This package provides functionality for quality control processing and statistical analysis of mass spectrometry (MS) omics data, in particular proteomic (either at the peptide or the protein level), lipidomic, and metabolomic data, as well as RNA-seq based count data and nuclear magnetic resonance (NMR) data. This includes data transformation, specification of groups that are to be compared against each other, filtering of features and/or samples, data normalization, data summarization (correlation, PCA), and statistical comparisons between defined groups. Implements methods described in: Webb-Robertson et al. (2014) <doi:10.1074/mcp.M113.030932>. Webb-Robertson et al. (2011) <doi:10.1002/pmic.201100078>. Matzke et al. (2011) <doi:10.1093/bioinformatics/btr479>. Matzke et al. (2013) <doi:10.1002/pmic.201200269>. Polpitiya et al. (2008) <doi:10.1093/bioinformatics/btn217>. Webb-Robertson et al. (2010) <doi:10.1021/pr1005247>.

Generic interface for the PX-Web/PC-Axis API. The PX-Web/PC-Axis API is used by organizations such as Statistics Sweden and Statistics Finland to disseminate data. The R package can interact with all PX-Web/PC-Axis APIs to fetch information about the data hierarchy, extract metadata and extract and parse statistics to R data.frame format. PX-Web is a solution to disseminate PC-Axis data files in dynamic tables on the web. Since 2013 PX-Web contains an API to disseminate PC-Axis files.

This package implements an n-dimensional parameter space partitioning algorithm for evaluating the global behaviour of formal computational models as described by Pitt, Kim, Navarro and Myung (2006) <doi:10.1037/0033-295X.113.1.57>.

Defines a data structure for profiler data, and methods to read and write from the Rprof and pprof file formats.

Collection of pivotal algorithms for: relabelling the MCMC chains in order to undo the label switching problem in Bayesian mixture models; fitting sparse finite mixtures; initializing the centers of the classical k-means algorithm in order to obtain a better clustering solution. For further details see Egidi, Pappadà , Pauli and Torelli (2018b)<ISBN:9788891910233>.

Construct parser combinator functions, higher order functions that parse input. Construction of such parsers is transparent and easy. Their main application is the parsing of structured text files like those generated by laboratory instruments. Based on a paper by Hutton (1992) <doi:10.1017/S0956796800000411>.

The probaverse is a suite of packages designed to facilitate creating advanced statistical models through probability distributions. These packages work best when loaded together because they share a common design philosophy and focus on different aspects of developing statistical models. Inspired by the tidyverse package, the probaverse package makes it easy to load the entire suite of probaverse packages together.

Principal component of explained variance (PCEV) is a statistical tool for the analysis of a multivariate response vector. It is a dimension- reduction technique, similar to Principal component analysis (PCA), that seeks to maximize the proportion of variance (in the response vector) being explained by a set of covariates.

This package provides a modeling tool dedicated to biological network modeling (Bertrand and others 2020, <doi:10.1093/bioinformatics/btaa855>). It allows for single or joint modeling of, for instance, genes and proteins. It starts with the selection of the actors that will be the used in the reverse engineering upcoming step. An actor can be included in that selection based on its differential measurement (for instance gene expression or protein abundance) or on its time course profile. Wrappers for actors clustering functions and cluster analysis are provided. It also allows reverse engineering of biological networks taking into account the observed time course patterns of the actors. Many inference functions are provided and dedicated to get specific features for the inferred network such as sparsity, robust links, high confidence links or stable through resampling links. Some simulation and prediction tools are also available for cascade networks (Jung and others 2014, <doi:10.1093/bioinformatics/btt705>). Example of use with microarray or RNA-Seq data are provided.

This package implements projection pursuit forest algorithm for supervised classification.

Seq2seq time-feature analysis based on variational model, with a wide range of distributions available for the latent variable.

This package provides an R interface to the PCATS API <https://pcats.research.cchmc.org/api/__docs__/>, allowing R users to submit tasks and retrieve results.

