This package provides a stochastic, spatially-explicit, demo-genetic model simulating the spread and evolution of a plant pathogen in a heterogeneous landscape to assess resistance deployment strategies. It is based on a spatial geometry for describing the landscape and allocation of different cultivars, a dispersal kernel for the dissemination of the pathogen, and a SEIR ('Susceptible-Exposed-Infectious-Removedâ ) structure with a discrete time step. It provides a useful tool to assess the performance of a wide range of deployment options with respect to their epidemiological, evolutionary and economic outcomes. Loup Rimbaud, Julien Papaïx, Jean-François Rey, Luke G Barrett, Peter H Thrall (2018) <doi:10.1371/journal.pcbi.1006067>.

This package implements non-parametric tests from Higgins (2004, ISBN:0534387756), including tests for one sample, two samples, k samples, paired comparisons, blocked designs, trends and association. Built with Rcpp for efficiency and R6 for flexible, object-oriented design, the package provides a unified framework for performing or creating custom permutation tests.

An implementation of the Input-Output model developed by Wassily Leontief that represents the interdependencies between different sectors of a national economy or different regional economies.

Computations related to group sequential boundaries. Includes calculation of bounds using the Lan-DeMets alpha spending function approach. Based on FORTRAN program ld98 implemented by Reboussin, et al. (2000) <doi:10.1016/s0197-2456(00)00057-x>.

Implementation of a theoretically supported alternative to k-nearest neighbors for functional data to solve problems of estimating unobserved segments of a partially observed functional data sample, functional classification and outlier detection. The approximating neighbor curves are piecewise functions built from a functional sample. Instead of a distance on a function space we use a locally defined distance function that satisfies stabilization criteria. The package allows the implementation of the methodology and the replication of the results in Elà as, A., Jiménez, R. and Yukich, J. (2020) <arXiv:2007.16059>.

This package implements bootstrap methods for linear regression models with errors following a time-varying process, focusing on approximating the distribution of the least-squares estimator for regression models with locally stationary errors. It enables the construction of bootstrap and classical confidence intervals for regression coefficients, leveraging intensive simulation studies and real data analysis.

This package provides functions to calculate lunar and other related environmental covariates.

Constructs likelihood models from heterogeneous observation types by composing named contributions. Each observation type (exact, left-censored, right-censored, interval-censored, or custom) contributes independently to the total log-likelihood, which is summed under an i.i.d. assumption. Provides contr_name() for standard R distributions and contr_fn() for user-defined contributions, composed via likelihood_contr() into objects compatible with the likelihood.model inference framework.

This package provides tools for detecting and correcting sample mix-ups between two sets of measurements, such as between gene expression data on two tissues. Broman et al. (2015) <doi:10.1534/g3.115.019778>.

Adds standardized regression coefficients to objects created by lm'. Also extends the S3 methods print', summary and coef with additional boolean argument standardized and provides xtable'-support.

Classification method obtained through linear programming. It is advantageous with respect to the classical developments when the distribution of the variables involved is unknown or when the number of variables is much greater than the number of individuals. Mathematical details behind the method are published in Nueda, et al. (2022) "LPDA: A new classification method based on linear programming". <doi:10.1371/journal.pone.0270403>.

Supervised learning techniques designed for the situation when the dimensionality exceeds the sample size have a tendency to overfit as the dimensionality of the data increases. To remedy this High dimensionality; low sample size (HDLSS) situation, we attempt to learn a lower-dimensional representation of the data before learning a classifier. That is, we project the data to a situation where the dimensionality is more manageable, and then are able to better apply standard classification or clustering techniques since we will have fewer dimensions to overfit. A number of previous works have focused on how to strategically reduce dimensionality in the unsupervised case, yet in the supervised HDLSS regime, few works have attempted to devise dimensionality reduction techniques that leverage the labels associated with the data. In this package and the associated manuscript Vogelstein et al. (2017) <arXiv:1709.01233>, we provide several methods for feature extraction, some utilizing labels and some not, along with easily extensible utilities to simplify cross-validative efforts to identify the best feature extraction method. Additionally, we include a series of adaptable benchmark simulations to serve as a standard for future investigative efforts into supervised HDLSS. Finally, we produce a comprehensive comparison of the included algorithms across a range of benchmark simulations and real data applications.

