This package provides methods for quality control and exploratory analysis of surface water quality data collected in Massachusetts, USA. Functions are developed to facilitate data formatting for the Water Quality Exchange Network <https://www.epa.gov/waterdata/water-quality-data-upload-wqx> and reporting of data quality objectives to state agencies. Quality control methods are from Massachusetts Department of Environmental Protection (2020) <https://www.mass.gov/orgs/massachusetts-department-of-environmental-protection>.

Train and make predictions from a multi-layer perceptron neural network with optional partial monotonicity constraints.

Implemented are the one-sided and two-sided multiple-direction logrank test for two-sample right censored data. In addition to the statistics p-values are calculated: 1. For the one-sided testing problem one p-value based on a wild bootstrap approach is determined. 2. In the two-sided case one p-value based on a chi-squared approximation and a second p-values based on a permutation approach are calculated. Ditzhaus, M. and Friedrich, S. (2018) <arXiv:1807.05504>. Ditzhaus, M. and Pauly, M. (2018) <arXiv:1808.05627>.

Estimate and test inter-generational social mobility effect on an outcome with cross-sectional or longitudinal data.

This is the core functions needed by the tsmp package. The low level and carefully checked mathematical functions are here. These are implementations of the Matrix Profile concept that was created by CS-UCR <http://www.cs.ucr.edu/~eamonn/MatrixProfile.html>.

Most multilevel methodologies can only model macro-micro multilevel situations in an unbiased way, wherein group-level predictors (e.g., city temperature) are used to predict an individual-level outcome variable (e.g., citizen personality). In contrast, this R package enables researchers to model micro-macro situations, wherein individual-level (micro) predictors (and other group-level predictors) are used to predict a group-level (macro) outcome variable in an unbiased way.

Perform correlation and linear regression test among the numeric fields in a data.frame automatically and make plots using pairs or lattice::parallelplot.

This package performs Monte Carlo hypothesis tests, allowing a couple of different sequential stopping boundaries. For example, a truncated sequential probability ratio test boundary (Fay, Kim and Hachey, 2007 <DOI:10.1198/106186007X257025>) and a boundary proposed by Besag and Clifford, 1991 <DOI:10.1093/biomet/78.2.301>. Gives valid p-values and confidence intervals on p-values.

Implementing a multiple imputation algorithm for multivariate data with missing and censored values under a coarsening at random assumption (Heitjan and Rubin, 1991<doi:10.1214/aos/1176348396>). The multiple imputation algorithm is based on the data augmentation algorithm proposed by Tanner and Wong (1987)<doi:10.1080/01621459.1987.10478458>. The Gibbs sampling algorithm is adopted to to update the model parameters and draw imputations of the coarse data.

This package implements likelihood-based estimation and diagnostics for multi-type recurrent event data with dynamic risk that depends on prior events and accommodates terminating events. Methods are described in Ghosh, Chan, Younes and Davis (2023) "A Dynamic Risk Model for Multitype Recurrent Events" <doi:10.1093/aje/kwac213>.

Novel method to unbiasedly include studies with Non-statistically Significant Unreported Effects (NSUEs) in a meta-analysis. First, the function calculates the interval where the unreported effects (e.g., t-values) should be according to the threshold of statistical significance used in each study. Afterward, the method uses maximum likelihood techniques to impute the expected effect size of each study with NSUEs, accounting for between-study heterogeneity and potential covariates. Multiple imputations of the NSUEs are then randomly created based on the expected value, variance, and statistical significance bounds. Finally, it conducts a restricted-maximum likelihood random-effects meta-analysis separately for each set of imputations, and it performs estimations from these meta-analyses. Please read the reference in metansue for details of the procedure.

Penalized regression methods, such as lasso and elastic net, are used in many biomedical applications when simultaneous regression coefficient estimation and variable selection is desired. However, missing data complicates the implementation of these methods, particularly when missingness is handled using multiple imputation. Applying a variable selection algorithm on each imputed dataset will likely lead to different sets of selected predictors, making it difficult to ascertain a final active set without resorting to ad hoc combination rules. miselect presents Stacked Adaptive Elastic Net (saenet) and Grouped Adaptive LASSO (galasso) for continuous and binary outcomes, developed by Du et al (2022) <doi:10.1080/10618600.2022.2035739>. They, by construction, force selection of the same variables across multiply imputed data. miselect also provides cross validated variants of these methods.

R Client for the Microsoft Cognitive Services Text-to-Speech REST API, including voice synthesis. A valid account must be registered at the Microsoft Cognitive Services website <https://azure.microsoft.com/en-us/products/ai-services/> in order to obtain a (free) API key. Without an API key, this package will not work properly.