Prepare pharmacokinetic/pharmacodynamic (PK/PD) data for PK/PD analyses. This package provides functions to standardize infusion and bolus dose data while linking it to drug level or concentration data.

An implementation of the "Design Analysis" proposed by Gelman and Carlin (2014) <doi:10.1177/1745691614551642>. It combines the evaluation of Power-Analysis with other inferential-risks as Type-M error (i.e. Magnitude) and Type-S error (i.e. Sign). See also Altoè et al. (2020) <doi:10.3389/fpsyg.2019.02893> and Bertoldo et al. (2020) <doi:10.31234/osf.io/q9f86>.

Binding models which are useful when analysing protein-ligand interactions by techniques such as Biolayer Interferometry (BLI) or Surface Plasmon Resonance (SPR). Naman B. Shah, Thomas M. Duncan (2014) <doi:10.3791/51383>. Hoang H. Nguyen et al. (2015) <doi:10.3390/s150510481>. After initial binding parameters are known, binding curves can be simulated and parameters can be varied. The models within this package may also be used to fit a curve to measured binding data using non-linear regression.

Given a SpatialPolygonsDataFrame and a set of populations for each polygon, compute a population density estimate based on Tobler's pycnophylactic interpolation algorithm. The result is a SpatialGridDataFrame. Methods are described in Tobler Waldo R. (1979) <doi:10.1080/01621459.1979.10481647>.

This package provides access to the latest Amazon Mechanical Turk ('MTurk') <https://www.mturk.com> Requester API (version 2017â 01â 17'), replacing the now deprecated MTurkR package.

This package implements permutation tests for any test statistic and randomization scheme and constructs associated confidence intervals as described in Glazer and Stark (2024) <doi:10.48550/arXiv.2405.05238>.

Multi-group (dynamical) structural equation models in combination with confirmatory network models from cross-sectional, time-series and panel data <doi:10.31234/osf.io/8ha93>. Allows for confirmatory testing and fit as well as exploratory model search.

This package provides a direct and flexible method for estimating an ICA model. This approach estimates the densities for each component directly via a tilted Gaussian. The tilt functions are estimated via a GAM Poisson model. Details can be found in "Elements of Statistical Learning (2nd Edition)" in Section 14.7.4.

Construct a principal surface that are two-dimensional surfaces that pass through the middle of a p-dimensional data set. They minimise the distance from the data points, and provide a nonlinear summary of data. The surfaces are nonparametric and their shape is suggested by the data. The formation of a surface is found using an iterative procedure which starts with a linear summary, typically with a principal component plane. Each successive iteration is a local average of the p-dimensional points, where an average is based on a projection of a point onto the nonlinear surface of the previous iteration. For more information on principal surfaces, see Ganey, R. (2019, "https://open.uct.ac.za/items/4e655d7d-d10c-481b-9ccc-801903aebfc8").

This package provides permutation methods for testing in high-dimensional linear models. The tests are often robust against heteroscedasticity and non-normality and usually perform well under anti-sparsity. See Hemerik, Thoresen and Finos (2021) <doi:10.1080/00949655.2020.1836183>.

This package provides the probability, distribution, and quantile functions and random number generator for the Poisson-Binomial distribution. This package relies on FFTW to implement the discrete Fourier transform, so that it is much faster than the existing implementation of the same algorithm in R.

Fit penalized splines mixed-effects models (a special case of additive models) for large longitudinal datasets. The package includes a psme() function that (1) relies on package mgcv for constructing population and subject smooth functions as penalized splines, (2) transforms the constructed additive model to a linear mixed-effects model, (3) exploits package lme4 for model estimation and (4) backtransforms the estimated linear mixed-effects model to the additive model for interpretation and visualization. See Pedersen et al. (2019) <doi:10.7717/peerj.6876> and Bates et al. (2015) <doi:10.18637/jss.v067.i01> for an introduction. Unlike the gamm() function in mgcv', the psme() function is fast and memory-efficient, able to handle datasets with millions of observations.