This package provides a downstream bioinformatics tool to construct and assist curation of microhaplotypes from short read sequences.

An implementation of the alternating expectation conditional maximization (AECM) algorithm for matrix-variate variance gamma (MVVG) and normal-inverse Gaussian (MVNIG) linear models. These models are designed for settings of multivariate analysis with clustered non-uniform observations and correlated responses. The package includes fitting and prediction functions for both models, and an example dataset from a periodontal on Gullah-speaking African Americans, with responses in gaad_res, and covariates in gaad_cov. For more details on the matrix-variate distributions used, see Gallaugher & McNicholas (2019) <doi:10.1016/j.spl.2018.08.012>.

Conducting linear and nonlinear dose-response meta-regression using study-level summary data. It supports both continuous and binary outcomes and allows modeling of dose-effect relationships using linear trends or nonlinear restricted cubic splines. The package is designed to facilitate transparent, flexible, and reproducible dose-response meta-analyses, with built-in visualization of fitted dose-response curves.

Projects mean squared out-of-sample error for a linear regression based upon the methodology developed in Rohlfs (2022) <doi:10.48550/arXiv.2209.01493>. It consumes as inputs the lm object from an estimated OLS regression (based on the "training sample") and a data.frame of out-of-sample cases (the "test sample") that have non-missing values for the same predictors. The test sample may or may not include data on the outcome variable; if it does, that variable is not used. The aim of the exercise is to project what what mean squared out-of-sample error can be expected given the predictor values supplied in the test sample. Output consists of a list of three elements: the projected mean squared out-of-sample error, the projected out-of-sample R-squared, and a vector of out-of-sample "hat" or "leverage" values, as defined in the paper.

Computational tools to represent phylogenetic signals using adapted eigenvector maps.

Calculate the maximal fat oxidation, the exercise intensity that elicits the maximal fat oxidation and the SIN model to represent the fat oxidation kinetics. Three variables can be obtained from the SIN model: dilatation, symmetry and translation. Examples of these methods can be found in Montes de Oca et al (2021) <doi:10.1080/17461391.2020.1788650> and Chenevière et al. (2009) <doi:10.1249/MSS.0b013e31819e2f91>.

Uses memory-mapping to enable the random access of elements of a text file of characters separated by characters as if it were a simple R(cpp) matrix.

Multi-criteria design of experiments algorithm that simultaneously optimizes up to six different criteria ('I', Id', D', Ds', A and As'). The algorithm finds the optimal Pareto front and, if requested, selects a possible symmetrical design on it. The symmetrical design is selected based on two techniques: minimum distance with the Utopia point or the TOPSIS approach.

This package provides tools to generate HTML interfaces for adaptive and non-adaptive tests using the shiny package (Chalmers (2016) <doi:10.18637/jss.v071.i05>). Suitable for applying unidimensional and multidimensional computerized adaptive tests (CAT) using item response theory methodology and for creating simple questionnaires forms to collect response data directly in R. Additionally, optimal test designs (e.g., "shadow testing") are supported for tests that contain a large number of item selection constraints. Finally, package contains tools useful for performing Monte Carlo simulations for studying test item banks.

Calculate predicted levels and marginal effects, using the delta method to calculate standard errors. This is an R-based version of the margins command from Stata.

Framework for merging and disambiguating event data based on spatiotemporal co-occurrence and secondary event characteristics. It can account for intrinsic "fuzziness" in the coding of events, varying event taxonomies and different geo-precision codes.

This package provides an extensive collection of datasets related to medicine, diseases, treatments, drugs, and public health. This package covers topics such as drug effectiveness, vaccine trials, survival rates, infectious disease outbreaks, and medical treatments. The included datasets span various health conditions, including AIDS, cancer, bacterial infections, and COVID-19, along with information on pharmaceuticals and vaccines. These datasets are sourced from the R ecosystem and other R packages, remaining unaltered to ensure data integrity. This package serves as a valuable resource for researchers, analysts, and healthcare professionals interested in conducting medical and public health data analysis in R.

This package provides a collection of functions to do some statistical inferences. On estimation, it has the function to get the method of moments estimates, the sampling interval. In terms of testing it has function of doing most powerful test.

Enables preparation of maps to be printed and drawn on. Modified maps can then be scanned back in, and hand-drawn marks converted to spatial objects.

