This package provides an easy way to create interactive KPI (key performance indicator) widgets for Quarto dashboards using Crosstalk'. The package enables visualization of key metrics in a structured format, supporting interactive filtering and linking with other Crosstalk'-enabled components. Designed for use in Quarto Dashboards.

We developed a package Keyboard for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The Keyboard designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972>). The Keyboard package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.

Producing kernel estimates of the unconditional and conditional hazard function for right-censored data including methods of bandwidth selection.

This package provides methods to extract information on pathways, genes and various single-nucleotid polymorphisms (SNPs) from online databases. It provides functions for data preparation and evaluation of genetic influence on a binary outcome using the logistic kernel machine test (LKMT). Three different kernel functions are offered to analyze genotype information in this variance component test: A linear kernel, a size-adjusted kernel and a network-based kernel).

Convert latex math expressions to HTML and MathML for use in markdown documents or package manual pages. The rendering is done in R using the V8 engine (i.e. server-side), which eliminates the need for embedding the MathJax library into your web pages. In addition a math-to-rd wrapper is provided to automatically render beautiful math in R documentation files.

Helps make implicit data assumptions explicit by attaching keys to flat-file data that error when those assumptions are violated. Designed for CSV-first workflows without database infrastructure or version control. Provides key definition, assumption checks, join diagnostics, and automatic drift detection via watched data frames that snapshot before each transformation and report cell-level changes.

Prediction with k* nearest neighbor algorithm based on a publication by Anava and Levy (2016) <arXiv:1701.07266>.

Read Swiss time series data from the KOF Data API, <https://datenservice.kof.ethz.ch>. The API provides macro economic time series data mostly about Switzerland. The package itself is a set of wrappers around the KOF Datenservice API. The kofdata package is able to consume public information as well as data that requires an API token.

Miscellaneous functions for classification and visualization, e.g. regularized discriminant analysis, sknn() kernel-density naive Bayes, an interface to svmlight and stepclass() wrapper variable selection for supervised classification, partimat() visualization of classification rules and shardsplot() of cluster results as well as kmodes() clustering for categorical data, corclust() variable clustering, variable extraction from different variable clustering models and weight of evidence preprocessing.

Computes Khattree-Bahuguna's univariate and multivariate skewness, principal-component-based Khattree-Bahuguna's multivariate skewness. It also provides several measures of univariate or multivariate skewnesses including, Pearsonâ s coefficient of skewness, Bowleyâ s univariate skewness and Mardia's multivariate skewness. See Khattree, R. and Bahuguna, M. (2019) <doi: 10.1007/s41060-018-0106-1>.

It uses species accumulation curves and diverse estimators to assess, at the same time, the levels of survey coverage in multiple geographic cells of a size defined by the user or polygons. It also enables the geographical depiction of observed species richness, survey effort and completeness values including a background with administrative areas.

Many data science problems reduce to operations on very tall, skinny matrices. However, sometimes these matrices can be so tall that they are difficult to work with, or do not even fit into main memory. One strategy to deal with such objects is to distribute their rows across several processors. To this end, we offer an S4 class for tall, skinny, distributed matrices, called the shaq'. We also provide many useful numerical methods and statistics operations for operating on these distributed objects. The naming is a bit "tongue-in-cheek", with the class a play on the fact that Shaquille ONeal ('Shaq') is very tall, and he starred in the film Kazaam'.

Various tools and data sets that support the study of kanji, including their morphology, decomposition and concepts of distance and similarity between them.

Most importantly, calculates Kullback-Leibler Divergence (KLD), Turing's perspective estimator and their confidence intervals.

One-way and two-way analysis of variance for replicated point patterns, grouped by one or two classification factors, on the basis of the corresponding K-functions.

Analysis of DNA copy number in single cells using custom genome-wide targeted DNA sequencing panels for the Mission Bio Tapestri platform. Users can easily parse, manipulate, and visualize datasets produced from the automated Tapestri Pipeline', with support for normalization, clustering, and copy number calling. Functions are also available to deconvolute multiplexed samples by genotype and parsing barcoded reads from exogenous lentiviral constructs.

K Quantiles Medoids (KQM) clustering applies quantiles to divide data of each dimension into K mean intervals. Combining quantiles of all the dimensions of the data and fully permuting quantiles on each dimension is the strategy to determine a pool of candidate initial cluster centers. To find the best initial cluster centers from the pool of candidate initial cluster centers, two methods based on quantile strategy and PAM strategy respectively are proposed. During a clustering process, medoids of clusters are used to update cluster centers in each iteration. Comparison between KQM and the method of randomly selecting initial cluster centers shows that KQM is almost always getting clustering results with smaller total sum squares of distances.

This package provides a progress bar similar to dplyr that can write progress out to a variety of locations, including stdout(), stderr(), or from file(). Useful when using knitr or rmarkdown', and you still want to see progress of calculations in the terminal.

This is a stochastic framework that combines biochemical reaction networks with extended Kalman filter and Rauch-Tung-Striebel smoothing. This framework allows to investigate the dynamics of cell differentiation from high-dimensional clonal tracking data subject to measurement noise, false negative errors, and systematically unobserved cell types. Our tool can provide statistical support to biologists in gene therapy clonal tracking studies for a deeper understanding of clonal reconstitution dynamics. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.07.08.499353>.

This package provides tools for estimate (joint) cumulants and (joint) products of cumulants of a random sample using (multivariate) k-statistics and (multivariate) polykays, unbiased estimators with minimum variance. Tools for generating univariate and multivariate Faa di Bruno's formula and related polynomials, such as Bell polynomials, generalized complete Bell polynomials, partition polynomials and generalized partition polynomials. For more details see Di Nardo E., Guarino G., Senato D. (2009) <arXiv:0807.5008>, <arXiv:1012.6008>.

Identification of putative causal variants in genome-wide association studies with trio and duo families. The package calculates the W feature statistics from KnockoffTrio and p-values from the family-based association test (FBAT) using trio and/or duo data. Compared to previous versions, a significant improvement has been made in Version 1.1.0 to allow the package to be applied not only to trio families but also to duo families. The package implements the methods in the paper: "Yang, Y., Wang, C., Liu, L., Buxbaum, J., He, Z., & Ionita-Laza, I. (2022). KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design. The American Journal of Human Genetics, 109(10), 1761-1776.".

Kernel Machine Score Test for Pathway Analysis in the Presence of Semi-Competing Risks. Method is detailed in: Neykov, Hejblum & Sinnott (2018) <doi: 10.1177/0962280216653427>.

Implementation of various kernel adaptive methods in nonparametric curve estimation like density estimation as introduced in Stute and Srihera (2011) <doi:10.1016/j.spl.2011.01.013> and Eichner and Stute (2013) <doi:10.1016/j.jspi.2012.03.011> for pointwise estimation, and like regression as described in Eichner and Stute (2012) <doi:10.1080/10485252.2012.760737>.

This package provides a user-friendly interface for interacting with the District Health Information Software 2 (DHIS2) instance. It streamlines data retrieval, empowering researchers, analysts, and healthcare professionals to obtain and utilize data efficiently.