Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Download Current & Historical Bhavcopy. Get Live Market data from NSE India of Equities and Derivatives (F&O) segment. Data source <https://www.nseindia.com/>.

Draw samples from truncated multivariate normal distribution using the sequential nearest neighbor (SNN) method introduced in "Scalable Sampling of Truncated Multivariate Normals Using Sequential Nearest-Neighbor Approximation" <doi:10.48550/arXiv.2406.17307>.

Supports staggered difference-in-differences designs with nonlinear outcomes for both panel and repeated cross-section data. Implements estimators for staggered treatment adoption with binary, count, and other nonlinear outcomes, extending Callaway and Sant'Anna (2021) <doi:10.1016/j.jeconom.2020.12.001> to settings with nonlinear outcome models such as logit, probit, and Poisson. For panel data, units are followed over time and idname identifies repeated observations. For repeated cross-section data, observations are independent within each time period; idname is optional and may identify survey records or households, but the estimator does not require the same units to appear across periods. Repeated cross-section estimation includes pooled quasi-maximum likelihood approaches motivated by Wooldridge (2023) <doi:10.1093/ectj/utad016>, with optional weighting and clustered inference. Methods also draw on Roth and Sant'Anna (2023) <doi:10.3982/ECTA19402> and Sant'Anna and Zhao (2020) <doi:10.1016/j.jeconom.2020.06.003>.

Stochastic collapsed variational inference on mixed-membership stochastic blockmodel for networks, incorporating node-level predictors of mixed-membership vectors, as well as dyad-level predictors. For networks observed over time, the model defines a hidden Markov process that allows the effects of node-level predictors to evolve in discrete, historical periods. In addition, the package offers a variety of utilities for exploring results of estimation, including tools for conducting posterior predictive checks of goodness-of-fit and several plotting functions. The package implements methods described in Olivella, Pratt and Imai (2019) Dynamic Stochastic Blockmodel Regression for Social Networks: Application to International Conflicts', available at <https://www.santiagoolivella.info/pdfs/socnet.pdf>.

This package provides a functional programming based implementation of the super learner algorithm with an emphasis on supporting the use of formulas to specify learners. This approach offers several improvements compared to past implementations including the ability to easily use random-effects specified in formulas (like y ~ (age | strata) + ...) and construction of new learners is as simple as writing and passing a new function. The super learner algorithm was originally described in van der Laan et al. (2007) <https://biostats.bepress.com/ucbbiostat/paper222/>.

Palettes generated from NBA jersey colorways.

This package provides tools to save nlmixr2 fitted models in a portable format readable outside of nlmixr2 and independent of the package version. nlmixr2 fits and compares nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving uses compiled C code from the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Snow water equivalent is modeled with the process based models delta.snow and HS2SWE and empirical regression, which use relationships between density and diverse at-site parameters. The methods are described in Winkler et al. (2021) <doi:10.5194/hess-25-1165-2021>, Magnusson et al. (2025) <doi:10.1016/j.coldregions.2025.104435>, Guyennon et al. (2019) <doi:10.1016/j.coldregions.2019.102859>, Pistocchi (2016) <doi:10.1016/j.ejrh.2016.03.004>, Jonas et al. (2009) <doi:10.1016/j.jhydrol.2009.09.021> and Sturm et al. (2010) <doi:10.1175/2010JHM1202.1>.

Noninferiority tests for difference in failure rates at a prespecified control rate or prespecified time. For details, see Fay and Follmann, 2016 <DOI:10.1177/1740774516654861>.

This package provides a reproducible workflow for binning and visualizing NMR (nuclear magnetic resonance) spectra from environmental samples. The nmrrr package is intended for post-processing of NMR data, including importing, merging and, cleaning data from multiple files, visualizing NMR spectra, performing binning/integrations for compound classes, and relative abundance calculations. This package can be easily inserted into existing analysis workflows by users to help with analyzing and interpreting NMR data.

