This package provides functions for solving systems of delay differential equations by interfacing with numerical routines written by Simon N. Wood, including contributions from Benjamin J. Cairns. These numerical routines first appeared in Simon Wood's solv95 program. This package includes a vignette and a complete user's guide. PBSddesolve originally appeared on CRAN under the name ddesolve'. That version is no longer supported. The current name emphasizes a close association with other PBS packages, particularly PBSmodelling'.

Efficient calculation of pseudo-ranks and (pseudo)-rank based test statistics. In case of equal sample sizes, pseudo-ranks and mid-ranks are equal. When used for inference mid-ranks may lead to paradoxical results. Pseudo-ranks are in general not affected by such a problem. See Happ et al. (2020, <doi:10.18637/jss.v095.c01>) for details.

Includes JavaScript files that allow plotly maps to render without an internet connection.

Supports propensity score weighting analysis of observational studies and randomized trials. Enables the estimation and inference of average causal effects with binary and multiple treatments using overlap weights (ATO), inverse probability of treatment weights (ATE), average treatment effect among the treated weights (ATT), matching weights (ATM) and entropy weights (ATEN), with and without propensity score trimming. These weights are members of the family of balancing weights introduced in Li, Morgan and Zaslavsky (2018) <doi:10.1080/01621459.2016.1260466> and Li and Li (2019) <doi:10.1214/19-AOAS1282>.

Levels and changes of productivity and profitability are measured with various indices. The package contains the multiplicatively complete Färe-Primont, Fisher, Hicks-Moorsteen, Laspeyres, Lowe, and Paasche indices, as well as the classic Malmquist productivity index. Färe-Primont and Lowe indices verify the transitivity property and can therefore be used for multilateral or multitemporal comparison. Fisher, Hicks-Moorsteen, Laspeyres, Malmquist, and Paasche indices are not transitive and are only to be used for binary comparison. All indices can also be decomposed into different components, providing insightful information on the sources of productivity and profitability changes. In the use of Malmquist productivity index, the technological change index can be further decomposed into bias technological change components. The package also allows to prohibit technological regression (negative technological change). In the case of the Fisher, Hicks-Moorsteen, Laspeyres, Paasche and the transitive Färe-Primont and Lowe indices, it is furthermore possible to rule out technological change. Deflated shadow prices can also be obtained. Besides, the package allows parallel computing as an option, depending on the user's computer configuration. All computations are carried out with the nonparametric Data Envelopment Analysis (DEA), and several assumptions regarding returns to scale are available. All DEA linear programs are implemented using lp_solve'.

An R implementation of the cross-platform, language-independent "port4me" algorithm (<https://github.com/HenrikBengtsson/port4me>), which (1) finds a free Transmission Control Protocol ('TCP') port in [1024,65535] that the user can open, (2) is designed to work in multi-user environments, (3), gives different users, different ports, (4) gives the user the same port over time with high probability, (5) gives different ports for different software tools, and (6) requires no configuration.

In short, this package is a locator for cool, refreshing beverages. It will find and return the nearest location where you can get a cold one.

Statistical methods for estimating preferential attachment and node fitness generative mechanisms in temporal complex networks are provided. Thong Pham et al. (2015) <doi:10.1371/journal.pone.0137796>. Thong Pham et al. (2016) <doi:10.1038/srep32558>. Thong Pham et al. (2020) <doi:10.18637/jss.v092.i03>. Thong Pham et al. (2021) <doi:10.1093/comnet/cnab024>.

Allows for highly flexible and generic function argument matching.

Implementation of the Partitioned Local Depth (PaLD) approach which provides a measure of local depth and the cohesion of a point to another which (together with a universal threshold for distinguishing strong and weak ties) may be used to reveal local and global structure in data, based on methods described in Berenhaut, Moore, and Melvin (2022) <doi:10.1073/pnas.2003634119>. No extraneous inputs, distributional assumptions, iterative procedures nor optimization criteria are employed. This package includes functions for computing local depths and cohesion as well as flexible functions for plotting community networks and displays of cohesion against distance.

Compute personal values scores from various questionnaires based on the theoretical constructs proposed by professor Shalom H. Schwartz. Designed for researchers and practitioners in psychology, sociology, and related fields, the package facilitates the quantification and visualization of different dimensions related to personal values from survey data. It incorporates the recommended statistical adjustment to enhance the accuracy and interpretation of the results.

This package provides a versatile R visualization package that empowers researchers with comprehensive visualization tools for seamlessly mapping peptides to protein sequences, identifying distinct domains and regions of interest, accentuating mutations, and highlighting post-translational modifications, all while enabling comparisons across diverse experimental conditions. Potential applications of PepMapViz include the visualization of cross-software mass spectrometry results at the peptide level for specific protein and domain details in a linearized format and post-translational modification coverage across different experimental conditions; unraveling insights into disease mechanisms. It also enables visualization of Major histocompatibility complex-presented peptide clusters in different antibody regions predicting immunogenicity in antibody drug development.

This package implements a partial linear semiparametric mixed-effects model (PLSMM) featuring a random intercept and applies a lasso penalty to both the fixed effects and the coefficients associated with the nonlinear function. The model also accommodates interactions between the nonlinear function and a grouping variable, allowing for the capture of group-specific nonlinearities. Nonlinear functions are modeled using a set of bases functions. Estimation is conducted using a penalized Expectation-Maximization algorithm, and the package offers flexibility in choosing between various information criteria for model selection. Post-selection inference is carried out using a debiasing method, while inference on the nonlinear functions employs a bootstrap approach.

