Prognostic Enrichment is a clinical trial strategy of evaluating an intervention in a patient population with a higher rate of the unwanted event than the broader patient population (R. Temple (2010) <DOI:10.1038/clpt.2010.233>). A higher event rate translates to a lower sample size for the clinical trial, which can have both practical and ethical advantages. This package is a tool to help evaluate biomarkers for prognostic enrichment of clinical trials.

Reads and plots phylogenetic placements.

Carry out Bayesian estimation and forecasting for a variety of stochastic mortality models using vague prior distributions. Models supported include numerous well-established approaches introduced in the actuarial and demographic literature, such as the Lee-Carter (1992) <doi:10.1080/01621459.1992.10475265>, the Cairns-Blake-Dowd (2009) <doi:10.1080/10920277.2009.10597538>, the Li-Lee (2005) <doi:10.1353/dem.2005.0021>, and the Plat (2009) <doi:10.1016/j.insmatheco.2009.08.006> models. The package is designed to analyse stratified mortality data structured as a 3-dimensional array of dimensions p à A à T (strata à age à year). Stratification can represent factors such as cause of death, country, deprivation level, sex, geographic region, insurance product, marital status, socioeconomic group, or smoking behavior. While the primary focus is on analysing stratified data (p > 1), the package can also handle mortality data that are not stratified (p = 1). Model selection via the Deviance Information Criterion (DIC) is supported.

Bayesian models to estimate causal effects of biological treatments on time-to-event endpoints in clinical trials with principal strata defined by the occurrence of antidrug antibodies. The methodology is based on Frangakis and Rubin (2002) <doi:10.1111/j.0006-341x.2002.00021.x> and Imbens and Rubin (1997) <doi:10.1214/aos/1034276631>, and here adapted to a specific time-to-event setting.

Bayesian approaches for analyzing multivariate data in ecology. Estimation is performed using Markov Chain Monte Carlo (MCMC) methods via Three. JAGS types of models may be fitted: 1) With explanatory variables only, boral fits independent column Generalized Linear Models (GLMs) to each column of the response matrix; 2) With latent variables only, boral fits a purely latent variable model for model-based unconstrained ordination; 3) With explanatory and latent variables, boral fits correlated column GLMs with latent variables to account for any residual correlation between the columns of the response matrix.

Perform bootstrap-based hypothesis testing procedures on three statistical problems. In particular, it covers independence testing, testing the slope in a linear regression setting, and goodness-of-fit testing, following (Derumigny, Galanis, Schipper and Van der Vaart, 2025) <doi:10.48550/arXiv.2512.10546>.

Broadly useful convenient and efficient R functions that bring users concise and elegant R data analyses. This package includes easy-to-use functions for (1) basic R programming (e.g., set working directory to the path of currently opened file; import/export data from/to files in any format; print tables to Microsoft Word); (2) multivariate computation (e.g., compute scale sums/means/... with reverse scoring); (3) reliability analyses and factor analyses; (4) descriptive statistics and correlation analyses; (5) t-test, multi-factor analysis of variance (ANOVA), simple-effect analysis, and post-hoc multiple comparison; (6) tidy report of statistical models (to R Console and Microsoft Word); (7) mediation and moderation analyses (PROCESS); and (8) additional toolbox for statistics and graphics.

This package provides the C++ header-only library barry for use in R packages. barry is a C++ template library for counting sufficient statistics on binary arrays and building discrete exponential-family models. It provides tools for sparse arrays, user-defined count statistics, support set constraints, power set generation, and includes modules for Discrete Exponential Family Models (DEFMs) and network statistics. By placing these headers in this package, we offer an efficient distribution system for CRAN as replication of this code in the sources of other packages is avoided. This package follows the same approach as the BH package which provides Boost headers for R packages.

This package provides functions to construct efficient block designs for 3-level factorial experiments in block size 3. The designs ensure the estimation of all main effects and two-factor interactions in minimum number of replications. For more details, see Dey and Mukerjee (2012) <doi:10.1016/j.spl.2012.06.014> and Dash, S., Parsad, R. and Gupta, V.K. (2013) <doi:10.1007/s40003-013-0059-5>.

This package provides a fast and intuitive batch effect removal tool for single-cell data. BBKNN is originally used in the scanpy python package, and now can be used with Seurat seamlessly.

Density, distribution function, quantile function random generation and estimation of bimodal GEV distribution given in Otiniano et al. (2023) <doi:10.1007/s10651-023-00566-7>. This new generalization of the well-known GEV (Generalized Extreme Value) distribution is useful for modeling heterogeneous bimodal data from different areas.

This package provides a Metropolis-coupled Markov chain Monte Carlo sampler, post-processing and parameter estimation functions, and plotting utilities for the generalized graded unfolding model of Roberts, Donoghue, and Laughlin (2000) <doi:10.1177/01466216000241001>.

