Implement Bayesian multilevel modelling for compositional data. Compute multilevel compositional data and perform log-ratio transforms at between and within-person levels, fit Bayesian multilevel models for compositional predictors and outcomes, and run post-hoc analyses such as isotemporal substitution models. References: Le, Stanford, Dumuid, and Wiley (2025) <doi:10.1037/met0000750>, Le, Dumuid, Stanford, and Wiley (2025) <doi:10.1080/00273171.2025.2565598>.

Normally building a GODB is fairly complicated, involving downloading multiple database files and using these to build e.g. a mySQL database. Accessing this database is also complicated, involving an intimate knowledge of the database in order to construct reliable queries. Here we have a more modest goal, generating GOGOA3, which is a stripped down version of the GODB that was originally restricted to human genes as designated by the HUGO Gene Nomenclature Committee (HGNC) (see <https://geneontology.org/>). I have now added about two dozen additional species, namely all species represented on the Gene Ontology download page <https://current.geneontology.org/products/pages/downloads.html>. This covers most of the model organisms that are commonly used in bio-medical and basic research (assuming that anyone still has a grant to do such research). This can be built in a matter of seconds from 2 easily downloaded files (see <https://current.geneontology.org/products/pages/downloads.html> and <https://geneontology.org/docs/download-ontology/>), and it can be queried by e.g. w<-which(GOGOA3[,"HGNC"] %in% hgncList) where GOGOA3 is a matrix representing the minimalist GODB and hgncList is a list of gene identifiers. This database will be used in my upcoming package GoMiner which is based on my previous publication (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003)<doi:10.1186/gb-2003-4-4-r28>). Relevant .RData files are available from GitHub (<https://github.com/barryzee/GO/tree/main/databases>).

This package provides a collection of functions for processing and analyzing metabolite data. The namesake function mrbin() converts 1D or 2D Nuclear Magnetic Resonance data into a matrix of values suitable for further data analysis and performs basic processing steps in a reproducible way. Negative values, a common issue in such data, can be replaced by positive values (<doi:10.1021/acs.jproteome.0c00684>). All used parameters are stored in a readable text file and can be restored from that file to enable exact reproduction of the data at a later time. The function fia() ranks features according to their impact on classifier models, especially artificial neural network models.

This package provides tools for general-purpose continuous optimization and feed-forward artificial neural network training using metaheuristic and gradient-based optimization algorithms. The package supports benchmark function optimization, regression, binary classification, and multi-class classification with multilayer perceptrons. The package implements several optimization methods, including particle swarm optimization Kennedy and Eberhart (1995) <doi:10.1109/ICNN.1995.488968>, differential evolution Storn and Price (1997) <doi:10.1023/A:1008202821328>, grey wolf optimizer Mirjalili et al. (2014) <doi:10.1016/j.advengsoft.2013.12.007>, secretary bird optimization Fu et al. (2024) <doi:10.1007/s10462-024-10729-y>, and Adam Kingma and Ba (2015) <doi:10.48550/arXiv.1412.6980>.

Package with multivariate analysis methodologies for experiment evaluation. The package estimates dissimilarity measures, builds dendrograms, obtains MANOVA, principal components, canonical variables, etc. (Pacote com metodologias de analise multivariada para avaliação de experimentos. O pacote estima medidas de dissimilaridade, construi de dendogramas, obtem a MANOVA, componentes principais, variaveis canonicas, etc.).

This package implements comprehensive Merger and Acquisition ('M&A') Autoregressive ('AR') time-series models with full statistical analysis capabilities. The package provides parameter estimation, forecasting with confidence intervals (80%, 90%, 95%, 99%), descriptive statistics, stationarity tests (Augmented Dickey-Fuller ('ADF'), Phillips-Perron, Kwiatkowski-Phillips-Schmidt-Shin ('KPSS'), Dickey-Fuller Generalized Least Squares ('DF-GLS')), autocorrelation analysis (Autocorrelation Function ('ACF'), Partial Autocorrelation Function ('PACF')), model diagnostics (Ljung-Box, Box-Pierce), accuracy measures (Mean Squared Error ('MSE'), Mean Absolute Error ('MAE'), Mean Absolute Scaled Error ('MASE'), Root Mean Squared Error ('RMSE'), Symmetric Mean Absolute Percentage Error ('SMAPE'), F-statistic), residual diagnostics (normality tests, heteroscedasticity tests), model stability analysis, impulse response, information criteria (Akaike Information Criterion ('AIC'), Bayesian Information Criterion ('BIC'), Hannan-Quinn Information Criterion ('HQIC')), structural break analysis, spectral analysis, and Monte Carlo simulation. Models are based on: Kumar, Mudassir, and Agiwal (2024) <https://ph02.tci-thaijo.org/index.php/thaistat/article/view/253436>, Kumar, Mudassir, and Srivastava (2025) <doi:10.1007/s44199-025-00104-3>, Kumar and Mudassir (2025) <doi:10.19139/soic-2310-5070-2029>.