This package provides functions to calculate commonly used public health statistics and their confidence intervals using methods approved for use in the production of Public Health England indicators such as those presented via Fingertips (<https://fingertips.phe.org.uk/>). It provides functions for the generation of proportions, crude rates, means, directly standardised rates, indirectly standardised rates, standardised mortality ratios, slope and relative index of inequality and life expectancy. Statistical methods are referenced in the following publications. Breslow NE, Day NE (1987) <doi:10.1002/sim.4780080614>. Dobson et al (1991) <doi:10.1002/sim.4780100317>. Armitage P, Berry G (2002) <doi:10.1002/9780470773666>. Wilson EB. (1927) <doi:10.1080/01621459.1927.10502953>. Altman DG et al (2000, ISBN: 978-0-727-91375-3). Chiang CL. (1968, ISBN: 978-0-882-75200-6). Newell C. (1994, ISBN: 978-0-898-62451-9). Eayres DP, Williams ES (2004) <doi:10.1136/jech.2003.009654>. Silcocks PBS et al (2001) <doi:10.1136/jech.55.1.38>. Low and Low (2004) <doi:10.1093/pubmed/fdh175>. Fingertips Public Health Technical Guide: <https://fingertips.phe.org.uk/profile/guidance/supporting-information/PH-methods/>.

This package provides functions to aid the identification of probable/possible duplicates in Plant Genetic Resources (PGR) collections using passport databases comprising of information records of each constituent sample. These include methods for cleaning the data, creation of a searchable Key Word in Context (KWIC) index of keywords associated with sample records and the identification of nearly identical records with similar information by fuzzy, phonetic and semantic matching of keywords.

Bindings for Poisson regression models for use with the parsnip package. Models include simple generalized linear models, Bayesian models, and zero-inflated Poisson models (Zeileis, Kleiber, and Jackman (2008) <doi:10.18637/jss.v027.i08>).

The plsdof package provides Degrees of Freedom estimates for Partial Least Squares (PLS) Regression. Model selection for PLS is based on various information criteria (aic, bic, gmdl) or on cross-validation. Estimates for the mean and covariance of the PLS regression coefficients are available. They allow the construction of approximate confidence intervals and the application of test procedures (Kramer and Sugiyama 2012 <doi:10.1198/jasa.2011.tm10107>). Further, cross-validation procedures for Ridge Regression and Principal Components Regression are available.

Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. The pharmacokinetics model explains that how the drug concentration change as the drug moves through the different compartments of the body. For pharmacokinetic modeling and analysis, it is essential to understand the basic pharmacokinetic parameters. All parameters are considered, but only some of parameters are used in the model. Therefore, we need to convert the estimated parameters to the other parameters after fitting the specific pharmacokinetic model. This package is developed to help this converting work. For more detailed explanation of pharmacokinetic parameters, see "Gabrielsson and Weiner" (2007), "ISBN-10: 9197651001"; "Benet and Zia-Amirhosseini" (1995) <DOI: 10.1177/019262339502300203>; "Mould and Upton" (2012) <DOI: 10.1038/psp.2012.4>; "Mould and Upton" (2013) <DOI: 10.1038/psp.2013.14>.

This package implements principal component analysis, orthogonal rotation and multiple factor analysis for a mixture of quantitative and qualitative variables.

This package provides functions to load Research Patient Data Registry ('RPDR') text queries from Partners Healthcare institutions into R. The package also provides helper functions to manipulate data and execute common procedures such as finding the closest radiological exams considering a given timepoint, or creating a DICOM header database from the downloaded images. All functionalities are parallelized for fast and efficient analyses.

Processing Chlorophyll Fluorescence & P700 Absorbance data. Four models are provided for the regression of Pi curves, which can be compared with each other in order to select the most suitable model for the data set. Control plots ensure the successful verification of each regression. Bundled output of alpha, ETRmax, Ik etc. enables fast and reliable further processing of the data.

This package provides functions and data sets for the text Probability and Statistics with R, Second Edition.

This package provides Partial least squares Regression and various regular, sparse or kernel, techniques for fitting Cox models in high dimensional settings <doi:10.1093/bioinformatics/btu660>, Bastien, P., Bertrand, F., Meyer N., Maumy-Bertrand, M. (2015), Deviance residuals-based sparse PLS and sparse kernel PLS regression for censored data, Bioinformatics, 31(3):397-404. Cross validation criteria were studied in <doi:10.48550/arXiv.1810.02962>, Bertrand, F., Bastien, Ph. and Maumy-Bertrand, M. (2018), Cross validating extensions of kernel, sparse or regular partial least squares regression models to censored data.

This package performs pathway enrichment analysis using a voting-based framework that integrates CpGâ gene regulatory information from expression quantitative trait methylation (eQTM) data. For a grid of top-ranked CpGs and filtering thresholds, gene sets are generated and refined using an entropy-based pruning strategy that balances information richness, stability, and probe bias correction. In particular, gene lists dominated by genes with disproportionately high numbers of CpG mappings are penalized to mitigate active probe biasâ a common artifact in methylation data analysis. Enrichment results across parameter combinations are then aggregated using a voting scheme, prioritizing pathways that are consistently recovered under diverse settings and robust to parameter perturbations.