This package provides functions for working with primary event censored distributions and Stan implementations for use in Bayesian modeling. Primary event censored distributions are useful for modeling delayed reporting scenarios in epidemiology and other fields (Charniga et al. (2024) <doi:10.48550/arXiv.2405.08841>). It also provides support for arbitrary delay distributions, a range of common primary distributions, and allows for truncation and secondary event censoring to be accounted for (Park et al. (2024) <doi:10.1101/2024.01.12.24301247>). A subset of common distributions also have analytical solutions implemented, allowing for faster computation. In addition, it provides multiple methods for fitting primary event censored distributions to data via optional dependencies.

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software. Some features are 1) CDISC SDTM terms 2) Automatic slope selection with the same criterion of WinNonlin(R) 3) Supporting both linear-up linear-down and linear-up log-down method 4) Interval(partial) AUCs with linear or log interpolation method * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

Piecewise constant hazard models for survival data. The package allows for right-censored, left-truncated, and interval-censored data.

Enables user to perform the following: 1. Roll n number of die/dice (roll()). 2. Toss n number of coin(s) (toss()). 3. Play the game of Rock, Paper, Scissors. 4. Choose n number of card(s) from a pack of 52 playing cards (Joker optional).

Assessment of habitat selection by means of the permutation-based combination of sign tests (Fattorini et al., 2014 <DOI:10.1007/s10651-013-0250-7>). To exemplify the application of this procedure, habitat selection is assessed for a population of European Brown Hares settled in central Italy.

Bayesian estimation and analysis methods for Probit Unfolding Models (PUMs), a novel class of scaling models designed for binary preference data. These models allow for both monotonic and non-monotonic response functions. The package supports Bayesian inference for both static and dynamic PUMs using Markov chain Monte Carlo (MCMC) algorithms with minimal or no tuning. Key functionalities include posterior sampling, hyperparameter selection, data preprocessing, model fit evaluation, and visualization. The methods are particularly suited to analyzing voting data, such as from the U.S. Congress or Supreme Court, but can also be applied in other contexts where non-monotonic responses are expected. For methodological details, see Shi et al. (2025) <doi:10.48550/arXiv.2504.00423>.

The goal of pak is to make package installation faster and more reliable. In particular, it performs all HTTP operations in parallel, so metadata resolution and package downloads are fast. Metadata and package files are cached on the local disk as well. pak has a dependency solver, so it finds version conflicts before performing the installation. This version of pak supports CRAN, Bioconductor and GitHub packages as well.

Calculates, via simulation, power and appropriate stopping alpha boundaries (and/or futility bounds) for sequential analyses (i.e., group sequential design) as well as for multiple hypotheses (multiple tests included in an analysis), given any specified global error rate. This enables the sequential use of practically any significance test, as long as the underlying data can be simulated in advance to a reasonable approximation. Lukács (2022) <doi:10.21105/joss.04643>.

The propensity score is one of the most widely used tools in studying the causal effect of a treatment, intervention, or policy. Given that the propensity score is usually unknown, it has to be estimated, implying that the reliability of many treatment effect estimators depends on the correct specification of the (parametric) propensity score. This package implements the data-driven nonparametric diagnostic tools for detecting propensity score misspecification proposed by Sant'Anna and Song (2019) <doi:10.1016/j.jeconom.2019.02.002>.

Plot marginal effects for interactions estimated from linear models.

This package provides a project infrastructure with a focus on manuscript creation. Creates a project folder with a single command, containing subdirectories for specific components, templates for manuscripts, and so on.

