This package performs logistic regression for binary longitudinal data, allowing for serial dependence among observations from a given individual and a random intercept term. Estimation is via maximization of the exact likelihood of a suitably defined model. Missing values and unbalanced data are allowed, with some restrictions. M. Helena Goncalves et al.(2007) <DOI: 10.18637/jss.v046.i09>.

Estimation and interpretation of Bayesian distributed lag interaction models (BDLIMs). A BDLIM regresses a scalar outcome on repeated measures of exposure and allows for modification by a categorical variable under four specific patterns of modification. The main function is bdlim(). There are also summary and plotting files. Details on methodology are described in Wilson et al. (2017) <doi:10.1093/biostatistics/kxx002>.

Package providing a number of functions for working with Two- and Four-parameter Beta and closely related distributions (i.e., the Gamma- Binomial-, and Beta-Binomial distributions). Includes, among other things: - d/p/q/r functions for Four-Parameter Beta distributions and Generalized "Binomial" (continuous) distributions, and d/p/r- functions for Beta- Binomial distributions. - d/p/q/r functions for Two- and Four-Parameter Beta distributions parameterized in terms of their means and variances rather than their shape-parameters. - Moment generating functions for Binomial distributions, Beta-Binomial distributions, and observed value distributions. - Functions for estimating classification accuracy and consistency, making use of the Classical Test-Theory based Livingston and Lewis (L&L) and Hanson and Brennan approaches. A shiny app is available, providing a GUI for the L&L approach when used for binary classifications. For url to the app, see documentation for the LL.CA() function. Livingston and Lewis (1995) <doi:10.1111/j.1745-3984.1995.tb00462.x>. Lord (1965) <doi:10.1007/BF02289490>. Hanson (1991) <https://files.eric.ed.gov/fulltext/ED344945.pdf>.

At the Swiss Federal Statistical Office (SFSO), spatial maps of Switzerland are available free of charge as Cartographic bases for small-scale thematic mapping'. This package contains convenience functions to import ESRI (Environmental Systems Research Institute) shape files using the package sf and to plot them easily and quickly without having to worry too much about the technical details. It contains utilities to combine multiple areas to one single polygon and to find neighbours for single regions. For any point on a map, a special locator can be used to determine to which municipality, district or canton it belongs.

Provide early termination phase II trial designs with a decreasingly informative prior (DIP) or a regular Bayesian prior chosen by the user. The program can determine the minimum planned sample size necessary to achieve the user-specified admissible designs. The program can also perform power and expected sample size calculations for the tests in early termination Phase II trials. See Wang C and Sabo RT (2022) <doi:10.18203/2349-3259.ijct20221110>; Sabo RT (2014) <doi:10.1080/10543406.2014.888441>.

Set of functions to perform various bootstrap unit root tests for both individual time series (including augmented Dickey-Fuller test and union tests), multiple time series and panel data; see Smeekes and Wilms (2023) <doi:10.18637/jss.v106.i12>, Palm, Smeekes and Urbain (2008) <doi:10.1111/j.1467-9892.2007.00565.x>, Palm, Smeekes and Urbain (2011) <doi:10.1016/j.jeconom.2010.11.010>, Moon and Perron (2012) <doi:10.1016/j.jeconom.2012.01.008>, Smeekes and Taylor (2012) <doi:10.1017/S0266466611000387> and Smeekes (2015) <doi:10.1111/jtsa.12110> for key references.

This package provides tools for bioinformatics modeling using recursive transformer-inspired architectures, autoencoders, random forests, XGBoost, and stacked ensemble models. Includes utilities for cross-validation, calibration, benchmarking, and threshold optimization in predictive modeling workflows. The methodology builds on ensemble learning (Breiman 2001 <doi:10.1023/A:1010933404324>), gradient boosting (Chen and Guestrin 2016 <doi:10.1145/2939672.2939785>), autoencoders (Hinton and Salakhutdinov 2006 <doi:10.1126/science.1127647>), and recursive transformer efficiency approaches such as Mixture-of-Recursions (Bae et al. 2025 <doi:10.48550/arXiv.2507.10524>).

Bayesian adaptive randomization is also called outcome adaptive randomization, which is increasingly used in clinical trials.

This package provides a light-weight object-oriented system with python'-like syntax which supports multiple inheritances and incorporates a python'-like method resolution order.

Efficient methods for Bayesian inference of state space models via Markov chain Monte Carlo (MCMC) based on parallel importance sampling type weighted estimators (Vihola, Helske, and Franks, 2020, <doi:10.1111/sjos.12492>), particle MCMC, and its delayed acceptance version. Gaussian, Poisson, binomial, negative binomial, and Gamma observation densities and basic stochastic volatility models with linear-Gaussian state dynamics, as well as general non-linear Gaussian models and discretised diffusion models are supported. See Helske and Vihola (2021, <doi:10.32614/RJ-2021-103>) for details.

