This package performs maximum a posteriori Bayesian estimation of individual pharmacokinetic parameters from a model defined in mrgsolve', typically for model-based therapeutic drug monitoring. Internally computes an objective function value from model and data, performs optimization and returns predictions in a convenient format. The performance of the package was described by Le Louedec et al (2021) <doi:10.1002/psp4.12689>.

This package provides tools for multivariate analyses of morphological data, wrapped in one package, to make the workflow convenient and fast. Statistical and graphical tools provide a comprehensive framework for checking and manipulating input data, statistical analyses, and visualization of results. Several methods are provided for the analysis of raw data, to make the dataset ready for downstream analyses. Integrated statistical methods include hierarchical classification, principal component analysis, principal coordinates analysis, non-metric multidimensional scaling, and multiple discriminant analyses: canonical, stepwise, and classificatory (linear, quadratic, and the non-parametric k nearest neighbours). The philosophy of the package is described in Å lenker et al. 2022.

Combination of either p-values or modified effect sizes from different studies to find differentially expressed genes.

Causal moderated mediation analysis using the methods proposed by Qin and Wang (2023) <doi:10.3758/s13428-023-02095-4>. Causal moderated mediation analysis is crucial for investigating how, for whom, and where a treatment is effective by assessing the heterogeneity of mediation mechanism across individuals and contexts. This package enables researchers to estimate and test the conditional and moderated mediation effects, assess their sensitivity to unmeasured pre-treatment confounding, and visualize the results. The package is built based on the quasi-Bayesian Monte Carlo method, because it has relatively better performance at small sample sizes, and its running speed is the fastest. The package is applicable to a treatment of any scale, a binary or continuous mediator, a binary or continuous outcome, and one or more moderators of any scale.

Multivariate functional principal component analysis via fast covariance estimation for multivariate sparse functional data or longitudinal data proposed by Li, Xiao, and Luo (2020) <doi: 10.1002/sta4.245>.

This package provides utilities for reading and processing microdata from Spanish official statistics with R.

Compute effect sizes and their sampling variances from factorial experimental designs. The package supports calculation of simple effects, overall effects, and interaction effects for use in factorial meta-analyses. See Gurevitch et al. (2000) <doi:10.1086/303337>, Morris et al. (2007) <doi:10.1890/06-0442>, Lajeunesse (2011) <doi:10.1890/11-0423.1> and Macartney et al. (2022) <doi:10.1016/j.neubiorev.2022.104554>.

High-performance MongoDB client based on mongo-c-driver and jsonlite'. Includes support for aggregation, indexing, map-reduce, streaming, encryption, enterprise authentication, and GridFS. The online user manual provides an overview of the available methods in the package: <https://jeroen.github.io/mongolite/>.

Three estimating equation methods are provided in this package for marginal analysis of longitudinal ordinal data with misclassified responses and covariates. The naive analysis which is solely based on the observed data without adjustment may lead to bias. The corrected generalized estimating equations (GEE2) method which is unbiased requires the misclassification parameters to be known beforehand. The corrected generalized estimating equations (GEE2) with validation subsample method estimates the misclassification parameters based on a given validation set. This package is an implementation of Chen (2013) <doi:10.1002/bimj.201200195>.

This package provides a set of tools for fitting Markov-modulated linear regression, where responses Y(t) are time-additive, and model operates in the external environment, which is described as a continuous time Markov chain with finite state space. Model is proposed by Alexander Andronov (2012) <arXiv:1901.09600v1> and algorithm of parameters estimation is based on eigenvalues and eigenvectors decomposition. Markov-switching regression models have the same idea of varying the regression parameters randomly in accordance with external environment. The difference is that for Markov-modulated linear regression model the external environment is described as a continuous-time homogeneous irreducible Markov chain with known parameters while switching models consider Markov chain as unobserved and estimation procedure involves estimation of transition matrix. These models have significant differences in terms of the analytical approach. Also, package provides a set of data simulation tools for Markov-modulated linear regression (for academical/research purposes). Research project No. 1.1.1.2/VIAA/1/16/075.

This package performs mean shift classification using linear and k-d tree based nearest neighbor implementations for the Gaussian, Epanechnikov, and biweight product kernels.

This package provides functions to analyze coherence, boundary clumping, and turnover following the pattern-based metacommunity analysis of Leibold and Mikkelson 2002 <doi:10.1034/j.1600-0706.2002.970210.x>. The package also includes functions to visualize ecological networks, and to calculate modularity as a replacement to boundary clumping.

Create an immutable container holding metadata for the purpose of better enabling programming activities and functionality of other packages within the clinical programming workflow.

