This package provides a flexible computational framework for mixture distributions with the focus on the composite models.

This package provides a downstream bioinformatics tool to construct and assist curation of microhaplotypes from short read sequences.

This package implements model-robust standardization for cluster-randomized trials (CRTs). Provides functions that standardize user-specified regression models to estimate marginal treatment effects. The targets include the cluster-average and individual-average treatment effects, with utilities for variance estimation and example simulation datasets. Methods are described in Li, Tong, Fang, Cheng, Kahan, and Wang (2025) <doi:10.1002/sim.70270>.

Gibbs sampler for fitting multivariate Bayesian linear regression with shrinkage priors (MBSP), using the three parameter beta normal family. The method is described in Bai and Ghosh (2018) <doi:10.1016/j.jmva.2018.04.010>.

This package provides a suite of tools to allow you to download all publicly available parasite rate survey points, mosquito occurrence points and raster surfaces from the Malaria Atlas Project <https://malariaatlas.org/> servers as well as utility functions for plotting the downloaded data.

Power of non-parametric Mann-Kendall test and Spearmanâ s Rho test is highly influenced by serially correlated data. To address this issue, trend tests may be applied on the modified versions of the time series data by Block Bootstrapping (BBS), Prewhitening (PW) , Trend Free Prewhitening (TFPW), Bias Corrected Prewhitening and Variance Correction Approach by calculating effective sample size. Mann, H. B. (1945).<doi:10.1017/CBO9781107415324.004>. Kendall, M. (1975). Multivariate analysis. Charles Griffin&Company Ltd,. sen, P. K. (1968).<doi:10.2307/2285891>. à nöz, B., & Bayazit, M. (2012) <doi:10.1002/hyp.8438>. Hamed, K. H. (2009).<doi:10.1016/j.jhydrol.2009.01.040>. Yue, S., & Wang, C. Y. (2002) <doi:10.1029/2001WR000861>. Yue, S., Pilon, P., Phinney, B., & Cavadias, G. (2002) <doi:10.1002/hyp.1095>. Hamed, K. H., & Ramachandra Rao, A. (1998) <doi:10.1016/S0022-1694(97)00125-X>. Yue, S., & Wang, C. Y. (2004) <doi:10.1023/B:WARM.0000043140.61082.60>.

This package provides a comprehensive collection of linkage methods for agglomerative hierarchical clustering on a matrix of proximity data (distances or similarities), returning a multifurcated dendrogram or multidendrogram. Multidendrograms can group more than two clusters when ties in proximity data occur, and therefore they do not depend on the order of the input data. Descriptive measures to analyze the resulting dendrogram are additionally provided. <doi:10.18637/jss.v114.i02>.

Visualization of multi-dimensional data arising in multi-objective optimization, including plots of the empirical attainment function (EAF), M. López-Ibáñez, L. Paquete, and T. Stützle (2010) <doi:10.1007/978-3-642-02538-9_9>, and symmetric Vorob'ev expectation and deviation, M. Binois, D. Ginsbourger, O. Roustant (2015) <doi:10.1016/j.ejor.2014.07.032>, among others.

Lightweight utilities for nucleic acid melting curve analysis are important in life sciences and diagnostics. This software can be used for the analysis and presentation of melting curve data from microbead-based assays (surface melting curve analysis) and reactions in solution (e.g., quantitative PCR (qPCR), real-time isothermal Amplification). Further information are described in detail in two publications in The R Journal [ <https://journal.r-project.org/archive/2013-2/roediger-bohm-schimke.pdf>; <https://journal.r-project.org/archive/2015-1/RJ-2015-1.pdf>].

Train and make predictions from a multi-layer perceptron neural network with optional partial monotonicity constraints.

Do multilevel mediation analysis with generalized additive multilevel models. The analysis method is described in Yu and Li (2020), "Third-Variable Effect Analysis with Multilevel Additive Models", PLoS ONE 15(10): e0241072.

Background - Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. Results - mulea employs a progressive empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 22 ontology types from 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, or GMT files from external sources (e.g., MSigDB or Enrichr), expanding its applicability across diverse research areas. Conclusions - mulea is distributed as a CRAN R package. It offers researchers a powerful and flexible toolkit for functional enrichment analysis, addressing limitations of traditional tools with its progressive eFDR and by supporting a variety of ontologies. Overall, mulea fosters the exploration of diverse biological questions across various model organisms.

