This package provides functions to perform Bayesian inference on absorption time data for Phase-type distributions. The methods of Bladt et al (2003) <doi:10.1080/03461230110106435> and Aslett (2012) <https://www.louisaslett.com/PhD_Thesis.pdf> are provided.

This package provides functions to load Research Patient Data Registry ('RPDR') text queries from Partners Healthcare institutions into R. The package also provides helper functions to manipulate data and execute common procedures such as finding the closest radiological exams considering a given timepoint, or creating a DICOM header database from the downloaded images. All functionalities are parallelized for fast and efficient analyses.

Offers an interactive RStudio gadget interface for communicating with OpenAI large language models (e.g., gpt-5', gpt-5-mini', gpt-5-nano') (<https://platform.openai.com/docs/api-reference>). Enables users to conduct multiple chat conversations simultaneously in separate tabs. Supports uploading local files (R, PDF, DOCX) to provide context for the models. Allows per-conversation configuration of system messages (where supported by the model). API interactions via the httr package are performed asynchronously using promises and future to avoid blocking the R console. Useful for tasks like code generation, text summarization, and document analysis directly within the RStudio environment. Requires an OpenAI API key set as an environment variable.

Statistical power analysis for designs including t-tests, correlations, multiple regression, ANOVA, mediation, and logistic regression. Functions accompany Aberson (2019) <doi:10.4324/9781315171500>.

Supports propensity score weighting analysis of observational studies and randomized trials. Enables the estimation and inference of average causal effects with binary and multiple treatments using overlap weights (ATO), inverse probability of treatment weights (ATE), average treatment effect among the treated weights (ATT), matching weights (ATM) and entropy weights (ATEN), with and without propensity score trimming. These weights are members of the family of balancing weights introduced in Li, Morgan and Zaslavsky (2018) <doi:10.1080/01621459.2016.1260466> and Li and Li (2019) <doi:10.1214/19-AOAS1282>.

Interface to the Pharmpy pharmacometrics library. The Reticulate package is used to interface Python from R.

This package implements piecewise structural equation modeling from a single list of structural equations, with new methods for non-linear, latent, and composite variables, standardized coefficients, query-based prediction and indirect effects. See <http://jslefche.github.io/piecewiseSEM/> for more.

This package contains sixteen moisture sorption isotherm models, which evaluate the fitness of adsorption and desorption curves for further understanding of the relationship between moisture content and water activity. Fitness evaluation is conducted through parameter estimation and error analysis. Moreover, graphical representation, hysteresis area estimation, and isotherm classification through the equation of Blahovec & Yanniotis (2009) <doi:10.1016/j.jfoodeng.2008.08.007> which is based on the classification system introduced by Brunauer et. al. (1940) <doi:10.1021/ja01864a025> are also included for the visualization of models and hysteresis.

This package implements transformations of p-values to the smallest possible Bayes factor within the specified class of alternative hypotheses, as described in Held & Ott (2018, <doi:10.1146/annurev-statistics-031017-100307>). Covers several common testing scenarios such as z-tests, t-tests, likelihood ratio tests and the F-test.

Shrinkage estimator for polygenic risk prediction (PRS) models based on summary statistics of genome-wide association (GWA) studies. Based upon the methods and original PANPRS package as found in: Chen, Chatterjee, Landi, and Shi (2020) <doi:10.1080/01621459.2020.1764849>.

Colour palettes for data, based on some well known public data sets. Includes helper functions to map absolute values to known palettes, and capture the work of image colour mapping as raster data sets.

Implementation of the exact, normal approximation, and simulation-based methods for computing the probability mass function (pmf) and cumulative distribution function (cdf) of the Poisson-Multinomial distribution, together with a random number generator for the distribution. The exact method is based on multi-dimensional fast Fourier transformation (FFT) of the characteristic function of the Poisson-Multinomial distribution. The normal approximation method uses a multivariate normal distribution to approximate the pmf of the distribution based on central limit theorem. The simulation method is based on the law of large numbers. Details about the methods are available in Lin, Wang, and Hong (2022) <DOI:10.1007/s00180-022-01299-0>.

