The permubiome R package was created to perform a permutation-based non-parametric analysis on microbiome data for biomarker discovery aims. This test executes thousands of comparisons in a pairwise manner, after a random shuffling of data into the different groups of study with a prior selection of the microbiome features with the largest variation among groups. Previous to the permutation test itself, data can be normalized according to different methods proposed to handle microbiome data ('proportions or Anders'). The median-based differences between groups resulting from the multiple simulations are fitted to a normal distribution with the aim to calculate their significance. A multiple testing correction based on Benjamini-Hochberg method (fdr) is finally applied to extract the differentially presented features between groups of your dataset. LATEST UPDATES: v1.1 and olders incorporates function to parse COLUMN format; v1.2 and olders incorporates -optimize- function to maximize evaluation of features with largest inter-class variation; v1.3 and olders includes the -size.effect- function to perform estimation statistics using the bootstrap-coupled approach implemented in the dabestr (>=0.3.0) R package. Current v1.3.2 fixed bug with "Class" recognition and updated dabestr functions.

Computes the optimal flow, Nash flow and the Price of Anarchy for any routing game defined within the game theoretical framework. The input is a routing game in the form of itâ s cost and flow functions. Then transforms this into an optimisation problem, allowing both Nash and Optimal flows to be solved by nonlinear optimisation. See <https://en.wikipedia.org/wiki/Congestion_game> and Knight and Harper (2013) <doi:10.1016/j.ejor.2013.04.003> for more information.

This package provides a bunch of convenience functions that transform the results of some basic statistical analyses into table format nearly ready for publication. This includes descriptive tables, tables of logistic regression and Cox regression results as well as forest plots.

This package implements Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints and longitudinal efficacy measure from multiple treatment cycles. The package provides flags to fit a variety of model-based phase I design, including 1 stage models with or without individualized dose modification, 3-stage models with or without individualized dose modification, etc. Functions are provided to recommend dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Bundles the datasets and functions used in the textbook by Philip Pollock and Barry Edwards, an R Companion to Essentials of Political Analysis, Second Edition.

It estimates power and sample size for Partial Least Squares-based methods described in Andreella, et al., (2024), <doi:10.48550/arXiv.2403.10289>.

This package provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) of Wages, Conaway and O'Quigley (2011) <doi:10.1177/1740774511408748> for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

Miscellaneous small utilities are provided to mitigate issues with messy, inconsistent or high dimensional data and help for preprocessing and preparing analyses.

Price comparisons within or between countries provide an overall measure of the relative difference in prices, often denoted as price levels. This package provides index number methods for such price comparisons (e.g., The World Bank, 2011, <doi:10.1596/978-0-8213-9728-2>). Moreover, it contains functions for sampling and characterizing price data.

This package provides methods to detect genetic markers involved in biological adaptation. pcadapt provides statistical tools for outlier detection based on Principal Component Analysis. Implements the method described in (Luu, 2016) <DOI:10.1111/1755-0998.12592> and later revised in (Privé, 2020) <DOI:10.1093/molbev/msaa053>.

This package provides tools for processing, analyzing, and visualizing spectral data collected from 3D laser-based scanning systems. Supports applications in agriculture, forestry, environmental monitoring, industrial quality control, and biomedical research. Enables evaluation of plant growth, productivity, resource efficiency, disease management, and pest monitoring. Includes statistical methods for extracting insights from multispectral and hyperspectral data and generating publication-ready visualizations. See Zieschank & Junker (2023) <doi:10.3389/fpls.2023.1141554> and Saric et al. (2022) <doi:10.1016/J.TPLANTS.2021.12.003> for related work.

This package provides data set and functions for exploration of Multiple Indicator Cluster Survey (MICS) 2014 Child questionnaire data for Punjab, Pakistan (<http://www.mics.unicef.org/surveys>).

Spearman's rank correlation test with precomputed exact null distribution for n <= 22.

Fitting and testing probabilistic knowledge structures, especially the basic local independence model (BLIM, Doignon & Flamagne, 1999) and the simple learning model (SLM), using the minimum discrepancy maximum likelihood (MDML) method (Heller & Wickelmaier, 2013 <doi:10.1016/j.endm.2013.05.145>).

This package provides access to the PlanScore Application Programming Interface (<https://github.com/PlanScore/PlanScore/blob/main/API.md>) for scoring redistricting plans. Allows for upload of plans from block assignment files and shape files. For shapes in memory, such as from sf or redist', it processes them to save and upload. Includes tools for tidying responses and saving output from the website.

