Suite of interactive functions and helpers for selecting and editing geospatial data.

Run flexible mediation analyses using natural effect models as described in Lange, Vansteelandt and Bekaert (2012) <DOI:10.1093/aje/kwr525>, Vansteelandt, Bekaert and Lange (2012) <DOI:10.1515/2161-962X.1014> and Loeys, Moerkerke, De Smet, Buysse, Steen and Vansteelandt (2013) <DOI:10.1080/00273171.2013.832132>.

This group of functions simplifies the creation of linked micromap plots. Please see <https://www.jstatsoft.org/v63/i02/> for additional details.

Calibrate and apply multivariate bias correction algorithms for climate model simulations of multiple climate variables. Three methods described by Cannon (2016) <doi:10.1175/JCLI-D-15-0679.1> and Cannon (2018) <doi:10.1007/s00382-017-3580-6> are implemented -- (i) MBC Pearson correlation (MBCp), (ii) MBC rank correlation (MBCr), and (iii) MBC N-dimensional PDF transform (MBCn) -- as is the Rank Resampling for Distributions and Dependences (R2D2) method. An additional multivariate rescaling method based on the linear Monge-Kantorovich map for Gaussian optimal transport of dependence structure is also included.

Multivariate Analysis methods and data sets used in John Marden's book Multivariate Statistics: Old School (2015) <ISBN:978-1456538835>. This also serves as a companion package for the STAT 571: Multivariate Analysis course offered by the Department of Statistics at the University of Illinois at Urbana-Champaign ('UIUC').

Computing functional traits-based distances between pairs of species for species gathered in assemblages allowing to build several functional spaces. The package allows to compute functional diversity indices assessing the distribution of species (and of their dominance) in a given functional space for each assemblage and the overlap between assemblages in a given functional space, see: Chao et al. (2018) <doi:10.1002/ecm.1343>, Maire et al. (2015) <doi:10.1111/geb.12299>, Mouillot et al. (2013) <doi:10.1016/j.tree.2012.10.004>, Mouillot et al. (2014) <doi:10.1073/pnas.1317625111>, Ricotta and Szeidl (2009) <doi:10.1016/j.tpb.2009.10.001>. Graphical outputs are included. Visit the mFD website for more information, documentation and examples.

Background - Traditional gene set enrichment analyses are typically limited to a few ontologies and do not account for the interdependence of gene sets or terms, resulting in overcorrected p-values. To address these challenges, we introduce mulea, an R package offering comprehensive overrepresentation and functional enrichment analysis. Results - mulea employs a progressive empirical false discovery rate (eFDR) method, specifically designed for interconnected biological data, to accurately identify significant terms within diverse ontologies. mulea expands beyond traditional tools by incorporating a wide range of ontologies, encompassing Gene Ontology, pathways, regulatory elements, genomic locations, and protein domains. This flexibility enables researchers to tailor enrichment analysis to their specific questions, such as identifying enriched transcriptional regulators in gene expression data or overrepresented protein domains in protein sets. To facilitate seamless analysis, mulea provides gene sets (in standardised GMT format) for 27 model organisms, covering 22 ontology types from 16 databases and various identifiers resulting in almost 900 files. Additionally, the muleaData ExperimentData Bioconductor package simplifies access to these pre-defined ontologies. Finally, mulea's architecture allows for easy integration of user-defined ontologies, or GMT files from external sources (e.g., MSigDB or Enrichr), expanding its applicability across diverse research areas. Conclusions - mulea is distributed as a CRAN R package. It offers researchers a powerful and flexible toolkit for functional enrichment analysis, addressing limitations of traditional tools with its progressive eFDR and by supporting a variety of ontologies. Overall, mulea fosters the exploration of diverse biological questions across various model organisms.

Map image classification efficacy (MICE) adjusts the accuracy rate relative to a random classification baseline (Shao et al. (2021)<doi:10.1109/ACCESS.2021.3116526> and Tang et al. (2024)<doi:10.1109/TGRS.2024.3446950>). Only the proportions from the reference labels are considered, as opposed to the proportions from the reference and predictions, as is the case for the Kappa statistic. This package offers means to calculate MICE and adjusted versions of class-level user's accuracy (i.e., precision) and producer's accuracy (i.e., recall) and F1-scores. Class-level metrics are aggregated using macro-averaging. Functions are also made available to estimate confidence intervals using bootstrapping and statistically compare two classification results.

Compute and select tuning parameters for the MRCE estimator proposed by Rothman, Levina, and Zhu (2010) <doi:10.1198/jcgs.2010.09188>. This estimator fits the multiple output linear regression model with a sparse estimator of the error precision matrix and a sparse estimator of the regression coefficient matrix.

Nonparametric approach to estimate the location of block boundaries (change-points) of non-overlapping blocks in a random symmetric matrix which consists of random variables whose distribution changes from block to block. BRAULT Vincent, OUADAH Sarah, SANSONNET Laure and LEVY-LEDUC Celine (2017) <doi:10.1016/j.jmva.2017.12.005>.

GEE solver for correlated nominal or ordinal multinomial responses using a local odds ratios parameterization.

Constructs multi-resolution thin-plate spline basis functions on the sphere for use in spatial regression and large-scale spatial prediction problems. Implements the basis system described in Huang, Huang, and Ing (2025) "Multi-Resolution Spatial Methods on the Sphere: Efficient Prediction for Global Data", Environmetrics, <doi:10.1002/env.70092>. Heavy computations are written in C++ via Rcpp with optional OpenMP parallelism.

