Defines thresholds for breaking data into a number of discrete levels, minimizing the (mean) squared error within all bins.

Single-cell datasets are growing in size, posing challenges as well as opportunities for genomics researchers. ondisc is an R package that facilitates analysis of large-scale single-cell data out-of-core on a laptop or distributed across tens to hundreds of processors on a cluster or cloud. In both of these settings, ondisc requires only a few gigabytes of memory, even if the input data are tens of gigabytes in size. ondisc mainly is oriented toward single-cell CRISPR screen analysis, but also can be used for single-cell differential expression and single-cell co-expression analyses. ondisc is powered by several new, efficient algorithms for manipulating and querying large, sparse expression matrices.

This package provides tools for converting Open-Source Tools for Training Resources (OTTR) courses into Leanpub or Coursera courses. ottrpal is for use with the OTTR Template repository to create courses.

The olr function systematically evaluates multiple linear regression models by exhaustively fitting all possible combinations of independent variables against the specified dependent variable. It selects the model that yields the highest adjusted R-squared (by default) or R-squared, depending on user preference. In model evaluation, both R-squared and adjusted R-squared are key metrics: R-squared measures the proportion of variance explained but tends to increase with the addition of predictorsâ regardless of relevanceâ potentially leading to overfitting. Adjusted R-squared compensates for this by penalizing model complexity, providing a more balanced view of fit quality. The goal of olr is to identify the most suitable model that captures the underlying structure of the data while avoiding unnecessary complexity. By comparing both metrics, it offers a robust evaluation framework that balances predictive power with model parsimony. Example Analogy: Imagine a gardener trying to understand what influences plant growth (the dependent variable). They might consider variables like sunlight, watering frequency, soil type, and nutrients (independent variables). Instead of manually guessing which combination works best, the olr function automatically tests every possible combination of predictors and identifies the most effective modelâ based on either the highest R-squared or adjusted R-squared value. This saves the user from trial-and-error modeling and highlights only the most meaningful variables for explaining the outcome. A Python version is also available at <https://pypi.org/project/olr>.

Seamlessly build and manipulate graph structures, leveraging its high-performance methods for filtering, joining, and mutating data. Ensures that mutations and changes to the graph are performed in place, streamlining your workflow for optimal productivity.

Supports the modeling of ordinal random variables, like the outcomes of races, via Softmax regression, under the Harville <doi:10.1080/01621459.1973.10482425> and Henery <doi:10.1111/j.2517-6161.1981.tb01153.x> models.

An implementation of the Rapid Assessment Method for Older People or RAM-OP <https://www.helpage.org/resource/rapid-assessment-method-for-older-people-ramop-manual/>. It provides various functions that allow the user to design and plan the assessment and analyse the collected data. RAM-OP provides accurate and reliable estimates of the needs of older people.

Runtime OpenCL support for R package developers: probe hardware and drivers, load and concatenate kernel sources, and manage dependency-annotated .cl libraries, so packages like nmathopencl and other ported libraries can offer GPU acceleration without each re-implementing the same plumbing. Vignettes use the glmbayes envelope-gradient example and likelihood subgradient methodology (Nygren and Nygren, 2006, <doi:10.1198/016214506000000357>).

The OLStrajr package provides comprehensive functions for ordinary least squares (OLS) trajectory analysis and case-by-case OLS regression as outlined in Carrig, Wirth, and Curran (2004) <doi:10.1207/S15328007SEM1101_9> and Rogosa and Saner (1995) <doi:10.3102/10769986020002149>. It encompasses two primary functions, OLStraj() and cbc_lm(). The OLStraj() function simplifies the estimation of individual growth curves over time via OLS regression, with options for visualizing both group-level and individual-level growth trajectories and support for linear and quadratic models. The cbc_lm() function facilitates case-by-case OLS estimates and provides unbiased mean population intercept and slope estimators by averaging OLS intercepts and slopes across cases. It further offers standard error calculations across bootstrap replicates and computation of 95% confidence intervals based on empirical distributions from the resampling processes.

This package performs robust cluster analysis allowing for outliers and noise that cannot be fitted by any cluster. The data are modelled by a mixture of Gaussian distributions and a noise component, which is an improper uniform distribution covering the whole Euclidean space. Parameters are estimated by (pseudo) maximum likelihood. This is fitted by a EM-type algorithm. See Coretto and Hennig (2016) <doi:10.1080/01621459.2015.1100996>, and Coretto and Hennig (2017) <https://jmlr.org/papers/v18/16-382.html>.

