This package provides functions and S4 methods to create and manage discrete time Markov chains more easily. In addition functions to perform statistical (fitting and drawing random variates) and probabilistic (analysis of their structural proprieties) analysis are provided. See Spedicato (2017) <doi:10.32614/RJ-2017-036>. Some functions for continuous times Markov chains depend on the suggested ctmcd package.

An increasingly important source of health-related bibliographic content are preprints - preliminary versions of research articles that have yet to undergo peer review. The two preprint repositories most relevant to health-related sciences are medRxiv <https://www.medrxiv.org/> and bioRxiv, both of which are operated by the Cold Spring Harbor Laboratory. medrxivr provides programmatic access to the Cold Spring Harbour Laboratory (CSHL) API <https://api.biorxiv.org/>, allowing users to easily download medRxiv and bioRxiv preprint metadata (e.g. title, abstract, publication date, author list, etc) into R. medrxivr also provides functions to search the downloaded preprint records using regular expressions and Boolean logic, as well as helper functions that allow users to export their search results to a .BIB file for easy import to a reference manager and to download the full-text PDFs of preprints matching their search criteria.

This package provides a number of functions to facilitate the handling and production of reports using time series data. The package was developed to be understandable for beginners, so some functions aim to transform processes that would be complex into functions with a few lines. The main advantage of using the metools package is the ease of producing reports and working with time series using a few lines of code, so the code is clean and easy to understand/maintain. Learn more about the metools at <https://metoolsr.wordpress.com>.

Plotting functions for mutational signatures and mutational spectra, including single base substitutions (SBS), doublet base substitutions (DBS), and small insertions and deletions (indels). Generates plots similar to those used previously in Alexandrov et al. (2020)<doi:10.1038/s41586-020-1943-3> and Rozen et al. (2026)<doi:10.5281/zenodo.18451842>.

Clean the MS/MS spectrum, calculate spectral entropy, unweighted entropy similarity, and entropy similarity for mass spectrometry data. The entropy similarity is a novel similarity measure for MS/MS spectra which outperform the widely used dot product similarity in compound identification. For more details, please refer to the paper: Yuanyue Li et al. (2021) "Spectral entropy outperforms MS/MS dot product similarity for small-molecule compound identification" <doi:10.1038/s41592-021-01331-z>.

Combination of either p-values or modified effect sizes from different studies to find differentially expressed genes.

Write so-called Integration Tests for your R web applications by declaring an HTTP request and the expectations its response should meet.

Collection of the state of the art multi-label resampling algorithms. The objective of these algorithms is to achieve balance in multi-label datasets.

This package provides methods for extracting results from mixed-effect model objects fit with the lme4 package. Allows construction of prediction intervals efficiently from large scale linear and generalized linear mixed-effects models. This method draws from the simulation framework used in the Gelman and Hill (2007) textbook: Data Analysis Using Regression and Multilevel/Hierarchical Models.

Estimates random effect latent measurement models, wherein the loadings, residual variances, intercepts, latent means, and latent variances all vary across groups. The random effect variances of the measurement parameters are then modeled using a hierarchical inclusion model, wherein the inclusion of the variances (i.e., whether it is effectively zero or non-zero) is informed by similar parameters (of the same type, or of the same item). This additional hierarchical structure allows the evidence in favor of partial invariance to accumulate more quickly, and yields more certain decisions about measurement invariance. Martin, Williams, and Rast (2020) <doi:10.31234/osf.io/qbdjt>.

This package provides flexible dictionary-based cleaning that allows users to specify implicit and explicit missing data, regular expressions for both data and columns, and global matches, while respecting ordering of factors. This package is part of the RECON (<https://www.repidemicsconsortium.org/>) toolkit for outbreak analysis.

BEAST2 (<https://www.beast2.org>) is a widely used Bayesian phylogenetic tool, that uses DNA/RNA/protein data and many model priors to create a posterior of jointly estimated phylogenies and parameters. BEAST2 is commonly accompanied by BEAUti 2 (<https://www.beast2.org>), which, among others, allows one to install BEAST2 package. This package allows to work with BEAST2 packages from R'.

This package implements survival analyses across multiple abundance thresholds, repeatedly partitioning samples into groups and evaluating survival differences to assess taxonomic associations with outcomes.

Set of tools for descriptive analysis of metaproteomics data generated from high-throughput mass spectrometry instruments. These tools allow to cluster peptides and proteins abundance, expressed as spectral counts, and to manipulate them in groups of metaproteins. This information can be represented using multiple visualization functions to portray the global metaproteome landscape and to differentiate samples or conditions, in terms of abundance of metaproteins, taxonomic levels and/or functional annotation. The provided tools allow to implement flexible analytical pipelines that can be easily applied to studies interested in metaproteomics analysis.

This package provides a collection of functions to perform various meta-analytical models through a unified mixed-effects framework, including standard univariate fixed and random-effects meta-analysis and meta-regression, and non-standard extensions such as multivariate, multilevel, longitudinal, and dose-response models.

Check concordance of a vector of mutation impacts with standard dictionaries such as Sequence Ontology (SO) <http://www.sequenceontology.org/>, Mutation Annotation Format (MAF) <https://docs.gdc.cancer.gov/Encyclopedia/pages/Mutation_Annotation_Format_TCGAv2/> or Prediction and Annotation of Variant Effects (PAVE) <https://github.com/hartwigmedical/hmftools/tree/master/pave>. It enables conversion between SO/PAVE and MAF terms and selection of the most severe consequence where multiple ampersand (&) delimited impacts are given.

Computation of standardized interquartile range (IQR), Huber-type skipped mean (Hampel (1985), <doi:10.2307/1268758>), robust coefficient of variation (CV) (Arachchige et al. (2019), <doi:10.48550/arXiv.1907.01110>), robust signal to noise ratio (SNR), z-score, standardized mean difference (SMD), as well as functions that support graphical visualization such as boxplots based on quartiles (not hinges), negative logarithms and generalized logarithms for ggplot2 (Wickham (2016), ISBN:978-3-319-24277-4).

This package provides functions to collapse a tidy data frame into matrices in a data frame and expand a data frame of matrices into a tidy data frame.

Fits latent Dirichlet allocation (LDA), supervised topic models, and multilevel supervised topic models for text data with multiple outcome variables. Core estimation routines are implemented in C++ using the Rcpp ecosystem. For topic models, see Blei et al. (2003) <https://www.jmlr.org/papers/volume3/blei03a/blei03a.pdf>. For supervised topic models, see Blei and McAuliffe (2007) <https://papers.nips.cc/paper_files/paper/2007/hash/d56b9fc4b0f1be8871f5e1c40c0067e7-Abstract.html>.

Algorithms to approximate the Pareto-front of multi-criteria minimum spanning tree problems.

Extract, transform and load MITRE standards. This package gives you an approach to cybersecurity data sets. All data sets are build on runtime downloading raw data from MITRE public services. MITRE <https://www.mitre.org/> is a government-funded research organization based in Bedford and McLean. Current version includes most used standards as data frames. It also provide a list of nodes and edges with all relationships.

Create and optimize (semi) MDPs with discrete time steps and state space. Both hierarchical and ordinary-traditional MDPs can be modeled.

This package performs the multiple testing procedures of Cox (2011) <doi:10.5170/CERN-2011-006> and Wong and Cox (2007) <doi:10.1080/02664760701240014>.

This toolkit allows performing continuous-time microsimulation for a wide range of life science (demography, social sciences, epidemiology) applications. Individual life-courses are specified by a continuous-time multi-state model as described in Zinn (2014) <doi:10.34196/IJM.00105>.