This package provides methods for Neutrosophic Analysis of Variance (NANOVA) for split-plot and strip-plot experimental designs using interval-valued observations. The package computes neutrosophic sums of squares, mean squares, interval-valued F-statistics, significance tests, and Least Significant Difference (LSD) based multiple comparisons for main plot, sub plot, horizontal factor, vertical factor, and interaction effects. For crisp data, users may provide identical lower and upper response values to obtain results equivalent to classical analysis of variance. The basic idea of neutrosophic statistics is obtained from Smarandache (2014) <https://fs.unm.edu/NeutrosophicStatistics.pdf>, while the analysis procedures implemented in this package are newly developed.

Near-far matching is a study design technique for preprocessing observational data to mimic a pair-randomized trial. Individuals are matched to be near on measured confounders and far on levels of an instrumental variable. Methods outlined in further detail in Rigdon, Baiocchi, and Basu (2018) <doi:10.18637/jss.v086.c05>.

An adaptation of Non-dominated Sorting Genetic Algorithm III for multi objective feature selection tasks. Non-dominated Sorting Genetic Algorithm III is a genetic algorithm that solves multiple optimization problems simultaneously by applying a non-dominated sorting technique. It uses a reference points based selection operator to explore solution space and preserve diversity. See the original paper by K. Deb and H. Jain (2014) <DOI:10.1109/TEVC.2013.2281534> for a detailed description.

An interface to Neptune. A metadata store for MLOps, built for teams that run a lot of experiments. It gives you a single place to log, store, display, organize, compare, and query all your model-building metadata. Neptune is used for: â ¢ Experiment tracking: Log, display, organize, and compare ML experiments in a single place. â ¢ Model registry: Version, store, manage, and query trained models, and model building metadata. â ¢ Monitoring ML runs live: Record and monitor model training, evaluation, or production runs live For more information see <https://neptune.ai/>.

With this package, it is possible to compute nonparametric simultaneous confidence intervals for relative contrast effects in the unbalanced one way layout. Moreover, it computes simultaneous p-values. The simultaneous confidence intervals can be computed using multivariate normal distribution, multivariate t-distribution with a Satterthwaite Approximation of the degree of freedom or using multivariate range preserving transformations with Logit or Probit as transformation function. 2 sample comparisons can be performed with the same methods described above. There is no assumption on the underlying distribution function, only that the data have to be at least ordinal numbers. See Konietschke et al. (2015) <doi:10.18637/jss.v064.i09> for details.

Set of functions to estimate kidney function and other traits of interest in nephrology.

Novel responsive tools for developing R based Shiny dashboards and applications. The scripts and style sheets are based on jQuery <https://jquery.com/> and Bootstrap <https://getbootstrap.com/>.

This package provides tools for estimating Receiver Operating Characteristic (ROC) curves, building confidence bands, comparing several curves both for dependent and independent data, estimating the cumulative-dynamic ROC curve in presence of censored data, and performing meta-analysis studies, among others.

Wraps the nametag library <https://github.com/ufal/nametag>, allowing users to find and extract entities (names, persons, locations, addresses, ...) in raw text and build your own entity recognition models. Based on a maximum entropy Markov model which is described in Strakova J., Straka M. and Hajic J. (2013) <https://ufal.mff.cuni.cz/~straka/papers/2013-tsd_ner.pdf>.

Next-Generation Clustered Heat Maps (NG-CHMs) allow for dynamic exploration of heat map data in a web browser. NGCHM allows users to create both stand-alone HTML files containing a Next-Generation Clustered Heat Map, and .ngchm files to view in the NG-CHM viewer. See Ryan MC, Stucky M, et al (2020) <doi:10.12688/f1000research.20590.2> for more details.

Imputation for both missing covariates and censored observations (optional) for survival data with missing covariates by the nearest neighbor based multiple imputation algorithm as described in Hsu et al. (2006) <doi:10.1002/sim.2452>, and Hsu and Yu (2018) <doi: 10.1177/0962280218772592>. Note that the current version can only impute for a situation with one missing covariate.

Optimizing regular numeric problems in optically stimulated luminescence dating, such as: equivalent dose calculation, dose rate determination, growth curve fitting, decay curve decomposition, statistical age model optimization, and statistical plot visualization.

This package provides a comprehensive toolkit for analyzing and visualizing neural data outputs, including Principal Component Analysis (PCA) trajectory plotting, Multi-Electrode Array (MEA) heatmap generation, and variable importance analysis. Provides publication-ready visualizations with flexible customization options for neuroscience research applications.