Computing functional traits-based distances between pairs of species for species gathered in assemblages allowing to build several functional spaces. The package allows to compute functional diversity indices assessing the distribution of species (and of their dominance) in a given functional space for each assemblage and the overlap between assemblages in a given functional space, see: Chao et al. (2018) <doi:10.1002/ecm.1343>, Maire et al. (2015) <doi:10.1111/geb.12299>, Mouillot et al. (2013) <doi:10.1016/j.tree.2012.10.004>, Mouillot et al. (2014) <doi:10.1073/pnas.1317625111>, Ricotta and Szeidl (2009) <doi:10.1016/j.tpb.2009.10.001>. Graphical outputs are included. Visit the mFD website for more information, documentation and examples.

This package performs multivariate meta-analysis for high-dimensional data to integrate and collectively analyse individual-level data from multiple studies, as well as to combine summary estimates. This approach accounts for correlation between outcomes, incorporates within- and between-study variability, handles missing values, and uses shrinkage estimation to accommodate high dimensionality. The MetaHD R package provides access to our multivariate meta-analysis approach, along with a comprehensive suite of existing meta-analysis methods, including fixed-effects and random-effects models, Fisher's method, Stouffer's method, the weighted Z method, Lancaster's method, the weighted Fisher's method, and vote-counting approach. Visualisation tools are provided for interpreting and comparing results across methods, including Venn diagrams, UpSet plots, and ROC curves, heatmaps of pooled effect sizes and correlations among outcomes. A detailed vignette with example datasets and code for data preparation and analysis is available at <https://alyshadelivera.github.io/MetaHD_vignette/>.

This package provides a framework to perform soft clustering using simplex-structured matrix factorisation (SSMF). The package contains a set of functions for determining the optimal number of prototypes, the optimal algorithmic parameters, the estimation confidence intervals and the diversity of clusters. Abdolali, Maryam & Gillis, Nicolas (2020) <doi:10.1137/20M1354982>.

Investigate the evolution of biological processes by capturing evolutionary signatures in transcriptomes (Drost et al. (2018) <doi:10.1093/bioinformatics/btx835>). This package aims to provide a transcriptome analysis environment to quantify the average evolutionary age of genes contributing to a transcriptome of interest.

This package provides a model designed to be a reliable testbed where various gene drive interventions for mosquito-borne diseases control. It is being developed to accommodate the use of various mosquito-specific gene drive systems within a population dynamics framework that allows migration of individuals between patches in landscape. Previous work developing the population dynamics can be found in Deredec et al. (2001) <doi:10.1073/pnas.1110717108> and Hancock & Godfray (2007) <doi:10.1186/1475-2875-6-98>, and extensions to accommodate CRISPR homing dynamics in Marshall et al. (2017) <doi:10.1038/s41598-017-02744-7>.

Includes functions for calculating basic indices of macrozoobenthos for water quality and is designed to provide researchers and environmental professionals with a comprehensive tool for evaluating the ecological health of aquatic ecosystems.The package is based on the following references: Paisley, M. F., Trigg, D. J. and Walley, W. J. (2014)<doi:10.1002/rra.2686>. Arslan, N., Salur, A., Kalyoncu, H. et al.(2016) <doi:10.1515/biolog-2016-0005>. Hilsenhoff W.L. (1987). Hilsenhoff. W.L. (1988) Barbour, M.T., Gerritsen, J., Snyder, B.D., and Stribling, J.B. (1999).

Meta-CART integrates classification and regression trees (CART) into meta-analysis. Meta-CART is a flexible approach to identify interaction effects between moderators in meta-analysis. The method is described in Dusseldorp et al. (2014) <doi:10.1037/hea0000018> and Li et al. (2017) <doi:10.1111/bmsp.12088>.

