Studies that report shifts in species distributions may be biased by the shape of the study area. The main functionality of this package is to calculate the Latitudinal Bias Index (LBI) for any given shape. The LBI is bounded between +1 (100% probability to exclusively record latitudinal shifts, i.e., range shifts data sampled along a perfectly South-North oriented straight line) and -1 (100% probability to exclusively record longitudinal shifts, i.e., range shifts data sampled along a perfectly East-West oriented straight line).

This package provides a family of three complementary goodness-of-fit tests based on an adaptation of Hotelling's T-squared statistic applied to vectors of sample log-cumulants (Mellin statistics) for positive-support reliability data. The package provides the asymptotic chi-squared reference and parametric bootstrap p-values for reliable finite-sample inference, covering the Weibull, Frechet, Gamma, Inverse-Gamma, Log-Normal, and Log-Logistic families. It also provides three diagnostic diagrams (log-cumulant, kurtosis-skewness, and coefficient-of-variation) with bootstrap concentration ellipses, in the spirit of moment-ratio diagrams. Methods are described in Santos, Ospina, Espinheira and Oliveira (2025).

Fits and tests logistic joinpoint models.

This package performs power and sample size calculation for non-proportional hazards model using the Fleming-Harrington family of weighted log-rank tests. The sequentially calculated log-rank test score statistics are assumed to have independent increments as characterized in Anastasios A. Tsiatis (1982) <doi:10.1080/01621459.1982.10477898>. The mean and variance of log-rank test score statistics are calculated based on Kaifeng Lu (2021) <doi:10.1002/pst.2069>. The boundary crossing probabilities are calculated using the recursive integration algorithm described in Christopher Jennison and Bruce W. Turnbull (2000, ISBN:0849303168). The package can also be used for continuous, binary, and count data. For continuous data, it can handle missing data through mixed-model for repeated measures (MMRM). In crossover designs, it can estimate direct treatment effects while accounting for carryover effects. For binary data, it can design Simon's 2-stage, modified toxicity probability-2 (mTPI-2), and Bayesian optimal interval (BOIN) trials. For count data, it can design group sequential trials for negative binomial endpoints with censoring. Additionally, it facilitates group sequential equivalence trials for all supported data types. Moreover, it can design adaptive group sequential trials for changes in sample size, error spending function, number and spacing or future looks. Finally, it offers various options for adjusted p-values, including graphical and gatekeeping procedures.

For high-dimensional correlated observations, this package carries out the L_1 penalized maximum likelihood estimation of the precision matrix (network) and the correlation parameters. The correlated data can be longitudinal data (may be irregularly spaced) with dampening correlation or clustered data with uniform correlation. For the details of the algorithms, please see the paper Jie Zhou et al. Identifying Microbial Interaction Networks Based on Irregularly Spaced Longitudinal 16S rRNA sequence data <doi:10.1101/2021.11.26.470159>.

Fits sex-specific life-history models for fish and other taxa where some of the individuals have unknown sex.

Simple functions to lookup items in key-value pairs. See Mehta (2021) <doi:10.1007/978-1-4842-6613-7_6>.

Extends the functionality of the tourr package by an interactive graphical user interface. The interactivity allows users to effortlessly refine their tourr results by manual intervention, which allows for integration of expert knowledge and aids the interpretation of results. For more information on tourr see Wickham et. al (2011) <doi:10.18637/jss.v040.i02> or <https://github.com/ggobi/tourr>.

Libreria di dati, scripts e funzioni che accompagna il libro "Ricerca sociale con R. Concetti e funzioni base per la ricerca sociale".

LineUp is an interactive technique designed to create, visualize and explore rankings of items based on a set of heterogeneous attributes. This is a htmlwidget wrapper around the JavaScript library LineUp.js'. It is designed to be used in R Shiny apps and R Markddown files. Due to an outdated webkit version of RStudio it won't work in the integrated viewer.

Various algorithms related to linguistic fuzzy logic: mining for linguistic fuzzy association rules, composition of fuzzy relations, performing perception-based logical deduction (PbLD), and forecasting time-series using fuzzy rule-based ensemble (FRBE). The package also contains basic fuzzy-related algebraic functions capable of handling missing values in different styles (Bochvar, Sobocinski, Kleene etc.), computation of Sugeno integrals and fuzzy transform.

This package provides functions for different purposes related to forest biometrics, including illustrative graphics, numerical computation, modeling height-diameter relationships, prediction of tree volumes, modelling of diameter distributions and estimation off stand density using ITD. Several empirical datasets are also included.

This package provides methods for the interpolation of large spatial datasets. This package uses a basis function approach that provides a surface fitting method that can approximate standard spatial data models. Using a large number of basis functions allows for estimates that can come close to interpolating the observations (a spatial model with a small nugget variance.) Moreover, the covariance model for this method can approximate the Matern covariance family but also allows for a multi-resolution model and supports efficient computation of the profile likelihood for estimating covariance parameters. This is accomplished through compactly supported basis functions and a Markov random field model for the basis coefficients. These features lead to sparse matrices for the computations and this package makes of the R spam package for sparse linear algebra. An extension of this version over previous ones ( < 5.4 ) is the support for different geometries besides a rectangular domain. The Markov random field approach combined with a basis function representation makes the implementation of different geometries simple where only a few specific R functions need to be added with most of the computation and evaluation done by generic routines that have been tuned to be efficient. One benefit of this package's model/approach is the facility to do unconditional and conditional simulation of the field for large numbers of arbitrary points. There is also the flexibility for estimating non-stationary covariances and also the case when the observations are a linear combination (e.g. an integral) of the spatial process. Included are generic methods for prediction, standard errors for prediction, plotting of the estimated surface and conditional and unconditional simulation. See the LatticeKrigRPackage GitHub repository for a vignette of this package. Development of this package was supported in part by the National Science Foundation Grant 1417857 and the National Center for Atmospheric Research.

