Finite Population bootstrap algorithms to estimate the variance of the Horvitz-Thompson estimator for single-stage sampling. For a survey of bootstrap methods for finite populations, see Mashreghi et Al. (2016) <doi:10.1214/16-SS113>.

Description: Provides streamlined tools for retrieving sequences from NCBI, performing sequence alignments (pairwise and multiple), and building phylogenetic trees. Implements the Needleman-Wunsch algorithm for global alignment (Needleman & Wunsch (1970) <doi:10.1016/0022-2836(70)90057-4>), Smith-Waterman for local alignment (Smith & Waterman (1981) <doi:10.1016/0022-2836(81)90087-5>), and Neighbor-Joining for tree construction (Saitou & Nei (1987) <doi:10.1093/oxfordjournals.molbev.a040454>).

An umbrella package providing a phenotype/genotype data structure and scalable and efficient computational methods for large genomic datasets in combination with several other packages: BEDMatrix', LinkedMatrix', and symDMatrix'.

Data Package that includes several examples of chemical and biological data networks, i.e. data graph structured.

This package provides functions and data sets reproducing some examples in Box, Hunter and Hunter II. Useful for statistical design of experiments, especially factorial experiments.

Implement in R interactive Circos-like visualizations of genomic data, to map information such as genetic variants, genomic fusions and aberrations to a circular genome, as proposed by the JavaScript library BioCircos.js', based on the JQuery and D3 technologies. The output is by default displayed in stand-alone HTML documents or in the RStudio viewer pane. Moreover it can be integrated in R Markdown documents and Shiny applications.

This package provides functions developed within Breeding Insight to analyze diploid and polyploid breeding and genetic data. BIGr provides the ability to filter variant call format (VCF) files, extract single nucleotide polymorphisms (SNPs) from diversity arrays technology missing allele discovery count (DArT MADC) files, and manipulate genotype data for both diploid and polyploid species. It also serves as the core dependency for the BIGapp Shiny app, which provides a user-friendly interface for performing routine genotype analysis tasks such as dosage calling, filtering, principal component analysis (PCA), genome-wide association studies (GWAS), and genomic prediction. For more details about the included breedTools functions, see Funkhouser et al. (2017) <doi:10.2527/tas2016.0003>, and the updog output format, see Gerard et al. (2018) <doi:10.1534/genetics.118.301468>.

Bayesian Model Averaging for linear models with a wide choice of (customizable) priors. Built-in priors include coefficient priors (fixed, hyper-g and empirical priors), 5 kinds of model priors, moreover model sampling by enumeration or various MCMC approaches. Post-processing functions allow for inferring posterior inclusion and model probabilities, various moments, coefficient and predictive densities. Plotting functions available for posterior model size, MCMC convergence, predictive and coefficient densities, best models representation, BMA comparison. Also includes Bayesian normal-conjugate linear model with Zellner's g prior, and assorted methods.

This package implements efficient NumPy'-like broadcasted operations for atomic and recursive arrays. In the context of operations involving 2 (or more) arrays, â broadcastingâ refers to efficiently recycling array dimensions, without making copies. Besides linking to Rcpp', broadcast does not use any external libraries in any way; broadcast was essentially made from scratch and can be installed out-of-the-box. The implementations available in broadcast include, but are not limited to, the following. 1) Broadcasted element-wise operations on any 2 arrays; they support a large set of relational, arithmetic, Boolean, string, and bit-wise operations. 2) A faster, more memory efficient, and broadcasted abind-like function, for binding arrays along an arbitrary dimension. 3) Broadcasted ifelse-like and apply-like functions. 4) Casting functions, that cast subset-groups of an array to a new dimension, cast nested lists to dimensional lists, and vice-versa. 5) A few linear algebra functions for statistics. The functions in the broadcast package strive to minimize computation time and memory usage (which is not just better for efficient computing, but also for the environment).

Bit-level reading and writing are necessary when dealing with many file formats e.g. compressed data and binary files. Currently, R connections are manipulated at the byte level. This package wraps existing connections and raw vectors so that it is possible to read bits, bit sequences, unaligned bytes and low-bit representations of integers.

Prior transcription factor binding knowledge and target gene expression data are integrated in a Bayesian framework for functional cis-regulatory module inference. Using Gibbs sampling, we iteratively estimate transcription factor associations for each gene, regulation strength for each binding event and the hidden activity for each transcription factor.

This package provides functions to create and select graphical themes for the base plotting system. Contains: 1) several custom pre-made themes 2) mechanism for creating new themes by making persistent changes to the graphical parameters of base plots.

Computes Blyth-Still-Casella exact binomial confidence intervals based on a refining procedure proposed by George Casella (1986) <doi:10.2307/3314658>.