This package provides essential tools for the pre-processing techniques of matching and weighting multiply imputed datasets. The package includes functions for matching within and across multiply imputed datasets using various methods, estimating weights for units in the imputed datasets using multiple weighting methods, calculating causal effect estimates in each matched or weighted dataset using parametric or non-parametric statistical models, and pooling the resulting estimates according to Rubin's rules (please see <https://journal.r-project.org/archive/2021/RJ-2021-073/> for more details).

Computational tools to represent phylogenetic signals using adapted eigenvector maps.

This package provides tools for econometric analysis and economic modelling with the traditional two-input Constant Elasticity of Substitution (CES) function and with nested CES functions with three and four inputs. The econometric estimation can be done by the Kmenta approximation, or non-linear least-squares using various gradient-based or global optimisation algorithms. Some of these algorithms can constrain the parameters to certain ranges, e.g. economically meaningful values. Furthermore, the non-linear least-squares estimation can be combined with a grid-search for the rho-parameter(s). The estimation methods are described in Henningsen et al. (2021) <doi:10.4337/9781788976480.00030>.

Fast simulation from ordinary differential equation (ODE) based models typically employed in quantitative pharmacology and systems biology.

Implementation of commonly used p-value-based and parametric multiple testing procedures (computation of adjusted p-values and simultaneous confidence intervals) and parallel gatekeeping procedures based on the methodology presented in the book "Multiple Testing Problems in Pharmaceutical Statistics" (edited by Alex Dmitrienko, Ajit C. Tamhane and Frank Bretz) published by Chapman and Hall/CRC Press 2009.

Algorithms for solving various Maximum Weight Connected Subgraph Problems, including variants with budget constraints, cardinality constraints, weighted edges and signals. The package represents an R interface to high-efficient solvers based on relax-and-cut approach (Ã lvarez-Miranda E., Sinnl M. (2017) <doi:10.1016/j.cor.2017.05.015>) mixed-integer programming (Loboda A., Artyomov M., and Sergushichev A. (2016) <doi:10.1007/978-3-319-43681-4_17>) and simulated annealing.

This package provides an extension of the shadow-test approach to computerized adaptive testing (CAT) implemented in the TestDesign package for the assessment framework involving multiple tests administered periodically throughout the year. This framework is referred to as the Multiple Administrations Adaptive Testing (MAAT) and supports multiple item pools vertically scaled and multiple phases (stages) of CAT within each test. Between phases and tests, transitioning from one item pool (and associated constraints) to another is allowed as deemed necessary to enhance the quality of measurement.

Extends finite mixtures of quantile regressions (the mixqr package) with a concomitant-covariate, quantile-indexed mixing gate. The mixing probabilities follow a multinomial-logit model whose coefficients may depend on a separate set of gating covariates and on the quantile level, so that latent-class membership can change across the conditional distribution. This turns the location-varying mixing idea of Furno (2025) into a likelihood and EM object with proper standard errors on the gate. Estimation reuses the mixqr component and error-density machinery; the gate is fit by a weighted multinomial-logistic M-step and reduces exactly to a constant gate when the gating model is an intercept only.

This package provides a complete toolkit to process the Munich ChronoType Questionnaire (MCTQ) for its three versions (standard, micro, and shift). MCTQ is a quantitative and validated tool to assess chronotypes using peoples sleep behavior, originally presented by Till Roenneberg, Anna Wirz-Justice, and Martha Merrow (2003, <doi:10.1177/0748730402239679>).

Estimation, inference and forecasting using the Bayesian approach for multivariate threshold autoregressive (TAR) models in which the distribution used to describe the noise process belongs to the class of Gaussian variance mixtures.

This package implements Multivariable Functional Mendelian Randomization (MV-FMR) to estimate time-varying causal effects of multiple longitudinal exposures on health outcomes. Extends univariable functional Mendelian Randomisation (MR) (Tian et al., 2024 <doi:10.1002/sim.10222>) to the multivariable setting, enabling joint estimation of multiple time-varying exposures with pleiotropy and mediation scenarios. Key features include: (1) data-driven cross-validation for basis component selection, (2) handling of mediation pathways between exposures, (3) support for both continuous and binary outcomes using Generalized Method of Moments (GMM) and control function approaches, (4) one-sample and two-sample MR designs, (5) bootstrap inference and instrument diagnostics including Q-statistics for overidentification testing. Methods are described in Fontana et al. (2025) <doi:10.48550/arXiv.2512.19064>.