Allows the user to convert PDF tables to formats more amenable to analysis ('.csv', .xml', or .xlsx') by wrapping the PDFTables API. In order to use the package, the user needs to sign up for an API account on the PDFTables website (<https://pdftables.com/pdf-to-excel-api>). The package works by taking a PDF file as input, uploading it to PDFTables, and returning a file with the extracted data.

Facilitates population-level analysis of ligand-receptor (LR) interactions using large-scale single-cell transcriptomic data. Identifies significant LR pairs and quantifies their interactions through correlation-based filtering and projection score computations. Designed for large-sample single-cell studies, the package employs statistical modeling, including linear regression, to investigate LR relationships between cell types. It provides a systematic framework for understanding cell-cell communication, uncovering regulatory interactions and signaling mechanisms. Offers tools for LR pair-level, sample-level, and differential interaction analyses, with comprehensive visualization support to aid biological interpretation. The methodology is described in a manuscript currently under review and will be referenced here once published or publicly available.

This package provides a testing workbench to evaluate tools that calculate precision-recall curves. Saito and Rehmsmeier (2015) <doi:10.1371/journal.pone.0118432>.

Run simulations to assess the impact of various designs features and the underlying biological behaviour on the outcome of a Patient Derived Xenograft (PDX) population study. This project can either be deployed to a server as a shiny app or installed locally as a package and run the app using the command populationPDXdesignApp()'.

This package provides tools for the practical management of financial portfolios: backtesting investment and trading strategies, computing profit/loss and returns, analysing trades, handling lists of transactions, reporting, and more. The package provides a small set of reliable, efficient and convenient tools for processing and analysing trade/portfolio data. The manual provides all the details; it is available from <https://enricoschumann.net/R/packages/PMwR/manual/PMwR.html>. Examples and descriptions of new features are provided at <https://enricoschumann.net/notes/PMwR/>.

Because larger (> 50 MB) data files cannot easily be committed to git, a different approach is required to manage data associated with an analysis in a GitHub repository. This package provides a simple work-around by allowing larger (up to 2 GB) data files to piggyback on a repository as assets attached to individual GitHub releases. These files are not handled by git in any way, but instead are uploaded, downloaded, or edited directly by calls through the GitHub API. These data files can be versioned manually by creating different releases. This approach works equally well with public or private repositories. Data can be uploaded and downloaded programmatically from scripts. No authentication is required to download data from public repositories.

An API wrapper around the ProPublica API <https://projects.propublica.org/api-docs/congress-api/> for U.S. Congressional Bills. Users can include their API key, U.S. Congress, branch, and offset ranges, to return a dataframe of all results within those parameters. This package is different from the RPublica package because it is for the ProPublica U.S. Congress data API, and the RPublica package is for the Nonprofit Explorer, Forensics, and Free the Files data APIs.

We innovatively defined a pathway mutation accumulate perturbation score (PMAPscore) to reflect the position and the cumulative effect of the genetic mutations at the pathway level. Based on the PMAPscore of pathways, identified prognosis-related pathways altered by somatic mutation and predict immunotherapy efficacy by constructing a multiple-pathway-based risk model (Tarca, Adi Laurentiu et al (2008) <doi:10.1093/bioinformatics/btn577>).

Computing Average and TPX Power under various BHFDR type sequential procedures. All of these procedures involve control of some summary of the distribution of the FDP, e.g. the proportion of discoveries which are false in a given experiment. The most widely known of these, the BH-FDR procedure, controls the FDR which is the mean of the FDP. A lesser known procedure, due to Lehmann and Romano, controls the FDX, or probability that the FDP exceeds a user provided threshold. This is less conservative than FWE control procedures but much more conservative than the BH-FDR proceudre. This package and the references supporting it introduce a new procedure for controlling the FDX which we call the BH-FDX procedure. This procedure iteratively identifies, given alpha and lower threshold delta, an alpha* less than alpha at which BH-FDR guarantees FDX control. This uses asymptotic approximation and is only slightly more conservative than the BH-FDR procedure. Likewise, we can think of the power in multiple testing experiments in terms of a summary of the distribution of the True Positive Proportion (TPP), the portion of tests truly non-null distributed that are called significant. The package will compute power, sample size or any other missing parameter required for power defined as (i) the mean of the TPP (average power) or (ii) the probability that the TPP exceeds a given value, lambda, (TPX power) via asymptotic approximation. All supplied theoretical results are also obtainable via simulation. The suggested approach is to narrow in on a design via the theoretical approaches and then make final adjustments/verify the results by simulation. The theoretical results are described in Izmirlian, G (2020) Statistics and Probability letters, "<doi:10.1016/j.spl.2020.108713>", and an applied paper describing the methodology with a simulation study is in preparation. See citation("pwrFDR").