Multivariable Fractional Polynomial algorithm for model-building. Fractional polynomials are used to represent curvature in regression models. A key reference is Royston and Altman, 1994.

This package provides an end-to-end workflow for estimating average treatment effects in clustered (multilevel) observational data. Core functionality includes cluster-aware propensity score estimation using fixed effects and Mundlak-style specifications, inverse probability weighting, within-cluster nearest-neighbor matching, covariate balance diagnostics at both individual and cluster-mean levels, outcome regression with cluster-robust standard errors, propensity score overlap visualization, and tipping-point sensitivity analysis for omitted cluster-level confounding.

Generates replicated sets of sequences with Monte Carlo simulated timing changes and computes various indicators for evaluating effects of timing uncertainty on sequence analysis results. See Ritschard, G. and Liao, T.F. (2026): "Assessing the Impact of Timing Errors in Sequence Analysis". International Journal of Social Research Methodology <doi:10.1080/13645579.2026.2666297>.

Researchers often need to calculate body-size growth rates for individuals that do not have associated age data. These growth rates are based on mark-recapture data where an individual was captured and measured at time 1 then recaptured and measured at time 2. The sizes at each time and amount of time between captures can be used to calculate growth rates. MRgrowth follows the approach in Edmonds et al. (2021) <doi:10.1371/journal.pone.0259978> and provides functions to calculate growth using three formulas, the Faben's reformulation of the von Bertalanffy formula, the Gompertz formula, and a logistic formula.

Calculates and differentiates probabilities and density of (conditional) multivariate normal distribution and Gaussian copula (with various marginal distributions) using methods described in A. Genz (2004) <doi:10.1023/B:STCO.0000035304.20635.31>, A. Genz, F. Bretz (2009) <doi:10.1007/978-3-642-01689-9>, H. I. Gassmann (2003) <doi:10.1198/1061860032283> and E. Kossova, B. Potanin (2018) <https://ideas.repec.org/a/ris/apltrx/0346.html>.

This package provides functions to access drug regulatory data from public RESTful APIs including the FDA Open API and the Health Canada Drug Product Database API', retrieving real-time or historical information on drug approvals, adverse events, recalls, and product details. Additionally, the package includes a curated collection of open datasets focused on drugs, pharmaceuticals, treatments, and clinical studies. These datasets cover diverse topics such as treatment dosages, pharmacological studies, placebo effects, drug reactions, misuses of pain relievers, and vaccine effectiveness. The package supports reproducible research and teaching in pharmacology, medicine, and healthcare by integrating reliable international APIs and structured datasets from public, academic, and government sources. For more information on the APIs, see: FDA API <https://open.fda.gov/apis/> and Health Canada API <https://health-products.canada.ca/api/documentation/dpd-documentation-en.html>.

Given an image of a formula (typeset or handwritten) this package provides calls to the Mathpix service to produce the LaTeX code which should generate that image, and pastes it into a (e.g. an rmarkdown') document. See <https://docs.mathpix.com/> for full details. Mathpix is an external service and use of the API is subject to their terms and conditions.

Multidimensional projection techniques are used to create two dimensional representations of multidimensional data sets.

This package implements the moment-matching approximation for differences of non-standardized t-distributed random variables in both univariate and multivariate settings. The package provides density, distribution function, quantile function, and random generation for the approximated distributions of t-differences. The methodology establishes the univariate approximated distributions through the systematic matching of the first, second, and fourth moments, and extends it to multivariate cases, considering both scenarios of independent components and the more general multivariate t-distributions with arbitrary dependence structures. Methods build on the classical moment-matching approximation method (e.g., Casella and Berger (2024) <doi:10.1201/9781003456285>).

Quick and simple Tcl/Tk Graphical User Interface to call functions. Also comprises a very simple experimental GUI framework.

Quantitative RT-PCR data are analyzed using generalized linear mixed models based on lognormal-Poisson error distribution, fitted using MCMC. Control genes are not required but can be incorporated as Bayesian priors or, when template abundances correlate with conditions, as trackers of global effects (common to all genes). The package also implements a lognormal model for higher-abundance data and a "classic" model involving multi-gene normalization on a by-sample basis. Several plotting functions are included to extract and visualize results. The detailed tutorial is available here: <https://matzlab.weebly.com/uploads/7/6/2/2/76229469/mcmc.qpcr.tutorial.v1.2.4.pdf>.

This package contains functions for multiple imputation which complements existing functionality in R. In particular, several imputation methods for the mice package (van Buuren & Groothuis-Oudshoorn, 2011, <doi:10.18637/jss.v045.i03>) are implemented. Main features of the miceadds package include plausible value imputation (Mislevy, 1991, <doi:10.1007/BF02294457>), multilevel imputation for variables at any level or with any number of hierarchical and non-hierarchical levels (Grund, Luedtke & Robitzsch, 2018, <doi:10.1177/1094428117703686>; van Buuren, 2018, Ch.7, <doi:10.1201/9780429492259>), imputation using partial least squares (PLS) for high dimensional predictors (Robitzsch, Pham & Yanagida, 2016), nested multiple imputation (Rubin, 2003, <doi:10.1111/1467-9574.00217>), substantive model compatible imputation (Bartlett et al., 2015, <doi:10.1177/0962280214521348>), and features for the generation of synthetic datasets (Reiter, 2005, <doi:10.1111/j.1467-985X.2004.00343.x>; Nowok, Raab, & Dibben, 2016, <doi:10.18637/jss.v074.i11>).