Stateful helpers for building Matrix (<https://matrix.org>) chat clients in R. Builds on the low-level mx.api Client-Server API bindings, adding local configuration persistence, room resolution, sync cursor handling, sync-event extraction, invite acceptance, a conservative Markdown-to-HTML converter for formatted messages, and Olm'/'Megolm end-to-end encryption orchestration over the optional mx.crypto package.

Fit and plot macroecological patterns predicted by the Maximum Entropy Theory of Ecology (METE).

Converts NIfTI format T1/FL neuroimages into structured, high-dimensional 2D data frames with a focus on region of interest (ROI) based processing. The package incorporates the partition algorithm, which offers a flexible framework for agglomerative partitioning based on the Direct-Measure-Reduce approach. This method ensures that each reduced variable maintains a user-specified minimum level of information while remaining interpretable, as each maps uniquely to one variable in the reduced dataset. The partition framework is described in Millstein et al. (2020) <doi:10.1093/bioinformatics/btz661>. The package allows customization in variable selection, measurement of information loss, and data reduction methods for neuroimaging analysis and machine learning workflows.

Mahalanobis-Taguchi (MT) system is a collection of multivariate analysis methods developed for the field of quality engineering. MT system consists of two families depending on their purpose. One is a family of Mahalanobis-Taguchi (MT) methods (in the broad sense) for diagnosis (see Woodall, W. H., Koudelik, R., Tsui, K. L., Kim, S. B., Stoumbos, Z. G., and Carvounis, C. P. (2003) <doi:10.1198/004017002188618626>) and the other is a family of Taguchi (T) methods for forecasting (see Kawada, H., and Nagata, Y. (2015) <doi:10.17929/tqs.1.12>). The MT package contains three basic methods for the family of MT methods and one basic method for the family of T methods. The MT method (in the narrow sense), the Mahalanobis-Taguchi Adjoint (MTA) methods, and the Recognition-Taguchi (RT) method are for the MT method and the two-sided Taguchi (T1) method is for the family of T methods. In addition, the Ta and Tb methods, which are the improved versions of the T1 method, are included.

This package performs multiple imputation of missing data using an ensemble super learner built with the tidymodels framework. For each incomplete column, a stacked ensemble of candidate learners is trained on a bootstrap sample of the observed data and used to generate imputations via predictive mean matching (continuous), probability draws (binary), or cumulative probability draws (categorical). Supports parallelism across imputed datasets via the future framework.

Background - Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. Results - mulea employs a progressive empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 22 ontology types from 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, or GMT files from external sources (e.g., MSigDB or Enrichr), expanding its applicability across diverse research areas. Conclusions - mulea is distributed as a CRAN R package. It offers researchers a powerful and flexible toolkit for functional enrichment analysis, addressing limitations of traditional tools with its progressive eFDR and by supporting a variety of ontologies. Overall, mulea fosters the exploration of diverse biological questions across various model organisms.

The unique function of this package allows representing in a single graph the relative occurrence and co-occurrence of events measured in a sample. As examples, the package was applied to describe the occurrence and co-occurrence of different species of bacterial or viral symbionts infecting arthropods at the individual level. The graphics allows determining the prevalence of each symbiont and the patterns of multiple infections (i.e. how different symbionts share or not the same individual hosts). We named the package after the famous painter as the graphical output recalls Mondrianâ s paintings.

An S4 implementation of the unbiased extension of the model- assisted synthetic-regression estimator proposed by Mandallaz (2013) <DOI:10.1139/cjfr-2012-0381>, Mandallaz et al. (2013) <DOI:10.1139/cjfr-2013-0181> and Mandallaz (2014) <DOI:10.1139/cjfr-2013-0449>. It yields smaller variances than the standard bias correction, the generalised regression estimator.

This package provides a set of functions to manage data shared on a MOLGENIS Armadillo server.

The iterative procedure estimates structural changes in the success probability of Bernoulli variables. It estimates the number and location of the breakpoints as well as the success probability of the different sequences between the breakpoints. In addition, it provides a graphical illustration of the result.

Exploratory and predictive methods for the analysis of several blocks of variables measured on the same individuals.

Build multiscalar territorial analysis based on various contexts.

