This package implements a tree-based method specifically designed for personalized medicine applications. By using genomic and mutational data, ODT efficiently identifies optimal drug recommendations tailored to individual patient profiles. The ODT algorithm constructs decision trees that bifurcate at each node, selecting the most relevant markers (discrete or continuous) and corresponding treatments, thus ensuring that recommendations are both personalized and statistically robust. This iterative approach enhances therapeutic decision-making by refining treatment suggestions until a predefined group size is achieved. Moreover, the simplicity and interpretability of the resulting trees make the method accessible to healthcare professionals. Includes functions for training the decision tree, making predictions on new samples or patients, and visualizing the resulting tree. For detailed insights into the methodology, please refer to Gimeno et al. (2023) <doi:10.1093/bib/bbad200>.

Advanced forecasting algorithms for long-term energy demand at the national or regional level. The methodology is based on Grandón et al. (2024) <doi:10.1016/j.apenergy.2023.122249>; Zimmermann & Ziel (2024) <doi:10.1016/j.apenergy.2025.125444>. Real-time data, including power demand, weather conditions, and macroeconomic indicators, are provided through automated API integration with various institutions. The modular approach maintains transparency on the various model selection processes and encompasses the ability to be adapted to individual needs. oRaklE tries to help facilitating robust decision-making in energy management and planning.

Data input/output functions for data that conform to the Digital Imaging and Communications in Medicine (DICOM) standard, part of the Rigorous Analytics bundle.

Primarily devoted to implementing the Univariate Bootstrap (as well as the Traditional Bootstrap). In addition there are multiple functions for DeFries-Fulker behavioral genetics models. The univariate bootstrapping functions, DeFries-Fulker functions, regression and traditional bootstrapping functions form the original core. Additional features may come online later, however this software is a work in progress. For more information about univariate bootstrapping see: Lee and Rodgers (1998) and Beasley et al (2007) <doi:10.1037/1082-989X.12.4.414>.

Makes it easy to display descriptive information on a data set. Getting an easy overview of a data set by displaying and visualizing sample information in different tables (e.g., time and scope conditions). The package also provides publishable LaTeX code to present the sample information.

Data integration Web application for biobanks by OBiBa'. Opal is the core database application for biobanks. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. Opal is such a central repository. It can import, process, validate, query, analyze, report, and export data. Opal is typically used in a research center to analyze the data acquired at assessment centres. Its ultimate purpose is to achieve seamless data-sharing among biobanks. This Opal client allows to interact with Opal web services and to perform operations on the R server side. DataSHIELD administration tools are also provided.

This package provides a data set package with the "Orsi" and "Park/Durand" fronts as SpatialLinesDataFrame objects. The Orsi et al. (1995) fronts are published at the Southern Ocean Atlas Database Page, and the Park et al. (2019) fronts are published at the SEANOE Altimetry-derived Antarctic Circumpolar Current fronts page, please see package CITATION for details.

This package provides functions to do O2PLS-DA analysis for multiple omics data integration. The algorithm came from "O2-PLS, a two-block (X±Y) latent variable regression (LVR) method with an integral OSC filter" which published by Johan Trygg and Svante Wold at 2003 <doi:10.1002/cem.775>. O2PLS is a bidirectional multivariate regression method that aims to separate the covariance between two data sets (it was recently extended to multiple data sets) (Löfstedt and Trygg, 2011 <doi:10.1002/cem.1388>; Löfstedt et al., 2012 <doi:10.1016/j.aca.2013.06.026>) from the systematic sources of variance being specific for each data set separately.

Additive proportional odds model for ordinal data using Laplace P-splines. The combination of Laplace approximations and P-splines enable fast and flexible inference in a Bayesian framework. Specific approximations are proposed to account for the asymmetry in the marginal posterior distributions of non-penalized parameters. For more details, see Lambert and Gressani (2023) <doi:10.1177/1471082X231181173> ; Preprint: <arXiv:2210.01668>).

This package contains data from the May 2021 Occupational Employment and Wage Statistics data release from the U.S. Bureau of Labor Statistics. The dataset covers employment and wages across occupations, industries, states, and at the national level. Metropolitan data is not included.

Implement a new stopping rule to detect anomaly in the covariance structure of high-dimensional online data. The detection procedure can be applied to Gaussian or non-Gaussian data with a large number of components. Moreover, it allows both spatial and temporal dependence in data. The dependence can be estimated by a data-driven procedure. The level of threshold in the stopping rule can be determined at a pre-selected average run length. More detail can be seen in Li, L. and Li, J. (2020) "Online Change-Point Detection in High-Dimensional Covariance Structure with Application to Dynamic Networks." <arXiv:1911.07762>.

Estimate the positron emission tomography (PET) neuroreceptor occupancies from the total volumes of distribution of a set of regions of interest. Fitting methods include the simple reference region', ordinary least squares (sometimes known as occupancy plot), and restricted maximum likelihood estimation'.