Set of the data science tools created by various members of the Long Term Ecological Research (LTER) community. These functions were initially written largely as standalone operations and have later been aggregated into this package.

Non-parametric prediction of survival outcomes for mixture data that incorporates covariates and a landmark time. Details are described in Garcia (2021) <doi:10.1093/biostatistics/kxz052>.

Constructs genotype x environment interaction (GxE) models where G is a weighted sum of genetic variants (genetic score) and E is a weighted sum of environments (environmental score) using the alternating optimization algorithm by Jolicoeur-Martineau et al. (2017) <arXiv:1703.08111>. This approach has greatly enhanced predictive power over traditional GxE models which include only a single genetic variant and a single environmental exposure. Although this approach was originally made for GxE modelling, it is flexible and does not require the use of genetic and environmental variables. It can also handle more than 2 latent variables (rather than just G and E) and 3-way interactions or more. The LEGIT model produces highly interpretable results and is very parameter-efficient thus it can even be used with small sample sizes (n < 250). Tools to determine the type of interaction (vantage sensitivity, diathesis-stress or differential susceptibility), with any number of genetic variants or environments, are available <arXiv:1712.04058>. The software can now produce mixed-effects LEGIT models through the lme4 package.

Estimate, fit and compare Structural Equation Models (SEM) and network models (Gaussian Graphical Models; GGM) using OpenMx. Allows for two possible generalizations to include GGMs in SEM: GGMs can be used between latent variables (latent network modeling; LNM) or between residuals (residual network modeling; RNM). For details, see Epskamp, Rhemtulla and Borsboom (2017) <doi:10.1007/s11336-017-9557-x>.

It is an extension of lmom R package: pel...()','cdf...()',qua...() function families are lumped and called from one function per each family respectively in order to create robust automatic tools to fit data with different probability distributions and then to estimate probability values and return periods. The implemented functions are able to manage time series with constant and/or missing values without stopping the execution with error messages. The package also contains tools to calculate several indices based on variability (e.g. SPI , Standardized Precipitation Index, see <https://climatedataguide.ucar.edu/climate-data/standardized-precipitation-index-spi> and <http://spei.csic.es/>) for multiple time series or spatially gridded values.

This package implements the LPC method of Witten&Tibshirani(Annals of Applied Statistics 2008) for identification of significant genes in a microarray experiment.

Helpers for customizing selected outputs from lavaan by Rosseel (2012) <doi:10.18637/jss.v048.i02> and print them. The functions are intended to be used by package developers in their packages and so are not designed to be user-friendly. They are designed to be let developers customize the tables by other functions. Currently the parameter estimates tables of a fitted object are supported.

Analysis, imputation, and multiple imputation of count data using covariates. LORI uses a log-linear Poisson model where main row and column effects, as well as effects of known covariates and interaction terms can be fitted. The estimation procedure is based on the convex optimization of the Poisson loss penalized by a Lasso type penalty and a nuclear norm. LORI returns estimates of main effects, covariate effects and interactions, as well as an imputed count table. The package also contains a multiple imputation procedure. The methods are described in Robin, Josse, Moulines and Sardy (2019) <doi:10.1016/j.jmva.2019.04.004>.

This package implements a partitioned Empirical Bayes Expectation Conditional Maximization (ECM) algorithm for sparse high-dimensional linear mixed modeling as described in Zgodic, Bai, Zhang, and McLain (2025) <doi:10.1007/s11222-025-10649-z>. The package provides efficient estimation and inference for mixed models with high-dimensional fixed effects.

Calculates insurance reserves and equivalence premiums using advanced numerical methods, including the Runge-Kutta algorithm and product integrals for transition probabilities. This package is useful for actuarial analyses and life insurance modeling, facilitating accurate financial projections.

Assess the proportion of treatment effect explained by a longitudinal surrogate marker as described in Agniel D and Parast L (2021) <doi:10.1111/biom.13310>; and estimate the treatment effect on a longitudinal surrogate marker as described in Wang et al. (2025) <doi:10.1093/biomtc/ujaf104>. A tutorial for this package can be found at <https://www.laylaparast.com/longsurr>.

This package produces a PDF diff of two rmarkdown', quarto', Sweave or TeX files, using the external latexdiff utility.