This package implements Interpretable Boosted Linear Models (IBLMs). These combine a conventional generalized linear model (GLM) with a machine learning component, such as XGBoost. The package also provides tools within for explaining and analyzing these models. For more details see Gawlowski and Wang (2025) <https://ifoa-adswp.github.io/IBLM/reference/figures/iblm_paper.pdf>.

Variance-aware Michaelis-Menten estimation, model screening, grouped enzyme-kinetic analyses, and clustered repeated-measurement workflows. The package implements profile-score estimators under working variance functions, together with a lightweight cluster-aware working-covariance extension, Wald and bootstrap confidence intervals, prediction utilities, and simulation helpers. Related methodology is discussed by Kim and Ma (2012) <doi:10.1007/s10463-011-0332-y>, Kim (2023) <doi:10.1002/sta4.606>, and Ma and Genton (2010) <doi:10.1111/j.1467-9868.2010.00741.x>.

This package provides a pipeline to process nominal mass spectrometry data to create .msp files for untargeted analyses.

Calculate AIC's and AICc's of unimodal model (one normal distribution) and bimodal model(a mixture of two normal distributions) which fit the distribution of indices of asymmetry (IAS), and plot their density, to help determine IAS distribution is unimodal or bimodal.

This package provides functions and classes to compute, handle and visualise incidence from dated events for a defined time interval. Dates can be provided in various standard formats. The class incidence2 is used to store computed incidence and can be easily manipulated, subsetted, and plotted.

Facilitates access to the International Union for Conservation of Nature (IUCN) Red List of Threatened Species, a comprehensive global inventory of species at risk of extinction. This package streamlines the process of determining conservation status by matching species names with Red List data, providing tools to easily query and retrieve conservation statuses. Designed to support biodiversity research and conservation planning, this package relies on data from the iucnrdata package, available on GitHub <https://github.com/PaulESantos/iucnrdata>. To install the data package, use pak::pak('PaulESantos/iucnrdata').

The IDSL.FSA package was designed to annotate standard .msp (mass spectra format) and .mgf (Mascot generic format) files using mass spectral entropy similarity, dot product (cosine) similarity, and normalized Euclidean mass error (NEME) followed by intelligent pre-filtering steps for rapid spectra searches. IDSL.FSA also provides a number of modules to convert and manipulate .msp and .mgf files. The IDSL.FSA workflow was integrated in the IDSL.CSA and IDSL.NPA packages introduced in <doi:10.1021/acs.analchem.3c00376>.

Calculates insulin secretion rates from C-peptide values based on the methods described in Van Cauter et al. (1992) <doi:10.2337/diab.41.3.368>. Includes functions to calculate estimated insulin secretion rates using linear or cubic spline interpolation of c-peptide values (see Eaton et al., 1980 <doi:10.1210/jcem-51-3-520> and Polonsky et al., 1986 <doi:10.1172/JCI112308>) and to calculate estimates of input coefficients (volume of distribution, short half life, long half life, and fraction attributed to short half life) as described by Van Cauter. Although the generated coefficients are specific to insulin secretion, the two-compartment secretion model used here is useful for certain applications beyond insulin.

This package provides a unified data layer for single-cell, spatial and bulk T-cell and B-cell immune receptor repertoire data. Think AnnData or SeuratObject, but for AIRR data, a.k.a. Adaptive Immune Receptor Repertoire, VDJ-seq, RepSeq, or VDJ sequencing data.

Estimating the mean and variance of a covariate for the complier, never-taker and always-taker subpopulation in the context of instrumental variable estimation. This package implements the method described in Marbach and Hangartner (2020) <doi:10.1017/pan.2019.48> and Hangartner, Marbach, Henckel, Maathuis, Kelz and Keele (2021) <doi:10.48550/arXiv.2103.06328>.

This package provides classes and functions for working with IP (Internet Protocol) addresses and networks, inspired by the Python ipaddress module. Offers full support for both IPv4 and IPv6 (Internet Protocol versions 4 and 6) address spaces. It is specifically designed to work well with the tidyverse'.

This package performs Goodness of Fit for regression models using Integrated Regression method. Works for several different fitting techniques.

