Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework is aimed at deciphering DNA mutational signatures operating in cancer. The framework includes modules that support raw data import and processing, mutational signature extraction, and results interpretation and visualization. The framework accepts widely used file formats storing information about DNA variants, such as Variant Call Format files. The framework performs Non-Negative Matrix Factorization to extract mutational signatures explaining the observed set of DNA mutations. Bootstrapping is performed as part of the analysis. The framework supports parallelization and is optimized for use on multi-core systems. The software was described by Fantini D et al (2020) <doi:10.1038/s41598-020-75062-0> and is based on a custom R-based implementation of the original MATLAB WTSI framework by Alexandrov LB et al (2013) <doi:10.1016/j.celrep.2012.12.008>.

User-friendly general package providing standard methods for meta-analysis and supporting Schwarzer, Carpenter, and Rücker <DOI:10.1007/978-3-319-21416-0>, "Meta-Analysis with R" (2015): - common effect and random effects meta-analysis; - several plots (forest, funnel, Galbraith / radial, L'Abbe, Baujat, bubble); - three-level meta-analysis model; - generalised linear mixed model; - logistic regression with penalised likelihood for rare events; - Hartung-Knapp method for random effects model; - Kenward-Roger method for random effects model; - prediction interval; - statistical tests for funnel plot asymmetry; - trim-and-fill method to evaluate bias in meta-analysis; - meta-regression; - cumulative meta-analysis and leave-one-out meta-analysis; - import data from RevMan 5'; - produce forest plot summarising several (subgroup) meta-analyses.

Calculate various indices, like Crude Migration Rate, different Gini indices or the Coefficient of Variation among others, to show the (un)equality of migration.

It finds Orthogonal Data Projections with Maximal Skewness. The first data projection in the output is the most skewed among all linear data projections. The second data projection in the output is the most skewed among all data projections orthogonal to the first one, and so on.

This package provides methods for fitting mixture distributions to univariate data using expectation maximization, HWHM and other methods. Supports Gaussian, Cauchy, Student's t and von Mises mixtures. For more details see Merkys (2018) <https://www.lvb.lt/permalink/370LABT_NETWORK/1m6ui06/alma9910036312108451>.

The Macroeconomics-at-Risk (MaR) approach is based on a two-step semi-parametric estimation procedure that allows to forecast the full conditional distribution of an economic variable at a given horizon, as a function of a set of factors. These density forecasts are then be used to produce coherent forecasts for any downside risk measure, e.g., value-at-risk, expected shortfall, downside entropy. Initially introduced by Adrian et al. (2019) <doi:10.1257/aer.20161923> to reveal the vulnerability of economic growth to financial conditions, the MaR approach is currently extensively used by international financial institutions to provide Value-at-Risk (VaR) type forecasts for GDP growth (Growth-at-Risk) or inflation (Inflation-at-Risk). This package provides methods for estimating these models. Datasets for the US and the Eurozone are available to allow testing of the Adrian et al (2019) model. This package constitutes a useful toolbox (data and functions) for private practitioners, scholars as well as policymakers.

This package provides a comprehensive set of tools for working with order statistics, including functions for simulating order statistics, censored samples (Type I and Type II), and record values from various continuous distributions. Additionally, it offers functions to compute moments (mean, variance, skewness, kurtosis) of order statistics for several continuous distributions. These tools assist researchers and statisticians in understanding and analyzing the properties of order statistics and related data. The methods and algorithms implemented in this package are based on several published works, including Ahsanullah et al (2013, ISBN:9789491216831), Arnold and Balakrishnan (2012, ISBN:1461236444), Harter and Balakrishnan (1996, ISBN:9780849394522), Balakrishnan and Sandhu (1995) <doi:10.1080/00031305.1995.10476150>, Genç (2012) <doi:10.1007/s00362-010-0320-y>, Makouei et al (2021) <doi:10.1016/j.cam.2021.113386> and Nagaraja (2013) <doi:10.1016/j.spl.2013.06.028>.

Counting process structure is fundamental to model time varying covariates. This package restructures dataframes in the counting process format for one or more variables. F. W. Dekker, et al. (2008) <doi:10.1038/ki.2008.328>.

This package provides weighted versions of several metrics and performance measures used in machine learning, including average unit deviances of the Bernoulli, Tweedie, Poisson, and Gamma distributions, see Jorgensen B. (1997, ISBN: 978-0412997112). The package also contains a weighted version of generalized R-squared, see e.g. Cohen, J. et al. (2002, ISBN: 978-0805822236). Furthermore, dplyr chains are supported.

This package provides a collection of functions for processing and analyzing metabolite data. The namesake function mrbin() converts 1D or 2D Nuclear Magnetic Resonance data into a matrix of values suitable for further data analysis and performs basic processing steps in a reproducible way. Negative values, a common issue in such data, can be replaced by positive values (<doi:10.1021/acs.jproteome.0c00684>). All used parameters are stored in a readable text file and can be restored from that file to enable exact reproduction of the data at a later time. The function fia() ranks features according to their impact on classifier models, especially artificial neural network models.

Build multiscalar territorial analysis based on various contexts.

