This package implements several spatial and spatio-temporal scalable disease mapping models for high-dimensional count data using the INLA technique for approximate Bayesian inference in latent Gaussian models (Orozco-Acosta et al., 2021 <doi:10.1016/j.spasta.2021.100496>; Orozco-Acosta et al., 2023 <doi:10.1016/j.cmpb.2023.107403> and Vicente et al., 2023 <doi:10.1007/s11222-023-10263-x>). The creation and develpment of this package has been supported by Project MTM2017-82553-R (AEI/FEDER, UE) and Project PID2020-113125RB-I00/MCIN/AEI/10.13039/501100011033. It has also been partially funded by the Public University of Navarra (project PJUPNA2001).

Analyse single case analyses against a control group. Its purpose is to provide a flexible, with good power and low first type error approach that can manage at the same time controls and patient's data. The use of Bayesian statistics allows to test both the alternative and null hypothesis. Scandola, M., & Romano, D. (2020, August 3). <doi:10.31234/osf.io/sajdq> Scandola, M., & Romano, D. (2021). <doi:10.1016/j.neuropsychologia.2021.107834>.

Model selection by bootstrapping the stepAIC() procedure.

Generate the James Blinding Index, as described in James et al (1996) <https://pubmed.ncbi.nlm.nih.gov/8841652/> and the Bang Blinding Index, as described in Bang et al (2004) <https://pubmed.ncbi.nlm.nih.gov/15020033/>. These are measures to assess whether or not satisfactory blinding has been maintained in a randomized, controlled, clinical trial. These can be generated for trial subjects, research coordinators and principal investigators, based upon standardized questionnaires that have been administered, to assess whether or not they can correctly guess to which treatment arm (e.g. placebo or treatment) subjects were assigned at randomization.

Designed to simplify the process of retrieving datasets from the Big Data PE platform using secure token-based authentication. It provides functions for securely storing, retrieving, and managing tokens associated with specific datasets, as well as fetching and processing data using the httr2 package.

Easily launch, track, and control functions as background-parallel jobs. Includes robust utilities for job status, error handling, resource monitoring, and result collection. Designed for scalable workflows in interactive and automated settings (local or remote). Integrates with multiple backends; supports flexible automation pipelines and live job tracking. For more information, see <https://anirbanshaw24.github.io/bakerrr/>.

Bayesian synthetic likelihood (BSL, Price et al. (2018) <doi:10.1080/10618600.2017.1302882>) is an alternative to standard, non-parametric approximate Bayesian computation (ABC). BSL assumes a multivariate normal distribution for the summary statistic likelihood and it is suitable when the distribution of the model summary statistics is sufficiently regular. This package provides a Metropolis Hastings Markov chain Monte Carlo implementation of four methods (BSL, uBSL, semiBSL and BSLmisspec) and two shrinkage estimators (graphical lasso and Warton's estimator). uBSL (Price et al. (2018) <doi:10.1080/10618600.2017.1302882>) uses an unbiased estimator to the normal density. A semi-parametric version of BSL (semiBSL, An et al. (2018) <arXiv:1809.05800>) is more robust to non-normal summary statistics. BSLmisspec (Frazier et al. 2019 <arXiv:1904.04551>) estimates the Gaussian synthetic likelihood whilst acknowledging that there may be incompatibility between the model and the observed summary statistic. Shrinkage estimation can help to decrease the number of model simulations when the dimension of the summary statistic is high (e.g., BSLasso, An et al. (2019) <doi:10.1080/10618600.2018.1537928>). Extensions to this package are planned. For a journal article describing how to use this package, see An et al. (2022) <doi:10.18637/jss.v101.i11>.

This package provides a collection of methods to determine the required sample size for the evaluation of inequality constrained hypotheses by means of a Bayes factor. Alternatively, for a given sample size, the unconditional error probabilities or the expected conditional error probabilities can be determined. Additional material on the methods in this package is available in Klaassen, F., Hoijtink, H. & Gu, X. (2019) <doi:10.31219/osf.io/d5kf3>.

Several implementations of a novel Bayesian hierarchical statistical model of nucleotide recoding RNA-seq experiments (NR-seq; TimeLapse-seq, SLAM-seq, TUC-seq, etc.) for analyzing and comparing NR-seq datasets (see Vock and Simon (2023) <doi:10.1261/rna.079451.122>). NR-seq is a powerful extension of RNA-seq that provides information about the kinetics of RNA metabolism (e.g., RNA degradation rate constants), which is notably lacking in standard RNA-seq data. The statistical model makes maximal use of these high-throughput datasets by sharing information across transcripts to significantly improve uncertainty quantification and increase statistical power. bakR includes a maximally efficient implementation of this model for conservative initial investigations of datasets. bakR also provides more highly powered implementations using the probabilistic programming language Stan to sample from the full posterior distribution. bakR performs multiple-test adjusted statistical inference with the output of these model implementations to help biologists separate signal from background. Methods to automatically visualize key results and detect batch effects are also provided.

