Managing and exploring parameter estimation results derived from Maximum Likelihood Estimation (MLE) using the likelihood package. It provides functions for organizing, visualizing, and summarizing MLE outcomes, streamlining statistical analysis workflows. By improving interpretation and facilitating model evaluation, it helps users gain deeper insights into parameter estimation and model fitting, making MLE result exploration more efficient and accessible. See Goffe et al. (1994) <doi:10.1016/0304-4076(94)90038-8> for details on MLE, and Canham and Uriarte (2006) <doi:10.1890/04-0657> for application of MLE using likelihood'.

This computes Lipinski Rule of Five parameters and offers visualization for drug discovery. It analyzes molecular properties like molecular weight, hydrogen bond donors, acceptors, and ALogP, providing histograms and pass/fail status plots for efficient compound evaluation, aiding in drug development.

Evaluates whether the relationship between two vectors is linear or nonlinear. Performs a test to determine how well a linear model fits the data compared to higher order polynomial models. Jhang et al. (2004) <doi:10.1043/1543-2165(2004)128%3C44:EOLITC%3E2.0.CO;2>.

This package provides likelihood functions as defined by Fisher (1922) <doi:10.1098/rsta.1922.0009> and a function that creates likelihood functions from density functions. The functions are meant to aid in education of likelihood based methods.

Bayesian Survival models via the mixture of Log-Normal distribution extends the well-known survival models and accommodates different behaviour over time and considers higher censored survival times. The proposal combines mixture distributions Fruhwirth-Schnatter(2006) <doi:10.1007/s11336-009-9121-4>, and data augmentation techniques Tanner and Wong (1987) <doi:10.1080/01621459.1987.10478458>.

Lipid Maps Rest service. Researchers can access the Lipid Maps Rest service programmatically and conveniently integrate it into the current workflow or packages.

Based on right or interval censored data, compute the maximum likelihood estimator of a (sub)probability density under the assumption that it is log-concave. For further information see Duembgen, Rufibach and Schuhmacher (2014) <doi:10.1214/14-EJS930>.

We developed an approach to detect differential expression features in long non-coding RNA low counts, using generalized linear model with zero-inflated exponential quasi likelihood ratio test. Methods implemented in this package are described in Li (2019) <doi:10.1186/s12864-019-5926-4>.

Trend filtering is a widely used nonparametric method for knot detection. This package provides an efficient solution for L0 trend filtering, avoiding the traditional methods of using Lagrange duality or Alternating Direction Method of Multipliers algorithms. It employ a splicing approach that minimizes L0-regularized sparse approximation by transforming the L0 trend filtering problem. The package excels in both efficiency and accuracy of trend estimation and changepoint detection in segmented functions. References: Wen et al. (2020) <doi:10.18637/jss.v094.i04>; Zhu et al. (2020)<doi:10.1073/pnas.2014241117>; Wen et al. (2023) <doi:10.1287/ijoc.2021.0313>.

Analysis, imputation, and multiple imputation of count data using covariates. LORI uses a log-linear Poisson model where main row and column effects, as well as effects of known covariates and interaction terms can be fitted. The estimation procedure is based on the convex optimization of the Poisson loss penalized by a Lasso type penalty and a nuclear norm. LORI returns estimates of main effects, covariate effects and interactions, as well as an imputed count table. The package also contains a multiple imputation procedure. The methods are described in Robin, Josse, Moulines and Sardy (2019) <doi:10.1016/j.jmva.2019.04.004>.

Linear model functions using permutation tests.

Constructs tree for continuous longitudinal data and survival data using baseline covariates as partitioning variables according to the LongCART and SurvCART algorithm, respectively. Later also included functions to calculate conditional power and predictive power of success based on interim results and probability of success for a prospective trial.

This package provides a comprehensive toolkit for the analysis of longitudinal integration site data, including data cleaning, quality control, statistical modeling, and visualization. It streamlines the entire workflow of integration site analysis, supports simple input formats, and provides user-friendly functions for researchers in virus integration site analysis. Ni et al. (2025) <doi:10.64898/2025.12.20.695672>.

