Pearson and Spearman correlation coefficients are commonly used to quantify the strength of bivariate associations of genomic variables. For example, correlations of gene-level DNA copy number and gene expression measurements may be used to assess the impact of DNA copy number changes on gene expression in tumor tissue. MVisAGe enables users to quickly compute and visualize the correlations in order to assess the effect of regional genomic events such as changes in DNA copy number or DNA methylation level. Please see Walter V, Du Y, Danilova L, Hayward MC, Hayes DN, 2018. Cancer Research <doi:10.1158/0008-5472.CAN-17-3464>.

This package provides tools for creating and issuing nicely-formatted text within R diagnostic messages and those messages given during warnings and errors. The formatting of the messages can be customized using templating features. Issues with singular and plural forms can be handled through specialized syntax.

Metadynamics is a state of the art biomolecular simulation technique. Plumed Tribello, G.A. et al. (2014) <doi:10.1016/j.cpc.2013.09.018> program makes it possible to perform metadynamics using various simulation codes. The results of metadynamics done in Plumed can be analyzed by metadynminer'. The package metadynminer reads 1D and 2D metadynamics hills files from Plumed package. It uses a fast algorithm by Hosek, P. and Spiwok, V. (2016) <doi:10.1016/j.cpc.2015.08.037> to calculate a free energy surface from hills. Minima can be located and plotted on the free energy surface. Transition states can be analyzed by Nudged Elastic Band method by Henkelman, G. and Jonsson, H. (2000) <doi:10.1063/1.1323224>. Free energy surfaces, minima and transition paths can be plotted to produce publication quality images.

Compute case-wise and cluster-wise derivative for mixed effects models with respect to fixed effects parameter, random effect (co)variances, and residual variance. This material is partially based on work supported by the National Science Foundation under Grant Number 1460719.

Facilitate frequentist and Bayesian meta-analysis of diagnosis and prognosis research studies. It includes functions to summarize multiple estimates of prediction model discrimination and calibration performance (Debray et al., 2019) <doi:10.1177/0962280218785504>. It also includes functions to evaluate funnel plot asymmetry (Debray et al., 2018) <doi:10.1002/jrsm.1266>. Finally, the package provides functions for developing multivariable prediction models from datasets with clustering (de Jong et al., 2021) <doi:10.1002/sim.8981>.

Sentiment analysis is a popular technique in text mining that attempts to determine the emotional state of some text. We provide a new implementation of a common method for computing sentiment, whereby words are scored as positive or negative according to a dictionary lookup. Then the sum of those scores is returned for the document. We use the Hu and Liu sentiment dictionary ('Hu and Liu', 2004) <doi:10.1145/1014052.1014073> for determining sentiment. The scoring function is vectorized by document, and scores for multiple documents are computed in parallel via OpenMP'.

Family Planning programs and initiatives typically use nationally representative surveys to estimate key indicators of a countryâ s family planning progress. However, in recent years, routinely collected family planning services data (Service Statistics) have been used as a supplementary data source to bridge gaps in the surveys. The use of service statistics comes with the caveat that adjustments need to be made for missing private sector contributions to the contraceptive method supply chain. Evaluating the supply source of modern contraceptives often relies on Demographic Health Surveys (DHS), where many countries do not have recent data beyond 2015/16. Fortunately, in the absence of recent surveys we can rely on statistical model-based estimates and projections to fill the knowledge gap. We present a Bayesian, hierarchical, penalized-spline model with multivariate-normal spline coefficients, to account for across method correlations, to produce country-specific,annual estimates for the proportion of modern contraceptive methods coming from the public and private sectors. This package provides a quick and convenient way for users to access the DHS modern contraceptive supply share data at national and subnational administration levels, estimate, evaluate and plot annual estimates with uncertainty for a sample of low- and middle-income countries. Methods for the estimation of method supply shares at the national level are described in Comiskey, Alkema, Cahill (2022) <arXiv:2212.03844>.

The sample mean and standard deviation are two commonly used statistics in meta-analyses, but some trials use other summary statistics such as the median and quartiles to report the results. Therefore, researchers need to transform those information back to the sample mean and standard deviation. This package implemented sample mean estimators by Luo et al. (2016) <arXiv:1505.05687>, sample standard deviation estimators by Wan et al. (2014) <arXiv:1407.8038>, and the best linear unbiased estimators (BLUEs) of location and scale parameters by Yang et al. (2018, submitted) based on sample quantiles derived summaries in a meta-analysis.

This package implements a minimum-spanning-tree-based heuristic for k-means clustering using a union-find disjoint set and the algorithm in Kruskal (1956) <doi:10.1090/S0002-9939-1956-0078686-7>.

Conducts and visualizes propensity score analysis for multilevel, or clustered data. Bryer & Pruzek (2011) <doi:10.1080/00273171.2011.636693>.

Data and code for the paper by Ehm, Gneiting, Jordan and Krueger ('Of Quantiles and Expectiles: Consistent Scoring Functions, Choquet Representations, and Forecast Rankings', JRSS-B, 2016 <DOI:10.1111/rssb.12154>).

