This package provides a comprehensive analytics framework for building reproducible pipelines on T-cell and B-cell immune receptor repertoire data. Delivers multi-modal immune profiling (bulk, single-cell, CITE-seq/AbSeq, spatial, immunogenicity data), feature engineering (ML-ready feature tables and matrices), and biomarker discovery workflows (cohort comparisons, longitudinal tracking, repertoire similarity, enrichment). Provides a user-friendly interface to widely used AIRR methods â clonality/diversity, V(D)J usage, similarity, annotation, tracking, and many more. Think Scanpy or Seurat, but for AIRR data, a.k.a. Adaptive Immune Receptor Repertoire, VDJ-seq, RepSeq, or VDJ sequencing data. A successor to our previously published "tcR" R package (Nazarov 2015).

This package provides a professional R interface to download and analyze spatial development indicators from the BBSR INKAR (Indicators and Maps for Spatial and Urban Development) database. Features a bilingual interactive wizard, fuzzy and normalized indicator search, multi-indicator downloads with automatic tidy merging (long/wide), guaranteed consistent output schema, robust disk caching with automatic retry, and ggplot2 themes for regional mapping.

Compute missing values on a training data set and impute them on a new data set. Current available options are median/mode and random forest.

This package provides native R access to Interactive Brokers Trader Workstation API.

Compute permutation- based performance measures and create partial dependence plots for (cross-validated) randomForest and ada models.

This package implements commonly used Indian farm cost concepts for agricultural economic analysis, including Cost A1, A2, B1, B2, C1, C2, and C3. Tools are provided to calculate cost concepts from farm-level input data, aggregate costs across groups, summarize distributions, compute returns and benefit-cost ratios, estimate cost of production and break-even values, decompose cost shares, conduct one-way sensitivity analysis, and visualize concept-wise costs. The implementation is designed for reproducible farm management and cost-of-cultivation studies.

Utility functions that implement and automate common sets of validation tasks. These functions are particularly useful to validate inputs, intermediate objects and output values in user-defined functions, resulting in tidier and less verbose functions.

This package provides classes and functions for working with IP (Internet Protocol) addresses and networks, inspired by the Python ipaddress module. Offers full support for both IPv4 and IPv6 (Internet Protocol versions 4 and 6) address spaces. It is specifically designed to work well with the tidyverse'.

IRT-M is a semi-supervised approach based on Bayesian Item Response Theory that produces theoretically identified underlying dimensions from input data and a constraints matrix. The methodology is fully described in Morucci et al. (2024), "Measurement That Matches Theory: Theory-Driven Identification in Item Response Theory Models"'. Details are available at <https://www.cambridge.org/core/journals/american-political-science-review/article/measurement-that-matches-theory-theorydriven-identification-in-item-response-theory-models/395DA1DFE3DCD7B866DC053D7554A30B>.

Generalized Odds Rate Hazards (GORH) model is a flexible model of fitting survival data, including the Proportional Hazards (PH) model and the Proportional Odds (PO) Model as special cases. This package fit the GORH model with interval censored data.

This package performs exploratory data analysis and variable screening for binary classification models using weight-of-evidence (WOE) and information value (IV). In order to make the package as efficient as possible, aggregations are done in data.table and creation of WOE vectors can be distributed across multiple cores. The package also supports exploration for uplift models (NWOE and NIV).

This package provides a variational Bayesian approach for fast integrative clustering and feature selection, facilitating the analysis of multi-view, mixed type, high-dimensional datasets with applications in fields like cancer research, genomics, and more.

Get open statistical data and metadata disseminated by the National Statistics Institute of Spain (INE). The functions return data frames with the requested information thanks to calls to the INE API <https://www.ine.es/dyngs/DAB/index.htm?cid=1100>.

This package provides functions and classes to compute, handle and visualise incidence from dated events for a defined time interval. Dates can be provided in various standard formats. The class incidence is used to store computed incidence and can be easily manipulated, subsetted, and plotted. In addition, log-linear models can be fitted to incidence objects using fit'. This package is part of the RECON (<https://www.repidemicsconsortium.org/>) toolkit for outbreak analysis.

Offers a pipe-friendly alternative to the dplyr functions case_when() and if_else(), as well as a number of user-friendly simplifications for common use cases. These functions accept a vector as an optional first argument, allowing conditional statements to be built using the magrittr dot operator. The functions also coerce all outputs to the same type, meaning you no longer have to worry about using specific typed variants of NA or explicitly declaring integer outputs, and evaluate outputs somewhat lazily, so you don't waste time on long operations that won't be used.

This package provides a method to integrate molecular profiles of cancer patients (gene copy number and mRNA abundance) to identify candidate gain of function alterations. These candidate alterations can be subsequently further tested to discover cancer driver alterations. Briefly, this method tests of genomic correlates of mRNA dysregulation and prioritise those where DNA gains/amplifications are associated with elevated mRNA expression of the same gene. For details see, Haider S et al. (2016) "Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia", Genome Biology, <https://pubmed.ncbi.nlm.nih.gov/27358048/>.

