This package contains a collection of functions for performing different kinds of calculation that are of interest to someone following a diet plan. Calculators for the Basal Metabolic Rate are based on Mifflin et al. (1990) <doi:10.1093/ajcn/51.2.241> and McArdle, W. D., Katch, F. I., & Katch, V. L. (2010, ISBN:9780812109917).

This package performs nonparametric estimation in mixture cure models, and significance tests for the cure probability. For details, see López-Cheda et al. (2017a) <doi:10.1016/j.csda.2016.08.002> and López-Cheda et al. (2017b) <doi:10.1007/s11749-016-0515-1>.

Assists actuaries and other insurance modellers in pricing, reserving and capital modelling for non-life insurance and reinsurance modelling. Provides functions that help model excess levels, capping and pure Incurred but not reported claims (pure IBNR). Includes capped mean, exposure curves and increased limit factor curves (ILFs) for LogNormal, Gamma, Pareto, Sliced LogNormal-Pareto and Sliced Gamma-Pareto distributions. Includes mean, probability density function (pdf), cumulative probability function (cdf) and inverse cumulative probability function for Sliced LogNormal-Pareto and Sliced Gamma-Pareto distributions. Includes calculating pure IBNR exposure with LogNormal and Gamma distribution for reporting delay. Includes three shiny tools: a claims simulator with reinsurance structures, a generalised linear model fitting tool, and a claims frequency and severity distribution fitting tool. Methods used in the package refer to Free for All by Yiannis Parizas (2023) <https://www.theactuary.com/2023/03/02/free-all>; Escaping the triangle by Yiannis Parizas (2019) <https://www.theactuary.com/features/2019/06/2019/06/05/escaping-triangle>; Taken to excess by Yiannis Parizas (2019) <https://www.theactuary.com/features/2019/03/2019/03/06/taken-excess>.

Near-far matching is a study design technique for preprocessing observational data to mimic a pair-randomized trial. Individuals are matched to be near on measured confounders and far on levels of an instrumental variable. Methods outlined in further detail in Rigdon, Baiocchi, and Basu (2018) <doi:10.18637/jss.v086.c05>.

This package provides a multi-core R package that contains a set of tools based on copula graphical models for accomplishing the three interrelated goals in genetics and genomics in an unified way: (1) linkage map construction, (2) constructing linkage disequilibrium networks, and (3) exploring high-dimensional genotype-phenotype network and genotype- phenotype-environment interactions networks. The netgwas package can deal with biparental inbreeding and outbreeding species with any ploidy level, namely diploid (2 sets of chromosomes), triploid (3 sets of chromosomes), tetraploid (4 sets of chromosomes) and so on. We target on high-dimensional data where number of variables p is considerably larger than number of sample sizes (p >> n). The computations is memory-optimized using the sparse matrix output. The netgwas implements the methodological developments in Behrouzi and Wit (2017) <doi:10.1111/rssc.12287> and Behrouzi and Wit (2017) <doi:10.1093/bioinformatics/bty777>.

This package provides quality control (QC), normalization, and batch effect correction operations for NanoString nCounter data, Talhouk et al. (2016) <doi:10.1371/journal.pone.0153844>. Various metrics are used to determine which samples passed or failed QC. Gene expression should first be normalized to housekeeping genes, before a reference-based approach is used to adjust for batch effects. Raw NanoString data can be imported in the form of Reporter Code Count (RCC) files.

This package provides Scilab n1qn1'. This takes more memory than traditional L-BFGS. The n1qn1 routine is useful since it allows prespecification of a Hessian. If the Hessian is near enough the truth in optimization it can speed up the optimization problem. The algorithm is described in the Scilab optimization documentation located at <https://www.scilab.org/sites/default/files/optimization_in_scilab.pdf>. This version uses manually modified code from f2c to make this a C only binary.

Scrapes and cleans data from the NHL and ESPN APIs into data.frames and lists. Wraps 125+ endpoints documented in <https://github.com/RentoSaijo/nhlscraper/wiki> from high-level multi-season summaries and award winners to low-level decisecond replays and bookmakers odds, making them more accessible. Features cleaning and visualization tools, primarily for play-by-plays.

Clustering unilayer and multilayer network data by means of finite mixtures is the main utility of netClust.