This package provides methods for assessing animal movement from telemetry and biologging data using non-parametric Bayesian methods. This includes features for pre- processing and analysis of data, as well as the visualization of results from the models. This framework does not rely on standard parametric density functions, which provides flexibility during model fitting. Further details regarding part of this framework can be found in Cullen et al. (2022) <doi:10.1111/2041-210X.13745>.

Generation of multiple binary and continuous non-normal variables simultaneously given the marginal characteristics and association structure based on the methodology proposed by Demirtas et al. (2012) <DOI:10.1002/sim.5362>.

This package provides maximum likelihood estimates of the performance parameters that drive a binomial distribution of observed errors, and takes full advantage of zero error observations. High performance communications systems typically have inherent noise sources and other performance limitations that need to be estimated. Measurements made at high signal to noise ratios typically result in zero errors due to limitation in available measurement time. Package includes theoretical performance functions for common modulation schemes (Proakis, "Digital Communications" (1995, <ISBN:0-07-051726-6>)), polarization shifted QPSK (Agrell & Karlsson (2009, <DOI:10.1109/JLT.2009.2029064>)), and utility functions to work with the performance functions.

This package provides a family of novel beta mixture models (BMMs) has been developed by Majumdar et al. (2022) <doi:10.48550/arXiv.2211.01938> to appositely model the beta-valued cytosine-guanine dinucleotide (CpG) sites, to objectively identify methylation state thresholds and to identify the differentially methylated CpG (DMC) sites using a model-based clustering approach. The family of beta mixture models employs different parameter constraints applicable to different study settings. The EM algorithm is used for parameter estimation, with a novel approximation during the M-step providing tractability and ensuring computational feasibility.

Miscellaneous R functions, including functions related to graphics (mostly for base graphics), permutation tests, running mean/median, and general utilities.

This package provides a suite of functions for finance, including the estimation of variance matrices via a statistical factor model or Ledoit-Wolf shrinkage.

High performance principal component analysis routines that operate directly on bigmemory::big.matrix objects. The package avoids materialising large matrices in memory by streaming data through BLAS and LAPACK kernels and provides helpers to derive scores, loadings, correlations, and contribution diagnostics, including utilities that stream results into bigmemory'-backed matrices for file-based workflows. Additional interfaces expose scalable singular value decomposition, robust PCA, and robust SVD algorithms so that users can explore large matrices while tempering the influence of outliers. Scalable principal component analysis is also implemented, Elgamal, Yabandeh, Aboulnaga, Mustafa, and Hefeeda (2015) <doi:10.1145/2723372.2751520>.

Component-wise gradient boosting for analysis of multiply imputed datasets. Implements the algorithm Boosting after Multiple Imputation (MIBoost), which enforces uniform variable selection across imputations and provides utilities for pooling. Includes a cross-validation workflow that first splits the data into training and validation sets and then performs imputation on the training data, applying the learned imputation models to the validation data to avoid information leakage. Supports Gaussian and logistic loss. Methods relate to gradient boosting and multiple imputation as in Buehlmann and Hothorn (2007) <doi:10.1214/07-STS242>, Friedman (2001) <doi:10.1214/aos/1013203451>, and van Buuren (2018, ISBN:9781138588318) and Groothuis-Oudshoorn (2011) <doi:10.18637/jss.v045.i03>; see also Kuchen (2025) <doi:10.48550/arXiv.2507.21807>.

The Bayesian optimal interval (BOIN) design is a novel phase I clinical trial design for finding the maximum tolerated dose (MTD). It can be used to design both single-agent and drug-combination trials. The BOIN design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. The prominent advantage of the BOIN design is that it achieves simplicity and superior performance at the same time. The BOIN design is algorithm-based and can be implemented in a simple way similar to the traditional 3+3 design. The BOIN design yields an average performance that is comparable to that of the continual reassessment method (CRM, one of the best model-based designs) in terms of selecting the MTD, but has a substantially lower risk of assigning patients to subtherapeutic or overly toxic doses. For tutorial, please check Yan et al. (2020) <doi:10.18637/jss.v094.i13>.

This package provides a collection of integrated tools designed to seamlessly interact with each other for the analysis of biogenic silica bSi in inland and marine sediments. These tools share common data representations and follow a consistent API design. The primary goal of the bSi package is to simplify the installation process, facilitate data loading, and enable the analysis of multiple samples for biogenic silica fluxes. This package is designed to enhance the efficiency and coherence of the entire bSi analytic workflow, from data loading to model construction and visualization tailored towards reconstructing productivity in aquatic ecosystems.

Defines operating characteristics of Bayesian Adaptive Trials considering a generalised linear model response via Monte Carlo simulations of Bayesian GLM fitted via integrated Laplace approximations (INLA).