This package provides classes and methods that allow the user to manage life table, actuarial tables (also multiple decrements tables). Moreover, functions to easily perform demographic, financial and actuarial mathematics on life contingencies insurances calculations are contained therein. See Spedicato (2013) <doi:10.18637/jss.v055.i10>.

Implementation of the Swiss Confederation's standard analysis model for salary analyses <www.ebg.admin.ch/en/equal-pay-analysis-with-logib> in R. The analysis is run at company-level and the model is intended for medium-sized and large companies. It can technically be used with 50 or more employees (apprentices, trainees/interns and expats are not included in the analysis). Employees with at least 100 employees are required by the Gender Equality Act to conduct an equal pay analysis. This package allows users to run the equal salary analysis in R, providing additional transparency with respect to the methodology and simple automation possibilities.

Parse various reflectance/transmittance/absorbance spectra file formats to extract spectral data and metadata, as described in Gruson, White & Maia (2019) <doi:10.21105/joss.01857>. Among other formats, it can import files from Avantes <https://www.avantes.com/>, CRAIC <https://www.microspectra.com/>, and OceanOptics'/'OceanInsight <https://www.oceanoptics.com/> brands.

This package provides a collection of tools for the calculation of freewater metabolism from in situ time series of dissolved oxygen, water temperature, and, optionally, additional environmental variables. LakeMetabolizer implements 5 different metabolism models with diverse statistical underpinnings: bookkeeping, ordinary least squares, maximum likelihood, Kalman filter, and Bayesian. Each of these 5 metabolism models can be combined with 1 of 7 models for computing the coefficient of gas exchange across the airâ water interface (k). LakeMetabolizer also features a variety of supporting functions that compute conversions and implement calculations commonly applied to raw data prior to estimating metabolism (e.g., oxygen saturation and optical conversion models).

Principal component analysis (PCA) is one of the most widely used data analysis techniques. This package provides a series of vignettes explaining PCA starting from basic concepts. The primary purpose is to serve as a self-study resource for anyone wishing to understand PCA better. A few convenience functions are provided as well.

Estimation of a multi-group count regression models (i.e., Poisson, negative binomial) with latent covariates. This packages provides two extensions compared to ordinary count regression models based on a generalized linear model: First, measurement models for the predictors can be specified allowing to account for measurement error. Second, the count regression can be simultaneously estimated in multiple groups with stochastic group weights. The marginal maximum likelihood estimation is described in Kiefer & Mayer (2020) <doi:10.1080/00273171.2020.1751027>.

This package provides functions to fits simple linear regression models with log normal errors and identity link, i.e. taking the responses on the original scale. See Muggeo (2018) <doi:10.13140/RG.2.2.18118.16965>.

This package provides a suite of tools for literature-based discovery in biomedical research. Provides functions for retrieving scientific articles from PubMed and other NCBI databases, extracting biomedical entities (diseases, drugs, genes, etc.), building co-occurrence networks, and applying various discovery models including ABC', AnC', LSI', and BITOLA'. The package also includes visualization tools for exploring discovered connections.

Implementation of the algorithm introduced in Shah, R. D. (2016) <https://www.jmlr.org/papers/volume17/13-515/13-515.pdf>. Data with thousands of predictors can be handled. The algorithm performs sequential Lasso fits on design matrices containing increasing sets of candidate interactions. Previous fits are used to greatly speed up subsequent fits, so the algorithm is very efficient.

Create tables from within R directly on Google Slides presentations. Currently supports matrix, data.frame and flextable objects.

Fast binning of multiple variables using parallel processing. A summary of all the variables binned is generated which provides the information value, entropy, an indicator of whether the variable follows a monotonic trend or not, etc. It supports rebinning of variables to force a monotonic trend as well as manual binning based on pre specified cuts. The cut points of the bins are based on conditional inference trees as implemented in the partykit package. The conditional inference framework is described by Hothorn T, Hornik K, Zeileis A (2006) <doi:10.1198/106186006X133933>.