This package implements anomaly detection as binary classification for cross-sectional data. Uses maximum likelihood estimates and normal probability functions to classify observations as anomalous. The method is presented in the following lecture from the Machine Learning course by Andrew Ng: <https://www.coursera.org/learn/machine-learning/lecture/C8IJp/algorithm/>, and is also described in: Aleksandar Lazarevic, Levent Ertoz, Vipin Kumar, Aysel Ozgur, Jaideep Srivastava (2003) <doi:10.1137/1.9781611972733.3>.

Optimize one or two-arm, two-stage designs for clinical trials with respect to several implemented objective criteria or custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz et al. (2019) <doi:10.1002/sim.8291> and Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09> for details.

This package creates interactive Venn diagrams using the amCharts5 library for JavaScript'. They can be used directly from the R console, from RStudio', in shiny applications, and in rmarkdown documents.

Implementation of a hybrid MCDM method build from the AHP (Analytic Hierarchy Process) and TOPSIS-2N (Technique for Order of Preference by Similarity to Ideal Solution - with two normalizations). This method is described in Souza et al. (2018) <doi: 10.1142/S0219622018500207>.

This package provides tools for validating, generating, reviewing, reporting, and visualising assessment item generation workflows. The package supports tabular item-bank templates, item-bank validation, Python'-backed agentic generation workflows, multimodal diagram generation, quality summaries, and HTML reporting. External artificial intelligence services and related API calls require user-supplied credentials and are not called during package checks. The workflow is informed by automatic item generation methods described by Gierl and Haladyna (2013, ISBN:9780415897518) and evidence-centered assessment design described by Mislevy et al. (2003) <doi:10.1002/j.2333-8504.2003.tb01908.x>.

We propose an age-dependent topic modelling (ATM) model, providing a low-rank representation of longitudinal records of hundreds of distinct diseases in large electronic health record data sets. The model assigns to each individual topic weights for several disease topics; each disease topic reflects a set of diseases that tend to co-occur as a function of age, quantified by age-dependent topic loadings for each disease. The model assumes that for each disease diagnosis, a topic is sampled based on the individualâ s topic weights (which sum to 1 across topics, for a given individual), and a disease is sampled based on the individualâ s age and the age-dependent topic loadings (which sum to 1 across diseases, for a given topic at a given age). The model generalises the Latent Dirichlet Allocation (LDA) model by allowing topic loadings for each topic to vary with age. References: Jiang (2023) <doi:10.1038/s41588-023-01522-8>.

Accumulated Local Effects (ALE) were initially developed as a model-agnostic approach for global explanations of the results of black-box machine learning algorithms. ALE has a key advantage over other approaches like partial dependency plots (PDP) and SHapley Additive exPlanations (SHAP): its values represent a clean functional decomposition of the model. As such, ALE values are not affected by the presence or absence of interactions among variables in a mode. Moreover, its computation is relatively rapid. This package reimplements the algorithms for calculating ALE data and develops highly interpretable visualizations for plotting these ALE values. It also extends the original ALE concept to add bootstrap-based confidence intervals and ALE-based statistics that can be used for statistical inference. For more details, see Okoli, Chitu. 2023. â Statistical Inference Using Machine Learning and Classical Techniques Based on Accumulated Local Effects (ALE).â arXiv. <doi:10.48550/arXiv.2310.09877>.

Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data. Integrates with the nlmixr2'/'rxode2 ecosystem via three estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.

This package provides a novel interpretable machine learning-based framework to automate the development of a clinical scoring model for predefined outcomes. Our novel framework consists of six modules: variable ranking with machine learning, variable transformation, score derivation, model selection, domain knowledge-based score fine-tuning, and performance evaluation.The details are described in our research paper<doi:10.2196/21798>. Users or clinicians could seamlessly generate parsimonious sparse-score risk models (i.e., risk scores), which can be easily implemented and validated in clinical practice. We hope to see its application in various medical case studies.

This package contains functions carrying out adaptive procedures using mixed scaling approach to establish bioequivalence for in-vitro permeation test (IVPT) data. Currently, the package provides procedures based on parallel replicate design and balanced data, according to the U.S. Food and Drug Administration's "Draft Guidance on Acyclovir" <https://www.accessdata.fda.gov/drugsatfda_docs/psg/Acyclovir_topical%20cream_RLD%2021478_RV12-16.pdf>. Potvin et al. (2008) <doi:10.1002/pst.294> provides the basis for our adaptive design (see Method B). For a comprehensive overview of the method, refer to Lim et al. (2023) <doi:10.1002/pst.2333>. This package reflects the views of the authors and should not be construed to represent the views or policies of the U.S. Food and Drug Administration.