Stan-based curve-fitting function for use with package breathtestcore by the same author. Stan functions are refactored here for easier testing.

Computational tools for outlier detection and influence diagnostics in meta-analysis (Noma et al. (2025) <doi:10.1101/2025.09.18.25336125>). Bootstrap distributions of influence statistics are computed, and explicit thresholds for identifying outliers are provided. These methods can also be applied to the analysis of influential centers or regions in multicenter or multiregional clinical trials (Aoki, Noma and Gosho (2021) <doi:10.1080/24709360.2021.1921944>, Nakamura and Noma (2021) <doi:10.5691/jjb.41.117>).

Analyze differences among time series curves with p-value adjustment for multiple comparisons introduced in Oleson et al (2015) <DOI:10.1177/0962280215607411>.

This package provides a likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) <doi:10.1002/pst.1661>.

Enables a user to consume the BambooHR API endpoints using R. The actual URL of the API will depend on your company domain, and will be handled by the package automatically once you setup the config file. The API documentation can be found here <https://documentation.bamboohr.com/docs>.

Tool to find where a function has its lowest value(minimum). The functions can be any dimensions. Recommended use is with eps=10^-10, but can be run with 10^-20, although this depends on the function. Two more methods are in this package, simple gradient method (Gradmod) and Powell method (Powell). These are not recommended for use, their purpose are purely for comparison.

Laplace approximations and penalized B-splines are combined for fast Bayesian inference in latent Gaussian models. The routines can be used to fit survival models, especially proportional hazards and promotion time cure models (Gressani, O. and Lambert, P. (2018) <doi:10.1016/j.csda.2018.02.007>). The Laplace-P-spline methodology can also be implemented for inference in (generalized) additive models (Gressani, O. and Lambert, P. (2021) <doi:10.1016/j.csda.2020.107088>). See the associated website for more information and examples.

This package provides a "Shiny"" web application for creating interactive Bayesian Network models, learning the structure and parameters of Bayesian networks, and utilities for classic network analysis.

Select balanced and spatially balanced probability samples in multi-dimensional spaces with any prescribed inclusion probabilities. It contains fast (C++ via Rcpp) implementations of the included sampling methods. The local pivotal method by Grafström, Lundström and Schelin (2012) <doi:10.1111/j.1541-0420.2011.01699.x> and spatially correlated Poisson sampling by Grafström (2012) <doi:10.1016/j.jspi.2011.07.003> are included. Also the cube method (for balanced sampling) and the local cube method (for doubly balanced sampling) are included, see Grafström and Tillé (2013) <doi:10.1002/env.2194>.

Implementing the Block Coordinate Ascent with One-Step Generalized Rosen (BCA1SG) algorithm on the semiparametric models for panel count data, interval-censored survival data, and degradation data. A comprehensive description of the BCA1SG algorithm can be found in Wang et al. (2020) <https://github.com/yudongstat/BCA1SG/blob/master/BCA1SG.pdf>. For details of the semiparametric models for panel count data, interval-censored survival data, and degradation data, please see Wellner and Zhang (2007) <doi:10.1214/009053607000000181>, Huang and Wellner (1997) <ISBN:978-0-387-94992-5>, and Wang and Xu (2010) <doi:10.1198/TECH.2009.08197>, respectively.

This project aims to enable the method of Path Analysis to infer causalities from data. For this we propose a hybrid approach, which uses Bayesian network structure learning algorithms from data to create the input file for creation of a PA model. The process is performed in a semi-automatic way by our intermediate algorithm, allowing novice researchers to create and evaluate their own PA models from a data set. The references used for this project are: Koller, D., & Friedman, N. (2009). Probabilistic graphical models: principles and techniques. MIT press. <doi:10.1017/S0269888910000275>. Nagarajan, R., Scutari, M., & Lèbre, S. (2013). Bayesian networks in r. Springer, 122, 125-127. Scutari, M., & Denis, J. B. <doi:10.1007/978-1-4614-6446-4>. Scutari M (2010). Bayesian networks: with examples in R. Chapman and Hall/CRC. <doi:10.1201/b17065>. Rosseel, Y. (2012). lavaan: An R Package for Structural Equation Modeling. Journal of Statistical Software, 48(2), 1 - 36. <doi:10.18637/jss.v048.i02>.

Different adjustment methods for batch effects in biomarker data, such as from tissue microarrays. Some methods attempt to retain differences between batches that may be due to between-batch differences in "biological" factors that influence biomarker values.

This package provides a suite of functions for finance, including the estimation of variance matrices via a statistical factor model or Ledoit-Wolf shrinkage.

Identifies genome-related molecular traits with significant evidence of genetic regulation and performs a bootstrap procedure to correct estimated effect sizes for over-estimation present in cis-QTL mapping studies (The "Winner's Curse"), described in Huang QQ *et al.* 2018 <doi: 10.1093/nar/gky780>.