This package provides a variety of tools relevant to the analysis of marine soundscape data. There are tools for downloading AIS (automatic identification system) data from Marine Cadastre <https://hub.marinecadastre.gov>, connecting AIS data to GPS coordinates, plotting summaries of various soundscape measurements, and downloading relevant environmental variables (wind, swell height) from the National Center for Atmospheric Research data server <https://gdex.ucar.edu/datasets/d084001/>. Most tools were developed to work well with output from Triton software, but can be adapted to work with any similar measurements.

Analyses and reports questionnaire and experiment data exported from PsyToolkit'. The package reads downloaded study folders, parses questionnaire structure, optionally merges demographic exports from CloudResearch or Prolific, and produces summary overviews of responses and completion times. It also provides helper functions to extract and aggregate experiment measures and survey variables, and to export results to spreadsheet files for further analysis and archiving. See Stoet (2017) <doi:10.1177/0098628316677643> for the PsyToolkit platform.

We provide inference for personalized medicine models. Namely, we answer the questions: (1) how much better does a purported personalized recommendation engine for treatments do over a business-as-usual approach and (2) is that difference statistically significant?

Infer the genetic composition of individuals in terms of haplotype dosages for a haploblock, based on bi-allelic marker dosages, for any ploidy level. Reference: Voorrips and Tumino: PolyHaplotyper: haplotyping in polyploids based on bi-allelic marker dosage data. Submitted to BMC Bioinformatics (2021).

An implementation of the sample size computation method for network models proposed by Constantin et al. (2023) <doi:10.1037/met0000555>. The implementation takes the form of a three-step recursive algorithm designed to find an optimal sample size given a model specification and a performance measure of interest. It starts with a Monte Carlo simulation step for computing the performance measure and a statistic at various sample sizes selected from an initial sample size range. It continues with a monotone curve-fitting step for interpolating the statistic across the entire sample size range. The final step employs stratified bootstrapping to quantify the uncertainty around the fitted curve.

This package provides a power analysis tool for jointly testing the cause-1 cause-specific hazard and the any-cause hazard with competing risks data.

This package provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.

Helps you determine the analysis window to use when analyzing densely-sampled time-series data, such as EEG data, using permutation testing (Maris & Oostenveld, 2007) <doi:10.1016/j.jneumeth.2007.03.024>. These permutation tests can help identify the timepoints where significance of an effect begins and ends, and the results can be plotted in various types of heatmap for reporting. Mixed-effects models are supported using an implementation of the approach by Lee & Braun (2012) <doi:10.1111/j.1541-0420.2011.01675.x>.

Improves genotype inference and downstream Adaptive Immune Receptor Repertoire Sequence data analysis. Inference of allele similarity clusters, an alternative naming scheme and genotype inference for immunoglobulin heavy chain repertoires. The main tools are allele similarity clusters, and allele based genotype. The first tool is designed to reduce the ambiguity within the immunoglobulin heavy chain V alleles. The ambiguity is caused by duplicated or similar alleles which are shared among different genes. The second tool is an allele based genotype, that determined the presence of an allele based on a threshold derived from a naive population. See Peres et al. (2023) <doi:10.1093/nar/gkad603>.

This work is an extension of the state space model for Poisson count data, Poisson-Gamma model, towards a semiparametric specification. Just like the generalized additive models (GAM), cubic splines are used for covariate smoothing. The semiparametric models are fitted by an iterative process that combines maximization of likelihood and backfitting algorithm.

This package implements principal component analysis, orthogonal rotation and multiple factor analysis for a mixture of quantitative and qualitative variables.

Pattern causality is a novel approach for detecting the hidden causality in the complex system.