Navigating the shift of clinical laboratory data from primary everyday clinical use to secondary research purposes presents a significant challenge. Given the substantial time and expertise required for lab data pre-processing and cleaning and the lack of all-in-one tools tailored for this need, we developed our algorithm lab2clean as an open-source R-package. lab2clean package is set to automate and standardize the intricate process of cleaning clinical laboratory results. With a keen focus on improving the data quality of laboratory result values and units, our goal is to equip researchers with a straightforward, plug-and-play tool, making it smoother for them to unlock the true potential of clinical laboratory data in clinical research and clinical machine learning (ML) model development. Functions to clean & validate result values (Version 1.0) are described in detail in Zayed et al. (2024) <doi:10.1186/s12911-024-02652-7>. Functions to standardize & harmonize result units (added in Version 2.0) are described in detail in Zayed et al. (2025) <doi:10.1016/j.ijmedinf.2025.106131>.

LINCS L1000 is a high-throughput technology that allows the gene expression measurement in a large number of assays. However, to fit the measurements of ~1000 genes in the ~500 color channels of LINCS L1000, every two landmark genes are designed to share a single channel. Thus, a deconvolution step is required to infer the expression values of each gene. Any errors in this step can be propagated adversely to the downstream analyses. We present a LINCS L1000 data peak calling R package l1kdeconv based on a new outlier detection method and an aggregate Gaussian mixture model. Upon the remove of outliers and the borrowing information among similar samples, l1kdeconv shows more stable and better performance than methods commonly used in LINCS L1000 data deconvolution.

Extracts zip files, converts Word', Excel', and html'/'htm files to pdf format. Word and Excel conversion uses VBScript', while html'/'htm conversion uses webshot and PhantomJS'. Additionally, the package merges pdf files into a single document. This package is only supported on Windows due to VBScript dependencies.

Perform two linear combination methods for biomarkers: (1) Empirical performance optimization for specificity (or sensitivity) at a controlled sensitivity (or specificity) level of Huang and Sanda (2022) <doi:10.1214/22-aos2210>, and (2) weighted maximum score estimator with empirical minimization of averaged false positive rate and false negative rate. Both adopt the algorithms of Huang and Sanda (2022) <doi:10.1214/22-aos2210>. MOSEK solver is used and needs to be installed; an academic license for MOSEK is free.

Originally design to characterise Aqueous Two Phase Systems, LLSR provide a simple way to analyse experimental data and obtain phase diagram parameters, among other properties, systematically. The package will include (every other update) new functions in order to comprise useful tools in liquid-liquid extraction research.

This package contains data sets to accompany the book: Lazic SE (2016). "Experimental Design for Laboratory Biologists: Maximising Information and Improving Reproducibility". Cambridge University Press.

This package provides a set of all-cause and cause-specific life expectancy sensitivity and decomposition methods, including Arriaga (1984) <doi:10.2307/2061029>, others documented by Ponnapalli (2005) <doi:10.4054/DemRes.2005.12.7>, lifetable, numerical, and other analytic or algorithmic approaches such as Horiuchi et al (2008) <doi:10.1353/dem.0.0033>, or Andreev et al (2002) <doi:10.4054/DemRes.2002.7.14>.

Set of tools for mapping of categorical response variables based on principal component analysis (pca) and multidimensional unfolding (mdu).

Estimation of a lognormal - Generalized Pareto mixture via the Expectation-Maximization algorithm. Computation of bootstrap standard errors is supported and performed via parallel computing. Functions for random number simulation and density evaluation are also available. For more details see Bee and Santi (2025) <doi:10.48550/arXiv.2505.22507>.

Label-free bottom-up proteomics expression data is often affected by data heterogeneity and missing values. Normalization and missing value imputation are commonly used techniques to address these issues and make the dataset suitable for further downstream analysis. This package provides an optimal combination of normalization and imputation methods for the dataset. The package utilizes three normalization methods and three imputation methods.The statistical evaluation measures named pooled co-efficient of variance, pooled estimate of variance and pooled median absolute deviation are used for selecting the best combination of normalization and imputation method for the given dataset. The user can also visualize the results by using various plots available in this package. The user can also perform the differential expression analysis between two sample groups with the function included in this package. The chosen three normalization methods, three imputation methods and three evaluation measures were chosen for this study based on the research papers published by Välikangas et al. (2016) <doi:10.1093/bib/bbw095>, Jin et al. (2021) <doi:10.1038/s41598-021-81279-4> and Srivastava et al. (2023) <doi:10.2174/1574893618666230223150253>.This work has published by Sakthivel et al. (2025) <doi:10.1021/acs.jproteome.4c00552>.

Conducts various numerical analyses and simulations in population genetics and evolutionary theory, primarily for the purpose of teaching (and learning about) key concepts in population & quantitative genetics, and evolutionary theory.