It contains the function to apply MARMoT balancing technique discussed in: Silan, Boccuzzo, Arpino (2021) <DOI:10.1002/sim.9192>, Silan, Belloni, Boccuzzo, (2023) <DOI:10.1007/s10260-023-00695-0>; furthermore it contains a function for computing the Deloof's approximation of the average rank (and also a parallelized version) and a function to compute the Absolute Standardized Bias.

This package contains the Maddison Project 2018 database, which provides estimates of GDP per capita for all countries in the world between AD 1 and 2016. See <https://www.rug.nl/ggdc/historicaldevelopment/maddison/> for more information.

Bayesian variable selection methods for data with multivariate responses and multiple covariates. The package contains implementations of multivariate Bayesian variable selection methods for continuous data (Lee et al., Biometrics, 2017 <doi:10.1111/biom.12557>) and zero-inflated count data (Lee et al., Biostatistics, 2020 <doi:10.1093/biostatistics/kxy067>).

Computing transitive (and non-transitive) index numbers (Coelli et al., 2005 <doi:10.1007/b136381>) for cross-sections and panel data. For the calculation of transitive indexes, the EKS (Coelli et al., 2005 <doi:10.1007/b136381>; Rao et al., 2002 <doi:10.1007/978-1-4615-0851-9_4>) and Minimum spanning tree (Hill, 2004 <doi:10.1257/0002828043052178>) methods are implemented. Traditional fixed-base and chained indexes, and their growth rates, can also be derived using the Paasche, Laspeyres, Fisher and Tornqvist formulas.

Clustering of data under a non-ignorable missingness mechanism. Clustering is achieved by a semi-parametric mixture model and missingness is managed by using the pattern-mixture approach. More details of the approach are available in Du Roy de Chaumaray et al. (2020) <arXiv:2009.07662>.

Estimates random effect latent measurement models, wherein the loadings, residual variances, intercepts, latent means, and latent variances all vary across groups. The random effect variances of the measurement parameters are then modeled using a hierarchical inclusion model, wherein the inclusion of the variances (i.e., whether it is effectively zero or non-zero) is informed by similar parameters (of the same type, or of the same item). This additional hierarchical structure allows the evidence in favor of partial invariance to accumulate more quickly, and yields more certain decisions about measurement invariance. Martin, Williams, and Rast (2020) <doi:10.31234/osf.io/qbdjt>.

Fast implementations of mathematical operations and performance metrics for multi-objective optimization, including filtering and ranking of dominated vectors according to Pareto optimality, hypervolume metric, C.M. Fonseca, L. Paquete, M. López-Ibáñez (2006) <doi:10.1109/CEC.2006.1688440>, epsilon indicator, inverted generational distance, computation of the empirical attainment function, V.G. da Fonseca, C.M. Fonseca, A.O. Hall (2001) <doi:10.1007/3-540-44719-9_15>, and Vorob'ev threshold, expectation and deviation, M. Binois, D. Ginsbourger, O. Roustant (2015) <doi:10.1016/j.ejor.2014.07.032>, among others.

Imputation of incomplete continuous or categorical datasets; Missing values are imputed with a principal component analysis (PCA), a multiple correspondence analysis (MCA) model or a multiple factor analysis (MFA) model; Perform multiple imputation with and in PCA or MCA.

Metric halfspace depth for object data, generalizing Tukey's depth for Euclidean data. Implementing the method described in Dai and Lopez-Pintado (2022) <doi:10.1080/01621459.2021.2011298>.

This package performs genetic association tests between SNPs (one-at-a-time) and multiple phenotypes (separately or in joint model).

Simulation and visualization of complex models for longitudinal data. The models are encoded using the model coding language Mlxtran and automatically converted into C++ codes. That allows one to implement very easily complex ODE-based models and complex statistical models, including mixed effects models, for continuous, count, categorical, and time-to-event data.

The purpose of this package is to share a collection of functions the author wrote during weekends for managing kitchen and garden tasks, e.g. making plant growth charts or Thanksgiving kitchen schedule charts, etc. Functions might include but not limited to: (1) aiding summarizing time related data; (2) generating axis transformation from data; and (3) aiding Markdown (with html output) and Shiny file editing.