Evaluating if values of vectors are within different open/closed intervals (`x %[]% c(a, b)`), or if two closed intervals overlap (`c(a1, b1) %[]o[]% c(a2, b2)`). Operators for negation and directional relations also implemented.

Data sets and scripts for text examples and exercises in P. Dalgaard (2008), `Introductory Statistics with R', 2nd ed., Springer Verlag, ISBN 978-0387790534.

This package provides a toolkit for idionomic science, a research philosophy that places the unit of the ensemble (individual/couple/group) at the center of analysis. Rather than assuming a common distribution, a similar enough process for each unit, and fitting a single model to the whole ensemble, idionomic methods model each unit separately, then aggregate upward if sensible. The group-level picture emerges from individual results, not the other way around, while explicitly evaluating whether aggregation is reasonable given the measured level of heterogeneity of effects. The package is built around intensive longitudinal data where each participant contributes a time series. It provides a pipeline from preprocessing through modeling to group-level summaries. Current functions: data quality screening (i_screener()), within-person standardization (pmstandardize()), linear detrending (i_detrender()), per-subject ARIMAX (AutoRegressive Integrated Moving Average with eXogenous inputs) modeling and meta-analysis (iarimax()), individual p-values (i_pval()), Sign Divergence and Equisyncratic Null tests (sden_test()), and directed loop detection (looping_machine()). Methods are described in Hernandez et al. (2024) <doi:10.1007/978-3-030-77644-2_136-1>, Ciarrochi et al. (2024) <doi:10.1007/s10608-024-10486-w>, and Sahdra et al. (2024) <doi:10.1016/j.jcbs.2024.100728>.

This package provides a phylogenetic modelling approach for predicting species invasion risk, out of a given pool of local species where a subset is known to be invasive elsewhere. The package uses phylogenetic signal estimation and phylogenetic linear and logistic models to estimate probabilities of being invasive based on phylogeny and any set of additional predictors. A ranking method is implemented to evaluate prioritisation strategies. A manuscript describing these methods, by Shahar Dubiner and Tamar Guy-Haim, is in preparation.

Different functions includes constructing composite indicators, imputing missing data, and evaluating imputation techniques. Additionally, different tools for data normalization. Detailed methodologies of Indicator package are: OECD/European Union/EC-JRC (2008), "Handbook on Constructing Composite Indicators: Methodology and User Guide", OECD Publishing, Paris, <DOI:10.1787/533411815016>, Matteo Mazziotta & Adriano Pareto, (2018) "Measuring Well-Being Over Time: The Adjusted Mazziottaâ Pareto Index Versus Other Non-compensatory Indices" <DOI:10.1007/s11205-017-1577-5> and De Muro P., Mazziotta M., Pareto A. (2011), "Composite Indices of Development and Poverty: An Application to MDGs" <DOI:10.1007/s11205-010-9727-z>.

This function predicts item response probabilities and item responses using the item-focused tree model. The item-focused tree model combines logistic regression with recursive partitioning to detect Differential Item Functioning in dichotomous items. The model applies partitioning rules to the data, splitting it into homogeneous subgroups, and uses logistic regression within each subgroup to explain the data. Differential Item Functioning detection is achieved by examining potential group differences in item response patterns. This method is useful for understanding how different predictors, such as demographic or psychological factors, influence item responses across subgroups.

Contain code to work with a C struct, in short cgeneric, to define a Gaussian Markov random (GMRF) model. The cgeneric contain code to specify GMRF elements such as the graph and the precision matrix, and also the initial and prior for its parameters, useful for model inference. It can be accessed from a C program and is the recommended way to implement new GMRF models in the INLA package (<https://www.r-inla.org>). The INLAtools implement functions to evaluate each one of the model specifications from R. The implemented functionalities leverage the use of cgeneric models and provide a way to debug the code as well to work with the prior for the model parameters and to sample from it. The `generic0` can be used to implement intrinsic models with the scaling as proposed in Sørbye & Rue (2014) <doi:10.1016/j.spasta.2013.06.004>, and the required constraints. A very useful functionality is the Kronecker product method that creates a new model from multiple cgeneric models. It also works with the rgeneric, the R version of the cgeneric intended to easy try implementation of new GMRF models. The Kronecker between two cgeneric models where each one needs a constraint, such as spatio-temporal intrinsic interaction models, the needed constraints are automatically set.

This package contains several tools to treat imaging flow cytometry data from ImageStream® and FlowSight® cytometers ('Amnis® Cytek®'). Provides an easy and simple way to read and write .fcs, .rif, .cif and .daf files. Information such as masks, features, regions and populations set within these files can be retrieved for each single cell. In addition, raw data such as images stored can also be accessed. Users, may hopefully increase their productivity thanks to dedicated functions to extract, visualize, manipulate and export IFC data. Toy data example can be installed through the IFCdata package of approximately 32 MB, which is available in a drat repository <https://gitdemont.github.io/IFCdata/>. See file COPYRIGHTS and file AUTHORS for a list of copyright holders and authors.