This package provides a complete and seamless Nonmem simulation interface within R. Turns Nonmem control streams into simulation control streams, executes them with specified simulation input data and returns the results. The simulation is performed by Nonmem', eliminating manual work and risks of re-implementation of models in other tools.

This package provides functions for manipulating nested data frames in a list-column using dplyr <https://dplyr.tidyverse.org/> syntax. Rather than unnesting, then manipulating a data frame, nplyr allows users to manipulate each nested data frame directly. nplyr is a wrapper for dplyr functions that provide tools for common data manipulation steps: filtering rows, selecting columns, summarising grouped data, among others.

Includes five particle filtering algorithms for use with state space models in the nimble system: Auxiliary', Bootstrap', Ensemble Kalman filter', Iterated Filtering 2', and Liu-West', as described in Michaud et al. (2021), <doi:10.18637/jss.v100.i03>. A full User Manual is available at <https://r-nimble.org>.

This package provides a flexible tool that can perform (i) traditional non-compartmental analysis (NCA) and (ii) Simulation-based posterior predictive checks for population pharmacokinetic (PK) and/or pharmacodynamic (PKPD) models using NCA metrics. The methods are described in Acharya et al. (2016) <doi:10.1016/j.cmpb.2016.01.013>.

Implementation of network integration approaches comprising unweighted and weighted integration methods. Unweighted integration is performed considering the average, per-edge average, maximum and minimum of networks edges. Weighted integration takes into account a weight for each network during the fusion process, where the weights express the predictiveness strength of each network considering a specific predictive task. Weights can be learned using a machine learning algorithm able to associate the weights to the assessment of the accuracy of the learning algorithm trained on the network itself. The implemented methods can be applied to effectively integrate different biological networks modelling a wide range of problems in bioinformatics (e.g. disease gene prioritization, protein function prediction, drug repurposing, clinical outcome prediction).

This package provides functions for revealing what happens when effect size estimates from previous studies are taken into account when evaluating each new dataset in a study sequence. The analyses can be conducted for cumulative meta-analyses and for Bayesian data analyses. The package contains sample data for a wide selection of research topics. Jointly considering previous findings along with new data is more likely to result in correct conclusions than does the traditional practice of not incorporating previous findings, which often results in a back and forth ping-pong of conclusions when evaluating a sequence of studies. O'Connor & Ermacora (2021, <doi:10.1037/cbs0000259>).

This package implements a method that builds the coefficients of a polynomial model that performs almost equivalently as a given neural network (densely connected). This is achieved using Taylor expansion at the activation functions. The obtained polynomial coefficients can be used to explain features (and their interactions) importance in the neural network, therefore working as a tool for interpretability or eXplainable Artificial Intelligence (XAI). See Morala et al. 2021 <doi:10.1016/j.neunet.2021.04.036>, and 2023 <doi:10.1109/TNNLS.2023.3330328>.

Fits sphere-sphere regression models by estimating locally weighted rotations. Simulation of sphere-sphere data according to non-rigid rotation models. Provides methods for bias reduction applying iterative procedures within a Newton-Raphson learning scheme. Cross-validation is exploited to select smoothing parameters. See Marco Di Marzio, Agnese Panzera & Charles C. Taylor (2018) <doi:10.1080/01621459.2017.1421542>.

Designed to create interactive and visually compelling network maps using R Shiny. It allows users to quickly analyze CSV files and visualize complex relationships, structures, and connections within data by leveraging powerful network analysis libraries and dynamic web interfaces.

This package implements several nonparametric regression approaches for the inclusion of covariate information on the receiver operating characteristic (ROC) framework.

In the working paper titled "Why You Should Never Use the Hodrick-Prescott Filter", James D. Hamilton proposes a new alternative to economic time series filtering. The neverhpfilter package provides functions and data for reproducing his work. Hamilton (2017) <doi:10.3386/w23429>.

This package implements the nonparametric causality-in-quantiles test (in mean or variance), returning a test object with an S3 plot() method. The current implementation uses one lag of each series (first-order Granger causality setup). Methodology is based on Balcilar, Gupta, and Pierdzioch (2016a) <doi:10.1016/j.resourpol.2016.04.004> and Balcilar et al. (2016) <doi:10.1007/s11079-016-9388-x>.

This package provides functions to access and download data from various NASA APIs <https://api.nasa.gov/#browseAPI>, including: Astronomy Picture of the Day (APOD), Mars Rover Photos, Earth Polychromatic Imaging Camera (EPIC), Near Earth Object Web Service (NeoWs), Earth Observatory Natural Event Tracker (EONET), and NASA Earthdata CMR Search. Most endpoints require a NASA API key for access. Data is retrieved, cleaned for analysis, and returned in a dataframe-friendly format.

This package provides a number series generator that creates number series items based on cognitive models.

