandelbrot sets) on the complex plane in the given region and resolution. Benoit B Mandelbrot (1982).

This package implements interpretable multi-biomarker fusion in joint longitudinal-survival models via semi-parametric association surfaces. Provides a two-stage estimation framework where Stage 1 fits mixed-effects longitudinal models and extracts Best Linear Unbiased Predictors ('BLUP's), and Stage 2 fits transition-specific penalized Cox models with tensor-product spline surfaces linking latent biomarker summaries to transition hazards. Supports multi-state disease processes with transition-specific surfaces, Restricted Maximum Likelihood ('REML') smoothing parameter selection, effective degrees of freedom ('EDF') diagnostics, dynamic prediction of transition probabilities, and three interpretability visualizations (surface plots, contour heatmaps, marginal effect slices). Methods are described in Bhattacharjee (2025, under review).

Read Japanese city codes (<https://www.e-stat.go.jp/municipalities/cities>) to get city and prefecture names, or convert to city codes at different points in time. In addition, it merges or splits wards of designated cities and gets all city codes at a specific point in time.

This package implements delete-d jackknife resampling for robust statistical estimation. The package provides both weighted (HC3-adjusted) and unweighted versions of jackknife estimation, with parallel computation support. Suitable for biomedical research and other fields requiring robust variance estimation.

An estimation method that can use computer simulations to approximate maximum-likelihood estimates even when the likelihood function can not be evaluated directly. It can be applied whenever it is feasible to conduct many simulations, but works best when the data is approximately Poisson distributed. It was originally designed for demographic inference in evolutionary biology (Naduvilezhath et al., 2011 <doi:10.1111/j.1365-294X.2011.05131.x>, Mathew et al., 2013 <doi:10.1002/ece3.722>). It has optional support for conducting coalescent simulation using the coala package.

Computes the Jackknife Mutual Information (JMI) between two random vectors and provides the p-value for dependence tests. See Zeng, X., Xia, Y. and Tong, H. (2018) <doi:10.1073/pnas.1715593115>.

This package provides tools to use API such as e-Stat (<https://www.e-stat.go.jp/>), the portal site for Japanese government statistics, and RESAS (Regional Economy and Society Analyzing System, <https://resas.go.jp>).

This package provides tools to explore and summarize relationship patterns between variables across one or multiple datasets. The package relies on efficient sampling strategies to estimate pairwise associations and supports quick exploratory data analysis for large or heterogeneous data sources.

Bayesian methods for estimating developmental age from ordinal dental data. For an explanation of the model used, see Konigsberg (2015) <doi:10.3109/03014460.2015.1045430>. For details on the conditional correlation correction, see Sgheiza (2022) <doi:10.1016/j.forsciint.2021.111135>. Dental scoring is based on Moorrees, Fanning, and Hunt (1963) <doi:10.1177/00220345630420062701>.

Jointly estimates two-group means and covariances for matrix-variate data and calculates test statistics. This package implements the algorithms defined in Hornstein, Fan, Shedden, and Zhou (2018) <doi:10.1080/01621459.2018.1429275>.

The free and open a statistical spreadsheet jamovi (<https://www.jamovi.org>) aims to make statistical analyses easy and intuitive. jamovi produces syntax that can directly be used in R (in connection with the R-package jmv'). Having import / export routines for the data files jamovi produces ('.omv') permits an easy transfer of data and analyses between jamovi and R.