This package provides a GUI with which the user can construct and interact with Bootstrap methods on Classical Biplots and with Clustering and/or Disjoint Biplot. This GUI is also aimed for estimate any numerical data matrix using the Clustering and Disjoint Principal component (CDPCA) methodology.

Fits a Bayesian zero-inflated Bernoulli regression model handling (potentially) different covariates for the zero-inflated and non zero-inflated parts. See Moriña D, Puig P, Navarro A. (2021) <doi:10.1186/s12874-021-01427-2>.

Preprocessing tools and biodiversity measures (species abundance, species richness, population heterogeneity and sensitivity) for analysing marine benthic data. See Van Loon et al. (2015) <doi:10.1016/j.seares.2015.05.002> for an application of these tools.

This package provides a set of Boolean operators which accept integers of any size, in any base from 2 to 36, including 2's complement format, and perform actions like "AND," "OR", "NOT", "SHIFTR/L" etc. The output can be in any base specified. A direct base to base converter is included.

This package implements a bootstrap aggregated (bagged) version of the k-nearest neighbors survival probability prediction method (Lowsky et al. 2013). In addition to the bootstrapping of training samples, the features can be subsampled in each baselearner to break the correlation between them. The Rcpp package is used to speed up the computation.

Extend the bigmemory package with table', tapply', and split support for big.matrix objects. The functions may also be used with native R matrices for improving speed and memory-efficiency.

This package implements the methodological developments found in Hermes, van Heerwaarden, and Behrouzi (2024) <doi:10.48550/arXiv.2408.10558>, and allows for the statistical modeling of multi-attribute pairwise comparison data.

This package performs Bayesian t Regression where mean and scale parameters are modeling by lineal regression structures, and the degrees of freedom parameters are estimated.

Implementation of the Bag-and-Whisker Plot for bivariate data. Provides a single user-facing function bag_whisker() that wraps the computation and plotting helpers in this package. For more details, please refer to the paper "The Bag-and-Whisker Plot: A New Bagplot for Bivariate Data" by Qin, Gang, Tong and Cui (2025) <doi:10.48550/arXiv.2512.06314>.

Biologically Explainable Machine Learning Framework for Phenotype Prediction using omics data described in Chen and Schwarz (2017) <doi:10.48550/arXiv.1712.00336>.Identifying reproducible and interpretable biological patterns from high-dimensional omics data is a critical factor in understanding the risk mechanism of complex disease. As such, explainable machine learning can offer biological insight in addition to personalized risk scoring.In this process, a feature space of biological pathways will be generated, and the feature space can also be subsequently analyzed using WGCNA (Described in Horvath and Zhang (2005) <doi:10.2202/1544-6115.1128> and Langfelder and Horvath (2008) <doi:10.1186/1471-2105-9-559> ) methods.

This package contains functions to perform Bayesian inference using a spectral analysis of Gaussian process priors. Gaussian processes are represented with a Fourier series based on cosine basis functions. Currently the package includes parametric linear models, partial linear additive models with/without shape restrictions, generalized linear additive models with/without shape restrictions, and density estimation model. To maximize computational efficiency, the actual Markov chain Monte Carlo sampling for each model is done using codes written in FORTRAN 90. This software has been developed using funding supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (no. NRF-2016R1D1A1B03932178 and no. NRF-2017R1D1A3B03035235).

This package provides functions for downloading data from the Bank for International Settlements (BIS; <https://www.bis.org/>) in Basel. Supported are only full datasets in (typically) CSV format. The package is lightweight and without dependencies; suggested packages are used only if data is to be transformed into particular data structures, for instance into zoo objects. Downloaded data can optionally be cached, to avoid repeated downloads of the same files.

The method models RNA-seq reads using a mixture of 3 beta-binomial distributions to generate posterior probabilities for genotyping bi-allelic single nucleotide polymorphisms. Elena Vigorito, Anne Barton, Costantino Pitzalis, Myles J. Lewis and Chris Wallace (2023) <doi:10.1093/bioinformatics/btad393> "BBmix: a Bayesian beta-binomial mixture model for accurate genotyping from RNA-sequencing.".

Bootstraps and imputes incomplete datasets. Then performs inference on estimates obtained from analysing the imputed datasets as proposed by von Hippel and Bartlett (2021) <doi:10.1214/20-STS793>.