Optimal scaling of a data vector, relative to a set of targets, is obtained through a least-squares transformation subject to appropriate measurement constraints. The targets are usually predicted values from a statistical model. If the data are nominal level, then the transformation must be identity-preserving. If the data are ordinal level, then the transformation must be monotonic. If the data are discrete, then tied data values must remain tied in the optimal transformation. If the data are continuous, then tied data values can be untied in the optimal transformation.

Utilize an orthogonality constrained optimization algorithm of Wen & Yin (2013) <DOI:10.1007/s10107-012-0584-1> to solve a variety of dimension reduction problems in the semiparametric framework, such as Ma & Zhu (2012) <DOI:10.1080/01621459.2011.646925>, Ma & Zhu (2013) <DOI:10.1214/12-AOS1072>, Sun, Zhu, Wang & Zeng (2019) <DOI:10.1093/biomet/asy064> and Zhou, Zhu & Zeng (2021) <DOI:10.1093/biomet/asaa087>. The package also implements some existing dimension reduction methods such as hMave by Xia, Zhang, & Xu (2010) <DOI:10.1198/jasa.2009.tm09372> and partial SAVE by Feng, Wen & Zhu (2013) <DOI:10.1080/01621459.2012.746065>. It also serves as a general purpose optimization solver for problems with orthogonality constraints, i.e., in Stiefel manifold. Parallel computing for approximating the gradient is enabled through OpenMP'.

Construct and evaluate directed tree structures that model the process of occurrence of genetic alterations during carcinogenesis as described in Szabo, A. and Boucher, K (2002) <doi:10.1016/S0025-5564(02)00086-X>.

This package provides functions to handle ordinal relations reflected within the feature space. Those function allow to search for ordinal relations in multi-class datasets. One can check whether proposed relations are reflected in a specific feature representation. Furthermore, it provides functions to filter, organize and further analyze those ordinal relations.

Ensemble functions for outlier/anomaly detection. There is a new ensemble method proposed using Item Response Theory. Existing outlier ensemble methods from Schubert et al (2012) <doi:10.1137/1.9781611972825.90>, Chiang et al (2017) <doi:10.1016/j.jal.2016.12.002> and Aggarwal and Sathe (2015) <doi:10.1145/2830544.2830549> are also included.

An interface to easily run local language models with Ollama <https://ollama.com> server and API endpoints (see <https://github.com/ollama/ollama/blob/main/docs/api.md> for details). It lets you run open-source large language models locally on your machine.

Setup and connect to OpenTripPlanner (OTP) <http://www.opentripplanner.org/>. OTP is an open source platform for multi-modal and multi-agency journey planning written in Java'. The package allows you to manage a local version or connect to remote OTP server to find walking, cycling, driving, or transit routes. This package has been peer-reviewed by rOpenSci (v. 0.2.0.0).

Maps of Australian coastline and administrative regions. Data can be drawn or accessed directly as simple features objects. Includes simple functions for country or state maps of Australia and in-built data sets of administrative regions from the Australian Bureau of Statistics <https://www.abs.gov.au/>. Layers include electoral divisions and local government areas, simplified from the original sources but with sufficient detail to allow mapping of a local municipality.

An object is called "outlier" if it remarkably deviates from the other objects in a data set. Outlier detection is the process to find outliers by using the methods that are based on distance measures, clustering and spatial methods (Ben-Gal, 2005 <ISBN 0-387-24435-2>). It is one of the intensively studied research topics for identification of novelties, frauds, anomalies, deviations or exceptions in addition to its use for outlier removing in data processing. This package provides the implementations of some novel approaches to detect the outliers based on typicality degrees that are obtained with the soft partitioning clustering algorithms such as Fuzzy C-means and its variants.

Detection of overdispersion in count data for multiple regression analysis. Log-linear count data regression is one of the most popular techniques for predictive modeling where there is a non-negative discrete quantitative dependent variable. In order to ensure the inferences from the use of count data models are appropriate, researchers may choose between the estimation of a Poisson model and a negative binomial model, and the correct decision for prediction from a count data estimation is directly linked to the existence of overdispersion of the dependent variable, conditional to the explanatory variables. Based on the studies of Cameron and Trivedi (1990) <doi:10.1016/0304-4076(90)90014-K> and Cameron and Trivedi (2013, ISBN:978-1107667273), the overdisp() command is a contribution to researchers, providing a fast and secure solution for the detection of overdispersion in count data. Another advantage is that the installation of other packages is unnecessary, since the command runs in the basic R language.

This package provides analyse, interpret and understand noise pollution data. Data are typically regular time series measured with sound meter. The package is partially described in Fogola, Grasso, Masera and Scordino (2023, <DOI:10.61782/fa.2023.0063>).

Facilitates the gathering of biodiversity occurrence data from disparate sources. Metadata is managed throughout the process to facilitate reporting and enhanced ability to repeat analyses.