Machine learning estimator specifically optimized for predictive modeling of ordered non-numeric outcomes. ocf provides forest-based estimation of the conditional choice probabilities and the covariatesâ marginal effects. Under an "honesty" condition, the estimates are consistent and asymptotically normal and standard errors can be obtained by leveraging the weight-based representation of the random forest predictions. Please reference the use as Di Francesco (2025) <doi:10.1080/07474938.2024.2429596>.

Detect the number and locations of change points. The locations can be either exact or in terms of ranges, depending on the available computational resource. The method is based on Jie Ding, Yu Xiang, Lu Shen, Vahid Tarokh (2017) <doi:10.1109/TSP.2017.2711558>.

An extension to the Regression Modeling Strategies package that facilitates plotting ordinal regression model predictions together with confidence intervals for each dependent variable level. It also adds a functionality to plot the model summary as a modifiable object.

The Sequence of Physical Processes (SPP) framework is a way of interpreting the transient data derived from oscillatory rheological tests. It is designed to allow both the linear and non-linear deformation regimes to be understood within a single unified framework. This code provides a convenient way to determine the SPP framework metrics for a given sample of oscillatory data. It will produce a text file containing the SPP metrics, which the user can then plot using their software of choice. It can also produce a second text file with additional derived data (components of tangent, normal, and binormal vectors), as well as pre-plotted figures if so desired. It is the R version of the Package SPP by Simon Rogers Group for Soft Matter (Simon A. Rogers, Brian M. Erwin, Dimitris Vlassopoulos, Michel Cloitre (2011) <doi:10.1122/1.3544591>).

This package provides functions for implementing different versions of the OSCV method in the kernel regression and density estimation frameworks. The package mainly supports the following articles: (1) Savchuk, O.Y., Hart, J.D. (2017). Fully robust one-sided cross-validation for regression functions. Computational Statistics, <doi:10.1007/s00180-017-0713-7> and (2) Savchuk, O.Y. (2017). One-sided cross-validation for nonsmooth density functions, <arXiv:1703.05157>.

This package provides clustering of genes with similar dose response (or time course) profiles. It implements the method described by Lin et al. (2012).

Observational studies are limited in that there could be an unmeasured variable related to both the response variable and the primary predictor. If this unmeasured variable were included in the analysis it would change the relationship (possibly changing the conclusions). Sensitivity analysis is a way to see how much of a relationship needs to exist with the unmeasured variable before the conclusions change. This package provides tools for doing a sensitivity analysis for regression (linear, logistic, and cox) style models.

Ordinal data classification, clustering and co-clustering using model-based approach with the BOS (Binary Ordinal Search) distribution for ordinal data (Christophe Biernacki and Julien Jacques (2016) <doi:10.1007/s11222-015-9585-2>).

Wrapper around the Open Source Routing Machine (OSRM) API <http://project-osrm.org/>. osrmr works with API versions 4 and 5 and can handle servers that run locally as well as the OSRM webserver.

Three-dimensional rendering for grid and ggplot2 graphics using cubes and cuboids drawn with an oblique projection. As a special case also supports primary view orthographic projections. Can be viewed as an extension to the isocubes package <https://github.com/coolbutuseless/isocubes>.

Consider a data matrix of n individuals with p variates. The objective general index (OGI) is a general index that combines the p variates into a univariate index in order to rank the n individuals. The OGI is always positively correlated with each of the variates. More details can be found in Sei (2016) <doi:10.1016/j.jmva.2016.02.005>.

This package implements a tree-based method specifically designed for personalized medicine applications. By using genomic and mutational data, ODT efficiently identifies optimal drug recommendations tailored to individual patient profiles. The ODT algorithm constructs decision trees that bifurcate at each node, selecting the most relevant markers (discrete or continuous) and corresponding treatments, thus ensuring that recommendations are both personalized and statistically robust. This iterative approach enhances therapeutic decision-making by refining treatment suggestions until a predefined group size is achieved. Moreover, the simplicity and interpretability of the resulting trees make the method accessible to healthcare professionals. Includes functions for training the decision tree, making predictions on new samples or patients, and visualizing the resulting tree. For detailed insights into the methodology, please refer to Gimeno et al. (2023) <doi:10.1093/bib/bbad200>.

It implements functions for simulation and estimation of the ordinal latent block model (OLBM), as described in Corneli, Bouveyron and Latouche (2019).

Offers a gene-based meta-analysis test with filtering to detect gene-environment interactions (GxE) with association data, proposed by Wang et al. (2018) <doi:10.1002/gepi.22115>. It first conducts a meta-filtering test to filter out unpromising SNPs by combining all samples in the consortia data. It then runs a test of omnibus-filtering-based GxE meta-analysis (ofGEM) that combines the strengths of the fixed- and random-effects meta-analysis with meta-filtering. It can also analyze data from multiple ethnic groups.