This package provides a collection of functions for working with time series data, including functions for drawing, decomposing, and forecasting. Includes capabilities to compare multiple series and fit both additive and multiplicative models. Used by iNZight', a graphical user interface providing easy exploration and visualisation of data for students of statistics, available in both desktop and online versions. Holt (1957) <doi:10.1016/j.ijforecast.2003.09.015>, Winters (1960) <doi:10.1287/mnsc.6.3.324>, Cleveland, Cleveland, & Terpenning (1990) "STL: A Seasonal-Trend Decomposition Procedure Based on Loess".

This package provides utilities to retrieve and manage ICD-10 code descriptions from Excel files. Supports vectors, data frame columns, and association rule outputs (e.g., arules objects) that require mapping to ICD-10 descriptions. Designed to simplify processing of healthcare datasets.

This package provides a collection of several utility functions related to binary incomplete block designs. Contains function to generate A- and D-efficient binary incomplete block designs with given numbers of treatments, number of blocks and block size. Contains function to generate an incomplete block design with specified concurrence matrix. There are functions to generate balanced treatment incomplete block designs and incomplete block designs for test versus control treatments comparisons with specified concurrence matrix. Allows performing analysis of variance of data and computing estimated marginal means of factors from experiments using a connected incomplete block design. Tests of hypothesis of treatment contrasts in incomplete block design set up is supported.

This package provides analysis results and trial simulation functions for the I-SPY Acute Respiratory Disease Syndrome trial based on composite ranked outcomes. The composite ranked outcome is a hierarchical outcome where trial participants are ranked first by 28 day mortality, then ventilator days, then by advanced respiratory support days. A Bayesian win probability approach is used for analysis. Trial design options include group sequential looks for safety, superiority, futility, and adjustment of randomization probabilities.

Programmatic access to NSIDC's sea ice concentration CDR <https://nsidc.org/data/g02202> via ERDAPP server and Sea Ice index <https://nsidc.org/data/g02135>. Supports caching results and optional fixes for some inconsistencies of the raw files.

Suite of functions that help simulate elections under different electoral systems, which are then used to compute incentives generated by these systems in terms of the inter- and intra-party dimensions of electoral competition.

Iterator for generating permutations and combinations. They can be either drawn with or without replacement, or with distinct/ non-distinct items (multiset). The generated sequences are in lexicographical order (dictionary order). The algorithms to generate permutations and combinations are memory efficient. These iterative algorithms enable users to process all sequences without putting all results in the memory at the same time. The algorithms are written in C/C++ for faster performance. Note: iterpc is no longer being maintained. Users are recommended to switch to arrangements'.

Analyzes raw abundance data from a cellular thermal shift experiment and calculates melt temperatures and melt shifts for each protein in the experiment. McCracken (2022) <doi:10.1101/2022.12.30.522131>.

This package provides a personalized dynamic latent factor model (Zhang et al. (2024) <doi:10.1093/biomet/asae015>) for irregular multi-resolution time series data, to interpolate unsampled measurements from low-resolution time series.

Fit a predictive model using iteratively reweighted boosting (IRBoost) to minimize robust loss functions within the CC-family (concave-convex). This constitutes an application of iteratively reweighted convex optimization (IRCO), where convex optimization is performed using the functional descent boosting algorithm. IRBoost assigns weights to facilitate outlier identification. Applications include robust generalized linear models and robust accelerated failure time models. Wang (2025) <doi:10.6339/24-JDS1138>.

This package contains functions that allow Bayesian inference on a parameter of some widely-used exponential models. The functions can generate independent samples from the closed-form posterior distribution using the inverse stable prior. Inverse stable is a non-conjugate prior for a parameter of an exponential subclass of discrete and continuous data distributions (e.g. Poisson, exponential, inverse gamma, double exponential (Laplace), half-normal/half-Gaussian, etc.). The prior class provides flexibility in capturing a wide array of prior beliefs (right-skewed and left-skewed) as modulated by a parameter that is bounded in (0,1). The generated samples can be used to simulate the prior and posterior predictive distributions. More details can be found in Cahoy and Sedransk (2019) <doi:10.1007/s42519-018-0027-2>. The package can also be used as a teaching demo for introductory Bayesian courses.

This package provides a set of utilities for manipulating index numbers series including chain-linking, re-referencing, and computing growth rates.