Analyse prescription drug deliveries to calculate several indicators of polypharmacy corresponding to the various definitions found in the literature. Bjerrum, L., Rosholm, J. U., Hallas, J., & Kragstrup, J. (1997) <doi:10.1007/s002280050329>. Chan, D.-C., Hao, Y.-T., & Wu, S.-C. (2009a) <doi:10.1002/pds.1712>. Fincke, B. G., Snyder, K., Cantillon, C., Gaehde, S., Standring, P., Fiore, L., ... Gagnon, D.R. (2005) <doi:10.1002/pds.966>. Hovstadius, B., Astrand, B., & Petersson, G. (2009) <doi:10.1186/1472-6904-9-11>. Hovstadius, B., Astrand, B., & Petersson, G. (2010) <doi:10.1002/pds.1921>. Kennerfalk, A., Ruigómez, A., Wallander, M.-A., Wilhelmsen, L., & Johansson, S. (2002) <doi:10.1345/aph.1A226>. Masnoon, N., Shakib, S., Kalisch-Ellett, L., & Caughey, G. E. (2017) <doi:10.1186/s12877-017-0621-2>. Narayan, S. W., & Nishtala, P. S. (2015) <doi:10.1007/s40801-015-0020-y>. Nishtala, P. S., & Salahudeen, M. S. (2015) <doi:10.1159/000368191>. Park, H. Y., Ryu, H. N., Shim, M. K., Sohn, H. S., & Kwon, J. W. (2016) <doi:10.5414/cp202484>. Veehof, L., Stewart, R., Haaijer-Ruskamp, F., & Jong, B. M. (2000) <doi:10.1093/fampra/17.3.261>.

Prepares data for statistical analysis (e.g., analysis of variance ;ANOVA) by enabling the user to easily and quickly merge (using the file_merge() function) raw data files into one merged table and then aggregate the merged table (using the prep() function) into a finalized table while keeping track and summarizing every step of the preparation. The finalized table contains several possibilities for dependent measures of the dependent variable. Most suitable when measuring variables in an interval or ratio scale (e.g., reaction-times) and/or discrete values such as accuracy. Main functions included are file_merge() and prep(). The file_merge() function vertically merges individual data files (in a long format) in which each line is a single observation to one single dataset. The prep() function aggregates the single dataset according to any combination of grouping variables (i.e., between-subjects and within-subjects independent variables, respectively), and returns a data frame with a number of dependent measures for further analysis for each cell according to the combination of provided grouping variables. Dependent measures for each cell include among others means before and after rejecting all values according to a flexible standard deviation criteria, number of rejected values according to the flexible standard deviation criteria, proportions of rejected values according to the flexible standard deviation criteria, number of values before rejection, means after rejecting values according to procedures described in Van Selst & Jolicoeur (1994; suitable when measuring reaction-times), standard deviations, medians, means according to any percentile (e.g., 0.05, 0.25, 0.75, 0.95) and harmonic means. The data frame prep() returns can also be exported as a txt file to be used for statistical analysis in other statistical programs.

This package contains the core methods for the evaluation of principal surrogates in a single clinical trial. Provides a flexible interface for defining models for the risk given treatment and the surrogate, the models for integration over the missing counterfactual surrogate responses, and the estimation methods. Estimated maximum likelihood and pseudo-score can be used for estimation, and the bootstrap for inference. A variety of post-estimation summary methods are provided, including print, summary, plot, and testing.

Looks for amino acid and/or nucleotide patterns and/or small ligands coordinated to a given prosthetic centre. Files have to be in the local file system and contain proper extension.

Optimization of conditional inference trees from the package party for classification and regression. For optimization, the model space is searched for the best tree on the full sample by means of repeated subsampling. Restrictions are allowed so that only trees are accepted which do not include pre-specified uninterpretable split results (cf. Weihs & Buschfeld, 2021a). The function PrInDT() represents the basic resampling loop for 2-class classification (cf. Weihs & Buschfeld, 2021a). The function RePrInDT() (repeated PrInDT()) allows for repeated applications of PrInDT() for different percentages of the observations of the large and the small classes (cf. Weihs & Buschfeld, 2021c). The function NesPrInDT() (nested PrInDT()) allows for an extra layer of subsampling for a specific factor variable (cf. Weihs & Buschfeld, 2021b). The functions PrInDTMulev() and PrInDTMulab() deal with multilevel and multilabel classification. In addition to these PrInDT() variants for classification, the function PrInDTreg() has been developed for regression problems. Finally, the function PostPrInDT() allows for a posterior analysis of the distribution of a specified variable in the terminal nodes of a given tree. In version 2, additionally structured sampling is implemented in functions PrInDTCstruc() and PrInDTRstruc(). In these functions, repeated measurements data can be analyzed, too. Moreover, multilabel 2-stage versions of classification and regression trees are implemented in functions C2SPrInDT() and R2SPrInDT() as well as interdependent multilabel models in functions SimCPrInDT() and SimRPrInDT(). Finally, for mixtures of classification and regression models functions Mix2SPrInDT() and SimMixPrInDT() are implemented. Most of these extensions of PrInDT are described in Buschfeld & Weihs (2025Fc). References: -- Buschfeld, S., Weihs, C. (2025Fc) "Optimizing decision trees for the analysis of World Englishes and sociolinguistic data", Cambridge Elements. -- Weihs, C., Buschfeld, S. (2021a) "Combining Prediction and Interpretation in Decision Trees (PrInDT) - a Linguistic Example" <doi:10.48550/arXiv.2103.02336>; -- Weihs, C., Buschfeld, S. (2021b) "NesPrInDT: Nested undersampling in PrInDT" <doi:10.48550/arXiv.2103.14931>; -- Weihs, C., Buschfeld, S. (2021c) "Repeated undersampling in PrInDT (RePrInDT): Variation in undersampling and prediction, and ranking of predictors in ensembles" <doi:10.48550/arXiv.2108.05129>.

