Fit univariate non-linear scale mixture of skew-normal(NL-SMSN) regression, details in Garay, Lachos and Abanto-Valle (2011) <doi:10.1016/j.jkss.2010.08.003> and Lachos, Bandyopadhyay and Garay (2011) <doi:10.1016/j.spl.2011.03.019>.

Perform non-bipartite matching and matched randomization. A "bipartite" matching utilizes two separate groups, e.g. smokers being matched to nonsmokers or cases being matched to controls. A "non-bipartite" matching creates mates from one big group, e.g. 100 hospitals being randomized for a two-arm cluster randomized trial or 5000 children who have been exposed to various levels of secondhand smoke and are being paired to form a greater exposure vs. lesser exposure comparison. At the core of a non-bipartite matching is a N x N distance matrix for N potential mates. The distance between two units expresses a measure of similarity or quality as mates (the lower the better). The gendistance() and distancematrix() functions assist in creating this. The nonbimatch() function creates the matching that minimizes the total sum of distances between mates; hence, it is referred to as an "optimal" matching. The assign.grp() function aids in performing a matched randomization. Note bipartite matching can be performed using the prevent option in gendistance()'.

This package provides functions for Bayesian analysis of data from randomized experiments with non-compliance. The functions are based on the models described in Imbens and Rubin (1997) <doi:10.1214/aos/1034276631>. Currently only two types of outcome models are supported: binary outcomes and normally distributed outcomes. Models can be fit with and without the exclusion restriction and/or the strong access monotonicity assumption. Models are fit using the data augmentation algorithm as described in Tanner and Wong (1987) <doi:10.2307/2289457>.

An implementation of a Neural Network using the Levenberg-Marquardt optimization from minpack.lm', ideal for small datasets. For more details see Moré (1978) <doi:10.1007/BFb0067700>.

This package provides Scilab n1qn1'. This takes more memory than traditional L-BFGS. The n1qn1 routine is useful since it allows prespecification of a Hessian. If the Hessian is near enough the truth in optimization it can speed up the optimization problem. The algorithm is described in the Scilab optimization documentation located at <https://www.scilab.org/sites/default/files/optimization_in_scilab.pdf>. This version uses manually modified code from f2c to make this a C only binary.

Analysis functions to quantify inputs importance in neural network models. Functions are available for calculating and plotting the inputs importance and obtaining the activation function of each neuron layer and its derivatives. The importance of a given input is defined as the distribution of the derivatives of the output with respect to that input in each training data point <doi:10.18637/jss.v102.i07>.

This package implements univariate continuous probability distributions and associated model diagnostics based on the Lindley, Logistic, Half-Cauchy, Half-Logistic, and Poisson families. Provides functions for probability density, cumulative distribution, quantile, and hazard evaluation, random variate generation, and diagnostic procedures including Q-Q and P-P plots, goodness-of-fit tests, and model selection criteria.

This package implements a procedure for detecting multiple location-scale change points in a sequence of univariate observations, as described in Ross (2026) "Nonparametric Detection of Multiple Location-Scale Change Points via Wild Binary Segmentation" <doi:10.48550/arXiv.2107.01742>. The method combines Wild Binary Segmentation with a rank-based statistic and provides calibrated thresholds for controlling the probability of incorrectly detecting a change point in a homogeneous sequence.

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.

This shows how NONMEM (Beal SL, Sheiner LB, Boeckmann AJ, Bauer RJ. NONMEM 7.5 Users Guides. Icon plc, 2020) software works. NONMEM classical estimation methods such as First Order (FO) approximation', First Order Conditional Estimation (FOCE)', and Laplacian approximation are explained. Functions are also provided for post-run processing of NONMEM output files, generating PDF diagnostic reports including objective function value analysis, parameter estimates, prediction and residual diagnostics, empirical Bayes estimate (EBE) analysis, input data summary, and individual pharmacokinetic parameter distributions. Helper utilities for building NONMEM-ready datasets from SDTM-style source tables are also included.

This package implements methods introduced in Chen, Christensen, and Kankanala (2024) <doi:10.1093/restud/rdae025> for estimating and constructing uniform confidence bands for nonparametric structural functions using instrumental variables, including data-driven choice of tuning parameters. All methods in this package apply to nonparametric regression as a special case.

Estimate the non-linear odds ratio and plot it against a continuous exposure.

An R interface to the Julia package NeuralEstimators.jl'. The package facilitates the user-friendly development of neural Bayes estimators, which are neural networks that map data to a point summary of the posterior distribution (Sainsbury-Dale et al., 2024, <doi:10.1080/00031305.2023.2249522>). These estimators are likelihood-free and amortised, in the sense that, once the neural networks are trained on simulated data, inference from observed data can be made in a fraction of the time required by conventional approaches. The package also supports amortised Bayesian or frequentist inference using neural networks that approximate the posterior or likelihood-to-evidence ratio (Zammit-Mangion et al., 2025, Sec. 3.2, 5.2, <doi:10.48550/arXiv.2404.12484>). The package accommodates any model for which simulation is feasible by allowing users to define models implicitly through simulated data.