An R interface to version 0.3 of the ROPTLIB optimization library (see <https://www.math.fsu.edu/~whuang2/> for more information). Optimize real- valued functions over manifolds such as Stiefel, Grassmann, and Symmetric Positive Definite matrices. For details see Martin et. al. (2020) <doi:10.18637/jss.v093.i01>. Note that the optional ldr package used in some of this package's examples can be obtained from either JSS <https://www.jstatsoft.org/index.php/jss/article/view/v061i03/2886> or from the CRAN archives <https://cran.r-project.org/src/contrib/Archive/ldr/ldr_1.3.3.tar.gz>.

The maybe type represents the possibility of some value or nothing. It is often used instead of throwing an error or returning `NULL`. The advantage of using a maybe type over `NULL` is that it is both composable and requires the developer to explicitly acknowledge the potential absence of a value, helping to avoid the existence of unexpected behaviour.

The Moving Epidemic Method, created by T Vega and JE Lozano (2012, 2015) <doi:10.1111/j.1750-2659.2012.00422.x>, <doi:10.1111/irv.12330>, allows the weekly assessment of the epidemic and intensity status to help in routine respiratory infections surveillance in health systems. Allows the comparison of different epidemic indicators, timing and shape with past epidemics and across different regions or countries with different surveillance systems. Also, it gives a measure of the performance of the method in terms of sensitivity and specificity of the alert week. memapp is a web application created in the Shiny framework for the mem R package.

Computation of standardized interquartile range (IQR), Huber-type skipped mean (Hampel (1985), <doi:10.2307/1268758>), robust coefficient of variation (CV) (Arachchige et al. (2019), <doi:10.48550/arXiv.1907.01110>), robust signal to noise ratio (SNR), z-score, standardized mean difference (SMD), as well as functions that support graphical visualization such as boxplots based on quartiles (not hinges), negative logarithms and generalized logarithms for ggplot2 (Wickham (2016), ISBN:978-3-319-24277-4).

Calculate predicted levels and marginal effects, using the delta method to calculate standard errors. This is an R-based version of the margins command from Stata.

Can detect relatively weak spatial genetic patterns by using Moran's Eigenvector Maps (MEM) to extract only the spatial component of genetic variation. Has applications in landscape genetics where the movement and dispersal of organisms are studied using neutral genetic variation.

Access to several Numerical Weather Prediction services both in raster format and as a time series for a location. Currently it works with GFS <https://www.ncei.noaa.gov/products/weather-climate-models/global-forecast>, MeteoGalicia <https://www.meteogalicia.gal/web/modelos/threddsIndex.action>, NAM <https://www.ncei.noaa.gov/products/weather-climate-models/north-american-mesoscale>, and RAP <https://www.ncei.noaa.gov/products/weather-climate-models/rapid-refresh-update>.

This package implements area level of multivariate small area estimation using Hierarchical Bayesian method under Normal and T distribution. The rjags package is employed to obtain parameter estimates. For the reference, see Rao and Molina (2015) <doi:10.1002/9781118735855>.

This package provides a suite of conversion functions to create internally standardized spatial polygons data frames. Utility functions use these data sets to return values such as country, state, time zone, watershed, etc. associated with a set of longitude/latitude pairs. (They also make cool maps.).

Create marimekko (mosaic) plots as a ggplot2 layer. Column widths encode marginal proportions of one categorical variable and segment heights encode conditional proportions of a second categorical variable.

This package provides tools that researchers can use to analyze untargeted metabolomics data generated using tandem mass spectroscopy from microbial communities. The overall approach taken to analyze metabolomics data parallels that used to analyze microbial communities using 16S rRNA gene sequencing data. Thus, we have a number of methods a user is able to use to generate data. Firstly, users can import Mass Spectrometry 1(MS1) data and filter it. Users are then able to match Mass Spectrometry 2(MS2) data to the filtered (or unfiltered) MS1 data. With the matched data users are able to cluster it, annotate it, predict de novo chemical formulas and calculate alpha and beta diversity. For chemical formula predictions, this was the method used; "Towards de novo identification of metabolites by analyzing tandem mass spectra" (Sebastian Böcker, Florian Rasche (2008) <doi:10.1093/bioinformatics/btn270>). The similarity/dissimilarity calculations we used to cluster our data together was: "Spectral entropy outperforms MS/MS dot product similarity for small-molecule compound identification" (Li, Y., Kind, T., Folz, J. et al. (2021) <doi:10.1038/s41592-021-01331-z>) and "Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking" (Wang, M., Carver, J., Phelan, V. et al. (2021) <doi:10.1038/nbt.3597>).