This package provides a collection of functions to perform various meta-analytical models through a unified mixed-effects framework, including standard univariate fixed and random-effects meta-analysis and meta-regression, and non-standard extensions such as multivariate, multilevel, longitudinal, and dose-response models.

Offering enhanced statistical power compared to traditional hypothesis testing methods, informative hypothesis testing allows researchers to explicitly model their expectations regarding the relationships among parameters. An important software tool for this framework is restriktor'. The mmirestriktor package provides shiny web applications to implement some of the basic functionality of restriktor'. The mmirestriktor() function launches a shiny application for fitting and analyzing models with constraints. The FbarCards() function launches a card game application which can help build intuition about informative hypothesis testing. The iht_interpreter() helps interpret informative hypothesis testing results based on guidelines in Vanbrabant and Rosseel (2020) <doi:10.4324/9780429273872-14>.

Helper functions to standardizes common workflows in the USGS Data Science Community of Practice to produce more robust, reproducible pipelines. It contains helper functions to standardize (1) the organization of project repositories and (2) the creation ofpipelines from the targets R Package (Landau et al. (2026) <doi:10.5281/zenodo.18555866>), using the DS CoP best practices. We draw upon community developed best practices as well as certain USGS-specific requirements. See Shrycock et al. (2023) <doi:10.3133/tm7B2> for examples of these USGS requirements.

Helpers for common data analysis tasks including missing-value summaries and filters, simple reporting and plotting utilities, Excel import and export workflows, and reading geospatial formats (for example shapefiles in zip archives, file geodatabases, KMZ, and KML) via sf and related packages. Also includes small project utilities such as creating directories, gitignore scaffolding, combined package loading, and optional lintr setup.

This package provides methods for quantifying the information gain contributed by individual modalities in multimodal regression models. Information gain is measured using Expected Relative Entropy (ERE) or pseudo-R² metrics, with corresponding p-values and confidence intervals. Currently supports linear and logistic regression models with plans for extension to additional Generalized Linear Models and Cox proportional hazard model.

Visualizes multiple sequence alignments dynamically within the Shiny web application framework.

Deconvolution of thermal decay curves allows you to quantify proportions of biomass components in plant litter. Thermal decay curves derived from thermogravimetric analysis (TGA) are imported, modified, and then modelled in a three- or four- part mixture model using the Fraser-Suzuki function. The output is estimates for weights of pseudo-components corresponding to hemicellulose, cellulose, and lignin. For more information see: Müller-Hagedorn, M. and Bockhorn, H. (2007) <doi:10.1016/j.jaap.2006.12.008>, à rfão, J. J. M. and Figueiredo, J. L. (2001) <doi:10.1016/S0040-6031(01)00634-7>, and Yang, H. and Yan, R. and Chen, H. and Zheng, C. and Lee, D. H. and Liang, D. T. (2006) <doi:10.1021/ef0580117>.

This package provides tools for computing Monte Carlo standard errors (MCSE) in Markov chain Monte Carlo (MCMC) settings (survey in <doi:10.1201/b10905>, Chapter 7). MCSE computation for expectation and quantile estimators is supported as well as multivariate estimations. The package also provides functions for computing effective sample size and for plotting Monte Carlo estimates versus sample size.

This package provides a framework to perform soft clustering using simplex-structured matrix factorisation (SSMF). The package contains a set of functions for determining the optimal number of prototypes, the optimal algorithmic parameters, the estimation confidence intervals and the diversity of clusters. Abdolali, Maryam & Gillis, Nicolas (2020) <doi:10.1137/20M1354982>.

Employing artificial intelligence to convert data analysis questions into executable code, explanations, and algorithms. The self-correction feature ensures the generated code is optimized for performance and accuracy. mergen features a user-friendly chat interface, enabling users to interact with the AI agent and extract valuable insights from their data effortlessly.

This package performs multivariate meta-analysis for high-dimensional data to integrate and collectively analyse individual-level data from multiple studies, as well as to combine summary estimates. This approach accounts for correlation between outcomes, incorporates withinâ and betweenâ study variability, handles missing values, and uses shrinkage estimation to accommodate high dimensionality. The MetaHD R package provides access to our multivariate meta-analysis approach, along with a comprehensive suite of existing meta-analysis methods, including fixed-effects and random-effects models, Fisherâ s method, Stoufferâ s method, the weighted Z method, Lancasterâ s method, the weighted Fisherâ s method, and vote-counting approach. A detailed vignette with example datasets and code for data preparation and analysis is available at <https://alyshadelivera.github.io/MetaHD_vignette/>.

Auto-downloads Parquet data from the MTGJSON CDN and exposes the full Magic: The Gathering dataset through R6-based query interfaces backed by DuckDB'.

Model infectious disease dynamics in populations with multiple subgroups having different vaccination rates, transmission characteristics, and contact patterns. Calculate final and intermediate outbreak sizes, form age-structured contact models with automatic fetching of U.S. census data, and explore vaccination scenarios with an interactive shiny dashboard for a model with two subgroups, as described in Nguyen et al. (2024) <doi:10.1016/j.jval.2024.03.039> and Duong et al. (2026) <doi:10.1093/ofid/ofaf695.217>.

