We developed an approach to detect differential expression features in long non-coding RNA low counts, using generalized linear model with zero-inflated exponential quasi likelihood ratio test. Methods implemented in this package are described in Li (2019) <doi:10.1186/s12864-019-5926-4>.

Tests whether the linear hypothesis of a model is correct specified using Dominguez-Lobato test. Also Ramsey's RESET (Regression Equation Specification Error Test) test is implemented and Wald tests can be carried out. Although RESET test is widely used to test the linear hypothesis of a model, Dominguez and Lobato (2019) proposed a novel approach that generalizes well known specification tests such as Ramsey's. This test relies on wild-bootstrap; this package implements this approach to be usable with any function that fits linear models and is compatible with the update() function such as stats'::lm(), lfe'::felm() and forecast'::Arima(), for ARMA (autoregressiveâ moving-average) models. Also the package can handle custom statistics such as Cramer von Mises and Kolmogorov Smirnov, described by the authors, and custom distributions such as Mammen (discrete and continuous) and Rademacher. Manuel A. Dominguez & Ignacio N. Lobato (2019) <doi:10.1080/07474938.2019.1687116>.

Obtain least-squares means for linear, generalized linear, and mixed models. Compute contrasts or linear functions of least-squares means, and comparisons of slopes. Plots and compact letter displays. Least-squares means were proposed in Harvey, W (1960) "Least-squares analysis of data with unequal subclass numbers", Tech Report ARS-20-8, USDA National Agricultural Library, and discussed further in Searle, Speed, and Milliken (1980) "Population marginal means in the linear model: An alternative to least squares means", The American Statistician 34(4), 216-221 <doi:10.1080/00031305.1980.10483031>. NOTE: lsmeans now relies primarily on code in the emmeans package. lsmeans will be archived in the near future.

Create interactive time series visualizations. linevis includes an extensive API to manipulate time series after creation, and supports getting data out of the visualization. Based on the timevis package and the vis.js Timeline JavaScript library <https://visjs.github.io/vis-timeline/docs/graph2d/>.

The Gaussian location-scale regression model is a multi-predictor model with explanatory variables for the mean (= location) and the standard deviation (= scale) of a response variable. This package implements maximum likelihood and Markov chain Monte Carlo (MCMC) inference (using algorithms from Girolami and Calderhead (2011) <doi:10.1111/j.1467-9868.2010.00765.x> and Nesterov (2009) <doi:10.1007/s10107-007-0149-x>), a parametric bootstrap algorithm, and diagnostic plots for the model class.

This package provides a wrapper around the LIBLINEAR C/C++ library for machine learning (available at <https://www.csie.ntu.edu.tw/~cjlin/liblinear/>). LIBLINEAR is a simple library for solving large-scale regularized linear classification and regression. It currently supports L2-regularized classification (such as logistic regression, L2-loss linear SVM and L1-loss linear SVM) as well as L1-regularized classification (such as L2-loss linear SVM and logistic regression) and L2-regularized support vector regression (with L1- or L2-loss). The main features of LiblineaR include multi-class classification (one-vs-the rest, and Crammer & Singer method), cross validation for model selection, probability estimates (logistic regression only) or weights for unbalanced data. The estimation of the models is particularly fast as compared to other libraries.

An implementation of locally Gaussian distributions. It provides methods for implementing locally Gaussian multivariate density estimation, conditional density estimation, various independence tests for iid and time series data, a test for conditional independence and a test for financial contagion.

This package provides histograms, boxplots and dotplots as alternatives to scatterplots of data when plotting fitted logistic regressions.

This package provides utilities to detect common data leakage patterns including train/test contamination, temporal leakage, and data duplication, enhancing model reliability and reproducibility in machine learning workflows. Generates diagnostic reports and visual summaries to support data validation. Methods based on best practices from Hastie, Tibshirani, and Friedman (2009, ISBN:978-0387848570).

R interface for working with nanometer scale secondary ion mass spectrometry (NanoSIMS) data exported from Look at NanoSIMS.

This package creates a consensus genetic map by merging linkage maps from different populations. The software uses linear programming (LP) to efficiently minimize the mean absolute error between the consensus map and the linkage maps. This minimization is performed subject to linear inequality constraints that ensure the ordering of the markers in the linkage maps is preserved. When marker order is inconsistent between linkage maps, a minimum set of ordinal constraints is deleted to resolve the conflicts.