Calculate Overall Survival or Recurrence-Free Survival for breast cancer patients, using NHS Predict'. The time interval for the estimation can be set up to 15 years, with default at 10. Incremental therapy benefits are estimated for hormone therapy, chemotherapy, trastuzumab, and bisphosphonates. An additional function, suited for SCAN audits, features a more user-friendly version of the code, with fewer inputs, but necessitates the correct standardised inputs. This work is not affiliated with the development of NHS Predict and its underlying statistical model. Details on NHS Predict can be found at: <doi:10.1186/bcr2464>. The web version of NHS Predict': <https://breast.predict.nhs.uk/>. A small dataset of 50 fictional patient observations is provided for the purpose of running examples with the main two functions, and an additional dataset is provided for running example with the dedicated SCAN function.

This package implements node subsampling methods for multivariate inference on network moments (rescaled motif counts), including: uniform node subsampling to approximate the joint distribution of multiple network moments (Algorithm 1); externally sparsified moments for density-matched comparisons (Algorithm 2); and a two-sample test for unmatchable networks with unequal edge densities via a split-and-sparsify subsampling procedure (Algorithm 3). Built-in support for V-shape (2-star), triangle, and 3-star motifs, with a user-extensible interface for arbitrary additional motifs. Parallel execution is supported via doParallel and foreach'. Based on Qi, Hua, Li and Zhou (2024) <doi:10.48550/arXiv.2409.01599>.

Fits nonlinear Bayesian extensions of the Fay-Herriot model for small area estimation using area-level direct estimates and corresponding sampling variances. The package provides model fitting, prediction, uncertainty summaries, and diagnostic tools for nonlinear small area estimation workflows.

This package performs variable selection in sparse negative binomial GLARMA (Generalised Linear Autoregressive Moving Average) models. For further details we refer the reader to the paper Gomtsyan (2023), <arXiv:2307.00929>.

This shows how NONMEM (Beal SL, Sheiner LB, Boeckmann AJ, Bauer RJ. NONMEM 7.5 Users Guides. Icon plc, 2020) software works. NONMEM classical estimation methods such as First Order (FO) approximation', First Order Conditional Estimation (FOCE)', and Laplacian approximation are explained. Functions are also provided for post-run processing of NONMEM output files, generating PDF or Markdown diagnostic reports including objective function value analysis, parameter estimates, prediction and residual diagnostics, empirical Bayes estimate (EBE) analysis, input data summary, and individual pharmacokinetic parameter distributions. Helper utilities for building NONMEM-ready datasets from SDTM-style source tables are also included.

Performing drug response analyses and IC50 estimations using n-Parameter logistic regression. Can also be applied to proliferation analyses.

Library to plot performance profiles (Dolan and More (2002) <doi:10.1007/s101070100263>) and nested performance profiles (Hekmati and Mirhajianmoghadam (2019) <doi:10.19139/soic-2310-5070-679>) for a given data frame.

This package provides a set of functions to scrape and analyze rugby data. Supports competitions including the National Rugby League, New South Wales Cup, Queensland Cup, Super League, and various representative and women's competitions. Includes functions to fetch player statistics, match results, ladders, venues, and coaching data. Designed to assist analysts, fans, and researchers in exploring historical and current rugby league data. See Woods et al. (2017) <doi:10.1123/ijspp.2016-0187> for an example of rugby league performance analysis methodology.

Simulate demand and attributes for ready to launch new products during their life cycle, or during their introduction and growth phases. You provide the number of products, attributes, time periods and/or other parameters and npdsim can simulate for you the demand for each product during the considered time periods, and the attributes of each product. The simulation for the demand is based on the idea that each product has a shape and a level, where the level is the cumulative demand over the considered time periods, and the shape is the normalized demand across those time periods.

Computes and plots the boundary between night and day.

Nonparametric methods for analysis of covariance (ANCOVA) are distribution-free and provide a flexible statistical framework for situations where the assumptions of parametric ANCOVA are violated or when the response variable is ordinal. This package implements several well-known nonparametric ANCOVA procedures, including Quade, Puri and Sen, McSweeney and Porter, Burnett and Barr, Hettmansperger and McKean, Shirley, and Puri-Sen-Harwell-Serlin. The package provides user-friendly functions to apply these methods in practice. These methods are described in Olejnik et al. (1985) <doi:10.1177/0193841X8500900104> and Harwell et al. (1988) <doi:10.1037/0033-2909.104.2.268>.

Nested Partially Balanced Bipartite Block (NPBBB) designs involve two levels of blocking: (i) The block design (ignoring sub-block classification) serves as a partially balanced bipartite block (PBBB) design, and (ii) The sub-block design (ignoring block classification) also serves as a PBBB design. More details on constructions of the PBBB designs and their characterization properties are available in Vinayaka et al.(2023) <doi:10.1080/03610926.2023.2251623>. This package calculates A-efficiency values for both block and sub-block structures, along with all parameters of a given NPBBB design.

