Extracts features from amplification curve data of quantitative Polymerase Chain Reactions (qPCR) according to Pabinger et al. 2014 <doi:10.1016/j.bdq.2014.08.002> for machine learning purposes. Helper functions prepare the amplification curve data for processing as functional data (e.g., Hausdorff distance) or enable the plotting of amplification curve classes (negative, ambiguous, positive). The hookreg() and hookregNL() functions of Burdukiewicz et al. (2018) <doi:10.1016/j.bdq.2018.08.001> can be used to predict amplification curves with an hook effect-like curvature. The pcrfit_single() function can be used to extract features from an amplification curve.

Converts TXT and XML data curated by the United States Patent and Trademark Office (USPTO). Allows conversion of bulk data after downloading directly from the USPTO bulk data website, eliminating need for users to wrangle multiple data formats to get large patent databases in tidy, rectangular format. Data details can be found on the USPTO website <https://bulkdata.uspto.gov/>. Currently, all 3 formats: 1. TXT data (1976-2001); 2. XML format 1 data (2002-2004); and 3. XML format 2 data (2005-current) can be converted to rectangular, CSV format. Relevant literature that uses data from USPTO includes Wada (2020) <doi:10.1007/s11192-020-03674-4> and Plaza & Albert (2008) <doi:10.1007/s11192-007-1763-3>.

This package provides functions to calculate commonly used public health statistics and their confidence intervals using methods approved for use in the production of Public Health England indicators such as those presented via Fingertips (<https://fingertips.phe.org.uk/>). It provides functions for the generation of proportions, crude rates, means, directly standardised rates, indirectly standardised rates, standardised mortality ratios, slope and relative index of inequality and life expectancy. Statistical methods are referenced in the following publications. Breslow NE, Day NE (1987) <doi:10.1002/sim.4780080614>. Dobson et al (1991) <doi:10.1002/sim.4780100317>. Armitage P, Berry G (2002) <doi:10.1002/9780470773666>. Wilson EB. (1927) <doi:10.1080/01621459.1927.10502953>. Altman DG et al (2000, ISBN: 978-0-727-91375-3). Chiang CL. (1968, ISBN: 978-0-882-75200-6). Newell C. (1994, ISBN: 978-0-898-62451-9). Eayres DP, Williams ES (2004) <doi:10.1136/jech.2003.009654>. Silcocks PBS et al (2001) <doi:10.1136/jech.55.1.38>. Low and Low (2004) <doi:10.1093/pubmed/fdh175>. Fingertips Public Health Technical Guide: <https://fingertips.phe.org.uk/profile/guidance/supporting-information/PH-methods/>.

Pupillometric data collected using SR Research Eyelink eye trackers requires significant preprocessing. This package contains functions for preparing pupil dilation data for visualization and statistical analysis. Specifically, it provides a pipeline of functions which aid in data validation, the removal of blinks/artifacts, downsampling, and baselining, among others. Additionally, plotting functions for creating grand average and conditional average plots are provided. See the vignette for samples of the functionality. The package is designed for handling data collected with SR Research Eyelink eye trackers using Sample Reports created in SR Research Data Viewer.

Calculates the pooled mean group (PMG) estimator for dynamic panel data models, as described by Pesaran, Shin and Smith (1999) <doi:10.1080/01621459.1999.10474156>.

This package implements entrywise splitting cross-validation (ECV) and its penalized variant (pECV) for selecting the number of factors in generalized factor models.

This package provides tools for interacting with data from experiments done in microtiter plates. Easily read in plate-shaped data and convert it to tidy format, combine plate-shaped data with tidy data, and view tidy data in plate shape.

Bayesian estimation and analysis methods for Probit Unfolding Models (PUMs), a novel class of scaling models designed for binary preference data. These models allow for both monotonic and non-monotonic response functions. The package supports Bayesian inference for both static and dynamic PUMs using Markov chain Monte Carlo (MCMC) algorithms with minimal or no tuning. Key functionalities include posterior sampling, hyperparameter selection, data preprocessing, model fit evaluation, and visualization. The methods are particularly suited to analyzing voting data, such as from the U.S. Congress or Supreme Court, but can also be applied in other contexts where non-monotonic responses are expected. For methodological details, see Shi et al. (2025) <doi:10.48550/arXiv.2504.00423>.

Computes probability-scale residuals and residual correlations for continuous, ordinal, binary, count, and time-to-event data Qi Liu, Bryan Shepherd, Chun Li (2020) <doi:10.18637/jss.v094.i12>.

An interface to simplify organizing parameters used in a package, using external configuration files. This attempts to provide a cleaner alternative to options().

Google Trends provides cross-sectional and time-series data on searches, but lacks readily available longitudinal data. Researchers, who want to create longitudinal Google Trends on their own, face practical challenges, such as normalized counts that make it difficult to combine cross-sectional and time-series data and limitations in data formats and timelines that limit data granularity over extended time periods. This package addresses these issues and enables researchers to generate longitudinal Google Trends data. This package is built on pytrends', a Python library that acts as the unofficial Google Trends API to collect Google Trends data. As long as the Google Trends API', pytrends and all their dependencies are working, this package will work. During testing, we noticed that for the same input (keyword, topic, data_format, timeline), the output index can vary from time to time. Besides, if the keyword is not very popular, then the resulting dataset will contain a lot of zeros, which will greatly affect the final result. While this package has no control over the accuracy or quality of Google Trends data, once the data is created, this package coverts it to longitudinal data. In addition, the user may encounter a 429 Too Many Requests error when using cross_section() and time_series() to collect Google Trends data. This error indicates that the user has exceeded the rate limits set by the Google Trends API'. For more information about the Google Trends API - pytrends', visit <https://pypi.org/project/pytrends/>.