Logistic-normal Multinomial (LNM) models are common in problems with multivariate count data. This package gives a simple implementation with a 30 line Stan script. This lightweight implementation makes it an easy starting point for other projects, in particular for downstream tasks that require analysis of "compositional" data. It can be applied whenever a multinomial probability parameter is thought to depend linearly on inputs in a transformed, log ratio space. Additional utilities make it easy to inspect, create predictions, and draw samples using the fitted models. More about the LNM can be found in Xia et al. (2013) "A Logistic Normal Multinomial Regression Model for Microbiome Compositional Data Analysis" <doi:10.1111/biom.12079> and Sankaran and Holmes (2023) "Generative Models: An Interdisciplinary Perspective" <doi:10.1146/annurev-statistics-033121-110134>.

Machine coded genetic algorithm (MCGA) is a fast tool for real-valued optimization problems. It uses the byte representation of variables rather than real-values. It performs the classical crossover operations (uniform) on these byte representations. Mutation operator is also similar to classical mutation operator, which is to say, it changes a randomly selected byte value of a chromosome by +1 or -1 with probability 1/2. In MCGAs there is no need for encoding-decoding process and the classical operators are directly applicable on real-values. It is fast and can handle a wide range of a search space with high precision. Using a 256-unary alphabet is the main disadvantage of this algorithm but a moderate size population is convenient for many problems. Package also includes multi_mcga function for multi objective optimization problems. This function sorts the chromosomes using their ranks calculated from the non-dominated sorting algorithm.

Multi-Dimensional Analysis (MDA) is an adaptation of factor analysis developed by Douglas Biber (1992) <doi:10.1007/BF00136979>. Its most common use is to describe language as it varies by genre, register, and use. This package contains functions for carrying out the calculations needed to describe and plot MDA results: dimension scores, dimension means, and factor loadings.

This package provides a modeltime extension that implements time series ensemble forecasting methods including model averaging, weighted averaging, and stacking. These techniques are popular methods to improve forecast accuracy and stability.

Policy evaluation using generalized Qini curves: Evaluate data-driven treatment targeting rules for one or more treatment arms over different budget constraints in experimental or observational settings under unconfoundedness.

N>=3 methods are used to measure each of n items. The data are used to estimate simultaneously systematic error (bias) and random error (imprecision). Observed measurements for each method or device are assumed to be linear functions of the unknown true values and the errors are assumed normally distributed. Pairwise calibration curves and plots can be easily generated. Unlike the ncb.od function, the omx function builds a one-factor measurement error model using OpenMx and allows missing values, uses full information maximum likelihood to estimate parameters, and provides both likelihood-based and bootstrapped confidence intervals for all parameters, in addition to Wald-type intervals.

This package provides an extension to MadanText for creating and analyzing co-occurrence networks in Persian text data. This package mainly makes use of the PersianStemmer (Safshekan, R., et al. (2019). <https://CRAN.R-project.org/package=PersianStemmer>), udpipe (Wijffels, J., et al. (2023). <https://CRAN.R-project.org/package=udpipe>), and shiny (Chang, W., et al. (2023). <https://CRAN.R-project.org/package=shiny>) packages.

Using this package, one can determine the minimum sample size required so that the mean square error of the sample mean and the population mean of a distribution becomes less than some pre-determined epsilon, i.e. it helps the user to determine the minimum sample size required to attain the pre-fixed precision level by minimizing the difference between the sample mean and population mean.

This is a implementation of design methods for multi-state reliability demonstration tests (MSRDT) with failure count data, which is associated with the work from the published paper "Multi-state Reliability Demonstration Tests" by Suiyao Chen et al. (2017) <doi:10.1080/08982112.2017.1314493>. It implements two types of MSRDT, multiple periods (MP) and multiple failure modes (MFM). For MP, two different scenarios with criteria on cumulative periods (Cum) or separate periods (Sep) are implemented respectively. It also provides the implementation of conventional design method, namely binomial tests for failure count data.

This package provides tools for high-dimensional peaks-over-threshold inference and simulation of Brown-Resnick and extremal Student spatial extremal processes. These include optimization routines based on censored likelihood and gradient scoring, and exact simulation algorithms for max-stable and multivariate Pareto distributions based on rejection sampling. Fast multivariate Gaussian and Student distribution functions using separation-of-variable algorithm with quasi Monte Carlo integration are also provided. Key references include de Fondeville and Davison (2018) <doi:10.1093/biomet/asy026>, Thibaud and Opitz (2015) <doi:10.1093/biomet/asv045>, Wadsworth and Tawn (2014) <doi:10.1093/biomet/ast042> and Genz and Bretz (2009) <doi:10.1007/978-3-642-01689-9>.

Create variable width bar charts i.e. "bar mekko" charts to include important quantitative context. Closely related to mosaic, spine (or spinogram), matrix, submarine, olympic, Mondrian or product plots and tree maps.

Hypothesis testing of the parameters of multivariate normal distributions, including the testing of a single mean vector, two mean vectors, multiple mean vectors, a single covariance matrix, multiple covariance matrices, a mean and a covariance matrix simultaneously, and the testing of independence of multivariate normal random vectors. Huixuan, Gao (2005, ISBN:9787301078587), "Applied Multivariate Statistical Analysis".

This package provides fast and accurate inference for the parameter estimation problem in Ordinary Differential Equations, including the case when there are unobserved system components. Implements the MAGI method (MAnifold-constrained Gaussian process Inference) of Yang, Wong, and Kou (2021) <doi:10.1073/pnas.2020397118>. A user guide is provided by the accompanying software paper Wong, Yang, and Kou (2024) <doi:10.18637/jss.v109.i04>.