An efficient unified nonconvex penalized estimation algorithm for Gaussian (linear), binomial Logit (logistic), Poisson, multinomial Logit, and Cox proportional hazard regression models. The unified algorithm is implemented based on the convex concave procedure and the algorithm can be applied to most of the existing nonconvex penalties. The algorithm also supports convex penalty: least absolute shrinkage and selection operator (LASSO). Supported nonconvex penalties include smoothly clipped absolute deviation (SCAD), minimax concave penalty (MCP), truncated LASSO penalty (TLP), clipped LASSO (CLASSO), sparse ridge (SRIDGE), modified bridge (MBRIDGE) and modified log (MLOG). For high-dimensional data (data set with many variables), the algorithm selects relevant variables producing a parsimonious regression model. Kim, D., Lee, S. and Kwon, S. (2021) <doi:10.32614/RJ-2021-003>, Lee, S., Kwon, S. and Kim, Y. (2016) <doi:10.1016/j.csda.2015.08.019>, Kwon, S., Lee, S. and Kim, Y. (2015) <doi:10.1016/j.csda.2015.07.001>. (This research is funded by Julian Virtue Professorship from Center for Applied Research at Pepperdine Graziadio Business School and the National Research Foundation of Korea.).

Training of neural networks using backpropagation, resilient backpropagation with (Riedmiller, 1994) or without weight backtracking (Riedmiller and Braun, 1993) or the modified globally convergent version by Anastasiadis et al. (2005). The package allows flexible settings through custom-choice of error and activation function. Furthermore, the calculation of generalized weights (Intrator O & Intrator N, 1993) is implemented.

This package provides a comprehensive set of functions providing frequentist methods for network meta-analysis (Balduzzi et al., 2023) <doi:10.18637/jss.v106.i02> and supporting Schwarzer et al. (2015) <doi:10.1007/978-3-319-21416-0>, Chapter 8 "Network Meta-Analysis": - frequentist network meta-analysis following Rücker (2012) <doi:10.1002/jrsm.1058>; - additive network meta-analysis for combinations of treatments (Rücker et al., 2020) <doi:10.1002/bimj.201800167>; - network meta-analysis of binary data using the Mantel-Haenszel or non-central hypergeometric distribution method (Efthimiou et al., 2019) <doi:10.1002/sim.8158>, or penalised logistic regression (Evrenoglou et al., 2022) <doi:10.1002/sim.9562>; - rankograms and ranking of treatments by the Surface under the cumulative ranking curve (SUCRA) (Salanti et al., 2013) <doi:10.1016/j.jclinepi.2010.03.016>; - ranking of treatments using P-scores (frequentist analogue of SUCRAs without resampling) according to Rücker & Schwarzer (2015) <doi:10.1186/s12874-015-0060-8>; - split direct and indirect evidence to check consistency (Dias et al., 2010) <doi:10.1002/sim.3767>, (Efthimiou et al., 2019) <doi:10.1002/sim.8158>; - scatter plot to visualize local inconsistency (Wilson et al., 2026) <doi:10.1017/rsm.2026.10082>; - league table with network meta-analysis results; - comparison-adjusted funnel plot (Chaimani & Salanti, 2012) <doi:10.1002/jrsm.57>; - net heat plot and design-based decomposition of Cochran's Q according to Krahn et al. (2013) <doi:10.1186/1471-2288-13-35>; - measures characterizing the flow of evidence between two treatments by König et al. (2013) <doi:10.1002/sim.6001>; - automated drawing of network graphs described in Rücker & Schwarzer (2016) <doi:10.1002/jrsm.1143>; - partial order of treatment rankings ('poset') and Hasse diagram for poset (Carlsen & Bruggemann, 2014) <doi:10.1002/cem.2569>; (Rücker & Schwarzer, 2017) <doi:10.1002/jrsm.1270>; - contribution matrix as described in Papakonstantinou et al. (2018) <doi:10.12688/f1000research.14770.3> and Davies et al. (2022) <doi:10.1002/sim.9346>; - path-based approach for detecting and assessing inconsistency; - network meta-regression with a single continuous or binary covariate (Kwarteng et al., 2026) <doi:10.21203/rs.3.rs-8235913/v1>; - subgroup network meta-analysis.