Loads and processes huge text corpora processed with the sally toolbox (<http://www.mlsec.org/sally/>). sally acts as a very fast preprocessor which splits the text files into tokens or n-grams. These output files can then be read with the PRISMA package which applies testing-based token selection and has some replicate-aware, highly tuned non-negative matrix factorization and principal component analysis implementation which allows the processing of very big data sets even on desktop machines.

Create, transform, and summarize custom random variables with distribution functions (analogues of p*()', d*()', q*()', and r*() functions from base R). Two types of distributions are supported: "discrete" (random variable has finite number of output values) and "continuous" (infinite number of values in the form of continuous random variable). Functions for distribution transformations and summaries are available. Implemented approaches often emphasize approximate and numerical solutions: all distributions assume finite support and finite values of density function; some methods implemented with simulation techniques.

High-quality real-world data can be transformed into scientific real-world evidence for regulatory and healthcare decision-making using proven analytical methods and techniques. For example, propensity score (PS) methodology can be applied to select a subset of real-world data containing patients that are similar to those in the current clinical study in terms of baseline covariates, and to stratify the selected patients together with those in the current study into more homogeneous strata. Then, statistical methods such as the power prior approach or composite likelihood approach can be applied in each stratum to draw inference for the parameters of interest. This package provides functions that implement the PS-integrated real-world evidence analysis methods such as Wang et al. (2019) <doi:10.1080/10543406.2019.1657133>, Wang et al. (2020) <doi:10.1080/10543406.2019.1684309>, and Chen et al. (2020) <doi:10.1080/10543406.2020.1730877>.

Calculate POTH for treatment hierarchies from frequentist and Bayesian network meta-analysis. POTH quantifies the certainty in a treatment hierarchy. Subset POTH, POTH residuals, and best k treatments POTH can also be calculated to improve interpretation of treatment hierarchies.

Generation of a chosen number of count, binary, ordinal, and continuous random variables, with specified correlations and marginal properties. The details of the method are explained in Demirtas (2012) <DOI:10.1002/sim.5362>.

Chromatin immunoprecipitation DNA sequencing results in genomic tracks that show enriched regions or peaks where proteins are bound. This package implements fast C code that computes the true and false positives with respect to a database of annotated region labels.

This package provides tools for Bayesian estimation of meta-analysis models that account for publications bias or p-hacking. For publication bias, this package implements a variant of the p-value based selection model of Hedges (1992) <doi:10.1214/ss/1177011364> with discrete selection probabilities. It also implements the mixture of truncated normals model for p-hacking described in Moss and De Bin (2019) <arXiv:1911.12445>.

Infer the genetic composition of individuals in terms of haplotype dosages for a haploblock, based on bi-allelic marker dosages, for any ploidy level. Reference: Voorrips and Tumino: PolyHaplotyper: haplotyping in polyploids based on bi-allelic marker dosage data. Submitted to BMC Bioinformatics (2021).

An implementation of a hybrid method of person-oriented method and perturbation on the model. Pompom is the initials of the two methods. The hybrid method will provide a multivariate intraindividual variability metric (iRAM). The person-oriented method used in this package refers to uSEM (unified structural equation modeling, see Kim et al., 2007, Gates et al., 2010 and Gates et al., 2012 for details). Perturbation on the model was conducted according to impulse response analysis introduced in Lutkepohl (2007). Kim, J., Zhu, W., Chang, L., Bentler, P. M., & Ernst, T. (2007) <doi:10.1002/hbm.20259>. Gates, K. M., Molenaar, P. C. M., Hillary, F. G., Ram, N., & Rovine, M. J. (2010) <doi:10.1016/j.neuroimage.2009.12.117>. Gates, K. M., & Molenaar, P. C. M. (2012) <doi:10.1016/j.neuroimage.2012.06.026>. Lutkepohl, H. (2007, ISBN:3540262393).

In the situation when multiple alternative treatments or interventions available, different population groups may respond differently to different treatments. This package implements a method that discovers the population subgroups in which a certain treatment has a better effect than the other alternative treatments. This is done by first estimating the treatment effect for a given treatment and its uncertainty by computing random forests, and the resulting model is summarized by a decision tree in which the probabilities that the given treatment is best for a given subgroup is shown in the corresponding terminal node of the tree.

This package provides tools for loading and processing passive acoustic data. Read in data that has been processed in Pamguard (<https://www.pamguard.org/>), apply a suite processing functions, and export data for reports or external modeling tools. Parameter calculations implement methods by Oswald et al (2007) <doi:10.1121/1.2743157>, Griffiths et al (2020) <doi:10.1121/10.0001229> and Baumann-Pickering et al (2010) <doi:10.1121/1.3479549>.

Estimate False Discovery Rates (FDRs) for importance metrics from random forest runs.

Compute detailed and aggregated performance spectrum for event data. The detailed performance spectrum describes the event data in terms of segments, where the performance of each segment is measured and plotted for any occurrences of this segment over time and can be classified, e.g., regarding the overall population. The aggregated performance spectrum visualises the amount of cases of particular performance over time. Denisov, V., Fahland, D., & van der Aalst, W. M. P. (2018) <doi:10.1007/978-3-319-98648-7_9>.