Computation of asymptotic confidence intervals for negative and positive predictive values in binary diagnostic tests in case-control studies. Experimental design for hypothesis tests on predictive values.

This package implements Bayesian spatio-temporal factor analysis models for multivariate data observed across space and time. The package provides tools for model fitting via Markov chain Monte Carlo (MCMC), spatial and temporal interpolation, and visualization of latent factors and loadings to support inference and exploration of underlying spatio-temporal patterns. Designed for use in environmental, ecological, or public health applications, with support for posterior prediction and uncertainty quantification. Includes functions such as BSTFA() for model fitting and plot_factor() to visualize the latent processes. Functions are based on and extended from methods described in Berrett, et al. (2020) <doi:10.1002/env.2609>.

This package provides a client for the Base Adresses Nationale ('BAN') API, which allows to (batch) geocode and reverse-geocode French addresses. For more information about the BAN and its API, please see <https://adresse.data.gouv.fr/outils/api-doc/adresse>.

Get z-scores, percentiles, absolute values, and percent of predicted of a reference cohort. Functionality requires installing the data packages adiposerefdata and musclerefdata'. For more information on the underlying research, please visit our website which also includes a graphical interface. The models and underlying data are described in Marquardt JP et al.(planned publication 2025; reserved doi 10.1097/RLI.0000000000001104), "Subcutaneous and Visceral adipose tissue Reference Values from Framingham Heart Study Thoracic and Abdominal CT", *Investigative Radiology* and Tonnesen PE et al. (2023), "Muscle Reference Values from Thoracic and Abdominal CT for Sarcopenia Assessment [column] The Framingham Heart Study", *Investigative Radiology*, <doi:10.1097/RLI.0000000000001012>.

Analyze and plot the abundance of different RNA biotypes present in a count matrix, this evaluation can be useful if you want to test different strategies of normalization or analyze a particular biotype in a differential gene expression analysis.

Fits Bayesian grouped weighted quantile sum (BGWQS) regressions for one or more chemical groups with binary outcomes. Wheeler DC et al. (2019) <doi:10.1016/j.sste.2019.100286>.

This package provides methods for piecewise smooth regression. A piecewise smooth signal is estimated by applying a bootstrapped test recursively (binary segmentation approach). Each bootstrapped test decides whether the underlying signal is smooth on the currently considered subsegment or contains at least one further change-point.

This package provides the functions for Brunner-Munzel test and permuted Brunner-Munzel test, which enable to use formula, matrix, and table as argument. These functions are based on Brunner and Munzel (2000) <doi:10.1002/(SICI)1521-4036(200001)42:1%3C17::AID-BIMJ17%3E3.0.CO;2-U> and Neubert and Brunner (2007) <doi:10.1016/j.csda.2006.05.024>, and are written with FORTRAN.

Bayesian regularization for feed-forward neural networks.

Utilities dedicated to the analysis of biological sequences by metric MultiDimensional Scaling with projection of supplementary data. It contains functions for reading multiple sequence alignment files, calculating distance matrices, performing metric multidimensional scaling and visualizing results.

Exploratory data analysis methods to summarize, visualize and describe datasets. The main principal component methods are available, those with the largest potential in terms of applications: principal component analysis (PCA) when variables are quantitative, correspondence analysis (CA) when variables are categorical, Multiple Factor Analysis (MFA) when variables are structured in groups.

Bayesian seemingly unrelated regression with general variable selection and dense/sparse covariance matrix. The sparse seemingly unrelated regression is described in Bottolo et al. (2021) <doi:10.1111/rssc.12490>, the software paper is in Zhao et al. (2021) <doi:10.18637/jss.v100.i11>, and the model with random effects is described in Zhao et al. (2024) <doi:10.1093/jrsssc/qlad102>.

This package provides tools to calibrate, validate, and make predictions with the General Unified Threshold model of Survival adapted for Bee species. The model is presented in the publication from Baas, J., Goussen, B., Miles, M., Preuss, T.G., Roessing, I. (2022) <doi:10.1002/etc.5423> and Baas, J., Goussen, B., Taenzler, V., Roeben, V., Miles, M., Preuss, T.G., van den Berg, S., Roessink, I. (2024) <doi:10.1002/etc.5871>, and is based on the GUTS framework Jager, T., Albert, C., Preuss, T.G. and Ashauer, R. (2011) <doi:10.1021/es103092a>. The authors are grateful to Bayer A.G. for its financial support.

Real-time quantitative polymerase chain reaction (qPCR) data sets by Boggy et al. (2008) <doi:10.1371/journal.pone.0012355>. This package provides a dilution series for one PCR target: a random sequence that minimizes secondary structure and off-target primer binding. The data set is a six-point, ten-fold dilution series. For each concentration there are two replicates. Each amplification curve is 40 cycles long. Original raw data file: <https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0012355.s004>.

Defines operating characteristics of Bayesian Adaptive Trials considering a generalised linear model response via Monte Carlo simulations of Bayesian GLM fitted via integrated Laplace approximations (INLA).