This package provides a set of functions providing several outlier (i.e., studies with extreme findings) and influential detection measures and methodologies in network meta-analysis : - simple outlier and influential detection measures - outlier and influential detection measures by considering study deletion (shift the mean) - plots for outlier and influential detection measures - Q-Q plot for network meta-analysis - Forward Search algorithm in network meta-analysis. - forward plots to monitor statistics in each step of the forward search algorithm - forward plots for summary estimates and their confidence intervals in each step of forward search algorithm.

Estimating the number of essential genes in a genome on the basis of data from a random transposon mutagenesis experiment, through the use of a Gibbs sampler. Lamichhane et al. (2003) <doi:10.1073/pnas.1231432100>.

This package provides a collection of tools that allow users to perform critical steps in the process of assessing ecological niche evolution over phylogenies, with uncertainty incorporated explicitly in reconstructions. The method proposed here for ancestral reconstruction of ecological niches characterizes species niches using a bin-based approach that incorporates uncertainty in estimations. Compared to other existing methods, the approaches presented here reduce risk of overestimation of amounts and rates of ecological niche evolution. The main analyses include: initial exploration of environmental data in occurrence records and accessible areas, preparation of data for phylogenetic analyses, executing comparative phylogenetic analyses of ecological niches, and plotting for interpretations. Details on the theoretical background and methods used can be found in: Owens et al. (2020) <doi:10.1002/ece3.6359>, Peterson et al. (1999) <doi:10.1126/science.285.5431.1265>, Soberón and Peterson (2005) <doi:10.17161/bi.v2i0.4>, Peterson (2011) <doi:10.1111/j.1365-2699.2010.02456.x>, Barve et al. (2011) <doi:10.1111/ecog.02671>, Machado-Stredel et al. (2021) <doi:10.21425/F5FBG48814>, Owens et al. (2013) <doi:10.1016/j.ecolmodel.2013.04.011>, Saupe et al. (2018) <doi:10.1093/sysbio/syx084>, and Cobos et al. (2021) <doi:10.1111/jav.02868>.

Accompanies the book "Nonparametric Statistical Methods Using R, 2nd Edition" by Kloke and McKean (2024, ISBN:9780367651350). Includes methods, datasets, and random number generation useful for the study of robust and/or nonparametric statistics. Emphasizes classical nonparametric methods for a variety of designs --- especially one-sample and two-sample problems. Includes methods for general scores, including estimation and testing for the two-sample location problem as well as Hogg's adaptive method.

Given a failure type, the function computes covariate-specific probability of failure over time and covariate-specific conditional hazard rate based on possibly right-censored competing risk data. Specifically, it computes the non-parametric maximum-likelihood estimates of these quantities and their asymptotic variances in a semi-parametric mixture model for competing-risks data, as described in Chang et al. (2007a).

This package provides a number of statistical tests have been proposed to compare two survival curves, including the difference in (or ratio of) t-year survival, difference in (or ratio of) p-th percentile survival, difference in (or ratio of) restricted mean survival time, and the weighted log-rank test. Despite the multitude of options, the convention in survival studies is to assume proportional hazards and to use the unweighted log-rank test for design and analysis. This package provides sample size and power calculation for all of the above statistical tests with allowance for flexible accrual, censoring, and survival (eg. Weibull, piecewise-exponential, mixture cure). It is the companion R package to the paper by Yung and Liu (2020) <doi:10.1111/biom.13196>. Specific to the weighted log-rank test, users may specify which approximations they wish to use to estimate the large-sample mean and variance. The default option has been shown to provide substantial improvement over the conventional sample size and power equations based on Schoenfeld (1981) <doi:10.1093/biomet/68.1.316>.

Th-U-Pb electron microprobe age dating of monazite, as originally described in <doi:10.1016/0009-2541(96)00024-1>.

Linear regression model and generalized linear models with nonparametric network effects on network-linked observations. The model is originally proposed by Le and Li (2022) <doi:10.48550/arXiv.2007.00803> and is assumed on observations that are connected by a network or similar relational data structure. A more recent work by Wang, Le and Li (2024) <doi:10.48550/arXiv.2410.01163> further extends the framework to generalized linear models. All these models are implemented in the current package. The model does not assume that the relational data or network structure to be precisely observed; thus, the method is provably robust to a certain level of perturbation of the network structure. The package contains the estimation and inference function for the model.

This package provides tools for data-driven statistical analysis using local polynomial regression and kernel density estimation methods as described in Calonico, Cattaneo and Farrell (2018, <doi:10.1080/01621459.2017.1285776>): lprobust() for local polynomial point estimation and robust bias-corrected inference, lpbwselect() for local polynomial bandwidth selection, kdrobust() for kernel density point estimation and robust bias-corrected inference, kdbwselect() for kernel density bandwidth selection, and nprobust.plot() for plotting results. The main methodological and numerical features of this package are described in Calonico, Cattaneo and Farrell (2019, <doi:10.18637/jss.v091.i08>).

Free United Kingdom National Health Service (NHS) and other healthcare, or population health-related data for education and training purposes. This package contains synthetic data based on real healthcare datasets, or cuts of open-licenced official data. This package exists to support skills development in the NHS-R community: <https://nhsrcommunity.com/>.