Calculate NOS (node overlap and segregation) and the associated metrics described in Strona and Veech (2015) <doi:10.1111/2041-210X.12395> and Strona et al. (2018) <doi:10.1111/ecog.03447>. The functions provided in the package enable assessment of structural patterns ranging from complete node segregation to perfect nestedness in a variety of network types. In addition, they provide a measure of network modularity.

This package creates collapsible, expandable HTML tables from hierarchical data. Supports data frame input with multi-level grouping, custom column formatters, bottom-up rollup aggregation, and CSS-variable-based theming. Works in Shiny applications, R Markdown, Quarto', and the RStudio Viewer.

Perform an exploration and a preliminary analysis on the dose- response relationship of nanomaterial toxicity. Several functions are provided for data exploration, including functions for creating a subset of dataset, frequency tables and plots. Inference for order restricted dose- response data is performed by testing the significance of monotonic dose-response relationship, using Williams, Marcus, M, Modified M and Likelihood ratio tests. Several methods of multiplicity adjustment are also provided. Description of the methods can be found in <https://github.com/rahmasarina/dose-response-analysis/blob/main/Methodology.pdf>.

Setup, run and analyze NetLogo (<https://www.netlogo.org>) model simulations in R'. nlrx experiments use a similar structure as NetLogos Behavior Space experiments. However, nlrx offers more flexibility and additional tools for running and analyzing complex simulation designs and sensitivity analyses. The user defines all information that is needed in an intuitive framework, using class objects. Experiments are submitted from R to NetLogo via XML files that are dynamically written, based on specifications defined by the user. By nesting model calls in future environments, large simulation design with many runs can be executed in parallel. This also enables simulating NetLogo experiments on remote high performance computing machines. In order to use this package, Java and NetLogo (>= 5.3.1) need to be available on the executing system.

Estimating the number of essential genes in a genome on the basis of data from a random transposon mutagenesis experiment, through the use of a Gibbs sampler. Lamichhane et al. (2003) <doi:10.1073/pnas.1231432100>.

Tidied data from the ASA 2006 data expo, as well as a number of useful other related data sets.

Package for a Network assisted algorithm for Epigenetic studies using mean and variance Combined signals: NEpiC. NEpiC combines both signals in mean and variance differences in methylation level between case and control groups searching for differentially methylated sub-networks (modules) using the protein-protein interaction network.

We proposed a package for the classification task which uses Negative Binomial distribution within Linear Discriminant Analysis (NBLDA). It is an extension of the PoiClaClu package to Negative Binomial distribution. The classification algorithms are based on the papers Dong et al. (2016, ISSN: 1471-2105) and Witten, DM (2011, ISSN: 1932-6157) for NBLDA and PLDA, respectively. Although PLDA is a sparse algorithm and can be used for variable selection, the algorithm proposed by Dong et al. is not sparse. Therefore, it uses all variables in the classifier. Here, we extend Dong et al.'s algorithm to the sparse case by shrinking overdispersion towards 0 (Yu et al., 2013, ISSN: 1367-4803) and offset parameter towards 1 (as proposed by Witten DM, 2011). We support only the classification task with this version.

This package provides a set of functions to access National Football League play-by-play data from <https://www.nfl.com/>.

Calculate Overall Survival or Recurrence-Free Survival for breast cancer patients, using NHS Predict'. The time interval for the estimation can be set up to 15 years, with default at 10. Incremental therapy benefits are estimated for hormone therapy, chemotherapy, trastuzumab, and bisphosphonates. An additional function, suited for SCAN audits, features a more user-friendly version of the code, with fewer inputs, but necessitates the correct standardised inputs. This work is not affiliated with the development of NHS Predict and its underlying statistical model. Details on NHS Predict can be found at: <doi:10.1186/bcr2464>. The web version of NHS Predict': <https://breast.predict.nhs.uk/>. A small dataset of 50 fictional patient observations is provided for the purpose of running examples with the main two functions, and an additional dataset is provided for running example with the dedicated SCAN function.

This package provides tools for visualizing and analyzing the shape of discrete nominal frequency distributions. The package introduces centered frequency plots, in which nominal categories are ordered from the most frequent category at the center toward less frequent categories on both sides, facilitating the detection of distributional patterns such as uniformity, dominance, symmetry, skewness, and long-tail behavior. In addition, the package supports Pareto charts for the study of dominance and cumulative frequency structure in nominal data. The package is designed for exploratory data analysis and statistical teaching, offering visualizations that emphasize distributional form rather than arbitrary category ordering.