This package performs efficient and scalable glm best subset selection using a novel implementation of a branch and bound algorithm. To speed up the model fitting process, a range of optimization methods are implemented in RcppArmadillo'. Parallel computation is available using OpenMP'.

Executes BASIC programs from the 1970s, for historical and educational purposes. This enables famous examples of early machine learning, artificial intelligence, natural language processing, cellular automata, and so on, to be run in their original form.

Get z-scores, percentiles, absolute values, and percent of predicted of a reference cohort. Functionality requires installing the data packages adiposerefdata and musclerefdata'. For more information on the underlying research, please visit our website which also includes a graphical interface. The models and underlying data are described in Marquardt JP et al.(planned publication 2025; reserved doi 10.1097/RLI.0000000000001104), "Subcutaneous and Visceral adipose tissue Reference Values from Framingham Heart Study Thoracic and Abdominal CT", *Investigative Radiology* and Tonnesen PE et al. (2023), "Muscle Reference Values from Thoracic and Abdominal CT for Sarcopenia Assessment [column] The Framingham Heart Study", *Investigative Radiology*, <doi:10.1097/RLI.0000000000001012>.

This package provides a random forest variant block forest ('BlockForest') tailored to the prediction of binary, survival and continuous outcomes using block-structured covariate data, for example, clinical covariates plus measurements of a certain omics data type or multi-omics data, that is, data for which measurements of different types of omics data and/or clinical data for each patient exist. Examples of different omics data types include gene expression measurements, mutation data and copy number variation measurements. Block forest are presented in Hornung & Wright (2019). The package includes four other random forest variants for multi-omics data: RandomBlock', BlockVarSel', VarProb', and SplitWeights'. These were also considered in Hornung & Wright (2019), but performed worse than block forest in their comparison study based on 20 real multi-omics data sets. Therefore, we recommend to use block forest ('BlockForest') in applications. The other random forest variants can, however, be consulted for academic purposes, for example, in the context of further methodological developments. Reference: Hornung, R. & Wright, M. N. (2019) Block Forests: random forests for blocks of clinical and omics covariate data. BMC Bioinformatics 20:358. <doi:10.1186/s12859-019-2942-y>.

The BioTIME database was first published in 2018 and inspired ideas, questions, project and research article. To make it even more accessible, an R package was created. The BioTIMEr package provides tools designed to interact with the BioTIME database. The functions provided include the BioTIME recommended methods for preparing (gridding and rarefaction) time series data, a selection of standard biodiversity metrics (including species richness, numerical abundance and exponential Shannon) alongside examples on how to display change over time. It also includes a sample subset of both the query and meta data, the full versions of which are freely available on the BioTIME website <https://biotime.st-andrews.ac.uk/home.php>.

Derived from the work of Kruschke (2015, <ISBN:9780124058880>), the present package aims to provide a framework for conducting Bayesian analysis using Markov chain Monte Carlo (MCMC) sampling utilizing the Just Another Gibbs Sampler ('JAGS', Plummer, 2003, <https://mcmc-jags.sourceforge.io>). The initial version includes several modules for conducting Bayesian equivalents of chi-squared tests, analysis of variance (ANOVA), multiple (hierarchical) regression, softmax regression, and for fitting data (e.g., structural equation modeling).

These are miscellaneous functions for working with panel data, quantiles, and printing results. For panel data, the package includes functions for making a panel data balanced (that is, dropping missing individuals that have missing observations in any time period), converting id numbers to row numbers, and to treat repeated cross sections as panel data under the assumption of rank invariance. For quantiles, there are functions to make distribution functions from a set of data points (this is particularly useful when a distribution function is created in several steps), to combine distribution functions based on some external weights, and to invert distribution functions. Finally, there are several other miscellaneous functions for obtaining weighted means, weighted distribution functions, and weighted quantiles; to generate summary statistics and their differences for two groups; and to add or drop covariates from formulas.

This package provides functions for training extreme gradient boosting model using propensity score A-learning and weight-learning methods. For further details, see Liu et al. (2024) <doi:10.1093/bioinformatics/btae592>.

This package provides a new class of Bayesian meta-analysis models that incorporates a model for internal and external validity bias. In this way, it is possible to combine studies of diverse quality and different types. For example, we can combine the results of randomized control trials (RCTs) with the results of observational studies (OS).

This package implements the Bayesian Augmented Control (BAC, a.k.a. Bayesian historical data borrowing) method under clinical trial setting by calling Just Another Gibbs Sampler ('JAGS') software. In addition, the BACCT package evaluates user-specified decision rules by computing the type-I error/power, or probability of correct go/no-go decision at interim look. The evaluation can be presented numerically or graphically. Users need to have JAGS 4.0.0 or newer installed due to a compatibility issue with rjags package. Currently, the package implements the BAC method for binary outcome only. Support for continuous and survival endpoints will be added in future releases. We would like to thank AbbVie's Statistical Innovation group and Clinical Statistics group for their support in developing the BACCT package.

The kernelSmoothing() function allows you to square and smooth geolocated data. It calculates a classical kernel smoothing (conservative) or a geographically weighted median. There are four major call modes of the function. The first call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth) for a classical kernel smoothing and automatic grid. The second call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, quantiles) for a geographically weighted median and automatic grid. The third call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, centroids) for a classical kernel smoothing and user grid. The fourth call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, quantiles, centroids) for a geographically weighted median and user grid. Geographically weighted summary statistics : a framework for localised exploratory data analysis, C.Brunsdon & al., in Computers, Environment and Urban Systems C.Brunsdon & al. (2002) <doi:10.1016/S0198-9715(01)00009-6>, Statistical Analysis of Spatial and Spatio-Temporal Point Patterns, Third Edition, Diggle, pp. 83-86, (2003) <doi:10.1080/13658816.2014.937718>.