Provide access to the lz-string <http://pieroxy.net/blog/pages/lz-string/index.html> C++ library for Lempel-Ziv (LZ) based compression and decompression of strings.

This package provides a bioinformatics pipeline for performing taxonomic assignment of DNA metabarcoding sequence data while considering geographic location. A detailed tutorial is available at <https://urodelan.github.io/Local_Taxa_Tool_Tutorial/>. A manuscript describing these methods is in preparation.

This package contains a suite of shiny applications meant to explore linear model inference feature through simulation and games.

This package provides functionality to train and evaluate algorithm selection models for portfolios.

This package provides methods for assessing agreement between repeated measurements obtained by two or more methods using the longitudinal concordance correlation coefficient (LCC). Polynomial mixed-effects models (via nlme') describe how concordance, Pearson correlation and accuracy evolve over time. Functions are provided for model fitting, diagnostic plots, extraction of summaries, and non-parametric bootstrap confidence intervals (including parallel computation), following Oliveira et al. (2018) <doi:10.1007/s13253-018-0321-1>.

Generates quotes from Lero Lero', a database for meaningless sentences filled with corporate buzzwords, intended to be used as corporate lorem ipsum (see <http://www.lerolero.com/> for more information). Unfortunately, quotes are currently portuguese-only.

This package performs extreme value analysis at multiple locations using functions from the evd package. Supports both point-based and gridded input data using the terra package, enabling flexible looping across spatial datasets for batch processing of generalised extreme value, Gumbel fits.

Evaluates whether the relationship between two vectors is linear or nonlinear. Performs a test to determine how well a linear model fits the data compared to higher order polynomial models. Jhang et al. (2004) <doi:10.1043/1543-2165(2004)128%3C44:EOLITC%3E2.0.CO;2>.

This package provides functions for computing the r and r* statistics for inference on an arbitrary scalar function of model parameters, plus some code for the (modified) profile likelihood.

Local partial likelihood estimation by Fan, Lin and Zhou(2006)<doi:10.1214/009053605000000796> and simultaneous confidence band is a set of tools to test the covariates-biomarker interaction for survival data. Test for the covariates-biomarker interaction using the bootstrap method and the asymptotic method with simultaneous confidence band (Liu, Jiang and Chen (2015)<doi:10.1002/sim.6563>).

Supervised learning techniques designed for the situation when the dimensionality exceeds the sample size have a tendency to overfit as the dimensionality of the data increases. To remedy this High dimensionality; low sample size (HDLSS) situation, we attempt to learn a lower-dimensional representation of the data before learning a classifier. That is, we project the data to a situation where the dimensionality is more manageable, and then are able to better apply standard classification or clustering techniques since we will have fewer dimensions to overfit. A number of previous works have focused on how to strategically reduce dimensionality in the unsupervised case, yet in the supervised HDLSS regime, few works have attempted to devise dimensionality reduction techniques that leverage the labels associated with the data. In this package and the associated manuscript Vogelstein et al. (2017) <arXiv:1709.01233>, we provide several methods for feature extraction, some utilizing labels and some not, along with easily extensible utilities to simplify cross-validative efforts to identify the best feature extraction method. Additionally, we include a series of adaptable benchmark simulations to serve as a standard for future investigative efforts into supervised HDLSS. Finally, we produce a comprehensive comparison of the included algorithms across a range of benchmark simulations and real data applications.

Computes power, or sample size or the detectable difference for a repeated measures model with attrition. It requires the variance covariance matrix of the observations but can compute this matrix for several common random effects models. See Diggle, P, Liang, KY and Zeger, SL (1994, ISBN:9780198522843).

This package provides a set of functions for analyzing the structure of forests based on the leaf area density (LAD) and leaf area index (LAI) measures calculated from Airborne Laser Scanning (ALS), i.e., scanning lidar (Light Detection and Ranging) data. The methodology is discussed and described in Almeida et al. (2019) <doi:10.3390/rs11010092> and Stark et al. (2012) <doi:10.1111/j.1461-0248.2012.01864.x>.