Estimates membership for the Mandelbrot set.

In the case of multivariate ordinal responses, parameter estimates can be severely biased if personal response styles are ignored. This packages provides methods to account for personal response styles and to explain the effects of covariates on the response style, as proposed by Schauberger and Tutz 2021 <doi:10.1177/1471082X20978034>. The method is implemented both for the multivariate cumulative model and the multivariate adjacent categories model.

66 data sets that were imported using read.table() where appropriate but more commonly after converting to a csv file for importing via read.csv().

Computation of an estimation of the long-memory parameters and the long-run covariance matrix using a multivariate model (Lobato (1999) <doi:10.1016/S0304-4076(98)00038-4>; Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>). Two semi-parametric methods are implemented: a Fourier based approach (Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>) and a wavelet based approach (Achard and Gannaz (2016) <doi:10.1111/jtsa.12170>; Achard and Gannaz (2024) <doi:10.1111/jtsa.12719>). Real and complex wavelets are implemented.

The inference in multi-state models is traditionally performed under a Markov assumption that claims that past and future of the process are independent given the present state. In this package, we consider tests of the Markov assumption that are applicable to general multi-state models. Three approaches using existing methodology are considered: a simple method based on including covariates depending on the history in Cox models for the transition intensities; methods based on measuring the discrepancy of the non-Markov estimators of the transition probabilities to the Markov Aalen-Johansen estimators; and, finally, methods that were developed by considering summaries from families of log-rank statistics where patients are grouped by the state occupied of the process at a particular time point (see Soutinho G, Meira-Machado L (2021) <doi:10.1007/s00180-021-01139-7> and Titman AC, Putter H (2020) <doi:10.1093/biostatistics/kxaa030>).

Designs plots in terms of core structure. See example(metaplot)'. Primary arguments are (unquoted) column names; order and type (numeric or not) dictate the resulting plot. Specify any y variables, x variable, any groups variable, and any conditioning variables to metaplot() to generate density plots, boxplots, mosaic plots, scatterplots, scatterplot matrices, or conditioned plots. Use multiplot() to arrange plots in grids. Wherever present, scalar column attributes label and guide are honored, producing fully annotated plots with minimal effort. Attribute guide is typically units, but may be encoded() to provide interpretations of categorical values (see ?encode'). Utility unpack() transforms scalar column attributes to row values and pack() does the reverse, supporting tool-neutral storage of metadata along with primary data. The package supports customizable aesthetics such as such as reference lines, unity lines, smooths, log transformation, and linear fits. The user may choose between trellis and ggplot output. Compact syntax and integrated metadata promote workflow scalability.

This package implements the multivariate adaptive shrinkage (mash) method of Urbut et al (2019) <DOI:10.1038/s41588-018-0268-8> for estimating and testing large numbers of effects in many conditions (or many outcomes). Mash takes an empirical Bayes approach to testing and effect estimation; it estimates patterns of similarity among conditions, then exploits these patterns to improve accuracy of the effect estimates. The core linear algebra is implemented in C++ for fast model fitting and posterior computation.

Extend the functionality of the mclust package for Gaussian finite mixture modeling by including: density estimation for data with bounded support (Scrucca, 2019 <doi:10.1002/bimj.201800174>); modal clustering using MEM (Modal EM) algorithm for Gaussian mixtures (Scrucca, 2021 <doi:10.1002/sam.11527>); entropy estimation via Gaussian mixture modeling (Robin & Scrucca, 2023 <doi:10.1016/j.csda.2022.107582>); Gaussian mixtures modeling of financial log-returns (Scrucca, 2024 <doi:10.3390/e26110907>).

The modified Adult Treatment Panel -III guidelines (ATP-III) proposed by American Heart Association (AHA) and National Heart, Lung and Blood Institute (NHLBI) are used widely for the clinical diagnosis of Metabolic Syndrome. The AHA-NHLBI criteria advise using parameters such as waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), triglycerides (TG) and high-density lipoprotein cholesterol (HDLC) for diagnosis of metabolic syndrome. Each parameter has to be interpreted based on the proposed cut-offs, making the diagnosis slightly complex and error-prone. This package is developed by incorporating the modified ATP-III guidelines, and it will aid in the easy and quick diagnosis of metabolic syndrome in busy healthcare settings and also for research purposes. The modified ATP-III-AHA-NHLBI criteria for the diagnosis is described by Grundy et al ., (2005) <doi:10.1161/CIRCULATIONAHA.105.169404>.

PDF is a standard file format for laying out text and images in documents. At its core, these documents are sequences of objects defined in plain text. This package allows for the creation of PDF documents at a very low level without any library or graphics device dependencies.

To calculate the Minimal Clinically Important Difference by applying the Anchor-based method and the Response shift effect by applying the Then-Test method.