This package provides a color palette generator inspired by Mexican politics, with colors ranging from red on the left to gray in the middle and green on the right. Palette options range from only a few colors to several colors, but with discrete and continuous options to offer greatest flexibility to the user. This package allows for a range of applications, from mapping brief discrete scales (e.g., four colors for Morena, PRI, and PAN) to continuous interpolated arrays including dozens of shades graded from red to green.

Leverages the R language to automate latent variable model estimation and interpretation using Mplus', a powerful latent variable modeling program developed by Muthen and Muthen (<https://www.statmodel.com>). Specifically, this package provides routines for creating related groups of models, running batches of models, and extracting and tabulating model parameters and fit statistics.

R Client for the Microsoft Cognitive Services Text-to-Speech REST API, including voice synthesis. A valid account must be registered at the Microsoft Cognitive Services website <https://azure.microsoft.com/en-us/products/ai-services/> in order to obtain a (free) API key. Without an API key, this package will not work properly.

Shiny for Open Science to visualize, share, and inventory the main existing human datasets for researchers.

Implementations of various robust and flexible model-based clustering methods for data sets with missing values at random (Tong and Tortora, 2025, <doi:10.18637/jss.v115.i03>). Two main models are: Multivariate Contaminated Normal Mixture (MCNM, Tong and Tortora, 2022, <doi:10.1007/s11634-021-00476-1>) and Multivariate Generalized Hyperbolic Mixture (MGHM, Wei et al., 2019, <doi:10.1016/j.csda.2018.08.016>). Mixtures via some special or limiting cases of the multivariate generalized hyperbolic distribution are also included: Normal-Inverse Gaussian, Symmetric Normal-Inverse Gaussian, Skew-Cauchy, Cauchy, Skew-t, Student's t, Normal, Symmetric Generalized Hyperbolic, Hyperbolic Univariate Marginals, Hyperbolic, and Symmetric Hyperbolic. Funding: This work was partially supported by the National Science foundation NSF Grant NO. 2209974.

This package provides matrix Gaussian mixture models, matrix transformation mixture models and their model-based clustering results. The parsimonious models of the mean matrices and variance covariance matrices are implemented with a total of 196 variations. For more information, please check: Xuwen Zhu, Shuchismita Sarkar, and Volodymyr Melnykov (2021), "MatTransMix: an R package for matrix model-based clustering and parsimonious mixture modeling", <doi:10.1007/s00357-021-09401-9>.

This package contains functions for mapping odds ratios, hazard ratios, or other effect estimates using individual-level data such as case-control study data, using generalized additive models (GAMs) or Cox models for smoothing with a two-dimensional predictor (e.g., geolocation or exposure to chemical mixtures) while adjusting linearly for confounding variables, using methods described by Kelsall and Diggle (1998), Webster at al. (2006), and Bai et al. (2020). Includes convenient functions for mapping point estimates and confidence intervals, efficient control sampling, and permutation tests for the null hypothesis that the two-dimensional predictor is not associated with the outcome variable (adjusting for confounders).

Apply tests of multiple comparisons based on studentized midrange and range distributions. The tests are: Tukey Midrange ('TM test), Student-Newman-Keuls Midrange ('SNKM test), Means Grouping Midrange ('MGM test) and Means Grouping Range ('MGR test). The first two tests were published by Batista and Ferreira (2020) <doi:10.1590/1413-7054202044008020>. The last two were published by Batista and Ferreira (2023) <doi:10.28951/bjb.v41i4.640>.

An implementation of the cross-validated difference in means (CVDM) test by Desmarais and Harden (2014) <doi:10.1007/s11135-013-9884-7> (see also Harden and Desmarais, 2011 <doi:10.1177/1532440011408929>) and the cross-validated median fit (CVMF) test by Desmarais and Harden (2012) <doi:10.1093/pan/mpr042>. These tests use leave-one-out cross-validated log-likelihoods to assist in selecting among model estimations. You can also utilize data from Golder (2010) <doi:10.1177/0010414009341714> and Joshi & Mason (2008) <doi:10.1177/0022343308096155> that are included to facilitate examples from real-world analysis.

This package provides a graphical user interface for the MuToss Project.

Implementation of a framework for cluster analysis with selection of the final number of clusters and an optional variable selection procedure. The package is designed to integrate the results of multiple imputed datasets while accounting for the uncertainty that the imputations introduce in the final results. In addition, the package can also be used for a cluster analysis of the complete cases of a single dataset. The package also includes specific methods to summarize and plot the results. The methods are described in Basagana et al. (2013) <doi:10.1093/aje/kws289>.

Use standard genomics file format (BED) and a table of orthologs to illustrate synteny conservation at the genome-wide scale. Significantly conserved linkage groups are identified as described in Simakov et al. (2020) <doi:10.1038/s41559-020-1156-z> and displayed on an Oxford Grid (Edwards (1991) <doi:10.1111/j.1469-1809.1991.tb00394.x>) or a chord diagram as in Simakov et al. (2022) <doi:10.1126/sciadv.abi5884>. The package provides a function that uses a network-based greedy algorithm to find communities (Clauset et al. (2004) <doi:10.1103/PhysRevE.70.066111>) and so automatically order the chromosomes on the plot to improve interpretability.

Package for fast computation of the maximum kernel likelihood estimator (mkle).