Generates Monte Carlo confidence intervals for standardized regression coefficients (beta) and other effect sizes, including multiple correlation, semipartial correlations, improvement in R-squared, squared partial correlations, and differences in standardized regression coefficients, for models fitted by lm(). betaMC combines ideas from Monte Carlo confidence intervals for the indirect effect (Pesigan and Cheung, 2024 <doi:10.3758/s13428-023-02114-4>) and the sampling covariance matrix of regression coefficients (Dudgeon, 2017 <doi:10.1007/s11336-017-9563-z>) to generate confidence intervals effect sizes in regression.

Estimation and interpretation of Bayesian distributed lag interaction models (BDLIMs). A BDLIM regresses a scalar outcome on repeated measures of exposure and allows for modification by a categorical variable under four specific patterns of modification. The main function is bdlim(). There are also summary and plotting files. Details on methodology are described in Wilson et al. (2017) <doi:10.1093/biostatistics/kxx002>.

This package contains functions for evaluating, analyzing, and fitting combined action dose response surfaces with the Bivariate Response to Additive Interacting Doses (BRAID) model of combined action, along with tools for implementing other combination analysis methods, including Bliss independence, combination index, and additional response surface methods.

This package provides a collection of S4 classes which implements different methods to estimate and deal with densities in bounded domains. That is, densities defined within the interval [lower.limit, upper.limit], where lower.limit and upper.limit are values that can be set by the user.

Generation of correlated artificial binary data.

This package provides an R interface for the Bureau of Economic Analysis (BEA) API (see <http://www.bea.gov/API/bea_web_service_api_user_guide.htm> for more information) that serves two core purposes - 1. To Extract/Transform/Load data [beaGet()] from the BEA API as R-friendly formats in the user's work space [transformation done by default in beaGet() can be modified using optional parameters; see, too, bea2List(), bea2Tab()]. 2. To enable the search of descriptive meta data [beaSearch()]. Other features of the library exist mainly as intermediate methods or are in early stages of development. Important Note - You must have an API key to use this library. Register for a key at <http://www.bea.gov/API/signup/index.cfm> .

This package implements the Beta Kernel Process (BKP) for nonparametric modeling of spatially varying binomial probabilities, together with its extension, the Dirichlet Kernel Process (DKP), for categorical or multinomial data. The package provides functions for model fitting, predictive inference with uncertainty quantification, posterior simulation, and visualization in one-and two-dimensional input spaces. Multiple kernel functions (Gaussian, Matern 5/2, and Matern 3/2) are supported, with hyperparameters optimized through multi-start gradient-based search. For more details, see Zhao, Qing, and Xu (2025) <doi:10.48550/arXiv.2508.10447>.

Create randomizations for block random clinical trials. Can also produce a pdf file of randomization cards.

Co-clustering of the rows and columns of a contingency or binary matrix, or double binary matrices and model selection for the number of row and column clusters. Three models are considered: the Poisson latent block model for contingency matrix, the binary latent block model for binary matrix and a new model we develop: the multiple latent block model for double binary matrices. A new procedure named bikm1 is implemented to investigate more efficiently the grid of numbers of clusters. Then, the studied model selection criteria are the integrated completed likelihood (ICL) and the Bayesian integrated likelihood (BIC). Finally, the co-clustering adjusted Rand index (CARI) to measure agreement between co-clustering partitions is implemented. Robert Valerie, Vasseur Yann, Brault Vincent (2021) <doi:10.1007/s00357-020-09379-w>.

This package provides tools for extraction and analysis of various n-grams (k-mers) derived from biological sequences (proteins or nucleic acids). Contains QuiPT (quick permutation test) for fast feature-filtering of the n-gram data.

Nonparametric detection of nonuniformity and dependence with Binary Expansion Testing (BET). See Kai Zhang (2019) BET on Independence, Journal of the American Statistical Association, 114:528, 1620-1637, <DOI:10.1080/01621459.2018.1537921>, Kai Zhang, Wan Zhang, Zhigen Zhao, Wen Zhou. (2023). BEAUTY Powered BEAST, <doi:10.48550/arXiv.2103.00674> and Wan Zhang, Zhigen Zhao, Michael Baiocchi, Yao Li, Kai Zhang. (2023) SorBET: A Fast and Powerful Algorithm to Test Dependence of Variables, Techinical report.

This package provides a way to simulate from the prior distribution of Bayesian trees by Chipman et al. (1998) <DOI:10.2307/2669832>. The prior distribution of Bayesian trees is highly dependent on the design matrix X, therefore using the suggested hyperparameters by Chipman et al. (1998) <DOI:10.2307/2669832> is not recommended and could lead to unexpected prior distribution. This work is part of my master thesis (expected 2016).