Conduct a noncompartmental analysis with industrial strength. Some features are 1) CDISC SDTM terms 2) Automatic or manual slope selection 3) Supporting both linear-up linear-down and linear-up log-down method 4) Interval(partial) AUCs with linear or log interpolation method 5) Produce pdf, rtf, text report files. * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

NONMEM has been a tool for running nonlinear mixed effects models since the 80s and is still used today (Bauer 2019 <doi:10.1002/psp4.12404>). This tool allows you to convert NONMEM models to rxode2 (Wang, Hallow and James (2016) <doi:10.1002/psp4.12052>) and with simple models nlmixr2 syntax (Fidler et al (2019) <doi:10.1002/psp4.12445>). The nlmixr2 syntax requires the residual specification to be included and it is not always translated. If available, the rxode2 model will read in the NONMEM data and compare the simulation for the population model ('PRED') individual model ('IPRED') and residual model ('IWRES') to immediately show how well the translation is performing. This saves the model development time for people who are creating an rxode2 model manually. Additionally, this package reads in all the information to allow simulation with uncertainty (that is the number of observations, the number of subjects, and the covariance matrix) with a rxode2 model. This is complementary to the babelmixr2 package that translates nlmixr2 models to NONMEM and can convert the objects converted from nonmem2rx to a full nlmixr2 fit.

This package provides functions for specifying and fitting nested dichotomy logistic regression models for a multi-category response and methods for summarising and plotting those models. Nested dichotomies are statistically independent, and hence provide an additive decomposition of tests for the overall polytomous response. When the dichotomies make sense substantively, this method can be a simpler alternative to the standard multinomial logistic model which compares response categories to a reference level. See: J. Fox (2016), "Applied Regression Analysis and Generalized Linear Models", 3rd Ed., ISBN 1452205663.

Designed to add datasets which are used in the Nonparametric Statistical Methods textbook, 3rd edition.

Wald Test for nonlinear restrictions on model parameters and confidence intervals for nonlinear functions of parameters using delta-method. Applicable after ANY model, provided parameters estimates and their covariance matrix are available.

Neural Additive Model framework based on Generalized Additive Models from Hastie & Tibshirani (1990, ISBN:9780412343902), which trains a different neural network to estimate the contribution of each feature to the response variable. The networks are trained independently leveraging the local scoring and backfitting algorithms to ensure that the Generalized Additive Model converges and it is additive. The resultant Neural Network is a highly accurate and interpretable deep learning model, which can be used for high-risk AI practices where decision-making should be based on accountable and interpretable algorithms.

This package implements methods in Mathur and VanderWeele (in preparation) to characterize global evidence strength across W correlated ordinary least squares (OLS) hypothesis tests. Specifically, uses resampling to estimate a null interval for the total number of rejections in, for example, 95% of samples generated with no associations (the global null), the excess hits (the difference between the observed number of rejections and the upper limit of the null interval), and a test of the global null based on the number of rejections.

Imputation for both missing covariates and censored observations (optional) for survival data with missing covariates by the nearest neighbor based multiple imputation algorithm as described in Hsu et al. (2006) <doi:10.1002/sim.2452>, and Hsu and Yu (2018) <doi: 10.1177/0962280218772592>. Note that the current version can only impute for a situation with one missing covariate.

Illustrate graphically the most common Null Hypothesis Significance Testing procedures. More specifically, this package provides functions to plot Chi-Squared, F, t (one- and two-tailed) and z (one- and two-tailed) tests, by plotting the probability density under the null hypothesis as a function of the different test statistic values. Although highly flexible (color theme, fonts, etc.), only the minimal number of arguments (observed test statistic, degrees of freedom) are necessary for a clear and useful graph to be plotted, with the observed test statistic and the p value, as well as their corresponding value labels. The axes are automatically scaled to present the relevant part and the overall shape of the probability density function. This package is especially intended for education purposes, as it provides a helpful support to help explain the Null Hypothesis Significance Testing process, its use and/or shortcomings.

This package provides functions for the normal Laplace distribution. Currently, it provides limited functionality. Density, distribution and quantile functions, random number generation, and moments are provided.

Statistical entropy analysis of network data as introduced by Frank and Shafie (2016) <doi:10.1177/0759106315615511>, and a in textbook which is in progress.

This package provides a collection of network analytic (convenience) functions which are missing in other standard packages. This includes triad census with attributes <doi:10.1016/j.socnet.2019.04.003>, core-periphery models <doi:10.1016/S0378-8733(99)00019-2>, and several graph generators. Most functions are build upon igraph'.

Optimization for nonlinear objective and constraint functions. Linear or nonlinear equality and inequality constraints are allowed. It accepts the input parameters as a constrained matrix.