Multivariate Surrogate Synchrony ('mvSUSY') estimates the synchrony within datasets that contain more than two time series. mvSUSY was developed from Surrogate Synchrony ('SUSY') with respect to implementing surrogate controls, and extends synchrony estimation to multivariate data. mvSUSY works as described in Meier & Tschacher (2021).

This package provides functions to calculate Unique Trait Combinations (UTC) and scaled Unique Trait Combinations (sUTC) as measures of multivariate richness. The package can also calculate beta-diversity for trait richness and can partition this into nestedness-related and turnover components. The code will also calculate several measures of overlap. See Keyel and Wiegand (2016) <doi:10.1111/2041-210X.12558> for more details.

This package provides a graphical user interface for the MuToss Project.

This package provides a flexible framework for fitting multivariate ordinal regression models with composite likelihood methods. Methodological details are given in Hirk, Hornik, Vana (2020) <doi:10.18637/jss.v093.i04>.

This package provides probability mass, distribution, quantile, random variate generation, and method-of-moments parameter fitting for the MBBEFD family of distributions used in insurance modeling as described in Bernegger (1997) <doi:10.2143/AST.27.1.563208> without any external dependencies.

This package provides the mean to parse and render markdown text with grid along with facilities to define the styling of the text.

Facilitates creation and manipulation of metric graphs, such as street or river networks. Further facilitates operations and visualizations of data on metric graphs, and the creation of a large class of random fields and stochastic partial differential equations on such spaces. These random fields can be used for simulation, prediction and inference. In particular, linear mixed effects models including random field components can be fitted to data based on computationally efficient sparse matrix representations. Interfaces to the R packages INLA and inlabru are also provided, which facilitate working with Bayesian statistical models on metric graphs. The main references for the methods are Bolin, Simas and Wallin (2024) <doi:10.3150/23-BEJ1647>, Bolin, Kovacs, Kumar and Simas (2023) <doi:10.1090/mcom/3929> and Bolin, Simas and Wallin (2023) <doi:10.48550/arXiv.2304.03190> and <doi:10.48550/arXiv.2304.10372>.

This package implements a methodology for the design and analysis of dose-response studies that combines aspects of multiple comparison procedures and modeling approaches (Bretz, Pinheiro and Branson, 2005, Biometrics 61, 738-748, <doi: 10.1111/j.1541-0420.2005.00344.x>). The package provides tools for the analysis of dose finding trials as well as a variety of tools necessary to plan a trial to be conducted with the MCP-Mod methodology. Please note: The MCPMod package will not be further developed, all future development of the MCP-Mod methodology will be done in the DoseFinding R-package.

This package provides a simple and effective tool for computing and visualizing statistical power for meta-analysis, including power analysis of main effects (Jackson & Turner, 2017)<doi:10.1002/jrsm.1240>, test of homogeneity (Pigott, 2012)<doi:10.1007/978-1-4614-2278-5>, subgroup analysis, and categorical moderator analysis (Hedges & Pigott, 2004)<doi:10.1037/1082-989X.9.4.426>.

Create vectors with sticky flags for elements that should not be displayed. Numeric vectors have basic subset and arithmetic methods implemented.

Simulate a (bivariate) multivariate renewal Hawkes (MRHawkes) self-exciting process, with given immigrant hazard rate functions and offspring density function. Calculate the likelihood of a MRHawkes process with given hazard rate functions and offspring density function for an (increasing) sequence of event times. Calculate the Rosenblatt residuals of the event times. Predict future event times based on observed event times up to a given time. For details see Stindl and Chen (2018) <doi:10.1016/j.csda.2018.01.021>.

This package provides a lightweight graph data model for representing, combining, querying, and summarizing evidence-backed biological mechanism graphs. A mechgraph is an S3 list holding a node table, an edge table, and provenance metadata. The package implements builders that convert STRING and BioGRID interaction tables into mechgraph objects, combiners (mg_bind(), mg_combine()) that merge graphs while preserving duplicate evidence records, accessors (mg_nodes(), mg_edges(), mg_metadata()) and mutators (mg_add_*(), mg_drop_*()) for node and edge tables, filters by type, source, identifier, and score, induced-subgraph construction, structural validation (mg_validate()), and quality-control summaries (mg_qc()). Szklarczyk et al. (2023) <doi:10.1093/nar/gkac1000> Oughtred et al. (2021) <doi:10.1002/pro.3938>.