BEAST2 (<https://www.beast2.org>) is a widely used Bayesian phylogenetic tool, that uses DNA/RNA/protein data and many model priors to create a posterior of jointly estimated phylogenies and parameters. BEAST2 is commonly accompanied by BEAUti 2 (<https://www.beast2.org>), which, among others, allows one to install BEAST2 package. This package allows to work with BEAST2 packages from R'.

This package provides a companion to the Chinese book ``Modern Statistical Graphics''.

Computes densities, probabilities, and random deviates of the Matrix Normal (Pocuca et al. (2019) <doi:10.48550/arXiv.1910.02859>). Also includes simple but useful matrix functions. See the vignette for more information.

Useful functions to analyze proteomic workflows including number of identifications, data completeness, missed cleavages, quantitative and retention time precision etc. Various software outputs are supported such as ProteomeDiscoverer', Spectronaut', DIA-NN and MaxQuant'.

This package provides tools for monitoring progress during parallel processing. Lightweight package which acts as a wrapper around mclapply() and adds a progress bar to it in RStudio or Linux environments. Simply replace your original call to mclapply() with pmclapply(). A progress bar can also be displayed during parallelisation via the foreach package. Also included are functions to safely print messages (including error messages) from within parallelised code, which can be useful for debugging parallelised R code.

Procedures for simulating biomes by equilibrium vegetation models, with a special focus on paleoenvironmental applications. Three widely used equilibrium biome models are currently implemented in the package: the Holdridge Life Zone (HLZ) system (Holdridge 1947, <doi:10.1126/science.105.2727.367>), the Köppen-Geiger classification (KGC) system (Köppen 1936, <https://koeppen-geiger.vu-wien.ac.at/pdf/Koppen_1936.pdf>) and the BIOME model (Prentice et al. 1992, <doi:10.2307/2845499>). Three climatic forest-steppe models are also implemented. An approach for estimating monthly time series of relative sunshine duration from temperature and precipitation data (Yin 1999, <doi:10.1007/s007040050111>) is also adapted, allowing process-based biome models to be combined with high-resolution paleoclimate simulation datasets (e.g., CHELSA-TraCE21k v1.0 dataset: <https://chelsa-climate.org/chelsa-trace21k/>).

This package provides a collection of functions for converting and visualization the free induction decay of mono dimensional nuclear magnetic resonance (NMR) spectra into an audio file. It facilitates the conversion of Bruker datasets in files WAV. The sound of NMR signals could provide an alternative to the current representation of the individual metabolic fingerprint and supply equally significant information. The package includes also NMR spectra of the urine samples provided by four healthy donors. Based on Cacciatore S, Saccenti E, Piccioli M. Hypothesis: the sound of the individual metabolic phenotype? Acoustic detection of NMR experiments. OMICS. 2015;19(3):147-56. <doi:10.1089/omi.2014.0131>.

This package contains functions for mapping odds ratios, hazard ratios, or other effect estimates using individual-level data such as case-control study data, using generalized additive models (GAMs) or Cox models for smoothing with a two-dimensional predictor (e.g., geolocation or exposure to chemical mixtures) while adjusting linearly for confounding variables, using methods described by Kelsall and Diggle (1998), Webster at al. (2006), and Bai et al. (2020). Includes convenient functions for mapping point estimates and confidence intervals, efficient control sampling, and permutation tests for the null hypothesis that the two-dimensional predictor is not associated with the outcome variable (adjusting for confounders).

This package provides a class for multi-companion matrices with methods for arithmetic and factorization. A method for generation of multi-companion matrices with prespecified spectral properties is provided, as well as some utilities for periodically correlated and multivariate time series models. See Boshnakov (2002) <doi:10.1016/S0024-3795(01)00475-X> and Boshnakov & Iqelan (2009) <doi:10.1111/j.1467-9892.2009.00617.x>.

Learning and using the Metropolis algorithm for Bayesian fitting of a generalized linear model. The package vignette includes examples of hand-coding a logistic model using several variants of the Metropolis algorithm. The package also contains R functions for simulating posterior distributions of Bayesian generalized linear model parameters using guided, adaptive, guided-adaptive and random walk Metropolis algorithms. The random walk Metropolis algorithm was originally described in Metropolis et al (1953); <doi:10.1063/1.1699114>.

Analyze multilevel networks as described in Lazega et al (2008) <doi:10.1016/j.socnet.2008.02.001> and in Lazega and Snijders (2016, ISBN:978-3-319-24520-1). The package was developed essentially as an extension to igraph'.