Generate a monochrome palette from a starting colour for a specified number of colours. The package can also be used to display colour palettes in the plot window, with or without hex codes and colour labels.

This package provides a compilation of more than 80 functions designed to quantitatively and visually evaluate prediction performance of regression (continuous variables) and classification (categorical variables) of point-forecast models (e.g. APSIM, DSSAT, DNDC, supervised Machine Learning). For regression, it includes functions to generate plots (scatter, tiles, density, & Bland-Altman plot), and to estimate error metrics (e.g. MBE, MAE, RMSE), error decomposition (e.g. lack of accuracy-precision), model efficiency (e.g. NSE, E1, KGE), indices of agreement (e.g. d, RAC), goodness of fit (e.g. r, R2), adjusted correlation coefficients (e.g. CCC, dcorr), symmetric regression coefficients (intercept, slope), and mean absolute scaled error (MASE) for time series predictions. For classification (binomial and multinomial), it offers functions to generate and plot confusion matrices, and to estimate performance metrics such as accuracy, precision, recall, specificity, F-score, Cohen's Kappa, G-mean, and many more. For more details visit the vignettes <https://adriancorrendo.github.io/metrica/>.

This package implements the method of successive dichotomizations by Bradley and Massof (2018) <doi:10.1371/journal.pone.0206106>, which estimates item measures, person measures and ordered rating category thresholds given ordinal rating scale data.

This package provides tools that facilitate ordinary differential equation (ODE) modeling in R'. This package allows one to perform simulations for ODE models that are encoded in the GNU MCSim model specification language (Bois, 2009) <doi:10.1093/bioinformatics/btp162> using ODE solvers from the R package deSolve (Soetaert et al., 2010) <doi:10.18637/jss.v033.i09>.

This package provides methods for quantifying the information gain contributed by individual modalities in multimodal regression models. Information gain is measured using Expected Relative Entropy (ERE) or pseudo-R² metrics, with corresponding p-values and confidence intervals. Currently supports linear and logistic regression models with plans for extension to additional Generalized Linear Models and Cox proportional hazard model.

Encodes several methods for performing Mendelian randomization analyses with summarized data. Summarized data on genetic associations with the exposure and with the outcome can be obtained from large consortia. These data can be used for obtaining causal estimates using instrumental variable methods.

Computationally efficient functions to provide direct likelihood-based inference for partially-observed multivariate birth-death processes. Such processes range from a simple Yule model to the complex susceptible-infectious-removed model in disease dynamics. Efficient likelihood evaluation facilitates maximum likelihood estimation and Bayesian inference.

Family Planning programs and initiatives typically use nationally representative surveys to estimate key indicators of a countryâ s family planning progress. However, in recent years, routinely collected family planning services data (Service Statistics) have been used as a supplementary data source to bridge gaps in the surveys. The use of service statistics comes with the caveat that adjustments need to be made for missing private sector contributions to the contraceptive method supply chain. Evaluating the supply source of modern contraceptives often relies on Demographic Health Surveys (DHS), where many countries do not have recent data beyond 2015/16. Fortunately, in the absence of recent surveys we can rely on statistical model-based estimates and projections to fill the knowledge gap. We present a Bayesian, hierarchical, penalized-spline model with multivariate-normal spline coefficients, to account for across method correlations, to produce country-specific,annual estimates for the proportion of modern contraceptive methods coming from the public and private sectors. This package provides a quick and convenient way for users to access the DHS modern contraceptive supply share data at national and subnational administration levels, estimate, evaluate and plot annual estimates with uncertainty for a sample of low- and middle-income countries. Methods for the estimation of method supply shares at the national level are described in Comiskey, Alkema, Cahill (2022) <arXiv:2212.03844>.

Facilitate frequentist and Bayesian meta-analysis of diagnosis and prognosis research studies. It includes functions to summarize multiple estimates of prediction model discrimination and calibration performance (Debray et al., 2019) <doi:10.1177/0962280218785504>. It also includes functions to evaluate funnel plot asymmetry (Debray et al., 2018) <doi:10.1002/jrsm.1266>. Finally, the package provides functions for developing multivariable prediction models from datasets with clustering (de Jong et al., 2021) <doi:10.1002/sim.8981>.

Uses dplyr and tidyeval to fit statistical models inside the database. It currently supports KMeans and linear regression models.