The aim of postpack is to provide the infrastructure for a standardized workflow for mcmc.list objects. These objects can be used to store output from models fitted with Bayesian inference using JAGS', WinBUGS', OpenBUGS', NIMBLE', Stan', or even custom MCMC algorithms. Although the coda R package provides some methods for these objects, it is somewhat limited in easily performing post-processing tasks for specific nodes. Models are ever increasing in their complexity and the number of tracked nodes, and oftentimes a user may wish to summarize/diagnose sampling behavior for only a small subset of nodes at a time for a particular question or figure. Thus, many postpack functions support performing tasks on a subset of nodes, where the subset is specified with regular expressions. The functions in postpack streamline the extraction, summarization, and diagnostics of specific monitored nodes after model fitting. Further, because there is rarely only ever one model under consideration, postpack scales efficiently to perform the same tasks on output from multiple models simultaneously, facilitating rapid assessment of model sensitivity to changes in assumptions.

Publish data sets, models, and other R objects, making it easy to share them across projects and with your colleagues. You can pin objects to a variety of "boards", including local folders (to share on a networked drive or with DropBox'), Posit Connect', AWS S3', and more.

This package provides functions to estimate the kinship matrix of individuals from a large set of biallelic SNPs, and extract inbreeding coefficients and the generalized FST (Wright's fixation index). Method described in Ochoa and Storey (2021) <doi:10.1371/journal.pgen.1009241>.

This package provides a suite of Propensity Score Predictive Inference (PSPI) methods to generalize treatment effects in trials to target populations. The package includes an existing model Bayesian Causal Forest (BCF) and four PSPI models (BCF-PS, FullBART, SplineBART, DSplineBART). These methods leverage Bayesian Additive Regression Trees (BART) to adjust for high-dimensional covariates and nonlinear associations, while SplineBART and DSplineBART further use propensity score based splines to address covariate shift between trial data and target population.

Genotyping arrays enable the direct measurement of an individuals genotype at thousands of markers. plinkQC facilitates genotype quality control for genetic association studies as described by Anderson and colleagues (2010) <doi:10.1038/nprot.2010.116>. It makes PLINK basic statistics (e.g. missing genotyping rates per individual, allele frequencies per genetic marker) and relationship functions accessible from R and generates a per-individual and per-marker quality control report. Individuals and markers that fail the quality control can subsequently be removed to generate a new, clean dataset. Removal of individuals based on relationship status is optimised to retain as many individuals as possible in the study. Additionally, there is a trained classifier to predict genomic ancestry of human samples.

Validate data in data frames, tibble objects, Spark DataFrames', and database tables. Validation pipelines can be made using easily-readable, consecutive validation steps. Upon execution of the validation plan, several reporting options are available. User-defined thresholds for failure rates allow for the determination of appropriate reporting actions. Many other workflows are available including an information management workflow, where the aim is to record, collect, and generate useful information on data tables.

For working with the Prevision.io AI model management platform's API <https://prevision.io/>.

This package contains functions to classify the pixels of an image file by its colour. It implements a simple form of the techniques known as Support Vector Machine adapted to this particular problem.