Implementation of Narrowest Significance Pursuit, a general and flexible methodology for automatically detecting localised regions in data sequences which each must contain a change-point (understood as an abrupt change in the parameters of an underlying linear model), at a prescribed global significance level. Narrowest Significance Pursuit works with a wide range of distributional assumptions on the errors, and yields exact desired finite-sample coverage probabilities, regardless of the form or number of the covariates. For details, see P. Fryzlewicz (2021) <https://stats.lse.ac.uk/fryzlewicz/nsp/nsp.pdf>.

Plot, process, and analyze NPO files produced by Nonpareil <http://enve-omics.ce.gatech.edu/nonpareil/>.

Retrieve and plot word frequencies through time from the "Google Ngram Viewer" <https://books.google.com/ngrams>.

Interface to the open location server API of Publieke Diensten Op de Kaart (<http://www.pdok.nl>). It offers geocoding, address suggestions and lookup of geographical objects. Included is an utility function for displaying leaflet tiles restricted to the Netherlands.

Automated population pharmacokinetic modeling framework for data-driven initialisation, model evaluation, and metaheuristic optimization. Supports genetic algorithms, ant colony optimization, tabu search, and stepwise procedures for automated model selection and parameter estimation within the nlmixr2 ecosystem.

Modelling the vegetation, carbon, nitrogen and water dynamics of undisturbed open bog ecosystems in a temperate to sub-boreal climate. The executable of the model can downloaded from <https://github.com/jeroenpullens/NUCOMBog>.

Collapse, partition, combine, fill gaps in and expand date/time ranges.

This package provides streamlined installation for packages from the natverse', a suite of R packages for computational neuroanatomy built on top of the nat NeuroAnatomy Toolbox package. Installation of the complete natverse suite requires a GitHub user account and personal access token GITHUB_PAT'. natmanager will help the end user set this up if necessary.

This package provides a set of techniques that can be used to develop, validate, and implement automated classifiers. A powerful tool for transforming raw data into meaningful information, ncodeR (Shaffer, D. W. (2017) Quantitative Ethnography. ISBN: 0578191687) is designed specifically for working with big data: large document collections, logfiles, and other text data.

Calculates a cumulative summation nonparametric extended median test based on the work of Brown & Schaffer (2020) <DOI:10.1080/03610926.2020.1738492>. It then generates a control chart to assess processes and determine if any streams are out of control.

This package provides standardized access to a range of re-scaling methods for numerical vectors and time-series features calculated within the theft ecosystem.

This package provides a fast negative binomial mixed model for conducting association analysis of multi-subject single-cell data. It can be used for identifying marker genes, differential expression and co-expression analyses. The model includes subject-level random effects to account for the hierarchical structure in multi-subject single-cell data. See He et al. (2021) <doi:10.1038/s42003-021-02146-6>.

This package provides a reproducible workflow for binning and visualizing NMR (nuclear magnetic resonance) spectra from environmental samples. The nmrrr package is intended for post-processing of NMR data, including importing, merging and, cleaning data from multiple files, visualizing NMR spectra, performing binning/integrations for compound classes, and relative abundance calculations. This package can be easily inserted into existing analysis workflows by users to help with analyzing and interpreting NMR data.

Nonparametric methods for analysis of covariance (ANCOVA) are distribution-free and provide a flexible statistical framework for situations where the assumptions of parametric ANCOVA are violated or when the response variable is ordinal. This package implements several well-known nonparametric ANCOVA procedures, including Quade, Puri and Sen, McSweeney and Porter, Burnett and Barr, Hettmansperger and McKean, Shirley, and Puri-Sen-Harwell-Serlin. The package provides user-friendly functions to apply these methods in practice. These methods are described in Olejnik et al. (1985) <doi:10.1177/0193841X8500900104> and Harwell et al. (1988) <doi:10.1037/0033-2909.104.2.268>.

This package provides a system for writing hierarchical statistical models largely compatible with BUGS and JAGS', writing nimbleFunctions to operate models and do basic R-style math, and compiling both models and nimbleFunctions via custom-generated C++. NIMBLE includes default methods for MCMC, Laplace Approximation, deterministic nested approximations, Monte Carlo Expectation Maximization, and some other tools. The nimbleFunction system makes it easy to do things like implement new MCMC samplers from R, customize the assignment of samplers to different parts of a model from R, and compile the new samplers automatically via C++ alongside the samplers NIMBLE provides. NIMBLE extends the BUGS'/'JAGS language by making it extensible: New distributions and functions can be added, including as calls to external compiled code. Although most people think of MCMC as the main goal of the BUGS'/'JAGS language for writing models, one can use NIMBLE for writing arbitrary other kinds of model-generic algorithms as well. A full User Manual is available at <https://r-nimble.org>.

The raw dataset and model used in Lai et al. (2021) Decoupled responses of native and exotic tree diversities to distance from old-growth forest and soil phosphorous in novel secondary forests. Applied Vegetation Science, 24, e12548.

Facilitates network clustering and evaluation of cluster configurations.

Fits non-homogeneous Markov multistate models and misclassification-type hidden Markov models in continuous time to intermittently observed data. Implements the methods in Titman (2011) <doi:10.1111/j.1541-0420.2010.01550.x>. Uses direct numerical solution of the Kolmogorov forward equations to calculate the transition probabilities.

This package provides a toolbox for calculating continuous norms for psychological tests, where the norms can be age-dependent. The norms are based Generalized Additive Models for Location, Scale, and Shape (GAMLSS) for the test scores in the normative sample. The package includes functions for model selection, reliability estimation, and calculating norms, including confidence intervals. For more details, see Timmerman et al. (2021) <doi:10.1037/met0000348>.

Box-constrained multiobjective optimization using the elitist non-dominated sorting genetic algorithm - NSGA-II. Fast non-dominated sorting, crowding distance, tournament selection, simulated binary crossover, and polynomial mutation are called in the main program. The methods are described in Deb et al. (2002) <doi:10.1109/4235.996017>.

An API client for NASA POWER global meteorology, surface solar energy and climatology data API. POWER (Prediction Of Worldwide Energy Resources) data are freely available for download with varying spatial resolutions dependent on the original data and with several temporal resolutions depending on the POWER parameter and community. This work is funded through the NASA Earth Science Directorate Applied Science Program. For more on the data themselves, the methodologies used in creating, a web-based data viewer and web access, please see <https://power.larc.nasa.gov/>.

We developed an inference tool based on approximate Bayesian computation to decipher network data and assess the strength of the inferred links between network's actors. It is a new multi-level approximate Bayesian computation (ABC) approach. At the first level, the method captures the global properties of the network, such as a scale-free structure and clustering coefficients, whereas the second level is targeted to capture local properties, including the probability of each couple of genes being linked. Up to now, Approximate Bayesian Computation (ABC) algorithms have been scarcely used in that setting and, due to the computational overhead, their application was limited to a small number of genes. On the contrary, our algorithm was made to cope with that issue and has low computational cost. It can be used, for instance, for elucidating gene regulatory network, which is an important step towards understanding the normal cell physiology and complex pathological phenotype. Reverse-engineering consists in using gene expressions over time or over different experimental conditions to discover the structure of the gene network in a targeted cellular process. The fact that gene expression data are usually noisy, highly correlated, and have high dimensionality explains the need for specific statistical methods to reverse engineer the underlying network.

Sends queries to a specified Neo4J graph database, capturing results in a dataframe where appropriate. Other useful functions for the importing and management of data on the Neo4J server and basic local server admin.

Extends package nat (NeuroAnatomy Toolbox) by providing objects and functions for handling template brains.