An efficient unified nonconvex penalized estimation algorithm for Gaussian (linear), binomial Logit (logistic), Poisson, multinomial Logit, and Cox proportional hazard regression models. The unified algorithm is implemented based on the convex concave procedure and the algorithm can be applied to most of the existing nonconvex penalties. The algorithm also supports convex penalty: least absolute shrinkage and selection operator (LASSO). Supported nonconvex penalties include smoothly clipped absolute deviation (SCAD), minimax concave penalty (MCP), truncated LASSO penalty (TLP), clipped LASSO (CLASSO), sparse ridge (SRIDGE), modified bridge (MBRIDGE) and modified log (MLOG). For high-dimensional data (data set with many variables), the algorithm selects relevant variables producing a parsimonious regression model. Kim, D., Lee, S. and Kwon, S. (2018) <arXiv:1811.05061>, Lee, S., Kwon, S. and Kim, Y. (2016) <doi:10.1016/j.csda.2015.08.019>, Kwon, S., Lee, S. and Kim, Y. (2015) <doi:10.1016/j.csda.2015.07.001>. (This research is funded by Julian Virtue Professorship from Center for Applied Research at Pepperdine Graziadio Business School and the National Research Foundation of Korea.).

Datasets and functions to benchmark (convergence, speed, ease of use) R packages dedicated to regression with neural networks (no classification in this version). The templates for the tested packages are available in the R, R Markdown and HTML formats at <https://github.com/pkR-pkR/NNbenchmarkTemplates> and <https://theairbend3r.github.io/NNbenchmarkWeb/index.html>. The submitted article to the R-Journal can be read at <https://www.inmodelia.com/gsoc2020.html>.

Based on Natural Earth <https://www.naturalearthdata.com/>, a subset of countries can easily be selected with their administrative boundaries, joined with an external data frame and plotted as a thematic map.

Draw samples from truncated multivariate normal distribution using the sequential nearest neighbor (SNN) method introduced in "Scalable Sampling of Truncated Multivariate Normals Using Sequential Nearest-Neighbor Approximation" <doi:10.48550/arXiv.2406.17307>.

This package provides a nomogram, which can be carried out in rms package, provides a graphical explanation of a prediction process. However, it is not very easy to draw straight lines, read points and probabilities accurately. Even, it is hard for users to calculate total points and probabilities for all subjects. This package provides formula_rd() and formula_lp() functions to fit the formula of total points with raw data and linear predictors respectively by polynomial regression. Function points_cal() will help you calculate the total points. prob_cal() can be used to calculate the probabilities after lrm(), cph() or psm() regression. For more complex condition, interaction or restricted cubic spine, TotalPoints.rms() can be used.

An implementation of some of the core network package functionality based on a simplified data structure that is faster in many research applications. This package is designed for back-end use in the statnet family of packages, including EpiModel'. Support is provided for binary and weighted, directed and undirected, bipartite and unipartite networks; no current support for multigraphs, hypergraphs, or loops.

This package provides a collection of NASCAR race, driver, owner and manufacturer data across the three major NASCAR divisions: NASCAR Cup Series, NASCAR Xfinity Series, and NASCAR Craftsman Truck Series. The curated data begins with the 1949 season and extends through the end of the 2024 season. Explore race, season, or career performance for drivers, teams, and manufacturers throughout NASCAR's history. Data was sourced with permission from DriverAverages.com.

Additional nonlinear regression functions using self-start (SS) algorithms. One of the functions is the Beta growth function proposed by Yin et al. (2003) <doi:10.1093/aob/mcg029>. There are several other functions with breakpoints (e.g. linear-plateau, plateau-linear, exponential-plateau, plateau-exponential, quadratic-plateau, plateau-quadratic and bilinear), a non-rectangular hyperbola and a bell-shaped curve. Twenty eight (28) new self-start (SS) functions in total. This package also supports the publication Nonlinear regression Models and applications in agricultural research by Archontoulis and Miguez (2015) <doi:10.2134/agronj2012.0506>, a book chapter with similar material <doi:10.2134/appliedstatistics.2016.0003.c15> and a publication by Oddi et. al. (2019) in Ecology and Evolution <doi:10.1002/ece3.5543>. The function nlsLMList uses nlsLM for fitting, but it is otherwise almost identical to nlme::nlsList'.In addition, this release of the package provides functions for conducting simulations for nlme and gnls objects as well as bootstrapping. These functions are intended to work with the modeling framework of the nlme package. It also provides four vignettes with extended examples.

This package provides a comprehensive toolkit for analyzing and visualizing neural data outputs, including Principal Component Analysis (PCA) trajectory plotting, Multi-Electrode Array (MEA) heatmap generation, and variable importance analysis. Provides publication-ready visualizations with flexible customization options for neuroscience research applications.

Waiting list management using queuing theory to analyse, predict and manage queues, based on the approach described in Fong et al. (2022) <doi:10.1101/2022.08.23.22279117>. Aimed at UK National Health Service (NHS) applications, waiting list summary statistics, target-value calculations, waiting list simulation, and scheduling functions are included.

Closed testing has been proved powerful for true discovery guarantee. The computation of closed testing is, however, quite burdensome. A general way to reduce computational complexity is to combine partial closed testings for some prespecified feature sets of interest. Partial closed testings are performed at Bonferroni-corrected alpha level to guarantee the lower bounds for the number of true discoveries in prespecified sets are simultaneously valid. For any post hoc chosen sets of interest, coherence property is used to get the lower bound. In this package, we implement closed testing with globaltest to calculate the lower bound for number of true discoveries, see Ningning Xu et.al (2021) <arXiv:2001.01541> for detailed description.