Querying, extracting, and processing large-scale network data from Neo4j databases using the Neo4j Bolt <https://neo4j.com/docs/bolt/current/bolt/> protocol. This interface supports efficient data retrieval, batch processing for large datasets, and seamless conversion of query results into R data frames, making it ideal for bioinformatics, computational biology, and other graph-based applications.

This package provides functionality to automatically detect groove locations via a Bayesian changepoint detection method to be used in the data preprocessing step of forensic bullet matching algorithms. The methods in this package are based on those in Stephens (1994) <doi:10.2307/2986119>. Bayesian changepoint detection will simply be an option in the function from the package bulletxtrctr which identifies the groove locations.

Supervised learning using Boltzmann Bayes model inference, which extends naive Bayes model to include interactions. Enables classification of data into multiple response groups based on a large number of discrete predictors that can take factor values of heterogeneous levels. Either pseudo-likelihood or mean field inference can be used with L2 regularization, cross-validation, and prediction on new data. <doi:10.18637/jss.v101.i05>.

Fits linear or generalized linear regression models using Bayesian global-local shrinkage prior hierarchies as described in Polson and Scott (2010) <doi:10.1093/acprof:oso/9780199694587.003.0017>. Provides an efficient implementation of ridge, lasso, horseshoe and horseshoe+ regression with logistic, Gaussian, Laplace, Student-t, Poisson or geometric distributed targets using the algorithms summarized in Makalic and Schmidt (2016) <doi:10.48550/arXiv.1611.06649>.

Computations for Bessel function for complex, real and partly mpfr (arbitrary precision) numbers; notably interfacing TOMS 644; approximations for large arguments, experiments, etc.

Two partially supervised mixture modeling methods: soft-label and belief-based modeling are implemented. For completeness, we equipped the package also with the functionality of unsupervised, semi- and fully supervised mixture modeling. The package can be applied also to selection of the best-fitting from a set of models with different component numbers or constraints on their structures. For detailed introduction see: Przemyslaw Biecek, Ewa Szczurek, Martin Vingron, Jerzy Tiuryn (2012), The R Package bgmm: Mixture Modeling with Uncertain Knowledge, Journal of Statistical Software <doi:10.18637/jss.v047.i03>.

Belief propagation methods in Bayesian Networks to propagate evidence through the network. The implementation of these methods are based on the article: Cowell, RG (2005). Local Propagation in Conditional Gaussian Bayesian Networks <https://www.jmlr.org/papers/v6/cowell05a.html>. For details please see Yu et. al. (2020) BayesNetBP: An R Package for Probabilistic Reasoning in Bayesian Networks <doi:10.18637/jss.v094.i03>. The optional cyjShiny package for running the Shiny app is available at <https://github.com/cytoscape/cyjShiny>. Please see the example in the documentation of runBayesNetApp function for installing cyjShiny package from GitHub.

Analyse single case analyses against a control group. Its purpose is to provide a flexible, with good power and low first type error approach that can manage at the same time controls and patient's data. The use of Bayesian statistics allows to test both the alternative and null hypothesis. Scandola, M., & Romano, D. (2020, August 3). <doi:10.31234/osf.io/sajdq> Scandola, M., & Romano, D. (2021). <doi:10.1016/j.neuropsychologia.2021.107834>.

Regression for data too large to fit in memory. This package functions exactly like the biglm package, but works with later versions of R.

This package implements a bootstrap-based heterogeneity test for standardized mean differences (d), Fisher-transformed Pearson's correlations (r), and natural-logarithm-transformed odds ratio (or) in meta-analysis studies. Depending on the presence of moderators, this Monte Carlo based test can be implemented in the random- or mixed-effects model. This package uses rma() function from the R package metafor to obtain parameter estimates and likelihoods, so installation of R package metafor is required. This approach refers to the studies of Anscombe (1956) <doi:10.2307/2332926>, Haldane (1940) <doi:10.2307/2332614>, Hedges (1981) <doi:10.3102/10769986006002107>, Hedges & Olkin (1985, ISBN:978-0123363800), Silagy, Lancaster, Stead, Mant, & Fowler (2004) <doi:10.1002/14651858.CD000146.pub2>, Viechtbauer (2010) <doi:10.18637/jss.v036.i03>, and Zuckerman (1994, ISBN:978-0521432009).

From R 4.5.0, the datasets package includes the penguins and penguins_raw data sets popularised in the palmerpenguins package. basepenguins takes files that use the palmerpenguins package and converts them to work with the versions from datasets ('R >= 4.5.0). It does this by removing calls to library(palmerpenguins) and making the necessary changes to column names. Additionally, it provides helper functions to define new files paths for saving the output and a directory of example files to experiment with.

This package provides a hodgepodge of hopefully helpful functions. Two of these perform shrinkage estimation: one using a simple weighted method where the user can specify the degree of shrinkage required, and one using James-Stein shrinkage estimation for the case of unequal variances.

Can be used to read and write a fwf with an accompanying Blaise datamodel. Blaise is the software suite built by Statistics Netherlands (CBS). It is essentially a way to write and collect surveys and perform statistical analysis on the data. It stores its data in fixed width format with an accompanying metadata file, this is the Blaise format. The package automatically interprets this metadata and reads the file into an R dataframe. When supplying a datamodel for writing, the dataframe will be automatically converted to that format and checked for compatibility. Supports dataframes, tibbles and LaF objects. For more information about Blaise', see <https://blaise.com/products/general-information>.